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Abstract
Background: The unique anatomy of the Asian upper eyelid requires specific adaptation to the levator advancement
technique for ptosis correction to achieve predictable and reproducible outcomes.
Objectives: The levator musculo-aponeurotic junction was employed as they key landmark. With a formula developed by
the authors, the location of fixation relative to this landmark can be predicted preoperatively. The authors’ clinical experi-
ence and outcomes with this technique are presented.
Methods: Inclusion criteria were Asian patients with mild to severe ptosis with at least fair levator function. Patients with
acquired or congenital ptosis and primary and revisional cases were all included. The location for placement of the ad-
vancement sutures was measured from the musculo-aponeurotic junction of the upper eyelid levator. This distance was
determined by a formula that considers (1) the amount of elevation of the upper eyelid margin needed, (2) the degree of
compensatory brow elevation present, and (3) eye dominance.
Results: A total 156 Asian patients were included in this prospective study. Of these, 148 were bilateral and 8 were uni-
lateral corrections. The technique was predictable with resolution of symptoms of eyelid ptosis post-surgery and good
long-term symmetry of the palpebral aperture and crisp upper eyelid creases. The formula for estimating the fixation point
on the levator was accurate to within ±1 mm in the majority of patients. The aperture revision rate was 2%.
Conclusions: This novel technique provides a predictable and reliable approach for upper eyelid ptosis correction in
Asian patients.
Level of Evidence: 4
Editorial Decision date: December 2, 2020; online publish-ahead-of-print February 28, 2021.
METHODS
Figure 1. Anatomy of the Asian upper eyelid. Features
unique to Asian upper eyelids include the thick, multi- Upper eyelid ptosis was diagnosed from a detailed his-
lamellated orbital septum, which fuses with the levator tory and physical examination. The symptoms of eyelid
aponeurosis at a relatively lower position, approximately ptosis, such as heaviness and difficulty opening the
at the level of the upper anterior edge of the tarsus. The upper eyelid, were noted. On examination, the severity
septum also bulges forward and prolapses inferiorly (over the of upper eyelid ptosis was measured employing the
fusion point with the lower edge of the levator aponeurosis).
margin-reflex distance 1 (MRD 1). The MRD 1 is the dis-
The tarsus is slightly smaller (on average 8-9 mm in height)
compared with the tarsus in the Caucasian upper eyelids. tance from the pupillary eye reflex in primary gaze to
Also, the pretarsal area has a distinct layer of fibrofatty tissue the upper lid margin. Measurement of less than 5 mm
that obscures the upper edge of the tarsus. was taken as the clinical threshold for the diagnosis of
upper eyelid ptosis in symptomatic patients.6 The le-
and the lack of a consistent anatomical reference point vator function was measured as excellent, good, fair, or
from which this tightening should be referred. The lower poor employing Berke’s method. Upper eyelid excur-
edge of the levator is the most commonly utilized land- sion was measured from downward to upward gaze with
mark, although this is quite a variable anatomical structure the negation of brow elevation due to the frontalis.3,4
and would have been altered in revision cases. A further Compensatory mechanisms, as a result of levator insuf-
compounding factor is the varying degree of compensa- ficiency, were noted preoperatively, with frontalis hyper-
tory frontalis activation assisting eye opening secondary activity indicated by brow elevation, forehead wrinkles,
to levator insufficiency.1-3 Effective ptosis correction elim- and supraorbital hollowing.4,7-9 Ocular dominance was
inates the need for compensatory frontalis activation. The determined by the Dolman method (hole in a card test),
subsequent relaxation of the brow results in a lowering of where a distant object is viewed through a hole in a card
the eyelid margin, thereby unmasking a greater degree with binocular vision and each eye is alternately closed.
of lid ptosis than was previously apparent, which in turn The eye that retains the centralized object through the
necessitates more tightening than expected from eyelid hole via monocular vision is the dominant eye.3,4,10 The
aperture analysis alone. Finally, eye dominance, a factor inclusion criteria for this study were the following: (1)
not previously discussed in ptosis correction, should be Asian patients with symptomatic upper eyelid ptosis; (2)
considered. As is commonly known, the non-dominant or with mild, moderate, or severe upper eyelid ptosis; (3)
“lazy-eye” requires more tightening to achieve a satisfac- excellent to fair levator function (a levator function of
tory result compared with the dominant eye.4 To maximize at least 5 mm); and (4) a minimum follow-up of at least
surgical precision and minimize intraoperative trial and 1 year. Cases with the ptosis from medical causes (such
error fixation, the ability to preoperatively determine the as myasthenia gravis) were included if they had been
1122 Aesthetic Surgery Journal 41(10)
3 mm: −2 Severe: +3 —
Estimated distance (in mm) for levator advancement from the MAJ to anterior RESULTS
tarsus: A + B + C. A was determined by taking the “ideal” MRD1 of +5 mm minus
preoperative MRD 1. B was assessed as mild when only the medial brow ele- A total 156 Asian patients were included in this study. Of
vates with eye opening, moderate when the medial and middle brow elevates
with eye opening, and severe when the entire brow elevates with eye opening
these, 148 patients underwent bilateral upper eyelid ptosis
(Video 1). The non-dominant eye requires more tightening than the non- correction and 8 patients underwent unilateral ptosis cor-
dominant eye, accordingly assigned a further value of +1 mm. MAJ, musculo- rection. There were 111 primary cases (71%) and 45 (29%)
aponeurotic junction; MRD, margin-reflex distance 1.
revision cases; 108 patients were female and 48 were
male. Three patients with myasthenia gravis were treated
optimally treated before surgery. Patients who had poor with this approach after their condition was optimally
levator function were excluded from the study. This treated medically. The mean follow-up was 19 months
study recruited patients from July 2012 to June 2019. (range, 12-59 months). The mean age of the patients was
No IRB approval for this prospective study was ac- 42 years (range, 14-78). The mean operative time (for pa-
quired. Informed consent and photo release to participate tients undergoing bilateral upper eyelid ptosis correction)
in this study were obtained from all patients. The study fol- was 72 minutes (range, 56-105 minutes). The majority of
lowed the tenets of the Declaration of Helsinki. patients were pleased with the outcome of their surgery
with good stability of their long-term result. Aesthetically,
a wider palpebral aperture gave the eyes a refreshed and
Preoperative Estimation of Location of brighter appearance. Functionally, all patients reported
Suture Placement on the Levator for that their postoperative eye opening was easier, with un-
Ptosis Correction hindered vision, and that the forehead felt lighter and more
relaxed.
A detailed explanation of our formula for preoperative es- Video 4 demonstrates the recovery and long-term re-
timation of the fixation point on the levator has been pre- sults of the patient shown in our operative video. This
viously described.11 Table 1 shows our formula. Factors in patient demonstrates the typical recovery process for
determining the advancement needed include (1) the amount Asian patients and illustrates the following: (1) postoper-
of upper lid margin elevation required, in millimeters, which ative swelling is generally more pronounced and more
is calculated by taking the target “ideal” MRD 1 of +5 mm prolonged in the upper eyelids of Asian patients; (2) with
minus the preoperative MRD 1; (2) the degree of compen- more significant levator advancements (0 or + from the
satory brow elevation present preoperatively (Video 1); and MAJ), it is usual to have some degree of lagopthalmos
(3) eye dominance. These factors were summated into an intraoperatively, which generally resolves within 1 week with
estimated fixation point, in millimeters, from the MAJ. This complete lid closure; (3) slight narrowing of the palpebral
was then sutured to the tarsal plate, 1 mm, below its upper aperture in the early postoperative period due to the signif-
edge.1,2,5 Video 2 shows the preoperative estimation of fix- icant swelling of the upper eyelids. With the robust crease
ation points for the patient shown in our operative video. fixation, the aperture gradually widens as the swelling sub-
sides; and (4) adequate correction of the ptosis restores
Surgical Technique the intrinsic eye-opening function of the upper eyelid,
thereby eliminating the compensatory frontalis contraction
Our surgical technique has previously been described11 with eye opening in the long-term results. Therefore, in ad-
and is demonstrated in Video 3. dition to symmetry and height of the palpebral aperture,
Wong et al1123
A B
A B
Figure 3. (A) This 52-year-old female presented with heaviness and difficulty opening her eyes. She had no previous eyelid
surgery. On examination, her margin-reflex distance 1 was +4 mm bilaterally. She was right eye dominant. The estimated
fixation point for her right eye was −3 mm from the musculo-aponeurotic junction (−4, +1, +0) and on her left was –1 mm (−4, +2,
+1). Intraoperatively, symmetry and adequate correction of her eyelid ptosis were achieved at a fixation point of –3 mm from the
musculo-aponeurotic junction on the right and –1 mm on the left. (B) She is shown here at 3 years postoperation.
A B
Figure 4. (A) This 29-year-old female presented with bilateral congenital upper eyelid ptosis more severe on the left side.
Margin-reflex distance 1 on the right was +4 mm and on the left was +2 mm. She was right eye dominant. Preoperative
estimation of the fixation point for the right eye was –4 mm (−4, +0, +0) and the left was –0 mm (−2, +1, +1). Intraoperative
symmetry of the palpebral aperture was achieved at a fixation point of –3 mm on the right and 0 mm on the left. (B) She is
shown here 2 years postoperation, with good long-term stability of the result.
Wong et al1125
A B
Figure 5. (A) This 21-year-old female with an absent upper eyelid crease underwent a cosmetic upper blepharoplasty. She
presented 6 months after her initial blepharoplasty with complaints of heaviness and difficulty opening her eyes. Margin-reflex
distance 1 on the right was +3 mm and left was +3 mm. Preoperative estimation of fixation point was –2 mm (−3, +1, +0) on the
A B
Figure 6. (A) This 70-year-old female with multiple previous upper blepharoplasties and upper eyelid fat grafting presented
with upper eyelid asymmetry and eyelid ptosis. Margin-reflex distance 1 on the right was +2 mm and left was +5 mm. The
preoperative estimation of fixation point was –1 mm (−2, +0, +1) on the right and –3 mm (−5, +2, +0) on the left. Intraoperative
symmetry was achieved at –1 mm on the right and –4 mm on the left. Extensive upper eyelid excision of injected fat was
performed. (B) She is shown here at 1 year postoperation.
This anatomy results in the presence of more fibrofatty long-term stability of the upper eyelid crease. To achieve
tissues consisting of the thick fusion area of the levator a crisp and stable upper eyelid crease, it is necessary to
aponeurosis-orbital septum and the reflected cut edges of excise some of the interposing thick orbicularis oculi at the
the orbital septum (when the septum has been opened) at location of the eyelid crease. This allows the formation of a
or below the upper edge of the tarsus (Figure 1). Careful precise, linear zone of firm adhesion between the dermis
excision of these layers of fibrofatty tissue is required to and the lower edge of the levator aponeurosis.4,14-19 This is
clearly visualize the upper edge of the tarsus.3,6,10-12 This achieved by a trapezoidal excision of the orbicularis oculi
is important because to achieve consistent results, the (Video 5). The resultant gap in the muscle enables the
point of suture placement into the tarsus should be 1 mm dermis to be in direct contact with the edge of the levator
below the upper edge to optimally transfer the mechanical aponeurosis without interposing orbicularis muscle, where
tightening of the levator to the upper eyelid. Other ana- it is secured with the placement of multiple dermal-levator
tomical features specific to the Asian upper eyelid are the fixation sutures
levator aponeurosis, which may be partially dehisced off A key step in the dissection is exposure of the levator
the tarsus and retracted superiorly, and the tarsus, which is aponeurosis/MAJ by cutting across the orbital septum. The
smaller and less robust compared with Caucasian eyelids, multi-lamellated orbital septum requires cutting through
making it less distinct during surgery.3,5,10-13 several layers of septum before the orbital septum has
Our technique was developed to address these spe- been completely cut. The levator aponeurosis is usually
cific challenges for Asian upper eyelids. The constant con- partially or completely detached from the tarsus (levator
tractions of the thick orbicularis oculi interfere with the dehiscence) and retracted superiorly.20-22 The lower edge
1126 Aesthetic Surgery Journal 41(10)
A B
A B
Figure 8. (A) This 36-year-old female presented bilateral asymmetric upper eyelid ptosis with significantly greater degree of
brow elevation on the left side with eye opening. Her margin-reflex distance 1 on the right was +3 mm and +5 mm on the left
and she was right eye dominant. Preoperative estimation of fixation point was –3 mm (−3, +0, +0) on the right and –1 mm (−5,
+3, +1) on the left. Intraoperatively, symmetry was achieved at –3 mm on the right and –2 mm on the left. (B) She is shown here
at 18 months postoperation. Note that with the ptosis correction, intrinsic eye-opening ability was restored, and the need for
activation of the frontalis to assist in eye opening was eliminated. This brought about the relaxation of the frontalis, relieved the
sensation of constant straining to kept the eyes open, and restored symmetry in brow positioning.
of the levator must be identified early in the dissection by upper eyelid) above the tarsus. This may result in bleeding
looking for the distinct whitish, fibrous edge of the levator and hematoma in the Müller’s muscle, making subse-
aponeurosis. The levator is then retracted caudally to fa- quent assessment of adequacy ptosis correction very
cilitate dissection in the correct surgical plane (Video 6). difficult.6,10,27,28
The key identifying landmark is the preaponeurotic orbital Conventionally, levator advancement has been most
fat pad. Once this discrete lobular fat has been identified, commonly referenced in terms of millimeters from the
the levator aponeurosis is located directly below and the lower edge of the levator.5,10,23,24,28 The commonly cited
orbital septum superficial to the fat pad may be safely cut recommendations range from 1:3 to 1:4 ratios; that is, for
to expose the levator aponeurosis below. Retraction of the every 1 mm of upper eyelid ptosis correction required,
orbital (pre-aponeurotic) fat pads cephalically will expose the levator should be shortened 3 mm or 4 mm, respec-
the levator and the MAJ, the key reference landmark with tively.1-5,20,21 However, the correlation between the eleva-
this technique.23-26 If correct traction is not applied to the tion of the upper eyelid margin and the amount of levator
levator aponeurosis, the cephalically retracted levator (and advancement is not linear, with surgeons employing this
the overlying orbital fat pad) could be missed. Dissection approach having to rely on significant amount of trial
may then be inadvertently taken into Müller’s muscle and and error and clinical experience to achieve the desired
the vascular arcade (the peripheral arterial arcade of the correction. Furthermore, the lower edge of the levator
Wong et al1127
aponeurosis itself is quite variable and inconsistent. It from the dominant eye. Once the dominant eye has been
is often stretched and attenuated in older patients. It corrected, the non-dominant eye will inevitably become
may also have been damaged iatrogenically during ex- slightly more ptotic as the central innervation to the non-
posure or shortened from previous surgery in revision dominant eye decreases. Accordingly, +1 mm was added
cases. Specifically, in the Asian eyelid, the fibrous multi- to the non-dominant eye to account for this expected drop
lamellated orbital septum, when cut and reflected cau- in eyelid margin in the non-dominant eye.
dally off its fusion point with the levator, appears as an The provision of a predetermined fixation point has sig-
extension of the lower edge of the levator aponeurosis. nificantly shortened our operating time by eliminating the
This makes accurate identification of the exact location intraoperative trial and error needed. The limitations of util-
of the lower edge of the levator more difficult, adding to izing a prescribed formula to predict the response of a bi-
poor predictability of this approach for ptosis correction ological system as complex as eyelid opening to surgical
in Asian patients.10-13,22,29-31 manipulations should also be acknowledged. The formula
To increase the precision of the surgery, it is critical to was able to predict the correct location of suture placement
have a fixed anatomical reference point. The junction of point in 67% of the eyelids we operated on and certainly
the levator muscle with the levator aponeurosis (MAJ) is provides an excellent guide to the initial trial fixation point.
a constant anatomical landmark. We have found utilizing However, the surgeon should be flexible and be ready to
this landmark with our formula as presented in Table 1 is adjust the fixation point above the below the estimated fix-
an accurate preoperative predictor of the point of fixation ation point as required intraoperatively. In 96% of patients,
needed for the specific requirements of each individual the correct location of fixation point was within ±1 mm of
patient. Our formula is the summation of the 3 factors the preoperative determined fixation location. One of the
important in achieving adequate ptosis correction. The keys to our low revision rate was intraoperatively sitting
first factor (A) is the amount of upper eyelid margin ele- the patient up and performing the necessary adjustment of
vation required. Based on the ptosis correction needed, fixation as required to achieve adequate height and sym-
the corresponding distances from the MAJ were devel- metry of the palpebral aperture.
oped and were validated in this study. The second factor The final intraoperative palpebral aperture should be ex-
(B) is brow elevation. This was categorized as absent, actly what the surgeon intended. An aperture that is insuffi-
mild, moderate, or severe. Assuming that each of these ciently wide intraoperatively is unlikely to improve or widen
ascending categories reflects a progressively greater de- with resolution of postoperative swelling. Equally important,
gree of upper eyelid elevation that is a direct effect of the overcorrection, resulting in lid retraction, must be avoided.
frontalis contraction, greater degrees of levator advance- The practice of producing a slight overcorrection to with-
ment would be necessary to achieve the desired aperture stand the postoperative swelling and stretching is not ap-
on complete relaxation of the frontalis with adequate cor- propriate with this technique. The strong fixation achieved
rection of the ptosis. This was the rationale for tightening with the technique reduces the likelihood of stretching or
of +1, +2, and +3 assigned to patients with mild, moderate, the lid relaxing downwards in the postoperative period.
and severe elevation of the brow, respectively. Finally, eye Some patients develop significant early postoperative
dominance (C) is a factor that is crucially important and not swelling, which may temporarily marginally narrow the ap-
discussed in ptosis correction. Conceptually, the central erture. Provided the eye opening achieved intraoperatively
stimulus for eye opening is primarily in response to input is adequate, gradual widening of the palpebral aperture
1128 Aesthetic Surgery Journal 41(10)
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