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LATUR – 413512
DEPARTMENT OF CHEMISTRY
Syllabus
CBCS Pattern
Paper Code No. Title of the course Hours/ In Sem End Sem Credits
Week
IX P-ASM-343 Advanced Spectroscopic 04 40 60 04
Methods
P-MDC- Elective:
346(A) A.Medicinal Chemistry
XII 04 40 60 04
P-POC-
B.Polymer Chemistry
346(B)
IX Lab Course-IX 04 20 30 02
P-LAC-347
Seminar 25 01
Total 575 23
Semester - IV
Marks (100)
Hours/
Paper Code No. Title of the course End Credits
Week In Sem
Sem
Advanced Synthetic
XIII P-ASM-439 04 40 60 04
Methods
Advanced Heterocyclic
XV P-AHC-441 04 40 60 04
Chemistry
P-AOC- Elective:
442(A)
A. Applied Organic
XVI P-DAI- 04 40 60 04
Chemistry
442(B)
Lab Course XV 04 40 60 04
XV P-LAC-446
( Project) Annual
Seminar 25 01
Total 725 27
Theory Papers 100 Marks: (Internal 40*+External 60*)
*External S.E.E. 60 Marks Theory
* Internal 40 Marks (Two unit test -30 marks+ Attendance 10Marks)
Unit Test I MCQ patterns 60 MCQ questions
Unit Test II Activity Based 60 Marks
Unit test ( I+ II) = 120 converted to 30 Marks
Rajarshi Shahu Mahavidyalaya (Autonomous), Latur
Syllabus
M.Sc. II (Organic Chemistry) (Semester – III)
(w.e.f. – 2018-19)
Paper IX
Core Course Title - Advanced Spectroscopic Methods
Course Code: P-ASM-343
Marks:100 Periods:60
Credit : 04 04 Per Week
Learning Objective:
1. 1. To study principles of different advanced spectroscopic methods such as UV, IR, 1H-
NMR and Mass-spectrometry methods for the analysis of organic compounds.
Course Outcome:
1. After studying UV, IR, 1H-NMR and Mass-spectrometry methods, students will be able to
detect the nature as well as structure of organic compounds
2. Students will be skilled in problem solving, critical thinking and analytical reasoning as
applied to scientific problems.
B) IR Spectroscopy
Introduction, molecular vibration, fundamental modes of vibration, Hookes law,
presentation of IR spectra, functional group region, finger print region, overtones;
combination bands and Fermi resonance. Characteristic vibrational frequencies of alkanes;
alkenes; alkynes; aromatic compounds; alcohols; ethers; phenols and amines. Detailed
study of vibrational frequencies of carbonyl compounds [ketones; aldehydes; esters;
amides; acids; anhydrides; lactones; lactams and conjugated carbonyl compounds] Effect of
hydrogen bonding and solvent on vibrational frequencies. FT-IR of gaseous; solids and
polymeric materials
References :
1. V.M. Parikh, Application spectroscopy of organic molecules. (Mehata)
2. D.W. Williams and Flemming, Spectroscopic methods of organic compound.
3. Silverstein and Basallar, Spectroscopic identification of organic compounds V.M.Parikh
4. Orption Spectroscipy of Organic Molecules ( J. Wiley )
5. P.S. Kalsi Spectroscope of organic compounds ( New age publisher )
6. J.R. Dyer. Application of absorption spectroscopy of organic compounds.
7. Jackman and Sterneil , Application of NMR spectroscopy
8. J.D. Roberts, Nuclear magnetic resonance (J. Wiley)
9. Jafee and Orchin, Theory and application of U.V,
10. K. Benjamin. Mass spectroscopy
11. Beynon J H et.al , The mass spectra of organic molecules.
12. Wehli F.W, Marchand A. P. Interpretation of carbon 13 NMR ( J. Wiley )
13. W. Kemp, Organic spectroscopy ELBS
14. Willard Merritt and Dean. Instrumental methods of analysis CBS
15. Das and Jame , Mass Spectroscopy..
16. Organic spectroscopy Y. R . Sharma
17. Organic spectroscopy Pavia
*****
Paper X
Core Course Title - Organic Transformation
Course Course Code: P- OTF-344
Marks:100 Periods:60
Credit : 04 04 Per Week
Learning Objective:
*****
Paper XI
Core Course Title - Chemistry of Natural Products
Course Code: P-CNP-345
Marks:100 Periods:60
Credit : 04 04 Per Week
Learning Objective:
1. To learn general methods of structure determination, isoprene rule and synthesis of
Terpenoids & Carotenoids.
2. To understand nomenclature, occurrence, isolation, classification and synthesis of
alkaloids
3. To know isolation, structure determination and synthesis of steroids.
4. To learn nomenclature and general methods of structure determination, and synthesis of
Anthocyanins and Flavones.
Course Outcome:
After successful completion of the course the students will:
1. Learn general methods of structure determination, isoprene rule and synthesis of Citral,
Geraniol, Menthol, Camphor, Phytol etc.
2. Uunderstand nomenclature, occurrence, isolation, classification and synthesis of
Ephedrine, atropine, Quinine and Morphine.
3. Know isolation, structure determination and synthesis of cholesterol, Bile acids,
Androsterone.
4. Learn nomenclature and general methods of structure determination, and synthesis of
cyanin, Hirsutidin chloride, Flavones and Flavonols, Qurcetin, and Isoflavones.
References :
1. The Organic chemistry of Drug Design and Drug Action, R.B.Silverman, Academicpress.
2. Natural Products: Chemistry and Biological Significance, J.Mann, R.S.Davidson,
3. J.B. Hobbs, D.V.Banthrope and J.B.Harborne, Longman, Essex.
4. Organic chemistry, Vol 2, I.L.Finar, ELBS.
5. Introduction to Flavonoids, B.A.Bohm, Harwood Academic publishers
6. New Trends in natural product chemistry, Atta-ur-Rahman and M.I.Choudhary,Harwood
Academic publishers.
*****
Elective
Paper XII
Course Title – Medicinal Chemistry
Course Code: P-MDC-346 (A)
Marks:100 Periods:60
Credit : 04 04 Per Week
Learning Objective:
1. Introduction of Medicinal chemistry and its terminology.
Course Outcome:
After successful completion of the course the students will :
2. Know about Drug designing methods, SAR and study of Pro and Soft drugs.
B] Antileprotic drugs.
Chaulmoogra and hydrocarpus oil, Multidrug therapy, SAR of sulphones, Dapsone (DDS),
Acedapsone, Diaminodipheyl thiourea, Rifampicin. (Synthesis of Acedapsone expected)
C] Antibiotics. drugs
a) Cell wall synthesis inhibitors (β-Lactam antibiotics): Synthesis of Penicillin-V,
Penicillin-G, amoxicillin, ampicilin from 6-APA, cephalexin, Structure and activity of
benzyl penicillin, semi-synthetic penicillin, cephalosporin, Mode of action of penicillin
and cephalosporin.
b) Protein synthesis inhibitors: Structure activity of tetracycline and synthesis of
chlortetracycline, Synthesis and SAR of chloramphenicol, Mode of action of
chloroamphenicol.
References :
1. Medicinal chemistry-William O. Foye
2. T. B. of Organic medicinal and pharmaceutical chemistry-Wilson and Gisvold’s
(Ed.Robert F. Dorge)
3. An introduction to medicinal chemistry-Graham L. Patrick
4. Principles of medicinal chemistry (Vol. I and II)-S. S. Kadam, K. R. Mahadik and K.
G. Bothara (Nirali prakashan)
5. Medicinal chemistry (Vol. I and II)-Burger
6. An introduction to drug design-S. S. Pandeya and J. R. Dimmock (New age international)
7. The organic chemistry of drug design and drug action-R. B. Silverman (Academic Press)
8. Strategies for organic drug synthesis and design-D. Lednicer Wiley
9. Pharmacological basis of therapeutics-Goodman and Gilman’s (McGraw Hill)
Elective Paper
Paper XII
P-POC-342(B)
Core Course Title – Polymer Chemistry
Marks:100 Periods:60
Credit : 04 04 Per Week
Learning Objective:
1. To understand the concepts of Petroleum based raw materials, types and source of crude
oils
acetylene and derivatives, propylene and derivatives
2. To know about Chain/step growth polymers, Nomenclature of polymers, names based
on source
3. To familiarize with , H-T and H-H polymerization, ATRP, RAFT and nitroxide mediated
polymerization.
4. To understand about basic concepts of cationic and anionic methods of polymerization,
Ring opening polymerization.
Course Outcome:
After completion of course students will know about:
1. The concepts of Petroleum based raw materials, types and source of crude oils acetylene
and derivatives, propylene and derivatives
2. Types of polymers. linear, branched, hyperbranched, star branched dendrimers.
3. Experimental determination of rate of polymerization. Initiation by free radical, redox,
photochemical, ionizing radiation and thermal methods.
Petroleum based raw materials: Crude oil, natural gas, petroleum hydrocarbons, types and
source of crude oil, refining various petroleum fractions, cracking ( thermal and catalytic),
knock and octane rating, petrochemical as building blocks, Acetylene and derivatives,
propylene and derivatives, butane/butene, butadiene fractions, BTX and their derivatives:
Polymer feed stocks (monomers, solvents), petroleum industry Carbon monoxide, Carbon
dioxide as building block for monomers and polymers
Unit 2: CLASSIFICATION OF POLYMERS 10 Periods
Polymerization which proceed with C-C, C-O and C-N bond formation Suzuki, Heck,
ADMET, Chain-growth polycondensation [examples-polyamides, polyether-ketones],
enzyme/metal catalyzed step growth polymerization; Reactivity of functional groups, basis
for analysis of step growth polymerization kinetics. Kinetic equation for polyesterification,
Carothers equation for DP, control of molecular weights in linear step-growth polymers.
References :
1. P. Rempp and E.W. Merill Polymer Synthesis Huethig and Wepf Verlag, Basel
3. Principles of Polymer Chemistry, 2Nd Ed. A Ravve Kluwer Academic Publisher (2000)
ISBN 0-306- 48368-7
13. Polymer Chemistry, M. G. Arora & M. Singh, (Amol Publ Pvt.Ltd. New Delhi- 11 0002)
M. Sc. III Semester
Laboratory Course-IX
Mixture Analysis
Course Code: P-LAC-347
Marks: 50 Periods: 60
Credit: 02 06 Periods Per Week
Learning Objective:
Course Outcome:
1. Students will able to separate ternary mixture and can analyse each component of the
mixture.
2. They can know about chromatographic Separation (TLC) techniques.
Semi-micro Qualitative Analysis of Ternary Mixtures (Two Solids and One Liquid)
containing single/poly functional compounds by Chemical and Physical Method with
Chromatographic Separation (TLC) for purity of all three components and its Expected
Theoretical Spectral Data (IR, 1H NMR & 13C NMR).
*****
M. Sc. Semester III
Laboratory Course-X
Synthesis of Organic Molecules
Course Code: P-LAC-348
Marks: 50 Periods: 60
Credit: 02 06 Periods Per Week
Learning Objective:
Learning Objective:
Course Outcome:
Note:
1. All required solutions must be prepared by the students.
2. In examination one experiment is on Instrumental and one should be on
noninstrumental.
References :
1. Modern Experimental organic chemistry by Royston M. Robert, John C. Gilbert, Lyuu
B. Rodewald & Alan S. Wingrove, Saunder International Edition
2. Advanced practical organic chemistry by N.K. Vishnoi
3. Experimental organic chemistry by L. M. Harwood & C. I. Moody, Blackwell Scientific
Publications.
4. The systematic identification os organic compounds by R.L. Shriner & D.Y. Curtin
5. Semi-microqualitative organic analysis by N.D. Cheronis, J.B. Entrikin & E.M. Wodnett
6. Small scale organic preparation by P.J. Hill
7. Vogel’s textbook of practical organic chemistry by ELBS, Longmann.
*****
Rajarshi Shahu Mahavidyalaya (Autonomous), Latur
M Sc II Year
Semester-IV
Paper - XIII
Core Course Title : Advanced Synthetic methods
Course Code: P-ASM-439
Marks:100 Periods:60
Credit : 04 04 Per Week
Learning Objective:
1. Can understand how to design a new route for synthesis of various reactions.
heterocyclic compounds.
4.Can know the role of LDA, DCC, DDQ, trimethyl silyl iodide etc. reagents in organic
synthesis.
Selenium dioxide, crown ethers, DDQ, Dess-Mart periodinane, periodic acid &
Iodoisobenzyl diacetate, Fetizons reagent, Lambardo
reagent, Tebbe reagent, AIBN, 9-BBN.
References :
1. S.Warren: Designing of Organic Synthesis
2. J. Fuhrhop & G. Penzlin. : Organic synthesis (2nd ed.)
3. Carruthres: Some modern methods of organic synthesis.
4. H.O.House: Modern synthetic reaction.
5. Fieser & Fieser : Reagent in organic synthesis
6. R.O.C.Norman: Principle of organic synthesis
7. Carey & Sundharg: Advanced organic Chemistry
8. P.E. Realand: Organic synthesis
9. Bartan and Ollis : Comprehensive organic Chemistry
10.R. Admas: Organic reactions
11. Stone & West: Advances in Organometallic Chemistry
12.C.W. Bird: Transition metal intermediate in organic synthesis
13.Swan & black: Organometallic in organic synthesis.
14.A. Mitra: Synthesis of prostaglandins
15. John Apsimon: Total synthesis of natural products
16. M. K. Mathur, C. K. Narang & R.E. Williams: Polymers as aid in organic
synthesis
17.P. Hodge & D.C. Sherrington: Polymer supported reaction in organic
synthesis.
18.C.J.Gray: Enzyme Catalysed reactions
19.T.W. Green & P.G.M. Wats : Protecting groups in organic Chemistry
20.T.Shona: Electroorganic Chemistry
21.Weber & Gokel : phase transfer catalyst in organic synthesis.
*****
Chemistry Paper – XIV
Core Course Title – Stereochemistry
Course Code: P-STE-440
Marks:100 Periods:60
Credit : 04 04 Per Week
Learning Objective:
1.To understand the basic concept of stereochemistry, sterio chemical principles.
2.To familiarize with newer methods of sterioselective synthesis.
3.To know about conformational analysis and stereochemistry of ring systems.
4.To learn about stereochemistry of fused and bridged rings.
Course Outcome:
After successful completion of the course the students will :
1. Understand the basic concept of stereochemistry like chirality, sterio chemical principles
like enantiometric and distereomeric relationship, D & L, R & S and E & Z nomenclature.
2. Familiarize with newer methods of sterioselective synthesis like Regioselective and
Chemoselective reactions, Stereospecific and stereoselective reactions etc.
3. Know about conformational analysis of cyclohexane, mono substituted and disubstituted
cyclohexanes and stereochemistry of ring systems.
4. Learn about stereochemistry of fused and bridged rings, O.R.D. and C.D
References :
1. E.L. Eliel : Stereochemistry of carbon compounds
2. D. Nasipuri : Stereochemistry of organic compounds
3. P.S. Kalsi: Stereochemistry: conformation and Mechanism.
4. Eliel, Allinger, Angyal and Morrison : Conformational analysis
5. Hallas: Organic stereochemistry
6. Mislow and Benjamin: Introduction to stereochemistry.
7. H. Kagan : Organic stereochemistry.
8. Carl Djerassi ; Optical rotatory dispersion.
9. P. Crabbe : Optical rotatory dispersion and C.D.
Chemistry Paper - XV
Core Course Title - Advanced Heterocyclic Chemistry
Course Code: P-AHC-441
Marks:100 Periods:60
Credit : 04 04 Per Week
Learning Objective:
1. To outline the role of heterocycles,their spectral characteristics , reactivity.
2. To understand the synthesis and aromatic character of heterocycles.
3. To know the synthesis of Indole Quinoline, Isoquinoline, Benzothiapene etc.
Course Outcome:
1.Student can understand the role of heterocycles,their spectral characteristics , reactivity.
2.They can know how to synthesize Azirines, Oxaranes, Thiiranes, Diazirenes etc.
3. They can understand the synthesis and reactivity of Indole Quinoline, Isoquinoline,
Benzothiapene etc.
Unit II : Five and six-membered heterocycles with two hetero atoms : 15 Periods
Synthesis, reactivity, aromatic character and importance of the following heterocycles:
Pyrazole, Imidazole, Oxazole, Thiazole, Pyrimidine, Pyrazine, Oxazine, and Thiazine.
Unit III: Heterocycles with more than two hetero atoms: 15 Periods
Synthesis, reactivity, aromatic character and importance of the following heterocycles:
Triazoles, Oxadiazoles, Thiadiazoles, Triazines, tetrazole, furazan.
Unit-IV:Larger ring and Benzofused heterocycles: 15 Periods
Synthesis and reactivity of Indole Quinoline, Isoquinoline, Benzothiapene, Benzofuran
Azepines, Oxepines and Thiepines, Synthesis and rearrangement of Diazepines, Synthesis
of Benzoazepines, Benzodiazepines, Benzooxepines, Benzothiepines, Azocines, and
Azonines.
References :
1. Heterocyclic Chemistry, T. L. Gilchrist.
2. An Introduction to the Chemistry of Heterocyclic compounds, R. M. Acheson.
3. Heterocylic chemistry, J. A. Joule & K. Mills.
4. Principals of Modern Heterocyclic Chemistry, A. Paquette.
5. Heterocyclic Chemistry, J. A. Joule & Smith.
6. Handbook of Heterocyclic Chemistry, A. R. Katritzky.
7. Heterocyclic Chemistry R.K. Bansal.
*****
Chemistry Paper – XVI
Semester IV
Course Title: Applied Organic chemistry
Course Code:P-AOC-442
Marks:100 Periods:60
Credit : 04 04 Per Week
Learning Objective:
Course Outcome:
After successful completion of the course the students will:
*****
Elective
Chemistry Paper – XVI
Semester IV
P-POC-342 (B)
Course Title: Dyes and Intermediates
Marks:100 Periods:60
Credit : 04 04 Per Week
Learning Objective:
1.To understand the concepts of Commercial processes for Azo dyes, reactive dyes
2.To know about Diazotization, mechanism and different methods of diazotization,
Evaluation of dyes.
3.To familiarize with Fluorescent Whitening Agents, Types of Fibres And Basic Operations
In Dyeing Process.
Course Outcome:
After completion of course students will understand:
1. Concepts of Commercial processes for Azo dyes, reactive dyes, thermal sensitive dyes,
dispenses dyes.
2. Synthesis of Monoazo dyes, Bisazo dyes and Azoic dyes. Evaluation of dyes
3. Theory of fluorescence–Classification of FWA, Various methods of dyeing, Different
classes of organic pigments and synthesis.
Synthesis of important dye intermediates. Commercial processes for Azo dyes, reactive
dyes, optical brighteners, thermal sensitive dyes, dispenses dyes.
UNIT-IV 15 Periods
(B) Pigments
Different classes of organic pigments and synthesis.
Synthesis of only the following: Basic Yellow 11, Basic Orange 21, Safranine B,
Rosinduline GG, Sirius Supra Blue FFRL, Brilliant Alizarin Blue 3R, Sirius Supra
Yellow RT, Acid Yellow 19, Copper Phthalocyanine, Sirius Supra Light Green FFGL.
References
1. The chemistry of synthetic Dyes, Vol. I to VII by Venkataraman, Academic Press, New
York.
2. Chemistry of Synthetic Dyes & Pigments by Lubs.
3. Dyes and their intermediates by E. N. Abrahart.
4. Handbook of synthetic dyes and pigments, Vol. I & II by K. M. Shah.
5. Industrial Dyes by Klans Hunger, Germany by Wiley-VCH.
6. Development in the Chemistry and technology of Organic Dyes by J.Griffiths, Blackwell
Sci. Pub., Oxford, London.
7. Principles of colour Technology by Fred W. Billmeyer and Max Saltzman, John Wiley &
Sons.
M. Sc. IV Semester
Laboratory Course-XII
Mixture Analysis
Course Code: P-LAC-443
Marks: 50 Periods: 60
Credit: 02 06 Periods Per Week
Learning Objective:
Course Objective:
Semi-micro Qualitative Analysis of Ternary Mixtures ( One Solid and Two Liquids)
containing single/poly functional compounds by Chemicaland Physical Method with
Chromatographic Separation (TLC) for purity of all three components and its Expected
Theoretical Spectral Data (IR, 1H NMR & 13C NMR).
*****
M. Sc. Semester IV
Laboratory Course- XIII
Physico-Organic Estimations
Course Code: P-LAC-444
Marks: 50 Periods: 60
Credit: 02 06 Periods Per Week
Learning Objective:
1. To develop the skill in the isolation and purification of natural products like beta
carotene, piperine licopene.
Course Outcome:
1. Students can develop the skill in the isolation and purification of natural products like
beta carotene, piperine licopene.
2. They can perform assay of drugs.
References :
1. Moden Experimental organic chemistry by Royston M.Robert, John C.Gilbert, Lyuu
B.Rodewald & alan S.Wingrove, Saunder International Edition
2. Advanced practical organic chemistry by N.K.Vishnoi
3. Experimental organic chemistry by L. M. Harwood & C. I. Moody, Blackwell Scientific
Publications.
4. The systematic identification of organic compounds by R.L.Shriner & D.Y.Curtin
5. Semi-microqualitative organic analysis by N.D.Cheronis, J.B.Entrikin & E.M.Wodnett
6. Small scale organic preparation by P.J.Hill
7. Vogel’s textbook of practical organic chemistry by ELBS, Longmann.
*****
M. Sc. Semester IV
Laboratory Course- XIV
Synthesis of Organic Molecules
Course Code: P-LAC-445
Marks: 50 Periods: 60
Credit: 02 06 Periods Per Week
Learning Objective:
1. To develop the skill in the synthesis of different antibacterial, abticancer, anti-convulsant
drugs.
2. To use ultrasound techniques in the synthesis of heterocyclic compounds.
Course Outcome:
1.Students can synthesize different drugs like antibacterial, abticancer, anti-convulsant etc.
2.They can use ultrasound techniques in the synthesis of heterocyclic compounds.
Note:
1. Synthesis is carried out in molar quantities (Less than 5 gm).
2. Reaction with possible mechanism.
3. Calculate Theoritical and practical % yield.
4. Product conformation by Physical constant and TLC.
5. Give expected spectral data (IR and NMR) of starting material, intermediate and final
product.
6. All the prepared organic compounds should be stored as a sample and present at the
time of University examination.
M. Sc. Semester IV
Laboratory Course-XV
Course Code:P-LAC-446
Project
Marks: 50 Periods: 60
Credit: 04 06 Periods Per Week
Learning Objective:
Note:
1. External and Internal Examiners will examine this project jointly at the time of
practical examination.
2. The students will have to give at least one seminar in each semester in their subject of
specialization is compulsory.
3. Project work must be carried out only in specialized branch.
4. All synthesized organic compounds should be submitted at the time of University
Examination.
5. The project work carried out during the year should be presented in power point
presentation in presence of University Examiners.
*****