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Strong opioid agonists are:

heroin, morphine, codeine, oxycodone, meperidine, and fentanyl.


Mild to moderate agonists:
Codeine, dihydrocodeine, hydrocodone, and oxycodone.

The two most commonly used centrally acting opioid receptor antagonists are naloxone and
naltrexone. Naloxone comes in intravenous, intramuscular, and intranasal formulations and is
FDA-approved for the use in an opioid overdose and the reversal of respiratory depression
associated with opioid use.

Mixed agonists and antagonists drugs are:


Buprenorphine, Pentazocine, Nalbuphine

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