Professional Documents
Culture Documents
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Department of Family Medicine, Clalit Health Services and Department of Geriatrics, Soroka University Medical Center and
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
IMAJ 2001;3:615±617
have been described in the literature, . Behavioral patterns that could lead to of these special characteristics can cause
ranging from the prevention of influenza beneficial or adverse effects on health irreversible damage, so knowledge of
to delay in admission to nursing homes. status. These health behaviors are risk these processes and their prevention
The vast majority of these objectives, factors rather than diseases or im- should be germane to geriatric practice.
however, can only be achieved by pairments. Evidence as to their im- An understanding of the clinical mani-
implementing multiple intervention stra- portance, or the reversibility of their festations of disease in the elderly is
based on the interacting concepts of diabetes, Parkinson's disease and os- These models are based on the principles
biological change, multiple pathology, teoarthritis easily lead to falls and of a multidisciplinary team approach
and social factors [5±7]. fractures. Drugs commonly used that (doctors, nurses, physiotherapists, occu-
The biological changes of aging affect can add to the risk of falling include pational therapists, social workers, psy-
every cell, organ and body system and diuretics or laxatives, beta-blockers, chologists, podiatrists, dentists,
their ability to function. Multiple pathol- anti-depressants and sedatives. Other dietitians, and others), continuous care
ogies in the elderly are characterized by causes of falls are eye pathology (catar- including acute care and rehabilitation,
the presence of several diseases in one acts, glaucoma), and common social and community services and long-term care.
person at the same time. Studies have environmental problems such as exces- The coordination of well-trained profes-
shown that people above the age of 65 sive or inadequate furniture, frayed sionals in these different service frame-
have three to six diseases, on the average carpets and inadequate lighting. works, both medical and social, should
[2]. In addition to the effect of biological In proper geriatric practice, the as- be implemented on a broad scale. In
and pathological conditions, social fac- sessment of functional loss and the aim Israel, generally, geriatric physicians
tors, such as loneliness, bereavement, of maintaining health ± not just the work in hospitals and do not take an
retirement, and poverty, play a major treatment of disease ± are emphasized. active part in community medicine,
role in determining the health status of Identifying people in the community neither in direct care nor as consultants.
the elderly. The clinical manifestations who are at high risk of losing their Recommended medical activities for
that result are often completely different ability to perform activities of daily which direct intervention and follow-up
from the symptomatology of similar living (loss of independence and auton- are warranted in the elderly include [14±
diseases in younger patients. These omy) should be a top priority. In this 17]:
multiple interacting processes can lead context the high risk elderly that should . Assessment of nutrition, physical
to the loss of ability to perform activities be targeted are [10]: activity and drug use (including
of daily living independently. . Those who live alone: they are prone over-the-counter medications)
Not all diseases or disabilities of the to loneliness, apathy and self-neglect. . Avoidance and discontinuation of
elderly are identified by physicians. One . Those who were recently bereaved: any unnecessary drugs
study showed that older adults attribute they are prone to depression, a first . Assessment of ability to perform
their functional decrements to ``old age'' step in the process of functional activities of daily living
[8] and therefore do not report them to deterioration. . Active check for sight and hearing
the physician at all. Conditions that are . Those with significant locomotor accuracy, appropriate teeth and den-
generally recognized are related mainly difficulties: they are in continuous tures
to the cardiovascular, respiratory and danger of falling, being injured and . Measurement of height, weight and
central nervous systems. In contrast, suffering subsequent additional phy- body mass index
there is a group of disabilities of which sical deterioration. . Annual measurement of blood pres-
doctors are less aware, especially those . Those with evidence of mental im- sure (in non-hypertensive patients)
associated with disease of the joints, feet pairment: early mental impairment is . Active search for signs of depression,
and urinary tract, and with mental illness not easily diagnosed and can only be mental deterioration, physical and
(especially dementia). Yet, these largely identified by appropriate screening. emotional abuse and neglect
unrecognized disabilities are of great . Those who were recently discharged . Search for a history of falls, and
significance for the affected individual. from the hospital. advise specifically about fall preven-
Locomotor disabilities are painful and Other high risk groups could be tion and exercise, driving, alcohol and
progressive and tend to restrict mobility. included in this list, such as the elderly cigarettes
Hence, they may readily lead to reduced living below the poverty level, those . Advise about heating in the winter
social activity, difficulty in shopping, above the age of 80, and the homebound . Search for urinary incontinence
and the danger of social isolation and and bedridden. The identification and . Mammography and colonoscopy are
loneliness with eventual apathy, depres- treatment of these groups requires dif- indicated for high risk persons, with
sion and the risk of malnutrition. ferent strategies, particularly screening annual check-up of occult blood in
Falls among the elderly are a good and case-finding [10,11]. stool until age 80
example of these interacting processes With a holistic approach to the care . Vaccines: influenza vaccine yearly,
[9]: biological changes due to aging that of the elderly, preventive activities can- diphtheria-tetanus vaccine every 10
affect the autonomic system include not be distinguished from the traditional years, and pneumovax every 6 years.
postural hypotension, disordered regula- practice of medicine. Thus, preventive Other conditions for which periodic
tion of body temperature, dysfunction of and curative care are intertwined in this assessment may be warranted [17] but
gastrointestinal motility, and dysfunc- age group. To achieve this goal effi- still need further research include: ane-
tion of bladder contraction. Other com- ciently, different models of geriatric mia, glaucoma, hyperglycemia, prostatic
mon medical conditions such as services have been developed [12,13]. and gynecological neoplasms, renal im-
pairment and tuberculosis. Conditions References LE, eds. Primary Care of the Elderly.
In summary, classical approaches to Improving the Health of Older People. Oxford: 12. Stuck A, Sin AL, Wielland GD, Adams J,
The World Health Organization, Oxford Uni- Rubenstein LZ. Comprehensive geriatric as-
prevention in the elderly aged 70±80
versity Press, 1990:316±37. sessment: a meta-analysis of controlled trials.
must be modified. Opportunities for
3. Lachs MS, Pillemer K. Abuse and neglect of Lancet 1993;342:1032.
primary prevention are scarce and the
elderly persons. N Engl J Med 1995;332:437±43.
13. Galinsky D. Geriatrics in the framework of
distinction between secondary and ter-
4. Cammer Paris BE, Meier DE, Goldstein T,
university based community medicine. Isr
tiary prevention obscured. The WHO Weiss M, Fein ED. Elder abuse and neglect:
J Med Sci 1987;23:136±8.
has proposed the maintenance of auton- how to recognize warning signs and intervene.
ing primary care physicians and nurses. Primary Care of the Elderly. A Practical
16. Zazove P, Mehr DR, Ruffin MT, Klinkman
Approach. Bristol: Wright, 1987:141.
Special attention should be paid to the
MS, Peggs JE, Davies TC. A criterion-based
7. Kasl SV, Berkman LF. Some psychosocial
elderly in the community who are at high review of preventive health care in the elderly.
influences on the health state of the elderly.
risk of losing their functional indepen- Part II. A geriatric health maintenance
In: McGraugh JL, Kiesler SB, eds. Ageing:
program. J Fam Pract 1992;34:320±47.
dence. The identification and treatment Biology and Behavior. New York: Academic
of these groups should be based on Press, 1981:345±85. 17. Magenheim MJ. Preventive Health Mainte-
models using the multidisciplinary team 8. Williamson JD. Characterization of older nance. In: Duthie E, Katz PR, eds. Practice of
adults who attribute functional decrements Geriatrics. 3rd edn. Philadelphia: W.B. Saun-
approach, and continuous care. Coordi-
to ``old age.'' J Am Geriatr Soc 1996;44(12): ders, 1998:115±29.
nating the efforts of well-trained profes-
1429±34.
sionals to provide adequate and relevant
9. Galinksy D. Falls in the elderly: a new
services will help in preventing the
challenge in medicine. Isr J Med Sci 1992; Correspondence: Dr. A. Biderman, P.O. Box
deterioration that threatens the elderly, 28:460±2. 90, Meitar 85025, Israel. Phone: (972-8) 647-
and in restoring their well being and self- 10. Williamson J. Screening, surveillance and case 5504, Fax: (972-8) 641-7314,
Tommy Trinder, English comedian (1909±89), on American troops in Britain during World War II
Capsule
Myocardin expression in the heart
The availability of large databases of expressed sequence tags through its physical association with another, more widely
and tissue-specific cDNA libraries has greatly facilitated the expressed, transcription factor called serum response factor
identification of novel factors regulating the development and (SRF). Studies in developing mice and Xenopus embryos
function of individual tissues and organs. The power of this revealed that myocardin is expressed exclusively in the
approach is illustrated by Wang et al. who used a bioinfor- myocardium after birth and is required for myocardial cell
matics-based screen to find a previously elusive transcription differentiation. It remains to be established whether myocar-
factor that selectively turns on gene expression in heart din participates in signaling pathways that are disrupted in
muscle. The new protein, designated myocardin, potently human heart disease.