Jane Dear M.

Pasal BSN-3 Journal: Volume 48, Issue 1, Pages 28-39 (January 1970)
0002-9343(70)90

July 3, 2010

Epidemic acute glomerulonephritis associated with type 49 streptococcal pyoderma: II. Correlative study of light, immunofluorescent and electron microscopic findings.
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Alfred

J. Fish, M.D. Roger C. Herdman, M.D. Alfred F. Michael, M.D. Richard J. Pickering, M.D. Robert A. Good, M.D., Ph.D. Received 23 January 1969 We have investigated the pathologic alterations in kidney biopsy specimens from twenty-seven patients with suspected acute poststreptococcal glomerulonephritis (AGN) occurring during an epidemic of this disease on the Indian Reservation at Red Lake, Minnesota in 1966. This epidemic of AGN was associated with introduction once again of type 49 beta hemolytic streptococcal infection in this population. Light microscopic evidence of proliferative AGN was found in twenty-one of the twenty-seven patients. Immunofluorescent microscopic study of the renal biopsy material revealed that discrete nodular deposits of IgG and 1C (beta-1-C globulin of complement), which are the characteristic immunopathologic lesion of sporadic AGN, were observed in six patients. In fourteen patients a different pathologic alteration consisting of the deposition of 1C alone focally in an interrupted fashion along the glomerular basement membrane was observed. By electron microscopy discrete electron-dense deposits were present on the epithelial side of the glomerular basement membrane and in some instances in a subendothelial location. In this study it has been possible for the first time to investigate a large group of patients encompassing the entire clinical spectrum of AGN and to correlate the light, immunofluorescent and electron microscopic findings with the bacteriologic and serum complement data. http://www.amjmed.com/article/0002-9343 (70)90095-1/abstract

Reactions:

o Laboratory evaluation should include urinalysis, urine culture, serum urea, creatinine and fasting glucose, serum albumin, 24-hour urine collection for quantification (24-hour total urinary protein) or random or spot urinary protein and creatinine measurement.
o Also, antibiotics may be prescribed to kill any lingering streptococcal bacteria, if their presence is confirmed. o In order of avoid this kind of disease we should avoid certain foods specifically the salty foods. o Well, its not so easy if we have this kind of disease because, complications include congestive heart failure, acute or chronic renal failure, and end-stage

renal disease.