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PEER
To view the CE test for this article, please CONTINUING REVIEWED
visit todaysveterinarytechnician.com. EDUCATION
M E ET TH E AUT H O R
Critical
Components of
Successful CPR:
The RECOVER Guidelines, Kenichiro Yagi, BS, RVT,
VTS (ECC, SAIM)
Airway Additional
Endotracheal tubes Vasopressin
Tube ties Dopamine
Laryngoscope Dobutamine
Syringe for cuff inflation Norepinephrine
Diazepam/midazolam
Venous
Furosemide
IV catheters (24- to 16-gauge)
Calcium gluconate
Tape
Sodium bicarbonate
Saline flush
Preassembled crystalloid Respiratory
fluid bag and IV sets Suction machine and tubing
T-ports and male adapter plugs Suction catheters or red rubber tubes
Scalpel blade and suture (for Manual resuscitator (eg, Ambu bag)
venous cutdowns) Thoracocentesis kit
Syringes (1–6 mL)
Needles (25- to 18-gauge) Surgical
Intraosseous (IO) catheter setup (IO drill, Tracheostomy tubes
bone biopsy needles, or large needles) Sterile gloves
Emergency surgical packs
Medication
Sterile gauze
Standard
Scalpel blade and handle
Epinephrine
Atropine Equipment
Reversal agents: atipamezole, Electrocardiograph
flumazenil, naloxone Capnometer
Anti-arrhythmic agents: Defibrillator
amiodarone, lidocaine
such as the CPR algorithm and CPR drug dosage dioxide from the pulmonary circulation. An
chart (available from veccs.org), which will unresponsive patient should be assessed for
improve efficiency during the event3 (FIGURE 2). possible arrest through auscultation of the
heart, palpation for pulses, and observation
Resuscitation Orders for breathing.4 The assessment should take no
Every animal admitted to the practice should longer than 10 to 15 seconds, and BLS should
have a designated resuscitation order be initiated as soon as possible once CPA is
established via a thorough conversation identified.5 It can be argued that BLS should
between the veterinary team and the owner be commenced as soon as possible even when
to prevent delays in implementing CPR if CPA cannot be confirmed: research shows that
needed. Color-coding housing labels, patient
charts, or patient tags to indicate the patient’s
A
resuscitation order can reduce confusion.
Patients with a chronic disease that has
progressed to the point of causing CPA
are less likely to respond to CPR. CPA as a
consequence of an acute condition is more
likely to have a successful outcome. Otherwise
healthy patients that arrest because of an
anesthetic event have a much higher chance
of survival, reported to be 47% in one study.2
B
Every effort should be made to ensure the
resuscitation order is appropriate for the patient
by accurately assessing its chances of survival.
A B
Epinephrine (high dose) 0.1 mg/kg IV, IO, or IT In prolonged CPR (>10 min)
Biphasic 2-4 J/kg (external) Can increase dose by 50% each cycle up to a
0.2-0.4 J/kg (internal) maximum of 10 J/kg
IO, intraosseous; IT, intratracheal; IV, intravenous; VF, ventricular fibrillation; VT, ventricular tachycardia.
other compression cycle. While there are no for correcting electrolyte disturbances other
high-quality studies showing clear benefits than severe hyperkalemia or hypocalcemia.7
of its use in CPR, there is no evidence of
harm. Atropine is thought to be beneficial Alkalinizing Agents
in patients with asystole or PEA, especially Routine administration of alkalinizing agents, such
those suspected to be experiencing high as sodium bicarbonate, as a buffer for metabolic
vagal tone (eg, vomiting, ileus, gastrointestinal acidosis is not recommended, but these agents
disease, respiratory disease).5,7 Intratracheal can be considered for prolonged CPA because
administration is also possible at 0.08 mg/kg. severe acidemia can affect the vasculature’s ability
to respond to vasopressors and impair normal
Reversal Agents enzymatic functions. Administration of sodium
If patients in CPA were under the influence of bicarbonate is accompanied with a cautionary note
any reversible anesthetic agent or sedation, that it can lead to alkalemia and paradoxic cerebral
reversal of said agent could improve the and metabolic acidosis.7 It is recommended
chances of successful outcome. Atipamezole, that sodium bicarbonate be reserved for severe
flumazenil, and naloxone are readily acidemia (pH <7.0) in prolonged CPR.5
available reversal agents for α2 agonists,
benzodiazepines, and opioids, respectively. Electrical Defibrillation
When a patient is experiencing VF, electrical
Antiarrhythmic Agents defibrillation is the appropriate therapy to convert
While no evidence supports the routine use to normal rhythm. The approach to electrical
of antiarrhythmics in CPR, administration of defibrillation depends on the phase of VF. In the
amiodarone has been suggested for patients first phase, which lasts approximately 4 minutes,
with VF refractory to electrical defibrillation. the heart experiences minimal ischemia and has
Hypotension and anaphylactic reactions have enough energy reserves to carry on metabolic
been documented in dogs receiving amiodarone, processes. In the second phase (subsequent
and careful monitoring is recommended 6 minutes), the heart experiences reversible
following ROSC.5,7 Lidocaine can be administered ischemic damage as the energy reserves in the
to patients with refractory VF, although the form of ATP are depleted. In the third phase,
evidence regarding its benefits is mixed.7 the heart experiences irreversible ischemic
damage as energy stores are exhausted.5
Intravenous Fluids If the patient is in the first phase of VF, it
The use of IV fluids during CPR largely depends should be defibrillated as soon as the defibrillator
on the state of IV fluid balance in the patient. is charged, allowing for interruption of chest
IV fluids are beneficial for patients experiencing compressions as the cellular energy reserves of the
hypovolemia as the increased intravascular heart makes successful defibrillation more likely.
volume leads to better preload, improving If the patient is suspected to be in the second
chances of creating effective blood flow phase or beyond, a full cycle of chest compressions
through chest compressions. Not every patient should be performed before defibrillation to allow
benefits from IV fluids, however, as euvolemic for replenishing of some cellular energy to improve
or hypervolemic individuals can become chances of success.5 Electrical defibrillation is also
overloaded with fluids, which leads to increased warranted when the patient is experiencing pulseless
central venous pressure that can in turn reduce ventricular tachycardia. VF and pulseless ventricular
MPP and cerebral perfusion pressure.5 Electrolyte tachycardia are referred to as “shockable rhythms”
disturbances can be a contributor to CPA or a based on their responsiveness to defibrillation.
result of metabolic acidosis, drug therapy, and When a shockable rhythm is identified during
other interventions. No evidence of benefit exists assessment between compression cycles, chest
Monitoring
Monitoring during CPR can be best accomplished
through the use of capnography and
electrocardiography (ECG).
Capnography
Monitoring end-tidal carbon dioxide (ETCO2)
values during CPR is the most useful method
to assess the effectiveness of compressions in FIGURE 9. The screen of a multiparameter ECG monitor
creating blood flow and lung perfusion. Because during CPR. The ECG is registering mechanical action
exerted by the compressions (blue circle). The
minute ventilation is relatively consistent during capnography (yellow circle) is displaying a breath
CPR, the measured ETCO2 value will increase (larger plateau) and compression-induced ventilation
(small spikes). The ETCO2 measurement (red circle) is
in proportion to the pulmonary blood flow reading 6 mm Hg and 11 breaths/min.
electrical activity without any palpable pulse, intensive process, with ROSC being only the
or pulseless electrical activity (PEA), in which first hurdle to overcome toward actual survival
case compressions should be resumed. The to discharge; a patient that has arrested once
possibility of PEA also highlights the importance is likely to re-arrest during this period.
of confirming actual pulses after visualizing
electrical activity on ECG. Ventricular fibrillation TEAM DYNAMICS
(VF) is less common and is treated through
defibrillation if present. Multiple members of Team Structure
the CPR team should be observing the ECG The presence of a CPR team leader significantly
readout during the assessment period between improves the flow during CPR. The leader
compression cycles to clearly communicate is responsible for assigning roles to team
the rhythm and swiftly move to the next step. members (TABLE 2), enforcing protocol, and
facilitating communication. Intermittently
Post–Cardiac Arrest Care summarizing the current status of the CPR
For patients that recover from CPA and achieve attempt, soliciting input from team members,
ROSC, post–cardiac arrest care includes respiratory and organizing changes in roles and next steps
status optimization, cardiovascular system are all important tasks performed by the CPR
support and optimization, and neuroprotective leader. Specific training for those taking on
therapy. An algorithm for postarrest care is the role of a CPR leader is recommended.
provided in the RECOVER guidelines. Care At my place of employment, the role of CPR
for a patient after achieving ROSC is an team leader, usually a veterinary technician, is
intentionally assigned to someone other than the
attending veterinarian to allow the CPR team and
A
veterinarian to function independently. The CPR
leader focuses on organizing the CPR, assigning
roles, and directing the CPR flow. The veterinarian
makes medical decisions, fills no other roles,
focuses on patient diagnosis and treatment, and
B
communicates with the client. This veterinarian
and CPR team arrangement has greatly enhanced
our ability to manage the controllable factors
of CPR and prevent delays and mistakes from
splitting the veterinarian’s attention between
C
the patient, client, and CPR flow (FIGURE 11).
Establish airway
Airway management
Ventilate
professionals can evaluate their CPR methods professionals, preparedness for CPA through
and training. The need for standardized certificate training should be considered
guidelines regarding veterinary CPR is well a standard in practice. The training is
recognized internationally, and to date, the reaching other animal workers and the lay
RECOVER guidelines have been translated public to improve chances of resuscitation
into Portuguese, Spanish, Japanese, and for out-of-hospital arrests as well.
Mandarin. All of RECOVER’s information will
be housed on a central Internet resource to be CONCLUSION
available worldwide (recover-initiative.org). Veterinary technicians play a critical role in
The RECOVER initiative is being updated, assessing patients at risk of experiencing CPA
with publication planned in 2018. The 2012 and swiftly initiating CPR when necesssary.
RECOVER review process revealed knowledge While the current success rate and the rate
gaps that are intended to be filled through of survival to discharge are expectedly low,
ongoing research in the field, with the establishment of organized training based on
RECOVER initiative directly contributing. an evidence-based protocol such as RECOVER
The establishment of the global registry and is a duty of the veterinary team to ensure the
a standardized record sheet will allow each best possible chance of a positive outcome.
practice to contribute to the data collection,
and additional methods are planned. Through Acknowledgment
the process, the RECOVER initiative has The author would like to thank Dr. Manuel Boller
pioneered a large-scale evidence-based and Dr. Dan Fletcher for providing the latest
guideline creation process that is translatable information on the plans of the RECOVER Initiative.
to a variety of topics in veterinary medicine.
References
Both online and physical CPR certification 1. Ellis S. Man uses CPR, saves dog’s life. Global Animal
courses have been created and approved [website]. March 29, 2011. globalanimal.org/2011/03/29/
by the American College of Veterinary man-uses-cpr-saves-dogs-life-video. Accessed March 2017.
2. Hofmeister EH, Brainard BM, Egger CM, et al. Prognostic
Emergency Critical Care and the Veterinary indicators for dogs and cats with cardiopulmonary arrest
Emergency and Critical Care Society. treated by cardiopulmonary cerebral resuscitation at a
university teaching hospital. JAVMA 2009;235(1):50-57.
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FIGURE 13. A debriefing session enhances the team 9. Salas E, Klein C, King H, et al. Debriefing medical teams:
dynamics and facilitates further improvement of CPR 12 evidence-based best practices and tips. Jt Comm J Qual
through open and transparent communication. Patient Saf 2008;34(9):518-527.