Post synaptic membsane \yhave vecepter fer Chemical substance How action Potential Coming on the Meter Newmn , bringing electrical siqal , which ave Comina Yaom spinal the membiane Motes Newron, when they veach at ending, How the fake the stimulatory ontormatiion “rom the mewe endiny fp the Muscle ? Action potential hich ave Comima on the mater meuron guvtace, ak newe indin) Jead to : release ot chemical teurotromsamitter, amd teat chewical memntransmitter bind with -recepter om muscle amembrane, This Part of Muscle membyame is Called Motoy emd plate. Becavse this poxt ef Muscle membrame is connected with the Meter weurm && this Plate of membrane receive For more medical not: ntact with us through 0chemical emessone Yoon the mene ending and than this Plate will Convert the Chemical message inte electrical Message. Fivst alt imation — Comm ag electvical signal m the membrane Fram the axon Chemical guestance Come out. Than the cherniCal signal oy substance stimulate the mene moter end plate, and than at mater end Plate again electrical signals are Jemevated - Those electvical signal which ave generated owe here these ave action potential in the muscle membrane, which wilt even kuably lead to the stimulation of muscle Contractility mechanism: Nevrotvamsmitey; These ore special chemical substances which are present in the newe ending amd They one velensed fmm ane mewe ending te tromstey the signal to postsynaptic membrame- SYMOPS’ synaps is the meeting point of membrane of two cells where witormation rom one cell Com be tvamster to sthey cellamd 4 ak newromuscuow Junction a synopsis made Biy the mnewrornal memlsrome and emusculay emembyane , ond im this synars whermation 4s Passes through chemi Gt anewrotvansmnitter , thot is wl mewrrmusculan Junctions ove classi fied ag cheyical SyNapsis. a The chemical suostance at memromnusculay function is « Acetyl choline" @® For more medical notes contact with us throughvesicle: These vesicles ave synthesized in cet body. These amemieane bound vesicle with ver SPeciol type of Proteins which hap in Storage amd Captove of -nenvotvamemiter: why these vesicles ave SyM thesized in cell body? Because these vesicles have various type st protein in theiy membrane ond we Know that Proteins ore Samthesized Yao amRNA- mRNA OC framslated ints Proteins, se tts ameams DNA Shevid be bramscriped into mRNA & than amRNA Sheutd be tramstated te Protems 5. Yor this vesicle Proteims ave needed, Tham these Proteins must be Comin “rom some Place where ONA should be present, while mewe ending hove ms DNA, amd DNA owe present in cell bod of newnn thats why vesicles axe made in cell bed, So whatever protems owe Present ot ewe ending (There axe protems which help in Stroge, theve ave Protems, which hep in movement of vesicle, there awe Protein & enzymes which hep im synthesis of mewn tramsmiter , Theve ore i transmitter) al of these Protein help iv uptore of neu Sri! ‘) Proteins which ove present mm mere emdiny they ore Coming, Yom cell body: And Yon gradually very ver Slowey se unh Exoplasmic Tlow they ane Corvnivondy te mewe Indiv For more medical notes contact with us through @® ; [peta or zanterventer — [G) srnmase2 , when thse vesicles ove produced Wm the cell bodd, and The Coming clown — fru sxoplarmic low, they each heve , Basically these ane empty bags , they dont hove memrotvamsamitter (Acetyl choline)- From where acdylcholine Comes? Acetylcholine is a small mmole calor weight meweotramsmiter 3 All the synall amoleculay weight Mnewrmlram Smiteny OE synthesized im the mewe termimol: Acetal theline is symnthesized w the mnewe ending but the enzymes & different Pro teins which ave -sesuived Jor the synthesis, storage amd -velease dt acetylcholine all of them Cowimm) Yorn Cell body, but acedy\choline 45 Synthesized in the newe terminal. Newe ending is Semiautenomos uni rich con synthesize, stove amd release the meuotvansmitter. The meme ending hos Protems im its membrane amd these proteins ove called Choline Tyansporterss @ For more medical notes contact with us through [Medical Notes By Dr Zahirullah YousufzaiThese choline Tramsparters actively tramsport Choline Yrom Extracellecwlon {vid to mene 19) The choline is absovoed Frm GIT to ciyoulodony system & tham choline Come Ece ott ovey the bodys $6 where every me chal ey Trams SUCK mere endi Which ave cholinergic mexve emule owe damping into Eck they have these special tramspartey which awe hetpi mene to Concentrate that rom ECE to nn 2 t ntrocellocutey There ave Mitochndxta in newe oe which preduce acetyt Co-A. The choline &, acety| CoA Yoses by the hele of chaline aces) wamsfevaxe € mace Acetylcholine The acehalcholine ove tromsported te vesicle & Stoved. when electric Whormahion cy sone of depolarization comes here how it lead te Release of newmbransmiter By hom mawatransmiter bind will postsynaptic nnembrone (muscle end Platt) and how on the muscle and Plate electrical events start amd eventual amuscle vmemlsrane develope action potemtiol ? @ For more medical notes contact with us through | |; ry erer™ **Saacety| Choline on (exocytosis) ushen Action potential (wove dt depolarization Yellowed by wore 4) wvepolarization) Come te ‘newe emding, voltage gated notchowmel bring a bet of Not in. 1 RMP was —Jomv due to mot witlux it reach te +lomv, as soon ag mewe ts depolarized , nerve Emding activake tts vex) speciod depolarization Semsitive Cotchamnel open, Ca” Concentration is emove outside So there will be cot wilux- There ane cit-semsitive proteins ashich ore Present om the surface of vesicle, amd alse on nenve ememlrrane 2 s vren of bind te SYMPARUWN, the syniosin will chem Ble cit on loot sides vepell each othev, and tre synaptobvavin come & ‘Fuses with them, 5. the vesic@ulay membbrame Tuse with newe membrane Yelease oe ane) the Process st Exocytosis ©By simple diffusion mechamism acetylcholine diffuse oot rom Presynaptic aven to posteynaptic aren -The gop Bis Presyraptic &, fostynaptic is cated SY MAPPIC Clagt. QO Acetyichaline DY nicotine Nicotine & acetylcholine coir Cholinendi seus aes 2 > nicotine cholinergic they ave Giud Acetyicholine channel. For more medical notes contact with us through Medical Note: By Dr Zahirullah VousufeatAs sem acelyicholine bind to the chamneh 4» the channel opens amd allows Cations te -move- Ne ane -vich outside Sy Kare vich inside So Not move iM amd Kt yes out But beleoe the SPenmn4, of chammel , this muscle have RMP of -Bomv, RMP of membrane is more ear to — Sxyuilibvium potential of KY amd ik is Yor unary, from Zapililniues polembial of Not. Whenevey membrane 5 righty permeable te a spedtic lon, that jon will Wreve down its electrochemical Bradient amd fries to fake the amembrome potemtial fowavd its own equilibvium potential. Now No Gm w & Not tm es out so Not Ito will hy to toxe smembrame potential Towond ‘ts OWN ssyuili baum Potential ,amd Kt will ties be “maintain the smemlsrame patential As when aceLyltheline bind to nicotinic cholinergic veceptey , 1k allow bean wile dh Not &, sMlux KY, go the heayy witux ef Not foke the RMP of md Plate te depolani zation: iW more medical notes contact with us through ® el Nott By Dr Zahialah Yousuf —f there is emouyh acetylcholine preset and theve ave enough acety|choline chamnels & ‘Yeceptoy responsive = Tham engh Not oil Come in & dapolarize the membrane §, fake the membosame potential Tom RMP to Omv. \when resti rmemlsvame potentiol yom -gomv gone upte omy, this lacol Potenhat is produced at end Plate, so we simply called iL EWA Plate Potential. -fowv——»omv End Plate Potential EPf This end plate potential Yrsm -Bemv to Omv does not producedt y Contents, Ft only one syraptic Vesicle Lets suppose only one vesicle telease its Content, than small ree oF acety| choline will come, theve will be vex itle stimulation of Cholimevgic vecep tor, \ Not will Come in and in that cote wonbeoae Potential will Fluctuate only Ondywny, this small tyre ot fluduotion is called miniadwre newe ond pstentiol MEPP Bot im Fact healthy newomuseuloy transmit the meal dupolarizatin Produce se much indlux eh Co iw mene ending that emomy vesicles ave velaased Omd amamy mom NEPP we Prduced simultonesus amd they ove odded tegathey te produce Just End Plate Pstential. For more medical notes contact with us through | tnt ranean (Gorman