BQ GIAO DYC VA DAO TAO KY THI CHQN HQC SINH GIOL QUOC GIA THPT
NAM 2017
DE TRE CHINN THUC Mén: HOA HOC
‘Thoi gian; 180 phiit (khdng ké thai gian giao dé)
Ngay thi tha nhdt: 05/01/2017
(Bé thi c6 03 trang, gdm 06 cau)
1, C = 12; N= 14; O = 16; K = 39; Mn = 55; 1 = 127; T(K) = ¢ (°C) + 273,15;
Tatm = 1,0132.10° N°; 1 nm = 10° m; Hing sb Avogadro, Na = 6,021.10 mot ';
3145 HK" mol | = 0:08205 atm LK" mot !; Dign tich nguyén te = 1,602.10" Cs
; Hing s Planck, A = 6,6261.10 Js, Té
Khoi lugng electron, me
Khai hagng notron, m, = 1,6749.10 kg; 1 nim = 365 ngly; 1 Bg = 1 pluin eigiiy, 625°C:
K: [Ar]is'; Rb: [Ke]5s!; Cs: (Xe]6s!; Cu: [Ar]3d!%4s!; Ag: [Kr]4d'5s!; Au: [Xe}4f"'5d"%6s!
Hing sb khi, R
Hing s6 dign, 6, = 8,854.10 SC?
¢=2,9979.10" mst; Khai lugmg proton, m, = 1,6726.10”
Cau l (2,5 diém) ,
Nang lugng E, (J) etia mot electron trong truxmg Ive mot hat nhdin duge tinh biing biéu thite
B= -2
en
Trong ds gn tich nguyén t6; 214 dign tich hat nhain; ¢, 1a hing s6 dign; A 1a hding 96 Planck;
nla sé lugng tr chinh (n = 1, 2, sw (kg) 1a khdi lugng rit gon cua hé, duge tinh bing
Digu thite: 1 ~ CmpgesdtnMtecvon) | (Mt in * Mlle)
a) Tinh bude séng Amax (nm) eta diy phd Lyman khi electron chuyén tir = 2 vé n= 1 trong
nguyén ti hidro,
b) Tin sé tuong img voi bude song Anas cia diy Lyman 66 sy khic bigt nbd gitta hidro va
doteri (mot ding vi cia hidro, trong hat nhn e6 mt proton va mot notron). Higu img nay goi la
su chuyén dich ding vj. Nguyén nhin la do sy khde bigt vé khdi Iugng nit gon gitta dateri va hidro.
‘Tinh sy khde bigt vé tin sd Av (Hz) cia photon phit xa khi electron chuyén tir = 2 vé n= 1 trong
doteri va hidro,
¢) Positron la mt hg gdm myjt positron, li hat o6 dign tich +1, va mgt electron. Khi electron chuyén
tim = 3 vén = 2, hé bite xa photon 6 bude sing 4 = 1312 nm. Tinh khdi lugng m (kg) cia positron,
Caw 11 (4,0 diém)
1. Thyte nghiém cho biét, NHy phan img vOi BP) tgo ra mt chat rin X duy nhit, ¢6 mau tring.
a) Viet phuong trinh hoa hoe cha phan tng. Phan img ndy thuge logi nao? Giai thich,
b) Viet cong thite Lewis cua mdi phin tir trong phan Gng trén. Cho biét dang hinh hoe eda
moi phin tir dé theo thuyét VSEPR (thuyét vé sy diy gitta cdc e$p electron & lip vo hoa tri).
¢) Dy dosin gid tr] eva mbi géc lién két trong phan tir chit X.
2. Gan diy, ngudi ta tim ra mot logi hgp chit méi, dy hita hen dé lim nhién ligu cho dng ea
cia tén lira ddy. Hop chit dé la NH«N(NO3), (amoni dinitroamit).
a) Viet cae cng thie Lewis cho anion N(NO,); va ce dang eng hudmg bén nit eva nd, Gid thigt
cde nguyén tir trong anion nay déu nim trong mOt mat phiing.
b) Khi nd, phin ti amoni bj phin hy thinh khi
phuong trinh héa hoe va tinh higu tig nhigt eda phin ing d.
Cho biét: . _ _
(Lien két N-H ]N-N | N=NTN-O [NO [NeN]/H-O | 0-0
[Nanguang (mot) | 391 | 160 | ais | 201 | 607 | 941 | 467 | 495
3. Nang hang ion hoa thi nbidt ea mt mol Br kh) gid ti 240,88 1. Tinh sing. (em!)
‘nhé nit cia mét photon dé c6 thé tich electron diw tién ra khoi mot phan tir Bra(khi).
4. Cho bidt loai lién két gitta ede hat & nit mang ludi trong mdi logi tinh thé eda ede chit rain sau:
bac; canxi oxit; kim cuong; than chi (graphit) va iot.
19, hoi nurde va khi oxi. Vidt
trang 1/3
Scanned with CamScanner (Cau IH (2,5 diém) ‘
1. Mt bénh nhan nang 60,0 kg bj sdt dot ngot. Trong thoi gian rit ngin, nhigt do cba co thé
bénh nhdn tang tir f) = 36,5°C len fy = 40,5°C, Mot catch giin diing thd, gid thiét, co thé bénh nhiin
tuong duong voi 60,0 kg nude tinh khiét khong trao déi nhigt va chét vGi mdi trudng bén ngoai.
Céc dai lung AHP, AS? va AG” dudi day chi xét rigng cho qua trinh nhigt 49 cia co thé ting tir 4
ln fy, Khdng xét cho ede phin img din dén sy thay 46i nhigt d d6 va duge tinh trong digu kign
ding ‘ip, p = const.
a) Khi s6t cao, co thé rit néng do nbn nhidu nhiét tir ede phan img sinh héa xity ra trong cq thé,
Tinh bién thién entanpy AH? (kJ) khi nhigt 49 ca co thé tng tir 4 In #2. Biét ring, nhigt dung
mol ding ap cia nuée,C3,, = 75,291 J-K"'mol", duge coi la khéng ddi trong khodng nhigt 46
tin dah,
b) Tinh bién thién entropy AS° (J-K~') khi nhiét do cla co thé tang tir fy len .
) Tinh bién thign ning lugng ty do Gibbs AG° (kJ) khi nhigt 46 cia co thé ting ti Hen f. Bidt ring,
entropy cia nude tgi 36,5°C, S° = 72,6 JK mol", AG? trong trudng hop nay duge tinh theo
cng thite: AG? = AH? — A(TS°) = AH? - AT.S° - T.AS*.
Néu thi sinh khing tinh duge céu ¢, gid sie ly AG = -1,2.10° J dé tinh tiép.
d) Khi sdt cao, co thé mit ning lugng mét cach vé ich. Gia sir cfing v6i phiin ning lugng 46,
Khi khée, ngudi dy chay duge mot quing duémg dai nhat la bao nhiéu km? Biét ring, ning lugng
tigu thy khi chay mdi I km 1a 200 kJ. .
2, Mgt mu Na(khi) (coi Np la khf li tuéng) tai 350 K va 2,50 bar duge cho ting thé tich lén gdp
tba Lin trong qua trinh gidin né doan nhigt bat thuin nghich chéng lai dp suat ben ngoai khong 46i,
Pegsss = 0,25 bar. Téng cong gidin né cita hé 1a -873 J.
a) Tinh cc bién thién entropy AS (J-K) cia hé, cba moi truomg xung quanh va cia hg cd lp
trong qué trinh trén.
'b) Dai lugng nao trong cdc dai lugng 4’ tinh cho biét kha nang ty dign bién cia hé?
Cu IV (3,5 diém)
1. Cacbon ty nhién chia 2 dang vj bén, ?C (98,9% khdi Iugng) va "°C (1,1% khéi lugng) cing
Iugng vét ding vj phéng xq “C (phan ra f°, fa = 5730 nim). Hogt 4} phong xq riéng cita cacbon
trong co thé song 14 230 Ba-kg", Nam 1983, ngudi ta tim thdy mgt con thuyén 6 chim ngoai khoi
Dai Tay Duong. Cacbon trong g® ciia con thuyén nay 6 hoat 46 phéng xq riéng la 180 Boks".
a) Ti lé sO nguyén tis gitta cdc ding vj ?C/"4C va “C/"C trong co thé séng la bao nhiéu?
b) Cay dé ding Lim gé déng thuyén trén duge dén ha vio nam nao?
¢) Gia thidt, 180 Bq-kg™ 1a tr sé trung binh cia ede gid tr} do duge, cdn sai sé trung binh trong vige
do hogt 4 phéng xa cla cacbon trong mau gb néi trén 1a +1,3%. Cho biét cdy duge ‘in he
trong khoang théi gian tir nim nao dén nim nio? .
2. Poli(etylen terephtalat), cdn goi la PET, ld m6t polime tng hop. PET duge sir dung ring rai
trong cong nghiép dét, bao bi va lim chai lo, PET duge tgo thanh tir phin img tring ngung gitta
hai monome A va B.
a) Cho biét tén goi va céng thite cdu tgo cia hai monome trén.
) Viet phuong trinh héa hoe cia phan img tong hop PET tir hai monome trén.
) Thy hign phan img tng hgp PET véi ning 46 ban di ciia hai monome bing nhau. Sy phy thuge
1g 46 cdc monome cdn Iai theo thdi gian duge cho trong bang dudi diy:
0 30 0 9 | 120
000 [2,000 334 | 1,000 | 0,800
Tinh hing s6 te 46 cia phan img tring ngumg va cho biét bic ting sone cia phan img. >
3. Gia thidt c6 phan img chuyén héa C thinh D va E nhu & hinh bén. k
3h the 46 06 pi 2.107 gidy"t; ky = 15.10" gly" lo=3,2.107 at Zo
ka= LO" gy Tai thoi diém = 0, ndng 46 cia cde chit nhursau: [Cly=1M; CQ 7!
Dh=(E}~0. SX
a) Tinh nong dé cde chit C, D va E tai thoi diém 1=30 gidy.
b) Tinh ndng d6 cdc chat C, D va E tai thoi diém ¢= 0,
tana 7
Scanned with CamScanner Ciu V 3.0.
1. Tién hanh 3 thi nghigm gia 3 dung dich déu chira 0,166 g KI & ede méi trutmg khéic nhau
véi dung dich KMnOs ndng 46 C (mob L™). Cie két qua nhur sau:
Thi nghiém 1; dung dich KI phan tmg vira dit v6i 4,00 mI. dung dich KMnOs.
Thi nghiém 2; dung dich KI phan img vita di v6i 40,00 mL dung dich KMnOs.
Thi nghiém 3: dung dich KI phan img visa di v6i 160,00 mL dung dich KMnO,.
a) Bign lun dé viét phuong trinh héa hoc xay ra trong mdi thi nghigm, biét trong Thi nghiém 3
6 mt cia Ba(NOs)s dur.
'b) Tinh ndng d6 C (mol-L“) cua dung dich KMnO, da ding.
©) Thém 5,00 mL dung dich CuSO, 0,02 M vo dung dich chia 0,166 g KI rbi digu chinh méi truimg
nhu trong Thi nghigm 1, thu duge hén hgp X. Tinh thé tich dung dich V (mL) KMnO, ning 45
C (mol-L™) trén dé phan img vira di voi hin bop X.
2. G trang thai hoi, cdc nguyén tir cia cde nguyén t6 kim logi nhém IA va nhém IB ¢6 kha nang
hinh thinh phan tir hat nguyén ta véi cae nang Iwgng lign két nhu sau:
Phan w Cu | Ag | Aw | K; | Rb | Ce
Ning lugng lign kat (kJmot) | 1743 | 157.5 | 210 | 30.2 [ 460 [41.8
a) So sinh va gidi thich d6 bén lign ket trong cde phan ti kim logi cba nhém IB véi do bin
lién két trong cde phan tir kim loai eda nhém TA.
b) Gidi thich sy khdie nhau vé quy lugt bién déi cua cde ning lugng lién két trong mdi diy
phan tir sau: Cuz ~ Ag ~ Au: vi K) ~ Rb - Cs2.
Clu VI (4.5 diém)
1. Tinh thé khir chuin cia c§p Fe'/Fe* wong méi trudmg axit va thé khir chuin cba ip
Fe(OH)yFe(OH), trong mdi trudmg kiém. Kha ning khit cia Fe(II) trong moi trig no manh hon?
Cho bi6t: E> 5.4, =-O,440 V5 E>», =~ 0,036 V ; pK,(Fe(OH):) = 14,78; pKs(Fe(OH)s) = 37,42.
2. Thém V (mL) dung djch KzCr20; 0,02 M vao 100 mL dung dich FeSO, 0,12 M (tai pl = 0 va
Khdng d3i trong suét qué trinh phan tmg), thu duge dung dich A. Tinh thé khir cia cp Fe"*/Fe™*
trong dung djch A 6 m6i truimg hgp sau day: i) V= $0 mL; ii) V= 100 mL; iti) V= 101 mL.
Cho bibt: Be x ye =O,7T1 V5 Be op yenee = 14330 V.
‘C,0F
3. M@t bai tip hoa phan tich 06 du bai nhur sau: “Tr§n 15,00 mL dung dich HCI nding 49 C (molL")
v6i 5,00 mL dung djch NazC204 0,100 M, thu duge dung dich X c6 pH = 1,25. Tinh néng d6
C(mobL").” Dé tinh néng dC (mol-L") d5, mot hoe sinh Kip lun nhur sau: “Vi pH = pK = 1,25,
suy ra [H,C,0,] = [HC,0;] >> [C,07}, nén hé thu duge la hé dém. Nhu vay, lugng axit cho vito
trung hda hét nde 1 va tung hda hét nita nde 2 cha C,O%", tire 1a trung hda hét 1,5 nde eta C,O7.
1,5.0,100.5,00 Hs
Do db, C= SE = 0,050 (mol)
a) Bing cae lap lugn va tinh todn, cho biét hge sinh 46 gidi dling hay sai.
b) Tinh néng 46 C (mol-L“) cia dung dich HCI da cho.
Néu thi sinh khéng tinh duge } b, gid sic dung dich X chi chia HzC 0, 0,016 M dé tinh tiép.
©) Trén 5,00 mL dung dich X véi 5,00 mL dung dich gm Ca’* 0,01 M va S?* 0,01 M. Khi hg
dat t6i trang thai cdin bing, cho biét c6 nhiing két tia ndo téch ra. Gia thiét khong c6 sy cng ket.
d) Thiét lap so 45 pin duge ghép boi dign cye Pi(Hz) nhiing trong dung dich X voi dign eye
Pt(H2) nhiing trong dung dich Y chiza (NH4):S 0,02 M. Ap sudt Hz 6 cd hai dign eye déu bing
1 atm. Viét niza phan tmg héa hoe xay ra 6 moi dign eye va phan tng ting eng khi pin hogt ding.
2 pKa(HaCi04) = 1,2 127; pK(CaCsOe) = 8.75; pKGrC204) = 640;
pK ,i(H2S) = 7,02; pKo(H2S) = 12,90; pK, (NH; )= 9.24; pK«(H20) = 14.
* Thi sinh khong duege sit dung tai ligu;
* Cain b6 coi thi khng gidi thich gi thém.
Scanned with CamScanner BQ GIAO DYCVADAOTAO KY THI CHON HQC SINH GIO! QUOC GIA THPT NAM 2017
DE THI CHINH THUC Mén: HOA HOC
‘Thai gian: 180 phat (thdng ké thdi gian giao dé)
Negay thi tht hai: 06/01/2017
(Dé thi c6 03 trang, gém 05 cdu)
Mét sé ki hifu vide tit: Me: metyl; Et: etyl; Ac: axetyl; mCPBA: axit m-cloropebenzoic; PCC: piridini clocromat.
‘Trong cdc quy tinh ting beyp hihu ca, céc chit vb co va didu kin cla thidt 5 di.
Cau l (3,5 diém)
1. Cho cae chit sau day:
2 ODL oo OI
Triguaacen Xidooctatete Adamantan Amada NADPH
‘9) Dé xult co ché phan img chuyén vj béi nhigt tir AI to thinh adamantan,
vb) Dé xult so 43 tdng hop triquinacen va Al tit A2.
He) De xuit so di téng hyp amantadin (thude khiing virut do de ché kénh bom proton) tit adamantan, “
pp Bini oc lt teh AS septa fe ote xiclooctatetraen vi HBr.
¢) Gidi thich tg sao tée nbain sinh boc NADPH e6 tinh khir tuong ty nhu NaBH.
2. Hidrocacbon epizonaren (CisH2) duye phin lip tir tinh diu loai Salvia fruticosa Mill. (Labiateae).
fo. ee ee i
QD ate ag itm ng Reco 5 sot gg 100i
(AYN CoHtyNO) 2 HONE CMO BONE (CiollsO0 ROH. (CidtO) 2H,90,¢ MMoreres,
Xie dinh cu tgo cde chit Ad, AS, AG vi AT. Khong cin xét dén héa Ijp thé.
3. Cho presol phin tmg véi anhidrit axctic, thu duge B1. Ding phin hda BI véi sy
6 mit cia AICI, dun néng, thu duye B2. Cho B2 phin img voi anhidrit phtalic, tha a
due B3. Thye hign phin img este hoa B3 bing CH:N3, thu duge B4. Trong ditu*¢.
kkign xée the bazo (KOWpiridin), B4 chuyén thinh BS lin lugt qua cée giai dogn OQ,
rngung ty Claisen, hemiaxetal héa va téch nue.
Xéc dinh clu to cde chdt BI, B2, B3 va BS, eae Tee
Cau II (4,0 diém)
1, Tit 2-metyl-1-(4-nitrobenzoy! )naphtalen, vist so db ditu ché axit p-nitrobenzoic va 2-metyl-1-naphtylamin,
143 digu ché p-phenylendiamin.
biét trong ting hop cin dang NH;OH. Tir axit p-nitrobenzoic, viet so:
2. Hop chit C1 (CicHy0) phan img visi CHyMgBr, tgo khf metan; phin img vi PCC, tgo thinh xeton; phin
ting voi KMn0, loing, lgnh tgo thanh chit C\qHaOs. Axetyl héa C1 bing CHyCOCI, sau d6 ozon phinvkhit
béa, thu duye C2 (CyzHsv0,). Oxi héa C2 bing nude brom, thu duge C3 (CisHae0s). Chit C3 tham gia
chuyén vj Bacyer Villiger voi m-CPBA (tj Ig mol 1:1) thu dure nhigu dng phin trong 46 06 C4 (CrzH20s).
‘Thy phin C4 véi H;SO/H,0, thu duge axit adipic HOOC[CH,}.COOH, butan-1,3-diol va axit axetic.
Xiic dinh cdu t90 ede chlt C1, C2, C3 va C4. ee
3. 8) Vit litu xbp potiuretan duge sir dung rng ri. D8 xult so 3 wing bp potiuretan ts toluen va etilen glicol.
Bidt ring, bude cubi cing Li phin img cia etilen glicol véi toluen-2,4-diisoxianat (chira nhdm chisc NCO).
1b) Amino axit arginin chuyén ba bot enzym arginaza thin D1 va A
omithin (D2). Trong oo thé nguti, D2 tham gia dio thi axit Ha mane HN
benzoic dirk dang bop chit D3 (CisHaoN,0,). D1 phan tng voi axit COOH
malonic tgo thinh axt barbituric la bop pha cia riboflavin. Hy
Xée dinh edu tyo ede chit D1, D2 va D3. Agen Axi bartiturie
4. Hop chit A (Cyl1is02) khdng téc dyng voi Hy/Ni dun ning. Cho A tie dung voi 1110, thu duge AL
(CyH,0) ¢6 kha ning tham gia phin tg iodofom va A2 (CsH,0). Dun néng A €6 mit HS. thu duge
J chit B (CacO) chia vOng 6 caah. Cho B phan ing vbi 24-diitrophenythirazin, thu cuge C; cho BB
phan img voi Hy/Ni dun néng, thu duge chit D, Dun néng D voi HySO, dhe, thu duge E (Cette). Ozon
phan E, sau 46 khir héa ozonit v6i Zn/HCl hoje oxi hda voi H,03, déu thu duye F
(CsH,.0;). F tham gia phan img iodofom sau dé axit héa, thu due G (CHO).
a) Xéc dinh cdu to cdc chit A, Al, A2, B, C, D, E, F vi G. Dé xudt co ché tir A sangB. 4
b) Dé xudt phuong phip didu ché B-xetoeste H tir A2 (CsHy0) va etanol,
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Scanned with CamScanner Ciu II (4,0 idm)
1, Hop chit A (Coul4vO) 1 hop phin wasabiside-E (phn lip tir r8 md tt). Mot mol A phan tg v6i 2 mol
AcO/piridin, thu dye chit B (C2sH3:0s). Oxi boa B bing KHSOVKBr, thu duge C (Crel4z20)9). Metyl hia
hola toin A, ri oxi ba bing KHSOyKBr, thu dupe D (CxHi204). Cho C phin tng voi mCPBA, sau 46
thiy phin Ring dung djch kiém, ri axit boa, thu diye E (C)HjOy) vi F (CqHy0>). Néu thay nhim metoxi
trong E bing hidro, thu duge hidroquinon (benzen-1,4-Siol). Cho F phin img vi CrOyH,SO,, thu duge
(HOOC);CH-CH(COOH). Thiy phin D bing dung dich NaOH, rbi axit héa; cho sin phim thiy phin phin
img véi CrO¥ACOH, thu duge G. Cho G phan img voi hia hop Ag:O va Bry, ri thiy phin sin phim t90
thinh bing dung dich kim, thu dupe H. Oxi héa mol H bing HIO,, thu duye ti da 2 mol axit
34-dimetoxibenzoic vi 2 mol HCOOH.
Xée dinh edu tyo cée chit A, B, C, D, E, F, G va I. ee
2, Bengamit (X) ob obng thite CysHyN20., lit hop chilt thign nhién trung tinh duge tich ra ti Lodi hii min,
(zon phi X, sau 6 khit hia ozonit voi ZaVHICI, tha duge 2-metylpropanal va X1. Thiy phn X1 bing dung
dich kiém, thu duye lysin HN[CH:}CH(NH2}COOH o6 edu hinh (S) va X2 (C;H,0;). Nhom hemiaxetal
cia X2 phan img voi CH)OH/HCl, thu duge X3 (CsH)«O»). Cho X3 phan img voi H1O. ds, sau 45 thiy phin,
thu duge ede sin phim: axit (2R,3R)-3-hidroxi-2-metoxi-4-oxobutanoic, etandial vi metanol.
a) Xéc dinh edu tg0 cdc cht XU, X2, X3 va X. Bigu didn mbi tim lip thé bing ki hifu Z, E, R, Sva(*).
b) Tinh sd d3ng phiin bp thé cba chit X (bao gdm cdc ding phin hinh hoc vi quang hoc).
~ Meloxicam Ta thude cha bénh viém vA thodi héa khép. So 43 thng hop meloxicam nhu sau:
Cia ay Sogo MOM yy IS a?
z
NaOH ‘MeOH aN,
PO Matosseam
a) Xéc djnh clu tgo cdc chit M1, M2, M3, Md vi
MS. Téng hyp chit MS tir thioure (NH:CSNH2). Qo
oJ thcontan i inl oo ot ox co: a CO - vagy
hain ti vi xtc tde sinh hoc theo sa 43 ben, eS R ¥ 8
Hoan thish co ché chuyén héa dito thai meloxicam, | © °™smom
4, Phan img da tic nhiin lA phuong phip tién tién dé ting hgp cdc di vong thom,
a) Dj ving 1 4~dihidropiridin tyo thinh qua che
jiai doqn ngung ty andol, go imin, eng Michsel, 0 a
[plank paduisepehaari Tyg or’ 0D mot Me in
P
'$0,0H f (CrH,NO,S)
De nubt co cht phin tng
'b) Hop chit da dj vOng chia pyrazin hinh i, coon H
thinh theo so d3 bén. oh ee Ore
DE xulit co chd phan ing. we Cocue ee
Cau IV (4,5 diém
1
(truy’ xung thin kinh), axit 3-indolylaxetic (kich thich sinh tnrimg cfiy non va chbi
qua tin hi¢u thy thé), Calis (4ieu tr bi logn cong duung théng qua tin higu thy thé dc hity trén té bao bicu
mé thinh mgch miu),... Chuyéa ding cia electron x trong indol twong ty nhu hat trong ging thé trdn, gay
ratinh thom vi eée trang thii “chim lung ti" thu phit ning luymg dudi dang wi tin higu dign ti.
4) Gi td ning lug cae electron x tong bi eng tom ind i theo md hich het tong sgt Wn,
FF ning hamg £, tinh theo biéu thie bén. Trong 45, 7 ld sb hung tir chinh (n= 0, 1, #2,
ng thom ingot 14 ap phn upén Un hit ch bot cfc owt dng cia if ho phy serioin
23, A sb Planck, A = 6,6261.10™ Js; m, Wa khSi hayng electron, pH
SB sioputot tse sigin (m) la bin kinh oda giéng dod tron, Ona
«= Tinh chu vi vi bin kinh chuyda ding cita cde electron x. Gid thidt chy vi
d§ng cla electon.x bing thd trom va bing chidu dai lida hop: 4) dai Jin két binh
fia cachon vd cacbon It 1a Kay daar a
« Tinh buts sing (sm) eta on ki ich | electron GF TOMO Ién LUMO. Bigt ¢ = 2,9979.10" (v/s),
‘b) Qué trinh sinh chuyén héa tir tryptophan theo so dé sau:
coon!
JV Tor
4, Drideut ponte 4 EL Bo ¢
(CutNOs) — (CyallyNO)— (CyLGNO)
Bikt ring. dec
‘Xée dinh cdu tao 66 chit AB va C.
Menzym decachoxy! héa, F2 1d enzym oxi ha, pyridoxal photphat ld the nhin log amin.
Trang 23
Scanned with CamScanner Vv
V
©) Tryptophan bj decacboxyl héa tgo thanh tryptamin (D) va chuyén héa thinh physostigmin theo so 43
" Neer mee
PRD we ON ° ON
ew pee ‘omy
Teyptamia(D)
Biét ring, E2 1d enzym oxi ha, SAM cé vai trd nhu tic nhin héa hoc CHsl, PP 1a gée diphotphat.
Xée dinh ede chat F va G. Dé xudt co ché chuyén héa tir D thinh E,
d) Chit K 1a hogt chit dé bio ché thube Calis. Chit K duge tng hop nhu sau: cho etyl este CHO
cia tryptophan phin tmg v6i piperonandehit c6 xc the axit, thu duge sin phim déng vong ery
Pictet Spengler H. Cho. H phn img voi CH,NIH3, thu duge chit I. Cho I phin img voi
CICH;COCI, thu duge chit K (Cz2HieNy0,). Xée dinh edu tgo cdc chdt H, Iva K. Eperonensena
2, Aciclovir 1a thudc khing virut Herpes. Tin thude cia aciclovir la valaciclovir.
a) Hoan thanh so dd ting hop valaciclovir ti ede chit cho dubi day:
:
wo ry se Q
WeCen,
‘Bocytosing Valin HOCHECHEOH
b) Dé xult so dd thng hyp isocytosine tir hgp cht cd ba nguyén tir cacbon va hgp cl
bee
oii
¢) Tién thude valaciclovir bj thay phan thinh aciclovir sau 46 chuyén thanh aciclovir monophotphat
(CalliNsO,P*) va di vito qué trinh digt virut. Xéc dinh cdu tgo cia aciclovir va aciclovir monophotphat.
bénh cao huyét dp theo og
3) Nifeipn host bl bo eh tbe a ocMe
Von °
ano
chen kénh canxi
trong tf bio co tron. Nifedipin duge tng hop
theo quy trinh theo so 43 bin,
de dinh cfu tgo ede chit N va Nifedipin.
b) Gliclazit 18 hogt chit dé bdo ché thudc
duing huyét. Gliclazit duge téng hyp theo
quy trinh theo sod bin.
‘Xée dinh edu tg0 cfie chit G1 va G2.
Cau V (4,0 diém)
oo
pain An
ome pid (Cure)
Ot se CFP
OT eee, ‘arate W
01 —2. 2
1. Thye hign qué trinh gitin né ding nhi¢t thugn nghjch 2 mol khi Ar (coi 1A 1y tudng) 6 400 K tir thé tich
$,0 dm? dén thé tich gdp 5 lan. Tinh Ong va nhiét cba qué trinh. Giai thich ¥ nghla cia cdc gid tr] cng va
nhigt thu duge. Biét, R= 83145 :K"-mol"!,
2. Cho phan img 2A + dune ibn inh ong du kif ding eh. Sy phy the cia nding 6) chit B
theo thai gian duge cho trong bang. Xée dinh bc va hin,
86 tbe 49 ciia phan img.
“(phat 0 10 20 30 40 2
B] (mot 17 0 0,089 0,153 0,200 0,230 0,312
/s, DE xc dinh pHi cia dung dich ¥ ghm HX 0,135 M, NaX 0,050 M va NH,CI 0,065 M, tiga hank thi nghifen
sau: nbd vii giot dung dich chit chi thj Hn (pK, = 4,533) vio dung dich Y (gid sir thd tich va pH cia dung dich Y
Khdng d8i), i do 45 hip thy quang A cha dung dich tha duge trong cuvet 6 bt dy lop dung dich = gn hai
Hin vi erp thy photon ta hai be sé ny). Ket
bude sing Ay = 490 nm va Ay = 625 nm (Gid sit chi 05 Hin.
qui, gid tr A it
dich tain inh lujt Lambert-Beer (A =:
Mn hugt 1a 0,157 va 0,2: iA i hip tng Act dong
‘va od tinh chit ong tinh (4 = Ay + A,).
Hé sd hip thy mol phan ti, ¢ (L-molcm”) ca Hin va In” tai cdc bude séng 490 nm va 625 nm
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