Joseph Feher,

7.4 - Tubular Reabsorption and Secretion,

Editor(s): Joseph Feher,
Quantitative Human Physiology (Second Edition),
Academic Press,
2017,
Pages 719-729,
ISBN 9780128008836,
https://doi.org/10.1016/B978-0-12-800883-6.00072-0.
(https://www.sciencedirect.com/science/article/pii/B9780128008836000720)
Abstract: This chapter begins with comparing the filtered load of materials with
the amount excreted and shows that in some cases all of the filtered load is
reabsorbed, and in others it is added to by secretion. It introduces renal
titration and considers the titration of inulin, glucose, phosphate, and PAH. It
defines the transport maximum for either reabsorption or secretion and shows how
the interpretation of the clearance depends on the renal handling of the material.
It shows how the endogenous creatinine clearance approximates the GFR. This chapter
then discusses the TF/P ratio. The TF/P ratio for inulin marks the reabsorption of
water because inulin is filtered but not reabsorbed or secreted. The double ratio
(TF/P)x/(TF/P)inulin marks reabsorption or filtration processes. The rest of the
chapter discusses the mechanisms of reabsorption of glucose, amino acids,
phosphate, bicarbonate, water, salt, urea, and proteins.
Keywords: Filtered load; GFR; sieving coefficient; renal titration; inulin; renal
threshold; transport maximum; splay; saturation kinetics; morphologic
heterogeneity; diabetes mellitus; glucosuria; polydipsia; clearance; PAH; para-
amino hippuric acid; creatinine; endogenous creatinine clearance; micropuncture;
proximal convoluted tubule; SGLT1; Na,K-ATPase; GLUT; GLUT1; GLUT2; secondary
active transport; facilitated diffusion; cotransporters; phosphate; bicarbonate;
urea transporters; aquaporins; AQP1; ASP7; endocytosis