gas exchange the process of oxygen uptake from the environment and carbon dioxide release to the environment by living organisms take place on the respiratory surface of the respiratory structure Respiratory structure is adjusted to maximise the rate of gas exchange between living organisms and their environments. Insects Spiracles small pores through which air enters and leaves through the tracheal system 10 pairs of spiracles on the thorax and abdomen of an insect Each spiracle has valves which control the openinng and closing the spiracle Trachea A network of air tubes which open to the outside through spiracles Supported by rings of chitin to prevent it from collapsing. Tracheoles fine tubes with thin and moist walls which end at muscle cell Respiratory surfaces for exchange of gas surrounded by fluid to facilitate the diffusion of gases. exchange of gases occurs between tracheoles and muscle cells. The large number of tracheoles provides a very large surface area for gas exchange. When muscle cell relax, body fluids diffuse into the tracheoles and air in the tracheoles dissolves oxygen moves into the cells in the body. This will speed up the simple diffusion process of oxygen to cells. Carbon dioxide released during respiration is diffused out from the cells, followinng the gradient of carbon dioxide from the cells into tracheoles, then the trachea and finally into the environment through the spiracles cells→trachea→spiracle Respiratory structure: Tracheal systems consists of spiracles, tracheae and tracheoles pathway of air through the tracheal system is spiracle →trachea→tracheole→body cells grasshopper have air sacs to pump air into and out of the tracheal system when the insect is active Respiratory mechanism of the tracheal system Gas exchannge in their tracheal system happens through simple diffusion for smaller insects Exhalation呼气 involves contraction of abdominal muscles to compress压缩 the abdomen腹部 for larger insects Volume of the abdominal cavity down ; Air pressure up During inhalation, the abdominal muscles relax and the volume returns to normal. Air pressure down then higher atmospheric pressure pushes the air into the tracheal system through the open spiracles. Air sacs filled with air are deflated 放气 to push air through the trachea,when insects are physically active. A circulatory system循环系统 is not needed to transport respiratory gases to cells in the body of insects. Fish Multicellular aquatic animals that breath through the gills. Gills Most fish have four gills Protected by the operculum鳃盖 on each side of the pharynx咽 Respiratory structure of fish Gill arch A bony skeletonn which support the gills Two lines of filaments on each arch arranged in a 'V' shape Gill rakers that are located on the gill arches function to filter sand from the water so prevent injury to the gill lamellae Gill filaments Mutiple thin and flat projections called gill lamellae on both sides, the upper surface and below it. The presence of many filaments and lamellae provides a large surface area for gas exchange. The thin epithelial layer that coats the filament and lamellae shortens the distance and increase the rate of oxygen diffusion into and carbon dioxide out of the blood capillaries. (facilitated 促进diffusion of gases ) Supplied by a network of blood capillaries to ease (easy) transportation of respiratory gases to the gas exchange surface. Inhalation Mouth opens, then the floor of buccal cavity口腔 is lowered and operculum bulges 凸起 outwards to the sides to increase volume and reduce air pressure within the buccal cavity 口腔内 外界的高水压使鳃盖开口关闭 water is pushed into the buccal cavity due to high pressure. Exhalation Mouth closes, then the buccal cavity floor ascends上升 and operculum moves inwards to reduce the volume and increase water pressure within the buccal cavity. The high water pressure inside the buccal cavity pushes water through the filament and outside via the opening of the operculum. Gaseous Exchange at the Respiratory Surface of Gill Lamellae Countercurrent flow of water and blood over the gill filaments in order to maximise the rate of oxygen diffusion from water into the blood capillaries. Ensures that diffusion takes place on the entire (all) surface area of the lamellae and maximises the oxygen intake. When water that is rich in dissolved oxygen will sucked in吸收 and flows through the lamellae, oxygen is diffused扩散 following its partial pressure gradient innto the blood capilaries to be transported to the cell bodies. Carbon dioxide from the blood capillaries is diffused out following its partial pressure gradient into the atmosphere. The water that has flowed through the respiratory surface of the lamellae is forced out when the operculum opens. Frogs Amphibians两栖动物 Respiratory structures of frogs : Skin, Lungs and lining 黏膜of the mouth On land : Skin & Lunngs In water: Skin Only a small amount of ges exchange happens through the lining of the mouth Oxygen is diffused through the membrane and moisth throat喉咙 into the blood capillary network beneath it. Carbon dioxide is diffused into the blood capillaries in the mouth and released through the nostrils. Adaptation适应of frog skin and mechanism of gas exchange Skin mucous gland 皮肤黏液腺:release mucus to ensure that frog's skin is always moist to dissolve respiratory gases. Thin and permeable透水 skin: helps in increasing the rate or diffusion of respiratory gases. Dissolved oxygen in surrounding water is diffused through the moist skin into the blood capillaries followinng the concentration gradient of oxygen. Carbon dioxide is diffused from the blood capillaries through the skin and released into the environment following the concentration gradient of carbon dioxide. Adaptation of the lungs of a frog for gas exchange Lungs = pair of air sac organs that connected to its mouth through an opening called glottis that can be opened and closed The walls of lungs are thin and moist are the respiratory surface of gas exchange. The walls of the lungs also have a network of blood capillaries underneath them Oxygen dissolves into the moist lungs before being diffused following the partial pressure gradient of oxygen through the lung walls into the blood capillaries.氧气溶 解到潮湿的肺部,然后根据氧分压梯度通过肺壁扩散到毛细血管中。 In exchange, carbon dioxide is diffused following partial pressure gradient from the blood capillaries and into the lungs to be excreted via exhalation. The blood capillary network transports respiratory gases to and from the cell bodies through the blood circulatory system. Gaseous Exchange within the mouth The upward and downward movement of the floor of the buccopharyngeal also enables gas exchange to take place through the thin and moist membrane layer present in the mouth. There are a network of blood capillaries underneath the membrane layer responsible for transporting respiratory gases to the cell bodies. Respiratory Mechanism of the Lungs of a Frog Inhalation Mouth and glottis close, the floor of the buccopharyngeal cavity mouves downwards to increase the volume of the mouth cavity and to reduce the air pressure. The surrounding air that is higher atmospheric pressure will flow in through the nostril into the mouth. Pumping air into the lungs To channel 输送 air into the lungs, the nostril close, the glottis open and the floor of buccopharyngeal cavity moves upwards to reduce the volume of the mouth cavity as well as increase the air pressure which then pushes the air from the mouth cavity into the lungs. Gas exchange take places in the lungs. Exhalation Glottis opens while the lung and abdominal muscles contract to reduce the volume of the lungs and increase their pressure. The air in the lungs is forced out through the glottis into the mouth adn then out through the nostrils. The contraction of the muscle of lungs is helped by the elasticity of the lungs. Human Breathing mechanism Inhalation The external intercostal muscles contract while the internal intercostal muscles relax Then the ribcage moves upwards and outwards The diaphragm muscles contract and the diaphragm moves downwards to become flat and horizontal. The volume of the thorax cavity increases and the pressure of the thorax cavity decreases. The higher atmospheric pressure from outside forces air into the lungs. Exhalation The external intercostal muscles relax while the internal intercostal muscles contract. This action causes the ribcage to move downwards and inwards. At the same time, the diaphragm muscles relax and the diaphragm curves upwards to form a dome. The volume of the thorax cavity reduces and the pressure of the thorax cavity increases. Air is pushed out of the lungs. Gaseous Exchange in Humans Gas diffusion depends on the partial difference between two areas Gas diffuses from an area where its partial pressure is higher to where its partial pressure is lower. 高去低 Blood from capillaries surrounding the alveoli carries low partial pressure of oxygen and high partial pressure of carbon dioxide. Oxygen diffuses from alveoli to blood capillaries following the partial pressure gradient. Carbon dioxide from blood capillaries to alveoli following the partial pressure gradient. Transport of respiratory gases from the lungs to the tissues Oxygen is diffused from the alveoli (high) into the blood capillaries (low) and binds with haemoglobin in the red blood cells (erythrocytes) to form oxyhaemoglobin. Each haemoglobin has four subunits of heme, and each has one iron ion (II) to bind with four oxygen molecules Hb (haemoglobin) + 4O 2→<-Hb (O2)4 Cell bodies have low partial pressure of oxygen because oxygen is used up during metabolism When oxyhaemoglobin reaches the cell bodies, it breaks down into haemoglobin and oxygen, therefore increasing the partial pressure of oxygen within the blood capillaries Oxygen will then be diffused from the blood capillaries into the cell bodies following the partial pressure gradient. Active cell bodies carry out metabolism using oxygen and releasing carbon dioxide Cell bodies have low partial pressure of oxygen and high partial pressure of carbon dioxide compared to blood capillaries Oxygen will be diffused following the partial pressure gradient from the blood capillaries into the cell bodies Carbon dioxide diffuses following the partial pressure gradient from the cell bodies and into the blood capillaries and then is transported back to the lungs to be eliminated through exhalation Transported of Carbon dioxide in the blood circulatory system Three ways: Bicarbonate ions(70%) Carbaminohaemoglobin (23%) Dissolved and carried as carbonic acid H2CO3(7%) Transported of carbon dioxide from body cells to tissue capillaries Carbon dioxide released by the body cells binds with water in the erythrocyte to form carbonic acid The carbonic anhydrase enzyme碳酸酐酶 in erythrocytes catalyses催化 this reaction Carbonic acid will break down into bicarbonate ions and hydrogen ion Then bicarbonate ion diffuses into the blood plasma and is carried to the lungs Transport of carbon dioxide from lung capillaries to the alveolus When the bicarbonate ion in blood plasma reaches the lung capillaries, it diffuses back into the erythrocyte The bicarbonate ion combines again with a hydrogen ion to form carbonic acid Carbonic acid then breaks down into carbon dioxide and water Carbon dioxide diffuses through the lung capillaries into the alveolus and is expelled during exhalation. Health issues related to the human respiratory system WHO defines chronic obstructive pulmonary disease COPD 慢性阻塞性肺疾病 as a lung disease characterized by blockage of the airways that disrupts normal respiration. COPD includes Asthma, Chronic bronchitis, Emphysema气肿 Asthma Cause chronic inflammation慢性炎症 of the airways (支气管&细支气管) Lifelong disease Prolonged cough, shortness of breath and wheezing 气喘 triggered by irritant and allergens 由刺激物和过敏原引发 Effect The walls of the airway become swollen and inflamed. Mucus excretion will increase and the airway muscles will contract, narrowing the lumen of the airway The effort to breathe through the narrow and congested airway becomes difficult and produces a wheezing sound The congestion and blockage of the bronchioles causes reduced oxygen to the alveoli causing other respiratory problems such as hypoxemia (low level of oxygen) and can damage other organs in the body An airway that is constantly congested and inflamed will eventually injure the lungs Emphysema Involves the damage to alveoli causing difficulty in breathing Emphysema happens when the alveoli walls are damaged, collapse and combine with adjacent alveoli to form larger air sacs symptom: dyspnea 呼吸困难 Exposure of lungs to irritants cause damage to the elastic alveoli walls and elastic fibres in the bronchiole tubes Effects: Damage to the alveoli walls prevents gas exchange between the respiratory surface and air within the alveoli The walls between the adjacent alveoli that collapse reduces the number of individual alveoli and form larger alveoli that will reduce the total surface area of respiration Alveoli walls that lose their elasticity cause difficulties in exhalation Damage to the elastic fibres within the walls of the bronchiole tubes will destroy the airways and trap air into the large alveoli at the end Chronic bronchitis Inflammation of the bronchiole tubes symptoms prolonged cough with excessive production of mucus within the bronchiole tubes for a long period of time Tight chest Difficulty in breathing Wheezing coughing with sputum痰 runny and blocked nose sore throat喉咙痛 lethargy嗜睡 Cause by repeated inflammation of the bronchiole tubes by irritants 刺激物and allergens Effects Inflammation and mucus production narrows the lumen of the bronchus, therefore blocking the airway to the lungs and from the lungs, causes the patient difficulty in breathing and hypoxemia 低氧血症 Inflammation injures the cilia on the bronchiole lining and exposes the patient to bacterial and viral infection