Additional questions from IS quiz na wala sa file si ARF

A smaller complement fragment that serves as chemotaxin for granulocytes, monocytes, APC and
mast cells
C2a
C3a
C4a
C5a

Which of the following complement pathways are part of the innate defense system and work in an
antibody independent manner? I. Classical pathway II. Alternative pathway III. MBL Pathway
I, II
II, III
I, III
I, II, III

Complement protein(s) uniquely present in the Alternative pathway

C1, C2, C4
MASP 1, 2, 3
Factor B and Factor D
C5b, C6, C7, C8, C9

If a patient's clinical sample shows low levels of both classic and alternative complement proteins as
shown in the results of CH50 and AH50 assays respectively, these would strongly suggest
deficiency in the early complement components of the two pathways
deficiency in complement proteins that form the C3 convertase
deficiency in the shared terminal complement pathways
deficiency in complement proteins that form the C5 convertase

The Effector functions of molecules generated from the cascade of events brought about by
activation of the complement pathways are categorized as I. opsonin II. anaphylatoxins III. immune
complex inhibitors IV. regulators V. Chemotaxins
I, II, III
 III, IV, V
I, II, IV
I, II, V
II, IV, V

How many cleavage products that function as opsonins are generated following activation
and enzyme amplification in the classical complement system?
1
2
3
4

Among the three pathways, the Alternative maintains a low-level activation process due to
its function as a monitoring system
water cannot easily hydrolyze the C3 thioester
bond
native C3 is unstable in plasma
absence of Factor H in the fluid medium

Inflammatory responses associated with Type I hypersensitivity is brought about by crosslinking of

Fc part of IgE with the allergen bound to the surface of mast cells/basophil thereby leading to the
degranulation of the immune cells.
True
False

Which of the following drugs may act as haptens that when they combine with membrane proteins
on RC would trigger autoimmune hemolytic anemia I. cephalosporins II. aspirin III. Penicillin IV.
cyclosporin
I, II
II, III
I, III
II, IV

Destruction of cell bound antigens that occur in a Type II hypersensitivity is solely mediated by
soluble factors which are part of innate and adaptive immunity.
 True
False

Atypical hemolytic uremic syndrome is a genetic and microvascular disease which occur when the
classical pathway is not properly regulated.
True
False