Nicotinamide WE Wintey Nicotinamide, also known as niacinamide, is a water-soluble vitamin B3 that offers a mul- titude of skin benefits, promoting healthier, more balanced, and youthful-looking skin It serves to visibly minimize enlarged pores and tighten lax or stretched out pores for its sebum regulation properties. Additionally, It enhances the skin's moisture levels, increa- ses barrier layer proteins, strengthens and maintains the skin barrier. With its antioxidant effects, nicotinamide helps protect the skin from free radicals, while supporting the pro- duction of collagen and elastin, thereby minimizing fine lines and wrinkles, and maintai- ning skin elasticity and firmness. Nicotinamide plays a significant role in reducing hyperpigmentation by blocking reversi- bly the transfer of melanosomes from melanocytes into keratinocytes, resulting in a more even skin tone, lightening dark spots, and reducing dullness. PRODUCT DESCRIPTION INCI Name Niacinamide CAS Number 98-92-0 ‘Appearance White crystalline powder Purity 299% PH 5.5~7.5 (10% solution) Compatibility Avoid strong acids, strong bases, and oxidizing agents. Multi-faceted Peptide Solution SpecialistNicotinamide EFFICACY TEST I In vitro test + Increases barrier layer proteins. 200 380 160 control 40 Wi siacinamide 6 of control 120 300 Invalucrin Alaggin| eatin Reference: Oblong JE, Bissett DL, Ritter JL, Kurtz KK, Schnicker MS. Effect of niacinamide on collagen synthesis and mar- kers of keratinocyte differentiation, 60th Annual Meeting of the American Academy of Dermatology, New Orle- ans, 2002 I In vivo test Test protocol ~50 Healthy white female subjects (ages 35 to 60 years, nonpregnant) were enrolled. ~ Each oil-in-water moisturizer test formulations (control and niacinamide formulation, the only difference between the two being the content of niacinamide) was applied to each side of the face, twice daily for 12 weeks, - Elasticity measurements were made with a Cutometer, and digital images of each side of the face of all subjects were captured at baseline and at weeks 4, 8, and 12. Multi-faceted Peptide Solution SpecialistNicotinamide WAC Winkey spot area vs. placebo control 6 reduction in total hyperplgmented improvementin red blotchiness vs, placebo control length zg 3 g = 3 3 3 Hh 5% riacinamide 5% niacinamide reduces the appearance of hyper-pigmented spots in white facial skin. ‘weeks weeks ‘2 weeks 035 030 0.25 020 i S%nincinamide oas 020 0.05 5% niacinamide reduces the appearance A of white facial skin redness. weeks Swecks ‘12 weeks “are 003 6 Wi s%niocinamise 5% niacinamide reduces the appearance of white facial skin wrinkles, ‘awecks -Sweeks ‘12 weeks Multi-faceted Peptide Solution SpecialistNicotinamide 050 oe = § ow EE oss BF on sca BS 2s s £ om ous : 5% niacinamide prevents skin yellowing oo (b* value from L*a*b* color measurements) ° wed Swe 12s Ws nocramise Mi menccnmide oon oa S omo 2 oor Es Bom Be coe é ge EE coos EB os BS aos 32 38 5 .go4 Sy 0003] 2 2” oom cee £ 2 = oom ° a Tomeks tweets 2 wecks (eds wens awe RS is measure of viscoelastic properties and R7 is measure of elastic recovery. The elasticity improvement effects are significant after 12 weeks of treatment. Reference: Bissett, D.L,, Oblong, .€. and Berge, CA, 2005. Niacinamide: AB vitamin that improves aging facial skin appea- rance, Dermatologic surgery, 31, pp.860-866. Contact us Email:sales@winkey-china.com ‘Add: Room315-317,No.8 Qide Road, Balyun District, Guangzhou, China ‘Webiste: vavwwinkey-china.com