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Parasympathetic drugs

Muscarinic receptor yPÉ→-,¥


↳÷i"f
Nicotinic receptor '

f- Inhibitory
Excited ( Gg) : M1 ,M3 ,
Ms
open Nat/ K+ Channel J U
s -
↳ Excitatory

|Inueaseiytrara
-
a 3
• - → Cbi ) : M2 ,M4
I ±
5
t④→bcAMP |Bindca1moÑ
P.MN/rDov

= .

§ -
1+0
mzniresponserdoumdwparasym.se
.
a
-


→ /MICKI
se €
secretion 1+0
gastric
.

-4
⇐ 9- gain -
M1 :

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&
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-
stcognition 1-ooth.com#tiorImm-
F- and
-

M2 :b Heart rate
contractility
'
Nicotinic receptor
Hemicholiniom Mzccvs )
effect
£ → Negative chronotropicgdromotropic ,
inotropic


to depolarization rate

→ No -
vasodilation - opts

¥ .

Non c. botulinum
f.
dnñ m3

Eye
-

papillary sphincter
mos .
Contraction ( Miosis)

- / of accommodation
kg
"

' LDSO :
try Endocytosis -

spasm
-
¥

Exocrine glands
lacrimation
Avtoinhibition salivation , sweat ,
fIT✗ • RS
-
q

broncho constrict 9 secretion


flaccid paralysis coñmmnñwÑo )
-

,
BTX →

GI
winning
-

# T •
cervical dystonia -

tmotility + tone

Cholinesterase inhibitor relax sphincters

,#¥iÉt
strabismus
-

indirect ) blatter
blepharospasm Vriary

%MzY
-

wrinkles

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t
"
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• hemi facial spasm & glabella -

Detusormvs contraction.

choline ester cnoiinomimetic


-
Relax sphincters brookland :Mib
①@ gjyy MR Ahhhhh
" 'M )
cpororabsorpt distribute alkaloids
Mr Micturition

%fgYhkM B
-

Acetic acid ester Muscarine

} Gq
-

Aminov

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" " "" "
Methacholine Lobeline
cholinesterase

resist to

§.~
-

Nicotine
carbonic acid ester
gradient

g

resistant Nat ,K+ move down conc
( arbachol
}
- .

most
↳ Depolarization


pethanecho , e

,b§µwµµ,yµµµ,[gmmgyd
ng ,an , ,
, , .my ,nµa , pumping.mg , ,
b
pupil constrict Xerostomia -A
Miwriisym para'M
v. .

/
'

f. iris blockade

yggnyan.gnyu.gg

,iawyµraiyb$
block
glaucoma
with pupillary

Acute Nicotinic toxicity


arrest
stimulation → convulsion coma , Respiratory nogs
y
long-acting
① CNS /
Envision www.io
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joUYbIwmsIJW7B@zogkew.aimus.gepnarization-neo.p
-

# } g,g ,
-

dumb
Gowran myasthenia
f) Rate
.→÷ocm
"
Gravis

& Arrhythmia 10Pa vasodil

③ Hypertension acting
short ,

#TanIñIñoiÑÑ
By
Tension Test
Gravis
for myasthenia

cholinergic drys ppg organophosphate


TMI ndirect Acting -
ago carbamates -

wvÑNMJ membrane B
-

Roc
) jpg
-


Acetylcholinesterase ( cholinergic
,
brain synapses Effect :
Parasym .

-
→ nsimiwnioeroo
Neostijmihl
Jg
conouonoiowsym.io )
-

1in tachycardia broncho dilute

Physostiyminl
,

restlessness
-

reflex
hypotension ,

, felirium
-

carbonyl
oiicarbamateooiowin-oio.li
-
Edrophonium SIE :/ ujfoww.mu oil organophosphate oioiloiw
liner GI ) MMMMM

putyryl cholinesterase CWVÑ plasma , / 2- panameno,
?⃝

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