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YIJOM-4649; No of Pages 13

Int. J. Oral Maxillofac. Surg. 2019; xxx: xxx–xxx


https://doi.org/10.1016/j.ijom.2021.02.012, available online at https://www.sciencedirect.com

A new classification of J. S. Brown, A. Khan, S. Wareing,


A. G. Schache
Liverpool Head and Neck Centre, Aintree

mandibular fractures University Hospital NHS Foundation Trust,


Liverpool, UK

J. S. Brown, A. Khan, S. Wareing, A. G. Schache: A new classification of mandibular


fractures. Int. J. Oral Maxillofac. Surg. 2019; xxx: xxx–xxx. ã 2021 Published by
Elsevier Inc. on behalf of International Association of Oral and Maxillofacial
Surgeons.

Abstract. There is no accepted method of reporting mandibular fracture that reflects


incidence, treatment and outcome for individual cases. As most series include
anatomical site only for all fractures, the aim was to establish a new method to report
fractures based on a systematic review of the literature and an internal audit. The
classification proposed is: Class I; condyle, II; angle, IIc; II + condyle, III; body/
symphysis, IIIc; III + condyle, IV; multiple fractures not including condyle, IVc;
IV + condyle, V; bilateral condyle  other fracture(s). A total of 10,971 adult and
914 paediatric cases were analyzed through systematic review, and 833 from the
regional audit. Only 32% (14/44) of reported series could be reclassified which,
when added to the audit data, showed Class IV was most common (29%), with
similar proportions of Class III, Class IIIc and Class II (18–23%). External
validation (literature review) in terms of treatment and outcome was non-
informative, but the internal validation (audit) demonstrated an increasing
requirement for adding maxillomandibular fixation (MMF) to open reduction and Keywords: Mandible; Wounds and injuries;
internal fixation (ORIF) as class increased. The heterogeneity of data reporting Incidence; Classification; Systematic review.
found in the systematic review confirms the need for a classification such as this,
likely to enhance comparison of varying management protocols. Accepted for publication

The fractured mandible is a common facial injuries and the risk of displacement based on number of fractures occurring in an indi-
injury and yet there is no generally accepted the muscle pull on the fragments.2–4 vidual patient. This ignores any combina-
format or classification into which the frac- The main therapeutic contention tion of the fractures which occurred and
tures can be placed indicating their inci- reported was with regards to the manage- how that may influence treatment and
dence, management and outcome or risk ment of condylar, sub-condylar and con- outcome. In some series the number of
of complication. Initial reading of the stan- dylar head (diacapitular)5 fractures and patients is not stated,11,12 whilst in others a
dard text in Maxillofacial Surgery1 does not whether these should be treated open or distinction is made between the single and
recommend a format for reporting a series of closed.5–7 Also contended was the man- multiple fractures, with a clear indication
fractures, which is surprising for such a agement of the angle fracture; whether to of the site of the single fractures,13 yet
common injury frequently requiring surgical use one or two plates,8,9 and whether plate only limited data on those with multiple
intervention. Review of all previously pro- placement should be via a buccal or injuries.13,14
posed classifications highlights their descrip- intraoral approach.10 The lack of a viable and useable method
tive nature; relying on the anatomical At present, the anatomical location of to classify and report these fractures as
position of the fracture and then including the fractures is most commonly reported, they occur in an individual patient has
simple and compound, associated soft tissue but there is no indication of the type and meant that no consensus exists with

0901-5027/000001+013 ã 2021 Published by Elsevier Inc. on behalf of International Association of Oral and Maxillofacial Surgeons.

Please cite this article in press as: Brown JS, et al. A new classification of mandibular fractures, Int J Oral Maxillofac Surg (2021),
https://doi.org/10.1016/j.ijom.2021.02.012
YIJOM-4649; No of Pages 13

2 Brown et al.

regards to incidence, treatment or compli- comparable method of fracture documen- criteria based on site of fracture (exclud-
cations. We propose a novel classification tation. The search included series reported ing other sites); (3) small case reports and
and aim to assess its capability to describe after 1990; a date after which the method series reporting (<21 cases); (4) other
increasing complexity of presentation and of open reduction and internal fixation topics from the PubMed search were ex-
management. It is our objective to propose (ORIF) was generally considered to have cluded as not relevant such as orthognathic
a new method of recording mandibular become universally accepted and applied surgery and distraction series.
fractures capable of ascribing increasing for mandibular fractures. Having examined the titles and
complexity of presentation and manage- The PubMed database was searched abstracts, 2143 papers were excluded
ment and outcome, through a systematic with the key words ‘mandible’ and and a total of 91 full papers made up of
review of the literature and our own expe- ‘fracture’ in either the title or the abstract. the 19 additional records identified
rience, with a planned audit. With this data This yielded a total of 2259 publications through cross-referencing and the 72
we hope to confirm the value of such a and the inclusion and exclusion criteria are downloaded from the PubMed search for
proposal, use the data to suggest the cur- as follows. Inclusion criteria: (1) retro- full reading and assessment (Fig. 1). After
rent classification and through internal and spective mandibular series with no exclu- due analysis, we were able to include 30
external validation assess its quality and sions of a site; (2) prospective series were adult and five paediatric series with data
potential value. included as long as all sites of the mandi- that could be assessed through the site of
ble were being reported on or treated; (3) the fractures (Table 1 11–40 and Table 2 41–
45
papers including a new proposal for clas- ). There were 14 adult and three paedi-
Method sification; (4) isolated mandibular injury. atric series reported with sufficient data for
A systematic search of the literature was Exclusion criteria are numbered in Fig. 1 them to be classified into the new proposal
undertaken to examine the methods used but we also excluded those papers in the (Table 3 46–59 and Table 4 60–62). The
to report mandibular fracture series, and to search that were clearly non-contributory search was carried out to establish primary
utilize these data to derive a classification as follows: (1) series including other max- outcomes which were the incidence of
that would ensure a more accurate and illofacial injuries; (2) series with exclusion each fracture, multiple fractures, site of

Full text arcles excluded with reasons


(n=39)

Studies included (n=52)

Fig. 1. Flow diagram of the systematic review through the PubMed database using the key words ‘mandible’ and ‘fracture’ in the title or abstract
after 1990.

Please cite this article in press as: Brown JS, et al. A new classification of mandibular fractures, Int J Oral Maxillofac Surg (2021),
https://doi.org/10.1016/j.ijom.2021.02.012
YIJOM-4649; No of Pages 13

A new classification of mandibular fractures 3

mandibular fracture and the number of demonstrating a similar incidence of the because displacement and/or instability
patients. Treatment and complications/ anatomical site of the fractures to the adult are more likely and ORIF a standard treat-
outcome were analyzed including fre- series. Tables 3 and 4 include 14 adult46–59 ment. Class IV is a multiple fracture but
quency of return to the operating room and three paediatric60–62 series in which not involving either condyle (Fig. 2).
under general anaesthesia (GA) within 90 there was sufficient detail to be able to re- These cases are common and often require
days. Secondary outcomes were the meth- classify the fractures as proposed. Includ- ORIF at both sites. In recognition of the
od of treatment and other outcome criteria ed in Table 3 is the summary data of the frequency of condylar fractures occurring
such as malocclusion and infection rates. regional audit with more detailed presen- as part of multiple fractures, Class IIc, IIIc
Quality assessment of the included stud- tation of this data in Table 5, also classi- and IVc were added as separate classes.
ies was based on the Newcastle–Ottawa fied as proposed. Assessment of quality The relevance of the condylar element in
Scale (NOS) for cohort studies.63 The and applicability of included studies uti- these double fractures is illustrated by
assessment is based on the following cri- lizing the Newcastle–Ottawa scale,63 is Ellis64 who suggests deciding on ORIF
teria. (1) Selectability (five points): (a) reported in Table 6. Using this system of the condylar fracture per-operatively
truly or broadly representative; (b) includ- adds credibility to the method and we have based on the mandibular movement and
ing all patients attending with fractured made some adjustments related to the occlusion once the angle, body, or sym-
mandibles; (c) no other maxillofacial in- specific reasons for this review. A score physeal fracture has been fixed. It was
juries; (d) secure attainment of data; (e) has been added for each publication to aid considered important to place bilateral
prospective study. (2) Comparability comparison of the contributions made. fractures of the condyles into a separate
(three points): (a) classification system class (V), due to the complexity of this
for mandibular fractures utilized in addi- form of injury, the controversy over its
Justification for proposed classification
tion to anatomical site; (b) data able to be management, and the reported poor out-
groups (Table 7)
classified into the current proposal; (c) comes.6,64
treatment recorded. (3) Outcome (two A condyle fracture including condylar
points): (a) adequate follow-up method head or subcondylar site (Fig. 2) repre-
Incidence
utilized; (b) complications recorded. sented 24% (3961/16,238) of adult frac-
The proposed classification was deter- tures reporting anatomical site only (Table A comparative classification performance
mined following analysis of the mandible 1), compared with 8% (305/3710) for between internal (regional audit) and ex-
fracture series from the systematic review isolated fractured condyles in the classifi- ternal (systematic review) validation cases
(Tables 1–4), and the approved audit of able group (Table 3). The paediatric is reported in Table 3. Having analyzed the
adult patients with an isolated fractured results report a condyle involved in the 14 studies46–59 that provided sufficient
mandible treated under GA at the Head & injury in 36% (465/1285, Table 2) com- detail to be classified as proposed, and
Neck Centre Liverpool, Aintree Universi- pared with 25% (49/195, Table 4) when adding the data from the regional audit,
ty Hospital (also referred to as the Region- isolated. Similarly, for an angle fracture we can now report that the most common
al audit) from July 3, 2016 to December occurring as either an isolated or com- fracture involves two sites of the mandible
31, 2019 (Table 5). The aim was to utilize bined fracture in 31% (5029/16,238) of excluding the condyle [Class IV, 29%
increasing Classification grade as an indi- adults (Table 1) but in 19% (694/3710) as (1096/3710)], followed by the anterior
cator of increasing fracture complexity an isolated fracture (Table 3). Paediatric or horizontal part of the mandible [Class
and to indicate potential treatment, and angle fractures occurring as either isolated III, 23% (854/3710)]. The most common
risk of complication. or combined was reported in 24% (312/ multiple fracture (2 sites) involving a
Having established a putative classifi- 1285, Table 2) compared with only 9% single condyle is Class IIIc with 18% (650/
cation from published cohorts, it was pos- (18/195, Table 4) as an isolated injury. 3710), which is a similar incidence to the
sible to validate the proposal with Combining body and symphysis fractures classic angle fracture [Class II, 19% (694/
adjustments as appropriate, through the reveal this part of the mandible is fractured 3710)].
current internal audit data. Once this pro- in 45% (7256/16,238) of adults (Table 1) A comparison of the incidence of clas-
cess was complete, and informed by the compared with only 23% (854/3710) aris- sifiable adult fractures in the literature and
incidence, treatment and complications ing as an isolated injury (Table 3). In the the regional audit showed comparable
demonstrated in the internal validation paediatric series, any fracture of the body results. Both reported Class IV as the most
(audit data), the published data from the or parasymphysis occurred in 40% (508/ common fracture; 26% (751/2877) in the
systematic review was analyzed to provide 1285, Table 2) compared with 29% (57/ literature and 38% (318/833) in the audit
external validation. 195) as an isolated injury (Table 4). of practice. Class III was more common in
Angle fractures (Class II) were separat- the literature at 25% (742/2877) compared
ed from the body and symphysis site as a with 13% (112/833) in the regional audit.
Results
fracture in this site is relatively common The results were similar for Class II with
Following analysis of 255 papers, 52 se- (Tables 1–4) and there was some contro- 18% (522/2877) from the literature com-
ries were included (presented in Tables 1– versy over the best way to manage this pared with 21% (172/833) from the audit
4). Table 1 includes those 30 papers11–41 fracture alluded to above.8–10 Ramus and and Class IIIc with 17% (498/2877) vs.
reporting adult mandibular series but with- coronoid fractures are included in this 18% (152/833), respectively.
out any indication as to the fracture pattern class, as they are few in number and are The number of isolated condyle adult
for multiply-injured patients. In some unlikely to contribute to any change in fractures (Class I) was 9.4% (270/2877) in
cases, the number of patients with single proposed treatment. In a similar way we the literature compared with 4.2% (35/
or multiple fractures was stated as shown, combined body, parasymphysis and sym- 833) in the regional audit (Table 3). An
but how those fractures were distributed physis into Class III (45%, 7256/16,238, aggregation of any mandibular fracture
between cases was not discernible. Table 2 Table 1) which are fractures anterior to the involving the condyle was found in 30%
shows the five paediatric reports,41–45 angles in the horizontal part of the jaw, (862/2877) of cases in the literature and

Please cite this article in press as: Brown JS, et al. A new classification of mandibular fractures, Int J Oral Maxillofac Surg (2021),
https://doi.org/10.1016/j.ijom.2021.02.012
4

YIJOM-4649; No of Pages 13
Table 1. Results of systematic review of the literature for adult series classified by anatomical site of fracture only.
https://doi.org/10.1016/j.ijom.2021.02.012
Please cite this article in press as: Brown JS, et al. A new classification of mandibular fractures, Int J Oral Maxillofac Surg (2021),

Angle Symphysis

Brown et al.
Ramus para Total Total patients Patients 2 Total Treatment (Rx) Complications
Author Year Condyle Coronoid Body symphysis fractures single fracture fractures (%) patients (%) (%) Type of study/comment
15
Adi M. 1990 165 158 166 121 610 178 200 378 Co 72 (19) 55/ NR R (9 years) audit
(76) single 13
(18) double 4
(5.6) triple
Closed 296 (78)
ORIF 10 (2.6)
Hall F.C.16 1991 21 44 81 25 171 68 48 116 Co 0 Non-U2 (4.3) R (3 years) Treated patients
Cl 74 (64)
ORIF 42 (36)
Edwards T.J.17 1994 99 194 81 116 491 164 160 324 NR NR R (3 years) Aetiology
Valentino J.18 1994 113 107 69 143 432 NR NR 246 NA Inf 4 (1.6) R (5 years) ORIF treatment
Non-U 4 (1.6)
Terris D.J.19 1994 32 74 19 51 176 70 42 112 Cl 37 (33) Re-op 16 (14) R (4 years) on treatment
ORIF 75 (67)
Vartanian J.20 2000 5 10 11 14 40 9 14 23 NA 0 R using bone screw fixation
Boole J.J.R.21 2001 716 1266 392 620 2994 1655 689 2344 NR NR P database (18 years) audit
Wilson I.F.22 2001 16 28 9 20 73 NR NR 42 Co 10 (24) ORIF NR R OPG and CT compared
32 (76)
David L.R.23 2003 12 13 2 8 35 NR NR 25 Cl 13 (52) Minor R comparing delayed and
ORIF 12 (48) immediate Rx
Lamphier J.24 2003 101 196 146 145 588 NR NR 358 Cl 112 (31) Non-U 26 R (4 years) comparing open
ORIF 246 (69) (7.3) and closed Rx
Sakr K.25 2006 142 183 157 221 703 NR NR 509 Cl 170 (33) NR R (9 years) Pattern of injury
ORIF 339 (67)
Simsek S.26 2007 287 356 313 325 1281 568 257 825 NR NR R (9 years) USA and
Turkish cities compared
Adayemu W.L.27 2008 50 121 137 135 443 175 139 314 Co 12 (3.8) Inf 12 (2.7) Mal R (6–8 years) Management
Cl 261 (83) 12 (2.7) Non-U 8 in a developing country
ORIF 41 (13) (1.8)
Czerwinski M.28 2008 75 88 42 95 300 72 109 181 NR NR R (5 years) Aetiology
Lee K.H.29 2008 358 552 221 326 1457 590 405 995* Co 361 (36), Cl NR P database (11 years)
65 (6.5)
ORIF 569 (57)
de Matos F.P.30 2010 57 49 50 45 201 NR NR 126 Co 17 (13) Inf 10 (5) R (3.4 years) Aetiology and
Cl 0 management
ORIF 109 (87)
Martins M.M.S.31 2011 33 29 22 59 143 50 45 95 NR NR R (1.8 years) Aetiology
Ramadhan A.32 2014 176 93 42 95 406 NR NR 266 NR NR R audit (10 years)
Boffano P.33 2015 590 387 207 307 1491 NR NR 997 Cl 125 (13) Re-op 8 (0.5) Inf P database comparing 2
ORIF 872 (87) 12 (0.8) centres (10 years) all
treated)
@
Tay A.B.11 2015 16 32 29 46 123 NR NR 81 Co 1 (1.3) AOB 1 (0.8) P Inferior alveolar nerve
Cl 27 (22) Non-U 1 (0.8) outcome
ORIF 95 (77)
YIJOM-4649; No of Pages 13

A new classification of mandibular fractures 5

maxillomandibular fixation; NA, not applicable; Non-U, non-union; NR, not reported; OPG, orthopantomogram; ORIF, open reduction and usually plated; P, prospective; PR, plate removal; R,
AOB, anterior open bite; Closed, MMF or external pin fixation; Co, conservative, soft diet and close review; CT, computerized tomography scan; Inf, infection; Mal, malocclusion; MMF,
R (3yrs) audit for incidence
R audit of operated fractures

Re-op 4 (2.5) for R audit of surgically treated

R (4 years) Audit of ORIF


28% (231/833) in the audit (Table 1). Less

F/P 1.45 (14,947/10,289)


R (3 years) (MMF) after

R (10 years) Edentulous


common fractures were similarly distrib-

R Use of repositioning
and pattern of injury
R audit (3.4 years)
uted in both the literature and the regional
audit; class IIc at 1.0% (30/2877) vs. 1.9%
R audit (3 years)

R audit (5 years)

cases (6 years)
(16/833), Class IVc at 1.3% (36/2877) vs.
1.7% (14/833) and Class V, 0.98% (28/
(5 years)

2877) vs. 1.7% (14/833), respectively.

forceps
ORIF.
The results from those series reporting

cases
paediatric fractures demonstrated con-
trasting findings to the adult literature in
that Class I occurred in 25% (49/195) of
Re-op 29 (14)

Re-op 8 (3.2)
cases compared with 4.2–9.4% in the
PR 68 (16)

adults (Table 4), and the most common


injury was Class III at 29% (57/195) com-
pared with 13–25% in adults. Class IV was
NR

NR

NR

NR

NR

NR
PR
less common for paediatric cases with
14% (27/195) compared with 26–38% in

1954/3671 (53)
ORIF 327 (79)

ORIF 135 (69)

Co 644/3671
adults although the incidence of Class IIIc
ORIF 99 (63)

Cl 1110/3671
Co 14 (3.4)
Co 50 (32)

Co 56 (28)

was similar at 19% (38/195) compared to


Cl 74 (18)
Cl 9 (5.7)

Cl 6 (3.0)

17–18%. The less common fracture sites

ORIF
are confirmed in the paediatric series with
(17)

(30)
NA

NA

NA

NA
NR

NR

NR

Class IIc at 1.0% (2/195), Class IVc with


#

none reported and Class V at 2.1% (4/


10,289

195).
111

653
283

312
201

175

131

197

593
94

When considering the incidence of frac-


tures per patient with data useable from
the anatomical site only reports (Tables 1
and 2), the number of patients was includ-
ed in most studies, as well as those reclas-
194
126

137
NR

NR

NR

NR

NR

NR
43

sified (Tables 3 and 4). For those studies


reporting only the anatomical site but
Data on treatment includes 995 patients although total number of patients was recorded as 1045.

including the number of patients there


were 1.45 fractures per patient in adults
Inclusions in this total had to have reported Conservative, Closed and ORIF techniques.

compared with 1.41 in paediatric series.


459
157

For those classifiable studies, the fractures


NR

NR

NR

NR

NR

NR
64

51

per patient was 1.48 from the review, 1.63


from the regional audit and 1.51 for the
16,238

total adult group. There were 1.36 frac-


159

851
415

503
329

238

252

285

162

886

tures per patient in the classifiable paedi-


atric series inferring a lower rate of
3961 (24) 5019 (31) 2806 (17) 4450 (28)

multiple injury in both paediatric cohorts.


retrospective; Re-op, further surgery within 90 days; Rx, treatment.
429
162

207
101

399
27

49

67

24

69

Treatment
Treatment reported by fracture site rather than by patient.

Although different methods of treatment


for fractured mandibles were reported,
102

114

148

variability in the format of data presenta-


13

43

47
53

23

54

13

tion did not allow the management of


individual patients to be discerned, hence
there was minimal validation for this as-
187
120

154

216

pect of care possible (Tables 1–4). For the


56

88

63

70

42

43

10,971 adult fractured mandibles (Tables


1 and 3) and 914 paediatric cases whose
management could be ascertained (Tables
2016 133

2017 161

2018 103

2019 105

2020 123
2015 63

2016 90

2018 21

2019 61

2019 37

2 and 4), the methods of treatment have


been recorded as far as possible and in-
cluded in a column in the Tables. If the

data from Tables 1 and 3 (adults) are


consolidated in terms of treatment intent
Balasundran S.40
Batbayer E.-O.37

Srinavasan B.39
Gadicherla S.35

Diaconu S.C.14

to conservative, closed reduction, or


Verma S.34

Samman J.36

Brucoli M.38
Oruc M.13

Lin K.-C.12

ORIF; which may have included MMR


Totals (%)

or a combination, an analysis of results can


be made as follows. Conservative treat-
*
#

ment was provided for 15% (705/4567),


@

Please cite this article in press as: Brown JS, et al. A new classification of mandibular fractures, Int J Oral Maxillofac Surg (2021),
https://doi.org/10.1016/j.ijom.2021.02.012
YIJOM-4649; No of Pages 13

6 Brown et al.

conservative Soft diet and close review; F/P, fractures per patient; Inf, infection; Mal, malocclusion; MMF, maxillomandibular fixation; Non-U, non-union; NR, not reported; ORIF, open reduction and
R (6 years) audit NB
R (17 years) audit for

The final total of fractures treated is 1112 rather than 914 as Ferriera42 recorded treatment by fracture rather than by patient adding 198 to the total. Closed, MMF or external pin fixation; Co,
R (9 years) Incidence

2 fracture patients

(P = 0.005) and 11/


closed reduction for 31% (1415/4567) and

13 body (P = 0.02)
R (10 years) audit

had complications
ORIF with or without MMR for 54%

treated patients
Type of study/

Incidence and
(2484/4567). In the paediatric series

R (2.5 years)

management

(1285/914)
(Tables 2 and 4) conservative treatment

F/P (1.41)
comment

was provided for 14% (167/1172), closed


reduction for 63% (731/1172) and ORIF
with or without MMR for 23% (274/
1172).

Deformity 1 (0.3)
vs. 17.4% single

Trismus 2 (0.7),
54.6% multiple
There were individual reports, however,
Complications

Reop 13 (2.1)

(1.3) Inf (1.0)


Co 38 (25) Cl 67 (45) Mal/Non-U 4
which did show validation, and an increas-

PR 2 (0.7)
P < 0.05 ing tendency for operative intervention as
the Classes increase. Adi15 reported on
(%)

NR

NR
378 patients of which 19% (72/378) were


treated conservatively with 76% (55/72)
of this group having single fractures, 18%
(13/72) with doubles and 5.6% (4/72) with

ORIF 261/1112
ORIF 159 (22)
patients Treatment (%)

triple fractures. Hence, the use of fixation


ORIF 41 (34)

ORIF 45 (30)

Co 159/1112
ORIF 8 (13)

ORIF 8 (13)

Cl 692/1112
Cl 504 (70)
Co 56 (7.8)

techniques increases with increasing com-


Co 34 (28)

Co 31 (50)
Cl 53 (87)

Cl 45 (38)

Cl 23 (37)

plexity of injury. In the study by Lee,29


more detail of the sites of single fractures
Co 0

(14)

(62)

(24)
was shown with condyles (Class I) man-
aged conservatively in 79% (166/211),
angles (Class II) 41% (111/269), body/
Total

521

120

150

914

parasymphysis/symphysis (Class III)


61

62
Table 2. Results of systematic review of the literature for paediatric series classified by anatomical site of fracture only.

24% (29/123), and for fractures involving


Patients 2

more than one site (Classes IIc, IIIc, IV,


single fracture (multiple)
Total patients fractures

IVc and V) only 13% (55/406) could be


treated conservatively. Valuable valida-
136

109

281
NR
28

tion was also available from the paediatric


8

series with Feriera41 showing increasing


use of ORIF from condylar fractures at 1%
(2/213), angles/ramus/coronoid at 21%
(41/194), and body/parasymphysis/sym-
605 (719 by 385

513
NR
33

54

41

physis at 36% (116/322), although this


usually plated; PR, plate removal; R, retrospective; Re-op, further surgery within 90 days.

included multiple fractures as reported


by site rather than patient. In the same
treatment)
symphysis fractures

way closed reduction decreased in fre-


Total

1285

quency from 87% (185/213) for condyles


215

310
85

70

to 71% (137/194) for angles, and 60%


(192/322) of body/symphysis/parasym-
Symphysis

194 (15) 314 (25)

physis fractures. The difference was less


striking for conservative management at
Para

143

22

58

13

78

12% (26/213) for condyles, 8.2% (16/194)


for angles and 4.3% (14/322) for the body/
parasymphysis/symphysis group. Smith43
Treatment reported by fracture site rather than by patient.
Year Condylar head Coronoid Body

reported a difference of 50.7% ORIF for


90

13

15

69
7

multiple fractures compared with 11.8%


312 (24)

of single fractures which was significant at


Ramus
Angle

P < 0.05. The difference was similar for


161

18

31

17

85

adverse outcomes with 54.6% in multiple


fractures compared with 17.4% in single
fracture cases (P < 0.05). Kao45 had simi-
Subcondyle

lar results in that 25% (38/250) of patients


465 (36)
Condyle

were treated conservatively and these


@Ferriera P.C.41 2004 211

2013 113

were very likely to be single fractures


2011 38

2015 25

2019 78

shown statistically (P = 0.007).


The data from the regional audit was
also non-informative as far as validation of

treatment intent is concerned as the vast


majority of patients (98%, 815/833) were
Namdev R.44
Glazier M.42

Smith DM43

treated by ORIF (Table 5). We can report,


Kao R.45

however, that MMF alone was most com-


Author

Totals

monly used for Class I (34%, 12/35), but


for only three other cases in Class III, IIIc
@

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Table 3. Results of systematic review of the literature for adult series classified by anatomical site but also including sufficient data to be able to reclassify into the current proposal (including the audit
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results of the Liverpool Head and Neck Centre, Liverpool).


Classes Complications Type of study/
Author Year Total Treatment (%) (%) comment
I II IIc III IIIc IV IVc V
Fordyce A.M.46 1999 – 26 5 23 20 37 – 2 113 NA NR R (1 year) MMF
vs. ORIF
Bolourian R.47 2002 – 19 – – 12 – – 31 NA 0 P ORIF and
MMF
Dongas P.48 2002 29 65 – 30 26 38 – – 188 Co 36 (19) NR R (6 years) audit
Cl 25 (14) Tasmania
ORIF 127 (67)
Kim Y.-K.49 2002 1 7 – 22 5 14 – – 49 NA Re-op 1 (2) P biodegradable
plates
Yerit K.C.50 2002 2 12 5 2 1 22 NA Re-op 1 (4.5) P (1.5 years)
biodegradable
plates
Burm J.S.51 2010 1 4 – 4 14 12 – 1 36 NA PR 1 (2.8) P microplates
Singh V.52 2011 – 11 – 16 3 18 1 1 50 NA 7 (14) (no details) P miniplates
Natu S.S.53 2012 7 6 – 23 13 16 – 1 66 NR NR R audit
Eskitascioglu T.54 2013 82 81 11 309 86 155 8 12 708 Co 25 (3.5) 61 (7.9) (no R (10 years) audit
Cl 280 (40) details)
ORIF 403 (57)
Mittal G.55 2013 12 27 – 63 5 12 – 2 121 NR NR R (3 years) audit
Gutta R.56 2014 26 69 10 45 76 131 2 – 359 NA Inf 85 (8.1) R (5 years) audit
Mal 44 (8.0) of ORIF
Non-U 32 (5.8)
Re-op 45 (8.1)
Jung H.-W.57 2014 67 155 3 127 168 206 9 – 735 NA NR R (10 years) audit
of ORIF
Buch K.58

A new classification of mandibular fractures


2016 29 51 2 15 22 68 12 8 207 NR NR R (4 years) CT
scans
59
Rashid S. 2019 16 12 – 60 22 17 – – 127 NR NR R (1 year) co-
morbidities
Totals (review) – 270 (9.4) 522 (18) 30 (1.0) 742 (25) 498 (17) 751 (26) 36 (1.3) 28 (0.98) 2877 Co 61/896 – F/P 1.48
(6.8) (4256/2877)
Cl 305/896
(34)
ORIF 530/896
(59)
Regional audit – 35 (4.2) 172 (21) 16 (1.9) 112 (13) 152 (18) 318 (38) 14 (1.7) 14 (1.7) 833 Cl 18(2.2) Table 5 F/P 1.63
ORIF 814(98) (1361/833)
Totals (%) – 305 (8.2) 694 (19) 46 (1.2) 854 (23) 650 (18) 1069 (29) 50 (1.4) 42 (1.1) 3710 NA – F/P 1.51 (5617/
3710)
Closed, MMF or external pin fixation; Co, conservative, soft diet and close review; F/P, fractures per patient; Inf, infection; Mal, malocclusion; NA, not applicable; Non-U, non-union; MMF,
maxillomandibular fixation; NR, not reported; ORIF, open reduction and usually plated; P, prospective; PR, plate removal; R, retrospective; Re-op, further surgery within 90 days.

7
YIJOM-4649; No of Pages 13

8 Brown et al.

R (5 years) audit of closed

Closed, MMF or external pin fixation; Co, conservative, soft diet and close review; F/P, fractures per patient; Inf, infection; MMF, maxillomandibular fixation; NA, not applicable; NR, not reported;
and IV (1.7%, 3/172). The combination of
additional MMF for ORIF cases was used
Table 4. Results of systematic review of the literature for paediatric series classified by anatomical site but also including sufficient data to be able to re-classify into the current proposal.

R (10 years) Arch bar


50% (116/231) of the time if a condyle
R (10 years) audit

or open reduction
was included compared with 8.3% (50/

treatment only
602) when not part of the injury. In order
to further validate the treatment of condy-
Comment

(266/195)
F/P 1.51
lar fractures, the current series demon-
strated the use of ORIF for a single
condyle (Class I) in 66% (23/35) of cases
compared with 22% (44/196) when anoth-
Comps related

er fracture was present. In the literature


to class (%)

Minor only

search, there was one study that reported


Inf 2 (1.8)

fractured condyles treated by ORIF in


66% (14/21) cases and although not dis-
NR

tinguishing between single and multiple


fractures there was only one case of a


Treatment (%)

single condyle indicating that 95% (20/


ORIF 55 (49)

ORIF 13 (22)

ORIF 13(22)
Co 57 (51)*

21) were multiple fractures.52


Cl 39 (65)
Co 8 (13)

Co 8 (13)
Cl 39(65)
NA

Complications
Complications were not always included
Totals

in the literature but there were 5271 adult


112

195
23

60

patients that could be analyzed and 830


from the paediatric series. In a similar way
4 (2.1)

to the treatment there was no useful data


from the Literature (external validation)
V

matching the rate of complication to a type


of fracture and how it was treated. Pro-
IVc

spective ramdomized studies did report


specific complications and treatment but


27 (14)

this was always in a single fracture site


such as the angle,8–10 and so did not fulfil
IV
13

the inclusion criteria. As can be seen from


the way that complication data is pre-
38 (19)

sented in most mandibular series (Tables


IIIc

1–4), we are unable to discern either the


14

10

14

most likely treatment or outcome relating


to the site and number of fractures per
57 (29)

ORIF, open reduction and usually plated; P, prospective; R, retrospective;.

patient. The major complication (requir-


III
26

31

ing a second operation under GA in the


regional audit data was evident in 3.4%


2 (1.0)

(28/833) of cases (Table 5). It was also


Some patients had 7–10 days’ immobilization with MMF.
IIc

apparent that the risk of a major compli-


cation increased from 1.5% (3/207) in


Classes I and II to 4.0% (17/430) in Clas-
18 (9.2)

ses III and IV (Table 5).


13
II

Discussion
49 (25)
Classes

This proposed classification (Table 7,


46

Fig. 2) provides a method of reporting


I

mandibular fractures accurately, including


2010

2014

2014
Year

isolated and multiple injuries per patient


and offering the potential to increase our


knowledge and understanding of the man-
Munante-Cardenas J.L.60

agement and outcome. In Tables 1 and 2


we have shown that simply reporting the
site of each fracture without indicating a
Andrade N.N.62

single or multiple fracture for each patient


is too simplistic and belies the complexity
Totals (%)
61
Naran S.

of the injury. In particular, it is not possi-


Author

ble to know how individual types of frac-


*

ture were treated nor their outcome. By

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A new classification of mandibular fractures 9

Table 5. Audit results of the Head and Neck Centre, Liverpool.


Classes (%)
Totals (%)
I II IIc III IIIc IV IVc V
No cases 35 (4) 172 (21) 16 (2) 112 (13) 152 (18) 318 (38) 14 (2) 14 (2) 833
Treatment
ORIF 19 (54) 165 (96) 4 (25) 106 (94) 68 (45) 276 (87) 8 (57) 3 (21) 649 (78)
MMF only 12 (34) 3 (1.7) – 1 (0.9) 1 (0.66) 1 (0.31) – – 18 (2.2)
ORIF & MMF 4 (11) 4 (2) 12 (75) 5 (5) 83 (54) 41 (13) 6 (43) 11 (79) 166 (20)
ORIF Condyle (%) 23 (34) – 4 (5.9) – 36 (54) – 2 (3.0) 2 (3.0) 67/231 (29)
Complications
Malocclusion 1 1 2 1 4 9 – – 18 (2.2)
Non-Union 1 4 1 2 – – 8 (0.96)
Infection – – – – 1 1 – – 2 (0.24)
Totals (%) 1 (2.9) 2 (1.2) 2 (13) 5 (4.5) 6 (3.9) 12 (3.8) – – 28 (3.4)
2* 1#
MMF, maxillomandibular fixation; ORIF, open reduction and internal fixation.
*
Two patients refractured due to dystonia.
#
Further assault and new fracture. These three cases not included in totals or percentages.

Table 6. Quality assessment based on the Newcastle–Ottawa assessment scale..


Author Date Selection Comparability Outcome Score/10
Table 1
Adi M.15 1990 3 1 2 6
Hall F.C.16 1991 3 1 2 6
Edwards T.J.17 1994 4 0 2 5
Valentino J.19 1994 2 1 5 5
Terris D.J.20 1994 3 1 2 6
Vartanian J.21 2000 3 1 2 6
Boole J.J.R.21 2001 2 1 0 3
Wilson I.F.23 2001 3 0 0 3
David L.R.24 2003 3 1 2 6
Lamphier J.25 2003 3 1 2 6
Sakr K.26 2006 2 1 0 3
Simsek S.27 2007 2 0 0 2
Adayemu W.28 2008 3 1 2 6
Czerwinski M.29 2008 3 0 0 3
Lee K.H.30 2008 3 0 2 5
de Matos F.P.31 2010 3 1 2 6
Martins M.M.S.32 2011 3 1 0 4
Ramadhan A.33 2014 3 0 0 3
Boffano P.34 2014 3 1 2 6
Tay A.B.11 2015 3 2 2 7
Verma S.35 2015 4 1 0 5
Gadicherla S.36 2016 3 0 0 3
Oruc M.13 2016 3 1 2 6
Lin K.12 2017 2 2
Diaconu S.C.14 2018 3 1 2 6
Samman J.37 2018 3 0 0 3
Batbayer E.-O.38 2019 3 1 2 6
Brucoli M.39 2019 3 2 2 7
Srinavasan B.40 2019 3 1 2 6
Balasundran S.41 2020 3 1 2 6
Table 2
Ferriera P.C.42 2004 2 1 2 5
Glazier M.43 2011 2 1 1 4
Smith D.M.44 2013 4 1 2 7
Namdev R.45 2015 4 1 0 5
Kao R.46 2019 4 2 2 8
Table 3
Fordyce A.M.47 1999 3 2 1 6
Bolourian R.48 2002 3 2 2 7
Dongas P.49 2002 2 2 0 4
Kim Y.-K.50 2002 3 2 1 6
Yerit K.C.51 2002 3 2 2 7
Burm J.S.52 2010 4 2 2 8

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10 Brown et al.

Table 6 (Continued )
Author Date Selection Comparability Outcome Score/10
53
Singh V. 2011 4 2 2 8
Natu S.S.54 2012 3 1 0 4
Eskitascioglu T.55 2013 2 2 2 6
Mittal G.56 2013 3 1 0 4
Gutta R.57 2014 2 2 2 6
Jung H.-W.58 2014 2 2 0 4
Buch K.59 2016 1 2 0 3
Rashid S.60 2019 2 1 0 3
Table 4
Munate-Cardinas J.L.61 2010 3 2 2 7
Naran S.62 2014 2 2 0 4
Andrade N.N.63 2014 3 2 2 7
Table 5
Regional audit – 3 2 2 7

Table 7. Proposed classification. quently; Class II using this technique in


Class I Condyle/subcondyle and/or condylar head 2% (4/172) vs. IIc 75% (12/16), Class III
Class II Angle/Ramus/Coronoid at 5% (5/112) vs. IIIc at 54% (83/152) and
Class IIc Class II and Condyle Class IV at 13% (41/318) vs. IVc 43% (6/
Class III Body/Parasymphysis/Symphysis 14). Also within these data was confirma-
Class IIIc Class III and Condyle
Class IV >1 fracture not including a Condyle
tion of a preference for ORIF alone for the
Class IVc Class IV and Condyle condyle when this fracture is isolated
Class V Bilateral Condyles  other fracture(s) (Class I) at 66% (23/35) compared with
25% (4/16) in Class IIc, 24% (36/152) in
Class IIIc, and 14% (2/14) in both Class
IVc and V.
introducing the classification as proposed, number of fractures per patient was The incorporation of deranged occlu-
the accurate reporting of several critical reported in most of these series and hence sion, fracture displacement, fracture mo-
elements of mandibular fractures is possi- we can summarize that in the non-classi- bility, comminution, compound or simple
ble; frequency of multiple mandibular fiable data there were 1.45 fractures per and associated soft tissue injuries for in-
fractures, fracture location, and individual patient in adults and 1.41 in the paediatric clusion into the proposed classification
patient’s management and outcome. series. This contrasts with 1.51 fractures was considered. These additional points
An isolated condyle or subcondylar frac- per patient in both the adult and paediatric would have to be qualified adding a further
ture was less common in this series of classifiable series (Tables 3 and 4). This complexity to the system and reducing its
patients [8.2% (305/3710)] and although similarity in the results provides a degree chances of routine clinical use. We also
it is considered important to include Class of assurance that this proposed classifica- considered the use of a severity score
IIc, IVc and certainly Class V, these cases tion can be accurately applied. system described for facial and skull frac-
are infrequent. Although the classifiable Many of the studies in the literature tures.66 Although it is acknowledged that
paediatric case series is small (three reported the treatment of the fractures as the presence of other fractures will have an
publications60–62), it shows that a multiple a frequency of treatment intervention impact on the decision for the treatment of
fracture not involving either condyle (Class types rather than which type of fracture the mandibular fracture, their inclusion
IV) is less likely at 14% (27/195), but there (single or multiple), was treated by any would complicate the classification into
is a higher incidence of fractures involving particular technique. By analysing the lit- a scoring system which has not been
the anterior or horizontal part of the mandi- erature in detail, we have tried to show the widely adopted.
ble with 29% (57/195) in Class III, and 19% management options reported. The results Reporting of outcomes was not evident
(38/195) in Class IIIc. do show that single fractures (Class I, II in the majority of series analyzed, and in
Evidence derived from the eight paedi- and III) are more frequently treated con- others the incidence and type of compli-
atric mandibular series41–45,60–62 demon- servatively,15,29,41,45 but apart from Class cation could not be explored within the
strate that this classification can work well I we have no data showing Class II are context of the classification as fracture
in this age group and the differences in treated more conservatively than Class III. sites only were included. Even within
management and incidence we hope can The data from the regional audit (internal Tables 3 and 4 showing series that could
be more accurately assessed. There was validation) series shows a preference for be classified, the complications could not
only one study reporting an edentulous ORIF in all fractures with Class II 95% be ascertained from the point of view of
mandible series,38 thus a comparative (165/172), Class III 94% (106/111) and each class. In the regional audit dataset
analysis was not worthwhile, although Class IV 87% (276/318), but there are (Table 5) we only included patients that
we feel that these cases can be incorporat- some differences in the choice of treat- had a further operation within 90 days. We
ed into this proposal. ment related to multiple fractures includ- can report, however, that this complication
The non-classifiable studies identified ing the condyle. If a condylar fracture is increased from 1.5% (3/207) in Class I and
in the systematic review (Tables 1 and part of a multiple injury the regional audit II to 4.0% (17/430) in Class III, IV.
2) confirm a high number of multiple data demonstrated that a combination of The difficulty in finding appropriate
fractures involving the mandible. The ORIF and MMF was required more fre- validation data for this proposal in terms

Please cite this article in press as: Brown JS, et al. A new classification of mandibular fractures, Int J Oral Maxillofac Surg (2021),
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A new classification of mandibular fractures 11

Fig. 2. The classes of fracture in diagrammatic form. Class I, II and III include single fractures  those also involving the condyle with Class IV
and V being multiple fractures and Class V involving both condyles.

of treatment and complications from the pares with 14%, 63%, and 23% for con- Patient consent
literature emphasizes the importance of servative closed and open reduction,
Not required.
adopting a more standardized approach respectively, for paediatric cases (Tables
to reporting. 1–4). In the regional audit, we were con-
There was demonstrable heterogeneity cerned that retrospective data for these
in the quality of data from the systematic patients may be unreliable given the com- Competing interests
review as would be expected from retro- plexities of data acquisition from a broad None declared.
spective case series (Table 6). It could be geographical service with multiple con-
considered a limitation of the proposal not tributing spoke hospitals. Hence, we
to include more complex fractures in class would welcome a prospective multicentre Acknowledgements. We are grateful for
I involving the temporomandibular joint study including all patients presenting secretarial help from Susannah Dowd
itself or the condylar head, but it was our with a mandible fracture so that the man- and the support of Fazilet Bekiroglu (Clin-
view that adding these additional fac- agement and outcome can be fully ana- ical Director).
tors5,67,68 would make this basic reporting lyzed and appropriate validation and/or
tool too cumbersome. Hence if these alteration of this proposal undertaken.
forms of fractured condyle were to be In conclusion, This report presents a
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https://doi.org/10.1016/j.ijom.2021.02.012
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E-mail: brownjs202@me.com
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Please cite this article in press as: Brown JS, et al. A new classification of mandibular fractures, Int J Oral Maxillofac Surg (2021),
https://doi.org/10.1016/j.ijom.2021.02.012

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