Platelet growth factor VS biomimetic peptides in antiaging therapies

In recent years we have witnessed an amazing development of the antiaging techniques

in their several approaches for Aesthetic Medicine: fillers contain more active
substances; electro-aesthetics has expanded the offer on cutting edge techniques with
great results (radiofrequencies, electroporation, etc.), nutricosmetics progresses with
active principles of great antioxidant power (resveratrol, idebenone…), and there is
another cutting age technique under research: with its several interpretations, it consists
of inoculating into the patient autologous growth factors coming from his/hers own
platelet.

Autologous growth factors obtention technique is not complicated. We draw blood from
the patient, it is centrifuged, added to a catalyser and, as a result, a serum rich in growth
factors coming from own platelet is obtained. This serum will subsequently be
inoculated into the donor in the area of interest by means of infiltration or classic
mesotherapy.

Nevertheless, not intending to undermine the technique, much less its results, which in
some cases can be astonishing, I cannot help wondering, in the interest of the rigour all
medical action requires: are we really inoculation?, Are all the components of the
inoculated serum perfectly identified?, Do we know all quantities and percentages?, Can
we establish a dose-response curve, as it is established in Pharmacology? If any side
effects, which of the several inoculated peptides should be made accountable?

The pharmaceutic industry has answered to several of these questions with a new
generation of biomimetic peptides. Obtained through bioengineering techniques, they
are exact replica of the serum content obtained from platelet. They are not a complete
copy of the aminoacid sequence, as they are smaller in size, but are made exclusively of
the active section of the corresponding peptides. These biomimetic peptides do not pose
sensitisation risks, they penetrate skin perfectly and they are well defined biological
actions.

Biomimetic peptides act exclusively in skin tissue throughout receptors that behave as
cell mechanisms antagonists and agonists, modulating, controlling and regulating the
biochemical functions of the tissue.

Some examples of the biomimetic peptides that we count on for our therapeutic action
in Aesthetic Medicine are:

Hexapeptide-8
Similar to the neuromuscular N-terminal, it effectively locks neurotransmissors release,
thus decreasing muscle contraction. Is an alternative to botulinum toxin, as it acts
differently on the same mechanism.

Tripeptide-38

Stimulates dermal matrix and dermo-epidermal juncture synthesis (collagen I, III and IV,
fibronectin, hyaluronic acid and laminin 5): great antiaging effect.

Decapeptide-15

Clarifying and skin whitening. Sunblock. Evens skin tone. Prevents photoaging. Inhibits
melanin synthesis through the inhibition of tyrosinase expression.

Copper Tripeptide-1

Slows down hair loss. Helps strengthen hair by stimulating follicle and increasing its
growth and thickness. Stimulates scalp microcirculation.

Apigening + Biotinoyl Tripeptide-1

Hair follicle structural protector and restorer. Specific for alopecia. Increases peri-
follicle microcirculation. Slows down follicle atrophy and aging.

The major benefits of biomimetic peptides are that they are quantifiable, and they are
perfectly defined and identified. All of them are supported by in vivo and in vitro
efficacy studies that prove their action tackling the organs where we intend to act. We
can perfectly establish a dose-response curse and, therefore, manage prescription doses.
If any side effects, the accountable peptide is perfectly identified. Finally, no
manipulation is needed for their availability and use.

In my opinion, they fully meet all requirements that all medical actions must meet in
accordance with Pharmacology and, as they offer astonishing results that can be easily
compared to the results obtained from platelet, I allow myself to recommend them in
our regular antiaging treatments.

Dr. Carlos Aznar Sánchez MD

Medical board number: 7.406
Master in Aesthetic Medicine by L’Union International de Médecine Esthétique (1991)
General Manager of Simildiet Laboratorios