Professional Documents
Culture Documents
Plant flavonoids
Intramural
Center for Cancer Research (https://ccr.cancer.gov)
The CCR includes approximately 250 internal NCI research groups in Frederick and
Bethesda.[19]
Extramural
Division of Cancer Biology
DCB oversees approximately 2000 grants per year in the areas of cancer cell
biology; cancer immunology, hematology, and etiology; DNA and chromosome
aberrations; structural biology and molecular applications; tumor biology and
microenvironment; and tumor metastasis.[21] "Special Research Programs" falling
under the aegis of the DCB include: Physical Sciences-Oncology Network, Cancer
Systems Biology Consortium, Oncology Models Forum, Barrett's Esophagus
Translational Research Network, New Approaches to Synthetic Lethality for Mutant
KRAS-Dependent Cancers, Molecular and Cellular Characterization of Screen-
Detected Lesions, Fusion Oncoproteins in Childhood Cancers, and Cancer Tissue
Engineering Collaborative.[22]
DCTD supports eight research programs: The Biometric Research Program, The
Cancer Diagnosis Program, The Cancer Imaging Program, The Cancer Therapy
Evaluation Program, The Developmental Therapeutics Program, The Radiation
Research Program, The Translational Research Program, and The Office of Cancer
Complementary and Alternative Medicine.[23]
DEA processes and supports the thousands of grant applications NCI receives each
year and compiles reports on the progress of research funded by the NCI's
programs.[24]
CCG was created in 2011 and is responsible for management of The Cancer
Genome Atlas and cancer genomics initiatives.
Programs
The NCI-designated Cancer Centers are one of the primary arms in the NCI's mission in supporting cancer
research. There are currently 71 so-designated centers; 12 clinical cancer centers, 52 comprehensive cancer
centers, and 7 basic laboratory cancer centers. NCI supports these centers with grant funding in the form of
P30 Cancer Center Support Grants to support shared research resources and interdisciplinary programs.
Additionally, faculty at the cancer centers receive approximately 75% of the grant funding awarded by the
NCI to individual investigators.[9][26]
The NCI cancer centers program was introduced in 1971 with 15 participating institutions.[27]
The National Clinical Trials Network (NCTN) was formed in 2014, from the Cooperative Group program
to modernize the existing system to support precision medicine clinical trials. With precision medicine,
many patients must be screened to determine eligibility for treatments in development.
Lead Academic Participating Sites (LAPS) were chosen at 30 academic institutions for their ability to
conduct clinical trials and screen a large number of participants and awarded grants to support the
infrastructure and administration required for clinical trials. Most LAPS grant recipients are also NCI-
designated cancer centers.[10] NCTN also stores surgical tissue from patients in a nationwide network of
tissue banks at various universities.
The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and
private-sector research communities worldwide to facilitate the discovery and development of new cancer
therapeutic agents.[28]
Under the label "Discovery & Development Services" several services are offered, among them the NCI-
60 human cancer cell line screen and the Molecular Target Program.[29]
In the Molecular Target Program thousands of molecular targets have been measured in the NCI panel of
60 human tumor cell lines. Measurements include protein levels, RNA measurements, mutation status and
enzyme activity levels.[30]
The evolution of strategies at the NCI illustrates the changes in screening that have resulted from advances
in cancer biology. The Developmental Therapeutics Program (DTP) operates a tiered anti-cancer
compound screening program with the goal of identifying novel chemical leads and biological mechanisms.
The DTP screen is a three phase screen which includes: an initial screen which first involves a single dose
cytotoxicity screen with the 60 cell line assay. Those passing certain thresholds are subjected to a 5 dose
screen of the same 60 cell-line panel to determine a more detailed picture of the biological activity. A
second phase screen establishes the maximum tolerable dosage and involves in vivo examination of tumor
regression using the hollow fiber assay. The third phase of the study is the human tumor xenograft
evaluation.
Active compounds are selected for testing based on several criteria: disease type specificity in the in vitro
assay, unique structure, potency, and demonstration of a unique pattern of cellular cytotoxicity or cytostasis,
indicating a unique mechanism of action or intracellular target.
A high correlation of cytotoxicity with compounds of known biological mechanism is often predictive of
the drugs mechanism of action and thus a tool to aid in the drug development and testing. It also tells if
there is any unique response of the drug which is not similar to any of the standard prototype compounds in
the NCI database.
Leadership
Portrait Director Tenure Notes
Roscoe Roy
August 1, 1943 – July 1, 1947
Spencer
Leonard
Served as the seventh Surgeon General
Andrew July 1, 1947 – April 6, 1948
of the United States from 1948 to 1956.
Scheele
John Roderick
May 15, 1948 – July 1, 1960
Heller
Carl Gwin
July 13, 1970 – May 5, 1972
Baker
Frank Joseph May 5, 1972 – November 1,
Rauscher, Jr. 1976
Notable people
Susan Shurin, senior adviser
Sudhir Srivastava, chief scientist at Cancer Biomarkers Research Group of the Division of
Cancer Prevention
See also
American Cancer Society Center
caBIG, the Cancer BioInformatics Grid, a National Cancer Institute (USA) initiative to link
cancer researchers and their data
Cancer Information Service (CIS)
European Organisation for Research and Treatment of Cancer (EORTC)
Journal of the National Cancer Institute
National Comprehensive Cancer Network
NCI-designated Cancer Center
General references
National Cancer Institute (https://web.archive.org/web/20100527085250/http://www.cancer.g
ov/aboutnci/director-announced?cid=B_ND) Retrieved 11 June 2010.
"NCI MISSION STATEMENT" (https://www.cancer.gov/aboutnci/overview/mission). National
Cancer Institute. Retrieved 18 August 2004.
"THE NATIONAL CANCER ACT OF 1971" (https://web.archive.org/web/20041018173821/h
ttp://www3.cancer.gov/legis/1971canc.html). National Cancer Institute. Retrieved 18 August
2004.
Developmental Therapeutics Program (DTP) (https://web.archive.org/web/2012062705101
1/http://dctd.cancer.gov/ProgramPages/dtp/default.htm)
External links
Official website (https://www.cancer.gov/)
NCI (https://www.usaspending.gov/federal_account/075-0849) account on
USAspending.gov
NCI Dictionaries (https://www.cancer.gov/publications/dictionaries): NCI Dictionary of
Cancer Terms (utilizing non-technical language) • NCI Dictionary of Genetics Terms (for
healthcare professionals) • NCI Drug Dictionary (includes links for potential clinical trials)
NCI (https://history.nih.gov/display/history/NCI) in A Short History of the National Institutes of
Health, an online exhibit by the Office of NIH History
Important Events in NCI History (https://www.nih.gov/about-nih/what-we-do/nih-almanac/nati
onal-cancer-institute-nci#events) from the NIH Almanac
Major NCI Milestones (https://www.cancer.gov/PublishedContent/Images/images/infographic
s/major-nci-milestones-enlarge.__v1100247949.gif) infographic