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News > WebMD Health News > Long COVID | Medscape

Tiny, Menacing Microclots May


Explain Long COVID’s Symptoms
Claire Sibonney
December 08, 2022

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2 Share Add to Email Alerts including Boxed Warning
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Mounjaro is indicated as an adjunct to diet and exercise to
improve glycemic control in adults with type 2 diabetes
mellitus.

When Hannah Davis saw the first visual confirmation of long COVID in her Limitations of Use

blood – a firework-like display of fluorescent green dots against a black Recommendations


background – she was overwhelmed with an odd sense of relief. In early
November, she became one of the first U.S. long COVID patients to be Without Guidelines, Docs
Make Their Own Long COVID
tested for microscopic blood clots, catching up to South Africa, Germany, Protocols
the U.K., and other countries that are already experimenting with related
treatments.  HEP-COVID Clinical Trial
Results on the Prevention of
Blood Clots
“It was validating,” says Davis, who excitedly shared the images of her clots
on Twitter. “It's basically the first test specific to long COVID that is
promising and scientifically sound and incorporates research from other
post-viral illnesses.”

Davis donated her blood at Mount Sinai Hospital in New York City, with a
few other founding members of the Patient-Led Research Collaborative, all
of whom had been infected in the first wave of the pandemic and are still
sick nearly 3 years later. Seeing the pictures of their blood clots, Davis and
her fellow patients cried what she called happy tears. Then the reality of Full Prescribing Information

having those notorious blood clots sank in. Indication and Important Safety Information,
including Boxed Warning
Indication
Early in the COVID-19 pandemic, emergency room doctors and others Mounjaro is indicated as an adjunct to diet and exercise to
improve glycemic control in adults with type 2 diabetes
treating patients noticed the sickest produced excessive blood clots. The
clots clogged kidney dialysis machines, caused strokes, and killed
patients long after they left the hospital. Some long COVID researchers
have suspected smaller, less obvious blood clots may be causing many of
the puzzling symptoms reported by patients who have lasting effects of the
virus.

The theory is that these weird and persistent clots, called microclots, might
be blocking delicate blood vessels throughout the body, and stopping
oxygen from getting to where it needs to go, causing everything
from shortness of breath and organ damage to brain fog and debilitating
fatigue. But if all the havoc is being done inside these minuscule
clots, regular pathology tests won’t pick it up. A network of specialists is
now setting out to see if specialized tests can be accessible and if the clots
can be treated.
Clots Are Complicated

Blood clotting is an important and elaborate process that prevents


excessive bleeding. Normally, the body will dissolve blood clots on its own,
but in certain conditions, such as chronic fatigue syndrome (also known as
myalgic encephalomyelitis or ME/CFS), diabetes, Alzheimer’s, Parkinson’s,
and acute and long COVID, researchers have noticed that damage to
the blood vessel walls caused by inflammation can lead to abnormal
proteins and platelet activity. This leads to small, strange clots that can
block capillaries – the smallest blood vessels – from taking enough oxygen
to tissues throughout the body.

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Mounjaro is indicated as an adjunct to diet and exercise
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