PRACTICAL PHARMACEUTICAL

CHEMISTRY
 SYNTHESIS OF POTASSIUM
ACETATE

Ph/ Mohammed Mostafa Al-Mutawakel

 PRACTICAL SKILL OUTCOMES

• 1. To synthesize potassium acetate from acetic acid and potassium

carbonate.
• 2. To write systematic report.
• 3. To handle equipment's, take and record observations.
• 4. To contribute of group working.
• 5. To perform calculation for the experiment.
• 6. To acquire and development the self confidence.
 POTASSIUM ACETATE

- Chemical name: potassium acetate

- Structure:
- Molar mass : 98.15 g/ mol
- Density: 1.8 g/cm³.
- Characteristics: deliquescent white
crystalline solid with melting point at
292°C. Insoluble in organic solvents like
ether, but soluble in both alcohol,
ammonia, and water.
- Pharmacological use: Hypokalemia ,
diuretic, diabetic ketoacidosis.
 SAFETY PRECAUTION:-

• Wear the lab coat and eye glasses.

• Do not swallow, smell or touch any chemicals.
• Keep The volatile substance away from the flame.
• Take the corrosive material carefully.
• Be aware when you use Bunsen burner.
 INSTRUMENTS

• Bunsen burner , tripod ( • Balance

iron ) • Cylinder
• Flask or beaker 2 (50-100 • Test tube holder ,
ml) chemical spoon,
• Oven • brushes
• Empty bottles and label • Evaporating dish.
 MATERIALS

• Acetic acid
• Potassium carbonate
• Purified water
 PRINCIPLE

 Potassium acetate synthesized by:-

The reaction for the equivalent quantity from acetic acid and potassium
carbonate
 The reaction happened as follow:-
2 CH3 COOH + K2CO3 -------- 2 CH3 COOK + H2O + CO2
2 (mole) of + 1 (mole) of ------- 2 (mole) of
Acetic acid potassium carbonate potassium acetate
 PROCEDURE

1-Suspend 5g potassium carbonate.

2. Add 6 ml of acetic acid .
3. Stir (or shake) the mixture vigorously and warm on a water bath to about 50-60c , for
about 30 min.
4. Cool the flask under tap water.
5.Evaporate the mixture of reaction till to produce crystals on the wall of evaporating
dish.
6.Dry the obtained product in (30-40) C by (oven) until produced a dry crystalline
powder.
7. Weight the result quantity of CH3COOK.
 ON THE DRY PRODUCT C ARRY OUT THE
FOLLOWING:

 Weigh the dry compound (actual yield).

 Determine the melting point.
 Label the product and submit it your demonstrator.
The label should include:
Product name, actual yield theoretical yield, % yield, melting point and your
name.