Professional Documents
Culture Documents
Congenital Abnormalities in The Infant of A Mother With Diabetes
Congenital Abnormalities in The Infant of A Mother With Diabetes
PRACTICE GAP
Diabetes mellitus rates are on the rise in the world. Many people who live
with diabetes are not aware of the diagnosis, including women of
childbearing age. Clinicians should be aware of the current knowledge of
the congenital abnormalities associated with maternal diabetes and be able
to identify mothers at risk of having offspring with these congenital defects.
ABSTRACT
Diabetes mellitus is among the most common chronic diseases worldwide.
Infants of diabetic mothers are at increased risk of having congenital
abnormalities. Tremendous progress has been achieved in the pregnancy
care of diabetic women; however, the risk of birth defects associated with AUTHOR DISCLOSURES Dr Kokhanov
maternal diabetes still exists. These anomalies might arise in many organs has disclosed no financial relationships
relevant to this article. This commentary
and systems of the developing fetus. Many mechanisms have been does not contain a discussion of an
implicated in the teratogenicity of maternal diabetes and it is critical to unapproved/investigative use of a
achieve good glycemic control before conception in women with diabetes. commercial product/device.
Neonatal clinicians must be able to identify patients at risk and recognize
the signs of diabetic embryopathy. This article presents a review of ABBREVIATIONS
congenital anomalies associated with maternal diabetes. AGE advanced glycation end
products
CRS caudal regression syndrome
DM diabetes mellitus
INTRODUCTION GDM gestational diabetes mellitus
Diabetes mellitus (DM) is among the most common chronic diseases affecting OAVD oculo-auriculo-vertebral
disorder
humans. (1) There are many different forms of diabetes, with differing etiologies
ROS reactive oxygen species
and clinical manifestations, with the common feature among them being VSD ventricular septal defect
e320 NeoReviews
e322 NeoReviews
e324 NeoReviews
e326 NeoReviews