R E S P I R ATO R Y I N F E C T I O N S T E S T I N G

Adenovirus
R-gene® US

Real-Time PCR for the Detection of

Adenoviruses in Respiratory Infections
 Adenovirus R-gene® US
Adenovirus R-gene® US Assay is a Real Time PCR in vitro diagnostic test
for the rapid and qualitative detection of Adenovirus viral DNA isolated and
purified from nasopharyngeal swab or nasopharyngeal wash/aspirate speci-
mens obtained from individuals exhibiting signs and symptoms of acute
© 2013 BIOMÉRIEUX, INC. • BIOMÉRIEUX, THE BLUE LOGO AND ARGENE ARE USED PENDING AND/OR REGISTERED TRADEMARKS BELONGING TO BIOMÉRIEUX SA OR ONE OF ITS SUBSIDIARIES. • PRINTED IN U.S.A. • MOL-014-13

respiratory infection. Easy assay set up and rapid turn around time
(< 1 h post extraction).

Reference Method
ADENOVIRUS COMPARISON RESULTS
Swab Specimens + - Total Comments
+ 44 43a 87 sensitivity 91.7% (80.0%-97.7%) 95% CI
Adenovirus R-gene® US
- 4b 1092 1096 specificity 96.2% (94.9%-97.2%) 95% CI
Total 48 1135 1183
a Among the 43 negative samples for rapid culture and positive for Adenovirus, 42 were confirmed as positive for adenovirus using Real Time PCR.
b Among the 4 positive samples for rapid culture and negative for Adenovirus, 1 was confirmed as positive for adenovirus using Real Time PCR.

Reference Method
ADENOVIRUS COMPARISON RESULTS
NP Wash/Aspirate Specimens + - Total Comments
+ 21 21a 42 sensitivity 100% (86.7%-100%) 95% CI
Adenovirus R-gene® US
- 0 351 351 specificity 94.4% (94.9%-97.2%) 95% CI
Total 21 372 393
a Among the 21 negative samples for rapid culture and positive for Adenovirus, 19 were confirmed as positive for adenovirus using Real Time PCR.

FDA cleared for extraction with the Adenovirus R-gene® US will enable the
NucliSENS® easyMAG® detection of all of the following serotypes:

Adenovirus A (AdV 12, 18, 31)

Adenovirus B (AdV 3, 7, 11, 14, 16, 21, 34, 35, 50)
Adenovirus C (AdV 1, 2, 5, 6)
Adenovirus D (AdV 8 to 10, 13, 15, 17, 19, 20, 22 to 30, 33, 36-39, 42-49, 51)
Adenovirus E (AdV 4)
Adenovirus F (AdV 40, 41)
Adenovirus G (AdV 52)
Unclassified (AdV 53 to 60)

bioMérieux, Inc.
100 Rodolphe Street
Durham, NC 27712
U.S.A.
Tel: (800) 682 2666
www.biomerieux.com/argene
Fax: (800) 968 9494

www.biomerieux-usa.com