REVIEW

Beneficial
Harmful
Neutral?
REVIEW

Beneficial
Harmful
Neutral?
 REVIEW

Beneficial, Harmful, or
Neutral?
 MUTATION TELEPHONE

Each group will be

given a message to
pass.
The last student
should write the
message on the
board.
Chromosomal
Mutations
 Learning about Mutations

 Identify the different types of

chromosomal mutation.
 Trace the chromosome that causes
each mutation.
 Inculcate the importance of
possessing a normal trait from our
parents.
 GUESS WHAT?

Each group will be

given an illustration.
Match the picture
with the correct term
provided.
Explain your answer
to the class.
GROUP PRESENTATION
LET’S WATCH!
QUESTION

What are the important details or

facts mentioned in the video?
 Superheroes

How did Cyclops from the X-Men get his

superpowers?
❖ He was born with the mutation
 Superheroes

How did the Hulk and Spiderman get

their superpowers?
❖ The Hulk was exposed to gamma radiation and
Spiderman was bitten by a radioactive spider
 Types of Chromosomal
Mutations

Deletion
Duplication
Inversion
Translocation
 DELETION #1
1. Deletion involves the loss of
all or part of a chromosome.
 DELETION #1
Cri du chat syndrome
is a rare chromosomal
disorder caused by a
deletion of genetic
material on part of
chromosome 5.
 Cri du chat syndrome

cries like the high-pitched

mewing of a cat
unusually small head
(microcephaly)
widely set eyes (hypertelorism)
downward slanting eyelid folds
abnormally small jaw
Cri du chat syndrome
Cri du chat syndrome
 DUPLICATION #2
2. Duplication produces an extra copy
of all or part of a chromosome.
 DUPLICATION #2
Pallister-Killian mosaic
syndrome is caused by
the presence of an extra
chromosome called an
isochromosome 12p or i
(12p).
Pallister-Killian mosaic syndrome

areas of unusual skin

coloring (pigmentation)
widely spaced eyes
congenital
diaphragmatic hernia,
hole in the muscle that
separates the abdomen
from the chest cavity
 INVERSION #3
3. Inversion reverses the direction of
parts of a chromosome.
 INVERSION #3
Hemophilia A, is a genetic bleeding disorder,
caused by chromosomal inversions that
involve a portion of the blood coagulation
factor VIII (F8) gene that encodes one of the
key enzymes in blood clotting.
Hemophilia A

People with hemophilia

A bleed longer than other
people.
Bleeds can occur
internally, into joints and
muscles, or externally,
from minor cuts, dental
procedures, or injuries.
Hemophilia A
 TRANSLOCATION #4
4. Translocation occurs when part of
one chromosome breaks off and
attaches to another.
 TRANSLOCATION #4
Translocation Down
syndrome is a type of
Down syndrome that is
caused when one
chromosome breaks off
and attaches to
another chromosome.
Down Syndrome
 Down Syndrome

•Almond-shaped eyes
•A short neck, small ears
•A tongue that tends to stick
out of the mouth.
•Tiny white spots on the iris
•Small hands and feet.
•A single line across the
palm of the hand (palmar
crease)
Amniocentesis and
chorionic villus
sampling (CVS)
TECHNOLOGY
ISSUE ON BIRTH DEFECTS

How will you deal with birth

defects during pregnancy? Are
you going to proceed with the
pregnancy or terminate the
pregnancy?
Any questions?
DRILL: Identify the type of chromosomal
mutation present in each picture.
(Deletion, Duplication, Inversion, or Translocation)
EVALUATION
ASSIGNMENT

Give at least five examples of

somatic and five examples of
gametic mutations. Write the
causes, signs, and symptoms
and print out the image.