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Review on Food poisoning (Types, Causes, Symptoms, Diagnosis, Treatment)

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DOI: 10.36348/gajpdr.2021.v03i04.001

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Global Academic Journal of Pharmacy and Drug
Research
Available online at https://www.gajrc.com
DOI: 10.36348/gajpdr.2021.v03i04.001

ISSN (P): 2706-9044


ISSN (O): 2707-255X

Review Article

Review on Food poisoning (Types, Causes, Symptoms, Diagnosis,


Treatment)
Dr. Nagham Mahmood Aljamali1*, Dr. Muhsin Mohammed Al Najim2, Anaam Jawad Alabbasy3
1Professor, Ph.D, Department of Chemistry, Synthetic Organic Field, Iraq
2Collegeof Medicine, University of Jaber Ibn Hayan, Najaf, Iraq
3Professor, M.Sc, Department of Biology, College of Education for Girls, Iraq

*Corresponding Author Abstract: Food poisoning is a common disease condition that usually results from
Dr. Nagham Mahmood
eating food contaminated with infectious microorganisms (viral, bacterial, parasitic
Aljamali
or fungal) or toxins secreted during the different stages of food processing,
Article History production or preservation. Most cases of food poisoning are considered moderate
Received: 16.09.2021 and their symptoms resolve spontaneously within several days without treatment,
Accepted: 27.10.2021
while severe and chronic cases require hospitalization. Food poisoning can usually
Published: 01.11.2021
be prevented by keeping hands clean and preparing food in proper, hygienic and
clean ways. The majority of reported cases of foodborne illness are individual or
sporadic. The origin of this sporadic infection often cannot be determined. For
example, the majority of foodborne disease outbreaks (58%) in the USA originate in
commercial food establishments (Foodnet 2004 data). An outbreak is defined as
when two or more people are exposed to the same disease after eating food from a
common food supply. There is often more than one reason for an outbreak or
outbreak, for example, food may be left at room temperature for many hours,
allowing the growth of bacteria that accumulate through inadequate cooking of the
food, resulting in failure to eliminate or kill Bacteria levels are very dangerous.
Keywords: Poisoning, toxicity, diaries, pollution, diarrhea, bacteria, fungi, parasitic.
Copyright © 2021 The Author(s): This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International
License (CC BY-NC 4.0) which permits unrestricted use, distribution, and reproduction in any medium for non-commercial use provided the original
author and source are credited.

INTRODUCTION illness, or foodborne disease, colloquially referred to


Food poisoning is a set of symptoms as food poisoning, represents every illness caused by
resulting from eating food contaminated with eating contaminated food. There are two types of
bacteria, or toxins produced by these organisms, and food poisoning cases: the case of botulism poisoning
food poisoning results from eating food and the case of botulism poisoning [2]. Food
contaminated with various types of viruses, germs, infections indicate the presence of bacteria or other
parasites and toxic chemicals such as poisoning microbes that cause infection in the body after
caused by eating mushrooms, and it is said that food eating. The possibility of food contamination has
poisoning may An outbreak if it happened that increased in our contemporary times due to the
symptoms of the disease appeared in more than two accelerated globalization in food production and
people, and laboratory studies have shown that the trade[3]. Some foodborne disease outbreaks that
ingested food is the direct cause by planting the were once contained within a small community may
bacteria that cause poisoning, and food poisoning now occur across larger communities or on global
caused by bacteria is the main cause in more than dimensions. This made food and food safety
80% of food poisoning cases[1]. Trusted? Foodborne authorities around the world acknowledge that the
Citation: Nagham Mahmood Aljamali et al. (2021). Review on Food poisoning (Types, Causes, Symptoms, Diagnosis, Treatment), Glob Acad J
Pharm Drug Res; Vol-3, Iss- 4 pp- 54-61.
54
Nagham Mahmood Aljamali et al., Glob Acad J Pharm Drug Res; Vol-3, Iss- 4 (Nov-Dec- 2021): 54-61

issue of food safety should not be dealt with at the  Salmonella.


local level, but also through the establishment of  Clostridium Batulinum.
closer relationships and links between those  Shigella.
authorities at the global level[4,5]. This is necessary  Toxigenic E.coli.
to exchange regulatory information on food safety  Campylobacter.
issues as well as facilitate access to data and  Yersinier.
information in the event of exposure to food safety  Listeria.
emergencies.” It is also difficult to estimate the  Aeromonas.
global incidence of foodborne diseases, but it was
reported that in 2000 About 2.1 million people died Poisoning is the harmful effect that occurs
from diarrheal diseases, many of these diseases are when a toxic substance is swallowed or inhaled or
attributed to the contamination of drinking water upon contact with the skin, eyes, or mucous
and food, in addition to that diarrhea is a major membranes, such as those in the mouth or nose.
cause of malnutrition in children and young people. Possible toxicants include over-the-counter and
prescription drugs, prohibited drugs, gases,
It has been reported that about 30% of the chemicals, vitamins, food, mushrooms, plants, and
total population in the industrialized countries animal poisons. Some toxins cause no harm, while
themselves suffer from foodborne illness infection others can cause severe damage or death. The
annually. The rate of infection with food-borne diagnosis is based on symptoms, information from
diseases is estimated at 76 million cases annually, of the poisoned person and those present, and
which about 325,000 cases are treated in hospitals, sometimes from urine and blood tests. Therefore,
in addition to about 5,000 deaths [6]. However, medicines should always be kept in their original
developing countries in particular suffer worse from containers, out of reach of children. Treatment
the risks of exposure to foodborne diseases due to involves supporting the person and preventing more
the wide spread of diseases, including those caused venom from being absorbed and, sometimes, an
by parasites. Here, we note that food-borne diseases increased excretion of the venom. More than two
cause serious and severe harm to society. In 1994, million people suffer from some form of poisoning in
an outbreak of salmonella infection caused by the United States each year[9]. Prescription or over-
contaminated ice cream occurred in the United the-counter and prohibited drugs are a common
States of America, resulting in the infection of source of serious poisoning-related poisoning and
224,000 individuals. In 1998, an outbreak of death (see acetaminophen poisoning; see also
hepatitis A occurred in China, which was caused by aspirin poisoning). Other common toxins include
eating contaminated mollusks, resulting in an gases (such as carbon monoxide), household
infection of 300,000 individuals. As a result, food products (see caustic poisoning), agricultural
contamination creates widespread social and products, plants, heavy metals (such as iron and
economic pressure on communities exposed to lead), vitamins, animal poison, and foods
outbreaks or disease outbreaks [7]. The medical cost (particularly certain types of mushrooms and fish).
and production losses of diseases caused by However, ingesting almost any substance in very
pathogens in the United States of America in 1997 large quantities can be toxic[10].
were estimated at 35 billion US dollars. The
outbreak of cholera in Peru in 1991 led to a loss of Accidental poisoning
500 million US dollars in losses in fish and fish Poisoning is the most common cause of non-
product exports during that year. As for body fatal accidents in the home. Young children are
toxicity, it refers to the ingestion and digestion of especially susceptible to accidental poisoning in the
toxins in foods, including exotoxins, which express home because of curiosity and a tendency to explore,
protein bio-toxins made by some organisms from and the elderly, who are often confused about their
plants and animals such as castor seed toxin. The medications. Since children often share discs and
toxin is no longer present or unable to cause items they find, siblings and playmates may also
infection. Despite that commonly used term, food have been poisoned. People at risk of accidental
poisoning, most cases are caused by a variety of poisoning are hospitalized people (due to
pathogenic bacteria, viruses or parasites, all of medication errors) and industrial workers (due to
which contaminate food, rather than chemical or exposure to toxic chemicals). Countries cannot
natural toxins. Scientists have limited the main types completely eliminate this problem by enacting laws,
of bacteria that cause food poisoning to twelve types monitoring places where food is prepared, and
[8]: periodically examining people involved in preparing
 Clostiridium perfringins. food [11]. The size of the problem is also inversely
 Staflo Aureus Staph. Aureus. proportional to the state's economic, cultural and
 Vibio Species: V. Cholorae: V. Parahaemolylicus. technological status, as well as the degree of
 Bacillus Cereus. education of workers in food preparation shops, and
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of the public consuming these foods. We see that strong and only cause problems with prolonged
cases of food poisoning in general are limited in exposure or frequent use of large amounts of the
developed countries, and widespread in poor poison. Others are so potent that a drop on the skin
countries [12]. Food preparation shops have the can cause severe symptoms. Some toxins cause
greatest responsibility towards the consumer by symptoms within seconds, while others cause
purchasing meat from approved and experienced symptoms only hours, days, or even years later.
food preservation places, and these stores must also Some toxins cause such obvious symptoms that vital
provide the necessary equipment for preserving organs, such as the kidneys or liver, are sometimes
meat in particular and other types of food in general. permanently damaged. Ingested (ingested) and
In order to prevent the proliferation of bacteria, absorbed toxins cause symptoms throughout the
which often need moderate temperatures for body because they often deprive the body's cells of
growth, as well as paying attention to places of oxygen or activate or block the action of enzymes
preparation in terms of sanitation, and general and receptors. Symptoms may include changes in
hygiene, as well as paying attention to workers in consciousness, body temperature, heart rate and
terms of education regarding food poisoning and breathing, and a number of other symptoms,
physical hygiene, washing hands well after depending on which organs are affected. Caustic or
defecation, and keeping patients away from the irritating substances Injury to the mucous
preparation process, especially those Who complain membranes of the mouth, throat, digestive tract, and
of stomach flu. Not leaving foods exposed or exposed lungs causes pain, coughing, vomiting and shortness
to insects or hot weather for long periods, using of breath [19, 20]. Skin exposure to toxins can cause
gloves when touching foods, getting rid of old foods various symptoms, such as rashes, pain, and blisters.
on a daily basis, not mixing old foods with fresh Also, prolonged exposure to toxins can cause skin
ones, especially getting rid of foods that change their inflammation. Eye exposure to toxins can damage
color, taste or smell, and a sense of responsibility the eye, causing eye pain, redness, and decreased
towards consumers and not acting out of purely vision [21].
materialistic [13, 14].
Bacteria
Deliberate poisoning Bacteria is one of the main underlying
Poisoning may be a deliberate attempt to causes of foodborne diseases. Where the bacteria
kill or commit suicide. Most adults who attempt involved in the infection of such diseases in the
suicide by poisoning use more than one drug and United Kingdom in 2000 were examples:
also drink alcohol. Poisoning can be used to weaken Campylobacter jejuni by 77.3%, Salmonella by
a person (for example, to rape or rob a person). In 20.9%, and E. coli O157:H7 by 1.4%, while other
rare cases, parents with a mental disorder poison types of bacteria represented no more than 0.1 % of
their children to make them ill, thereby gaining the underlying causes of foodborne diseases. It used
medical attention (a disorder called Factitious to be that bacterial infection was more common
Disorder). Foodborne diseases often result from because only a few places were able to test for
poor handling, improper preparation and norovirus, and passive surveillance for that agent
processing, and poor food storage. Noting that good was done. Noting that the symptoms of a bacterial
hygiene practices before, during and after food infection are delayed because the bacteria need a
processing reduce the chances of exposure to period of time to multiply. It is often hidden and not
foodborne diseases. A common awareness trend seen until 12-72 hours or more after eating the
among the public health community is that regular contaminated food among the most common
hand washing is one of the most effective defenses bacterial pathogens are:
against the spread of foodborne diseases. This
movement to control and control food to ensure that Campylobacter jejuni, which leads to a
it does not cause exposure to foodborne diseases is secondary form of Guillain-Barré syndrome and
known as food safety. This makes the underlying periodontitis. Clostridium perfringens, which is
cause of exposure to foodborne diseases a wide called the "cafeteria germ".
variety of toxins affecting the environment. For
more information on chemical-borne diseases, see Salmonella - Eating eggs that have not been
Food contamination. Foodborne diseases can also be cooked enough causes typhimurium infection, or
caused by pesticides or medicines in foods, in other pathogens that are transmitted between
addition to natural toxic substances, including humans and animals [22-25].
poisonous mushrooms or reef fish [15-18].

Symptoms Salmonella
Symptoms of poisoning vary depending on Escherichia coli
the poison, the amount used, the age, and the health O157:H7enterohemorrhagic causes hemolytic-
of the person using it. Some poisons are not very
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uremic syndrome. Other bacterial pathogens that


transmit disease through food include: Aflatoxin is a product of the parasitic
Aspergillus parasiticus and Aspergillus flavus. Which
Bisilis Ceres is often found in liqueur trees, peanuts, corn, and
Escherichia coli, which are of the most important sorghum, in addition to the seeds of other oils such
classes according to their malignant characteristics as corn and cotton seeds. The obvious forms of
(strains): enteroinvasive strains, enteropathogenic aflatoxin are B1, B2, G1, and G2, noting that aflatoxin
strains, enterotoxigenic strains, and E coli strains B! It often targets the liver specifically, which often
clustered in The intestines (enteroaggregative). results in necrosis, cirrhosis and liver cancer, and
 Listeria monocytogenes. carcinoma. This led the United States of America to
 Shigella set acceptable levels of total aflatoxin in food to be
 Staphylococcus aureus less than 20 μg/kg. The official document can be
 streptococcus bacteria obtained on the US Food and Drug Administration's
 Vibrio cholerae bacteria, including O1 and non- website.
O1 species.
 Staphylococcus aureus (Vibrio Alternaria Fungi Poisoning – Caused by
parahaemolyticus) Alternariol fungi including Alternariol (AOH),
 Yersinia enterocolitica, Yersinia Alternariol methyl ether (AME), Altenuene (ALT),
pseudotuberculosis Altertoxin-1 (ATX-1), Tenuazonic acid (TeA) and
 The least common bacterial species are: Radicinin (RAD). Some of these toxins may be found
in sorghum plants, finger millet (Eleusine coracana),
Brucella wheat, and tomato fruit. Noting that some
 Corynebacteriumulcerans experimental studies have demonstrated the ease of
transfer of these toxins between grain commodities,
 Coxiellaburnetii, or question fever.
and indicated that the manufacture and storage of
 Plesiomonasshigelloides
grain commodities is a vital practice in this process
 exotoxins
[30-33].
 Citrinin
In addition to some diseases caused directly
 Citreoviridin
by bacterial infection, there are also some foodborne
diseases caused by exotoxins that are secreted by a  Cyclopiazonic acid
specific cell during the growth of bacteria. Hence,  Cytochalasins
exotoxins have the potential to cause disease even  Ergot alkaloids / ergotamine alkaloids.
when the microbes that produce those toxins die or
are killed. Symptoms appear immediately after 1-6 Fumonisins - Corn grains may be easily
hours, depending on the amount of toxin that was contaminated with Fusariummoniliforme.
ingested and digested. From here, the outbreak can Fumonisin B1 causes leukoencephalomalacia in
be identified by the infected individuals getting to horses, edema of pigs with pulmonary edema
know each other. However, more outbreaks or syndrome, liver cancer in mice, and esophageal
outbreaks are identified by the public health team's cancer in humans. To respect and preserve the
interview with increasing reports of laboratory test health of both humans and animals, the US Food and
results for some strains of bacteria. Noting that the Drug Administration and the European Commission
detection and investigation of disease outbreaks is regulate the toxin content of food and animal feed as
the responsibility of the local health jurisdictions of well.
the states, making them incompatible from one
province to another. It has also been estimated that Coco toxin – The limit of reporting level for
only about 1-2% of outbreaks are detected [26-29]. fumonisin A analyzes in the Australian Total Diet
Survey in the 20th century was 1 µg/kg, while the
Mycotoxins and the effect of mycotoxins in food: European Commission limits the content of
The term alimentary mycotoxicoses refers fumonisin A A to 5 µg/kg in cereal commodities
to the effect of mycotoxins through food intake. food, up to 3 µg/kg in processed products and 10
Sometimes mycotoxins have important effects on µg/kg in dried vine fruits.
the health of both humans and animals. For example,
a stranded species caused the death of about Oosporeine
100,000 turkeys in 1960 in the UK after they all ate Patulin - notes that this trait is currently
peanut meal contaminated with aflatoxin. And 5,000 well regulated in food products. The European
people died in the Soviet Union during World War II Commission and the US Food and Drug
due to a dearth of toxic dietary white blood cells. Administration have limited its use to less than 50
Diseases caused by fungal and foodborne toxins µg/kg in fruit juice and fruit flavors, while the
include: European Commission has limited its use to 25

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Nagham Mahmood Aljamali et al., Glob Acad J Pharm Drug Res; Vol-3, Iss- 4 (Nov-Dec- 2021): 54-61

µg/kg in solid fruit products and 10 µg/kg in baby location of the ingested substances. Toxins that may
food. be visible on x-rays include iron, lead, arsenic, and
 phomopsin other metals, and large packets of cocaine or other
 sporidismin A prohibited drugs swallowed through so-called body
 stigmatocystin pounders or drug carriers (see Body Filling and
Body Filling). Batteries and magnets can also be
Tremorgenicmycotoxins - Five types of distinguished on x-rays, as well as canines, teeth,
tremorgenicmycotoxins have been reported to be cartilaginous spines, and other animal parts that
found in fermented meat. They are: Fumitremorgen may disintegrate and remain as an integral part of
B, Paxilline, Penitrem A, Verrucosidin, and the body after an animal attack or exposure to insect
Verruculogen Trichothecenes - Its sources are venom[37].
Cephalosporium, Fusarium, Myrothecium, Stucky
botris and Trichoderma. The toxins are usually Natural toxins
found in rotting corn, wheat, peanuts, and rice, as Many foods naturally contain toxins, most of
well as animal feed straw and hay. Both humans and which are not caused by bacteria. Plants in
animals suffer from four common types of particular can be poisonous; While animals are
Trichothecenes toxins: T-2 toxin, HT-2 toxin, rarely naturally poisonous. Evolutionarily speaking,
diacetoxyscirpenol (DAS) and deoxynivalenol animals have the ability to escape if they are preyed
(DON). Oral administration of these toxins upon or eaten; However, plants use only negative
subsequently results in toxic and foodborne defense techniques, including toxins and revolting
leukopenia, as well as hematological disorders, substances that taste bad, such as capsaicin in chili
aplastic anemia, thrombocytopenia and/or peppers and pungent sulfur compounds in garlic and
irritation. Skin. This prompted the US Food and Drug onions. Noting that the majority of animal toxins are
Administration to issue a document in 1993 that not made by animals themselves, but they acquire
limits the content of deoxynivalenol in human foods them by eating poisonous plants to which these
and animal feeds as an indicative. The United States animals are immune to their toxicity, or by the
of America has also published a promising patent for action of bacteria. The harmful activity of these
farmers to produce trichothecene-control crops. bacteria in the digestive system is due to
 Zearalenone enterotoxins, which are divided into two groups,
 Zearalenols exotoxins (toxins secreted from microorganisms
into the surrounding environment) and endotoxins
Diagnosis (which remain inside the cells of microorganisms
Determining the poison, sometimes urine and are released when cells are destroyed).
and blood tests, x-rays of the abdomen In rare cases, Exotoxins are released mainly by Gram-positive
knowledge of the poison is useful for treatment. The bacteria during their growth. They are made up
labels on the bottles and other information from the mostly of very toxic and antigenic proteins that
person, family members, or co-workers make it become active after a quiescent period. This group
easier for the doctor or poison center to identify includes toxins released by Clostridium botulinum
poisons. However, if labels are not available, the (botulin toxin, a neurotoxic globular protein), C.
drugs can often be identified by the markings and perfringens and Staphylococcus aureus. Poisoning
colors on the tablets or capsules. It is highly unlikely with St. aureus is the most common food poisoning,
that laboratory tests can identify the toxin, since and its symptoms include vomiting, diarrhea,
many drugs and toxins cannot be easily identified or stomach pain, and its main cause is food of animal
their levels measured in the hospital. However, origin, meat and its products, poultry, cheese, potato
blood and urine tests can sometimes help identify salad, and pastries). The basis of endotoxins from
the toxin. Sometimes blood tests can reveal the Gram-negative bacteria, they act as antigens and
severity of the poisoning, but these tests are limited bind tightly to the cell wall of bacteria and are
to a few toxins [34-36]. Doctors examine people for complex in nature, consisting of protein,
signs of a particular type of substance. For example, polysaccharides, and lipids. Endotoxins are
doctor’s check for needle marks or track for signs relatively stable thermally, and are generally active
that these people have injected drugs (see Using without requiring an incubation period. The toxins
Injectable Drugs). They also test people who have that cause typhoid and paratyphoid, salmonellosis
symptoms characteristic of certain types of and bacterial dysentery are of this group.
poisoning. Doctors look to see if people have traces Salmonellosis is very dangerous and is an infection
of a drug or substance on their skin, or whether drug with toxins numbering about 300 species: but they
labels for drugs absorbed through the skin are are closely related organisms. The infection is
hidden in skin folds, on the roof of the mouth, or characterized by internal fever, gastroenteritis, and
under the tongue. In some cases of poisoning, an salmonellosis septicemia: the sources of infection
abdominal x-ray may show the presence and are different, but they are closely related organisms.

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Nagham Mahmood Aljamali et al., Glob Acad J Pharm Drug Res; Vol-3, Iss- 4 (Nov-Dec- 2021): 54-61

The infection is characterized by endogenous fever, slicer in an Aberdeen food store, and because of the
gastroenteritis and salmonellosis septicemia: egg poor cleaning procedures of the machine, the
products, frozen poultry, ground beef, candy contamination spread to the meat stored in other
products and coca are sources of infection [38]. The boxes that were cut using the same machine. The
presence of E. coli bacteria first indicates the people of Aberdeen then ate the contaminated meat,
presence of fecal contamination, and this gives became infected and became ill. Foodborne disease
special attention. This bacterium introduces an outbreaks during the seventies of the twentieth
endotoxin strain, a particularly dangerous strain century prompted the United Kingdom to bring
that was discovered in 1983. about fundamental and drastic changes in food
safety law in the Kingdom of Britain. These
Prevention of bacterial food poisoning outbreaks included the deaths of about 19 patients
Proper frozen storage of foods helps in an outbreak that occurred at Stanley Royal
prevent food poisoning. Prevention is often the role Hospital [43] in the 1980s. And about 17 deaths in
of government, by setting strict rules for health and 1996 in Wishu from infection with E. coli O157,
public services for veterinary surveys of animal which was an indication for the establishment of the
products in the food chain, from the agricultural Food Standards Agency, which according to the
field to manufacturing and delivering products to comment of former British Prime Minister Tony
supermarkets and restaurants. Here, the organizing Blair in 1998 that the white document [44,45]: A
process includes: Traceability: the origin of the Force for Change Cm 3830 It will have executive
ingredients in the final product must be known authority and power, as well as be open and
(whether from the parent farm from which the oriented to serve the interests of consumers.
ingredients were collected, by identifying the crop or
animal sources) and where and when they were CONCLUSIONS
processed; Then the source of the disease can be Food poisoning, also known as foodborne
found, traced, and then try to find solutions to treat illness, is an illness caused by eating contaminated
it (and it may be possible to punish the responsible), food. Infectious germs, including bacteria, viruses,
in addition to providing the opportunity to dispose and parasites, or their toxins, are the most common
of the final products and withdraw them from the cause of food poisoning. Infectious germs and their
market if a problem is proven; Implementation of toxins can contaminate food at any stage of
sanitary procedures including HACCP and “cold processing or production. Contamination can also
chain” certification standards; Control, control, occur in the home if food is prepared or cooked
deterrence and law enforcement authority for incorrectly. Symptoms of food poisoning, which can
veterinarians. In the year 2006, the US Food and begin within hours of eating contaminated food,
Drug Administration in the United States of America often include nausea, vomiting or diarrhea. Often,
adopted the methodology of phage therapy, which food poisoning is mild and goes away without
includes spraying meat with viruses that infect treatment. But some patients need to go to hospital.
bacteria, thus preventing the spread of infection.
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