Predisposing Factors Upper Gastrointestinal Bleeding Precipitating Factors

• (+) HPN on Maternal Side

• Smoker
• Hos pitalized last 2017 due t high blood
• Occa sional drinker
pressure Chronic Intake of NSAID

Interferes with Inhibition if NSAIDS being weak acids when

COX pathways Cyclooxygenase -1 enzyme exposed to gastric acid

Remains in epithelial
Less production of prostaglandins causes cells thus increases
cellular permeability
` inteferance on mucous – bicarbonate barrier

Physical Cellular injury to the

gastric mucosal cells

Bloody Diarrhea
and Nausea