By *Zakivullah Yousetzai - 1k is also Called plasma membrame. - Premarily cell membrame is Composed of phosphelipids ama associated proteins. Cell membrome is basically double layye of molecules, so it is called "Lipid biloyye ** Actually a Phospholipid has ome folay & they Fay acid Emd- —As we Know thot there is Lot of umter outside of call membrome Ey inside of Cem membrome, ips means Eextracelleculay rvivewment is Aqyvous & the mnbracellecatay Environment is also Asuous; go call membrane Separoting extracelleculoy Envivormet bom ntraceleculon Environment: 5} —chang e/ange Pn channels hosphotipid Tepdr cated Chydrophitic) Fatty acid Chydvephobic) Polay Compounds always dissolve inte Polay Compounds, co Phospholipid has me polay Component this Component has some chavge so thats why this is wotey soluble end, the othey md has two Fatty acids, which ave mot wotey soluble. The poloy Component ef the awvolecule is coiled hydrophilic & the they exd which is mot woker soluble ave called hydrophobic ipid smo has: f Se Phra alee Bi tyne For more high quality medical notes contact with whatsapp:+93728888256when we talk about the = structure of membyame than the hydwphilic end is oviented outward of the amembyane amd hydrophobic end is oviented toward the twternal — Environment - As we know thot Cell membrane is double layve of phospholipids, so omethey layve is alse present but in opposite divection & the purpose of such orientation is thok Bf Folly acids ove mot going to disselve im water but problem is thot woter is present in beth sides of the cell, to awcid the wotey in ovtev loyre of membramt FA ave divected omen dom the water, go In ‘this wom Fatty acids Jused with tach other, amd water Loving emds ave divected towond the wakey. So, the Cove of membrame is made by Lipids go if there is substamce which is Lipid seluble , cam easily cross the membyome, the smalley ‘moleawoy useight Substamces Com also cress the smembrome. dy Gpid seluble : GVA senall amet woeigit] CES the cell membrane Those Compounds which ave highly charged ey which ove vex loge Cont divectly enter into cell, by — simple diffusion vim the. membyome there ave Special tyPe of protein made of tuultiple peptides chain, arranged in the membyame. in the center of this molecule theve is a Longitudinal tumnel CAilled bon usotey) > the loge woter goluble substamces can Pass toroug the funnel of this Channel: such Protein ave cotled channel: @® For more high quality medical notes contact with whatsapp:+93728888256Phospholipids which ore Present in ocutey leatlet ane slightly different Yrom wer leaflet They one asyrmatyical). Due to 3- reason: ® ovtev Leatlet: phospholioia-. cy Phosphat idyleholine ‘P olipids; 1c) Sphinjomyeline inney Leatlet Phospholipids; @ phosphatidyl Ethamolamine Gi) Phosphatidyl sevine (2) Proteins attached to outer lectlet is different Prom mer (3) ovtey Leoftet hos lot of Covbohydvates —atttached to iL, wey leaflet has mo Gybshydrote molecules: poor on OH Lo ROQ™~ Cholestevole ave present oH owe polar , coe amembrome , te : A b, Se thea cn & 08 : inteydated im b/w Attached outside. - : ou legs of pho spholipids. sp when Fatty acid owe uly ee a ave ‘relotively i ¢ Straight chai straight legs). If mot Yully saturated they bend ‘di iw theiy structure: Fluidity: Phospholipids ave not ‘Tiked, they ave “mobile they Keep on moving Lotevally & this Concept Is Coiled YUvidity Sof the mom brome: Suppose that, cel has synthesize hormones, For more high quality medical notes contact with whatsapp:+93728888256hormone molecule are Packed inte membrane bound vesicle. This vesicle ray Come amd use with smembrame & these substance ma r out: eg: B-cell of Pamcrease secrete insulin | whem insulin is going to veleose, vesicle will amove toward smembrane amd membrane of vesicle will Juse yall with cell membrane & where thea amake a puncture Point § imsulin will ge out amd due tb Poidity te puncture point will be Completely closed. This Process is Colled Exoey tosis. Endocytosis: During Endocytosis 0 piece of membrane has mnvaginated & tham pitch off ctit there is No hele im emembyame, as soon as it ‘move awa, phosphelipid will seal it Fludity is also important in membrome biogemesis Cmembren synthesis) - fF when cells ave initial small & divided, the For more high quality medical notes contact with whatsapp:+93728888256dovghtey cell ove small,” with the time cent Keep on growing | so its ameoms that they ~membyame should alse grow. How the membrane gow? cell symthesize mew Phospholipids amd Keep inserting tw the membrome, And b£ membyame ave Ywia \% accomudole the new molecule embarge ae surtace Qven. x & 2g ¥ Plidicity is tmportomt Fer: & ? W Exocytosis . G) Endocytosis oy Gi) Membrane biosynthesis rat 4, D We a * Factors that alter Fluidity ti) f tempevatuve ~_, t Wuidity Gi f cholesterole ~_, 4 Puidity (b, Legs ove thiytly held) Git) Unsoduvated FA» t Fluidity dv) Saturated FAA, 4 pividity Recepter <——| Im some port of cell membrane Phospholipids ave mare thightly packed: Thery Foilly acid Compenemt ave more sakvyoted & they ove mere Longer, ond this aves has high level of Cholesterole. In that area For more high quality medical notes contact with whatsapp:+93728888256Special type of protein present over there Called Ye ceptor. ec eptor Receptor, Receptor ave Special macromolecules which will bind with Specific substamce amd thon produce Modification in biole gical System, such molecule, ove Colled Yeceptor. specific substamce cam be hormones, meuretvansmitey, oy thok mm be dug. These veceptrs ave as Like door bell. » $f a substance is Lipid soluble & It Com ge inside the, Cell its veceptey will be presevt inside the cell. @if a hormone is very lavge oy Pola, tts veeeptey Should be on the Surtace. @ Receptor (on surtace) and theiy associated Proteins couted LIPId vaft. The associated Protein May be: Ci) tegyal Protein o8 Transmembrane protein Gi) Pevephyal proteins © For more high quality medical notes contact with whatsapp:+93728888256i ee Protein if eee LS 8685 i integra protein (tramsmembrone proteim) : 7 Pass throughot the amembrame athe, have Extracelleculay demin amd mivacelleculey dawin Gi) Pevephyal Proteins: > They ave sither Expressed on mntemal ev extemal svvtace. eta one nosey othached (non-covalently) to membrome , by chomging the Tonic Composition oy chamging the PH, the prephral proteins ave removed. > Momy of Perephyal Proteins present inside of mmembyame, ack as a cytoskeleton. + Sometime to ‘integral proteins (2 - Pass srecepter) msidety pevephvol proteins (2nd messenger) we Present. Channel o y corsa aire ; 15 Spex, 8 Inteqyat Proteim also work a5 wy on a channel, trom these water pote” oe Soluble substances Com Pass, ces it on gobs, 0%) ae For more high quality medical notes contact with whatsapp:+93728888256. : ; > carier Peake also integval py . Some protein tran Stormation 5 \f th bind with a substance, These Called Comey protein. Carver proteins ove very specific | gome corey ME substame, othey Cary other substam ce- Axe: aa : Theiy ove geome — Emzymes which ave Present within tne Cell membyame, 5, take one product & Convert tt te amothey prduct- om ee c+). hep in Linke py (this PY pe pass veer Factor! stabil 4 internal a Oren eee ; goined = called ae Ra Pevephval P ut y Function of Integral Protein. ss Cd) chammel Gil) Gaview Preterm _ © qi) Enzymes Gv) Linkey protein ge “et Ww) Recep tars For more high quality medical notes contact with whatsapp:+93728888256