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Hint Sol Green Chem It 3
Hint Sol Green Chem It 3
a) Over the last 20 years, the use of supercritical fluid extraction research has increased in the field of
natural products. SFE methods have been used to harvest a large range of extracts from oils,
oleoresin, groups of bioactive compounds (alkaloids, terpenes, and phenolic) as well as single
compounds (α-humulene, lycopene and α-tocopherol). Solvent SCF offers a more selective and
environmentally sustainable alternative to traditional methods in natural products extraction; solvent
SCF-based extraction methods do not require organic solvents. In addition, solvent SFE may offer
improved selectively of bioactive extraction, while the use of ultrasonic-assisted
b) Sitagliptin—Sitagliptin, an antidiabetic compound, was successfully produced via biocatalytic
approach. It finds application in the treatment of type II diabe-tes and is sold under the trade name
“Januvia” by Merck. Boceprevir—This is a product of chiral amine synthesis and is marketed by
Merck under trade name Victrelis. It is used for the treatment of chronic hepatitis C infections.