Annexure-14-N, Page 3596 of 3873

Course Title: Chemistry of Organometallics

Course Code: CHEM5115
Credit Hours: 3(3+0)
Objectives:
Students should be able to understand:
 Organometallic compounds, their structure, bonding and reactivity.
 Industrial applications of organometallic compounds.
Course Outlines:
Synthesis, Bonding and Reactivity: Ionic and metal-carbon sigma bonding in
organometallic compounds, Factors which make metal-carbon sigma bond in transition
metal alkyls kinetically stable and unstable, Organolithium compounds, π-metal-ethylene
complexes, Acetylene complexes, π-Allyl complexes, Transition metal complexes with
conjugated dienes, Metallocenes, π-Arene complexes. Metal carbenes and metal carbynes.
Organometallic Reactions: Ligand dissociation and substitution, Oxidative coupling and
reductive extrusions, Nucleophilic displacement reactions, Insertion and de-insertion
reactions, Hydride elimination reactions, Abstraction.
Organometallic Catalysts: Hydroformylation, Hydrogenation by Wilkinson`s catalyst,
Olefin metathesis, Ziegler-Natta polymerizations, Metal-Hydrogen exchange reactions,
Hydrometallation, Oxometalation, Water gas reactions.
Recommended Books:
 Jordan, R.B.Reaction Mechanisms of Inorganic and Organometallic Systems, 2nd
Edition, 1998, Oxford University Press, New York.
 Atwood, J.D. Inorganic and Organometallic Reaction Mechanisms, 2ndEdition;
1997, Wiley-VCH, Inc.
 Crabtree, R.H. TheOrganometallic Chemistry of the Transition Metals, 5th
Edition;2011,John-Wiley and Sons, New Jersey.
 Powell, P. Principles of Organometallics Chemistry, 2nd Edition, 1998, Springer.
 Miessler, G.L., Fisher, P.J. and Tar, D.A. Inorganic Chemistry, 5th Edition;2013,
Prentice Hall.
 Douglas, B., McDaniel, D. and Alexander, J. Concepts and Models of Inorganic
Chemistry, 3rd Edition; 1994, John-Wiley & Sons, Inc.

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 Annexure-14-N, Page 3625 of 3873

Course Title: Organic Pharmaceutical Chemistry

Course Code: CHEM5125
Credit Hours: 3(3+0)
Objectives
After studying this course, students should be able to understand:
 Pharmacognosy, characterization & quality control analysis.
 Manufacturing of pharmaceutical dosage from (sustained release & conventional
drugs).
Course Outlines:
Phytopharmaceuticals: Pharmacognosy, Screening and extraction of active ingredients,
Characterization, Formulations standardization and quality control in pharmaceutical
drugs.
Drug Manufacturing: Antibiotics (Penicillins, Cephalosporins, Sulfonamides,
Macrolides, Quinolones), Anti-inflammatory drugs, Anti-allergy drugs, Analgesics,
Antipyretics, Sedatives and hypnotics.
Sustained Release Technology: Sustained release drug design and in-vitro studies of
drugs, Formulation of E.R. (Extended release) matrix tablets, Angle of repose, Loose and
tapped bulk density, Hausner ratio, Carr’s compressibility index, Polymers and
physiochemical parameters for extended release, (API’s) in tablet and syrup formulations.
Recommended Books:
 Donald C. Essentials of Pharmaceutical Chemistry, 4th Edition, 2012.
 Kleemann, J.E., Kutscher B.D. Reichert Pharmaceutical Substances, 4th Edition;
2001.
 Georg T.V., Thomas G., Fundamentals of Medicinal Chemistry, 1stEdition; 2003.
 Eric F., Wolfgang L. Chirality in Drug Research, 1st Edition, 2006.
 Ganellin C.R., Fischer J. Analogue-Based Drug Discovery, 1st Edition; 2006,
ISBN: 3-527-31257-9.

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 Annexure-14-N, Page 3626 of 3873

Course Title: Advanced Heterocyclic Chemistry

Course Code: CHEM5126
Credit Hours: 3(3+0)
Objectives:
Students should be able to:
 Understand the C-Hetero atom bond, chemistry of sulfur, phosphorus and silicon
compounds with emphasis on how it is formed and how it reacts.
 Apply the knowledge in teaching and research.
Course Outline:
Five Membered and Six Membered Rings: Typical reactivity, Synthesis and reactions
of pyrroles, Thiophenes, Furans, Pyridines, Quinolines, Isoquinolines, Indoles,
Benzo[b]thiophenes, Benzo[b]furans, Isoindoles, Benzo[c]thiophenes, Isobenzofurans.
Heterocycles Containing More than Two Hetero Atoms: Reactivity, Synthesis and
reactions of 1,3-azoles: Imidazoles, Thiazoles and oxazoles; 1,2-Azoles: Pyrazoles,
Isothiazoles, Isoxazoles, Isoazoles, Diazines, Pyridazines, Pyrimidines, and pyrazines.
Heterocycles Containing Ring-Junctions Nitrogen: Synthesis, Reactions and reactivity
of indolizines, Aza-indolizines, Quinolizinium and related systems, Pyrrolizine and related
systems, Cyclazines.
Organic Compounds Containing Sulphur, Phosphorus and Silicon: Chemistry of
sulfur, Phosphorus and silicon compounds including application in organic synthesis.
Recommended Books:
 Finar, I.L. Organic Chemistry, 6thEdition; 2009, Vol. I, Pearson Education,
Singapore, ISBN: 978-81-7758-542-1.
 Katritzky, A.R., Rees, C.W. Comprehensive Heterocyclic Chemistry: The
Structure, Reactions, Synthesis and Uses of Heterocyclic Compounds. 1996, Vol.
1-8, Pergamon Press: Oxford, ISBN: 978-08-096519-2.
 Joule, J.A., Mills, K. Heterocyclic Chemistry, 4thEdition; 2000, Blackwell
Publishing, ISBN: 978-14-0513-300-5.
 Scriven, E.F.V., Ramsden, C.A. Advances in Heterocyclic Chemistry. Wiley
Intrscience, 2016, Vol 118, pp 1-314, ISBN: 978-0-12-804696-8.
 Clayden, J., Geeves, N., Warren, S. Organic Chemistry. 2nd Edition; 2000, Oxford
University Press, ISBN: 978-0-19927-029-3.

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 Annexure-14-N, Page 3662 of 3873

Course Outline [Biochemistry (Table E)]

Course Title: Enzymes Kinetics

Course Code: CHEM5165

Credit Hours: 3(3+0)
Objectives:
Students should be able to understand:
 The different binding modes between enzyme, Substrate, Inhibitor and enzymes
pattern in different diseases of heart and liver.
 Pharmaceutical applications of enzymes in drug design process.
Course Outlines:
Enzyme Kineticsand Kinetic Analysis of Enzyme Inhibitors: The Michaelis-Menten
equation, Lineweaver-Burk plot, Positive and negative cooperatively, The steady-state
assumption, Derivation of velocity equations from models, Fitting of data by non-linear
regression. Dissociation constants of substrates and inhibitors, Inhibition patterns,
Competitive, Non-competitive and uncompetitive inhibition, Tight-binding inhibitors,
Slow tight-binding inhibitors, Enzyme pattern in diseases, Myocardial infarction, Cardial
troponins, Enzymes estimation in serum for diagnosis of muscle, Liver and cancer
enzymes.
Enzyme Inhibitors as Drugs: Mechanisms of drug resistance, Assays for kinetic analysis
of enzymes, Measurement of initial reaction velocities, Chirality and enzymes,Prochiral
substrates (aconitase), D-Form of human immunodeficiency virus (HIV) protease.
Regulation of Enzymes: Zymogens (chymotrypsinogen) and activation of latent
enzymes, Competitive inhibitors, Bovine pancreatic trypsin inhibitor (BPTI). Protein
conformation and regulation, Intrasteric control.Allosteric regulation, Glycogen
phosphorylase, Feedback and metabolic control, Enzyme degradation and
compartmentation of metabolic pathways.
Recommended Books:
 Alejandro, G.M. Enzyme Kinetics: A Modern Approach by Department of Food
Science, University of Guelph; John Wiley & Sons: 2003, ISBN: 0-471-15985-9.
 Arthur, R.S. Enzyme Kinetics: From Diastase to Multi-Enzyme Systems,
Cambridge University Press: 2009, ISBN: 978-051160843-8.
 Robert, A.A. Enzyme Kinetics: Rapid-Equilibrium Applications of Mathematica,
John Wiley & Sons: 2011; Vol. 53; ISBN: 978-0-470-63932-0.

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