Republic of the Philippines

PROFESSIONAL REGULATION COMMISSION

Manila

BOARD OF MEDICAL TECHNOLOGY

Medical Technology Licensure Examination

Clinical Chemistry
INSTRUCTION: Select the correct answer for each of the following
questions. Mark only one answer for each item by shading the box
corresponding to the letter of your choice on the answer sheet
provided.
STRICTLY NO ERASURES ALLOWED.

1. It is a system where it house samples and reagents into a

separate container, wherein multiple tests can be run on a
single sample or vice versa? (Hubbard p.3/Rodriguez p30)
a. Centrifugal analyzer (give the meaning)
b. Discrete analyzer
c. Continuous flow analyzer (give meaning to the student)
d. Fibrometer

2. Which of the following disease gives of increase renin

concentration? (Hubbard p.17)
a. hypertension
b. SIADH
c. Cardiac failure (hypotension)
d. ARD (acute renal dse)

3. Compute for the anion gap

Na = 90
K = 50
Na – (Cl – HCO3)
 Cl = 120
HCO3 = 5
a. 15 mol
b. 20 mol
c. 10 mol
d. 5 mol

4. What is the compensatory mechanism for metabolic acidosis?

“MACIPER” (Rodriguez or Hubbard p19)
a. Hyperventilation
b. Hypoventilation
c. Both
d. Neither

5. What is the compensatory mechanism for person suffering from

metabolic alkalosis? “ALKAPO” (Rodriguez or Hubbard p19)
a. Hyperventilation
b. Hypoventilation
c. Both
d. Neither

6. What are the major Non-protein nitrogen or wastes of the body

in ascending order?
I. Urea
II. Amino acid
III. Uric acid
IV. Creatine
V. Creatinine

a. I, II, III, IV, V c. I, II, III, V, IV

b. II, III, V, I, IV d. III, II, V, IV, I
7. Problem for creatinine clearance:
URINE VOL- 770
SERUM CREA- 2.0
URINE CREA- 240
PATIENT WITH AVERAGE BODY SURFACE (1.73)
a. 60.0
b. 55.0
c. 70.0
d. 65.0

8. What is the difference of VLDL to HDL to LDL? (Rodriguez p74-

75)
a. Cholesterol, protein
b. phospholipid, TAG
c. Cholesterol, phospholipid
d. Protein, phospholipid

9. Vitamin B6 deficiency leads to? (Rodriguez p161)

a. Rickets
b. Facial saborrhea
c. Beri-beri
d. Wernicke-korsakoff

10. Increase in enzyme concentration of ALT, AST, and ALP leads

to what condition?
a. Viral hepatitis
b. Auto Immune Hemolytic anemia
c. Bile obstruction
d. Paget’s disease

11. Transport protein of iron?

a. Ferritin
b. Transferrin
c. Hemoglobin
d. Ceruloplasmin

12. Bilirubin fraction that increase in case of viral hepatitis?

I. Direct bilirubin
II. Indirect bilirubin
III. Total bilirubin
IV. All of the above

a. I & II
b. I & III
c. II & IV
d. II & III

13. What enzyme group is CK, SGOT and SGPT belongs?

a. Oxidoreductase
b. Transferases
c. Hydrolases
d. Lyases

14. It is where the reaction rate is directly proportional to

substrate concentration?
a. Zero-order kinetics
b. First-order kinetics
c. Line-Weaver Burk plot
d. Enzyme Concentration

15. S.I. unit for enzyme activity? (Rodriguez p125)*KATAL UNIT

a. Umol/min
b. Mol/sec
c. Umol/sec
d. None of these

16. A person suffering from hypothyroidism with a decrease T3

level but normal level of T4. Which parameter will help to
confirm the diagnosis?
a. T3u
b. TSH
c. FT4
d. TBG

17. Hashish belongs to what group of addictive drugs?

a. Amphetamines
b. Cannabinoids
c. Steroids
d. Opiates

18. Drug used to treat people with manic depression?

a. Valproic acid
b. Phenytoin
c. Lithium
d. Carbamazepine

19. Which assay of creatinine is simple and non-specific?

a. Colorimetric: end point
b. Enzymatic
c. Colorimetric: kinetic
d. Enzymatic: UV

20. In case of type I Crigler-Najjar syndrome, an increase in

indirect bilirubin and deposition within the brain of an
infant leads to what condition?
a. Kernicterus
b. Viral hepatitis
c. Bile obstruction
d. Dubbin-Johnson syndrome

21. A 10% contamination of 5% glucose will eventually increase

to what level?
a. 50 mg/dl
b. 200 mg/dl
c. 500 mg/dl
d. 100 mg/dl

22. Which of the following is not part of POCT?

a. A medtech trying to measure the patient’s glucose level using
a glucometer.
b. Drawing blood using multiple syringe system.
c. A patient refuses to draw his blood for laboratory testing.
d. None of these

23. If fever exist _ decrease in pO2 and a _ increase in pCO2?

(Rodriguez p160)
a. 7% & 5%
b. 7% & 3%
c. 3% & 7%
d. 5% & 3%

24. Color assigned to reactivity hazard.

a. Blue
b. Yellow
c. White
d. Red
25. Bilirubin fraction that increases in person with bile
obstruction?
a. Unconjugated bilirubin
b. Direct bilirubin
c. Total bilirubin
d. All of the above

26. Bilirubin fraction that increases in person with hepatic

jaundice?
I. Total bilirubin
II. Conjugated bilirubin
III. Uncojugated bilirubin
IV. None of these

a. I & II
b. II&IV
c. I & III
d. II & III

27. Conversion factor of Uric acid?

a. 0.0595
b. 10
c. 1
d. .0555

28. A 10x increase in Creatinine Kinase concentration leads to?

a. Myocardial infarction
b. Duschenne mascular dystrophy
c. Exercise
d. Auto-immune hemolytic anemia
29. What is the medical condition of increase Growth hormone
(GH) in adults?
a. Gigantism
b. Hirsutism
c. Acromegaly
d. Pheochromocytoma

30. Drug of choice for petit mal?

a. Lithium
b. Phenobarbital
c. Dylantin
d. Valproic acid

31. Conversion factor of IgD?

a. 10
b. .0555
c. .0595
d. .133

32. What enzyme is used for investigation of alleged rape?

a. Alanine aminotransferase
b. Acid phosphatase
c. Creatinine kinase
d. Lactate dehydrogenase

33. Light transmitted at wavelength below 400 nm?

a. Ultra violet
b. Infrared
c. Visible light
d. None of the above
34. All of the following are used for the derivation of LDL
except:
a. HDL
b. VLDL
c. TOT. CHOLESTEROL
d. TAG

35. Formula for VLDL-C in mmol/L

a. TAG/5
b. TAG/2.175
c. TAG/2
d. TAG/1.35

36. What age group of man is with total cholesterol cut off:
moderate risk >220 mg/dl, high risk >240 mg/dl?
a. 2-19
b. 20-29
c. 30-39
d. >40

37. Number of hours of fasting for Triglyceride (TAG) testing?

a. 12-14 mins
b. 6-8 hrs
c. 12-14 hrs
d. 8-10 hrs

38. Benzoylecgonine is the metabolite of what drug?

a. Cannabis sativa
b. Methamphetamine hydrochloride
c. Cocaine
d. Epinephrine
39. All of the following are emergency situation except?
a. Hypokalemia
b. Glycosuria
c. Hypoglycemia
d. Diabetic ketoacidosis

40. True about diabetes mellitus type I.

a. Early onset
b. Absolute insulin deficiency
c. All of the above
d. With antibodies against beta cells of pancreas

41. Cholesterol concentration on people having hypothyroidism

a. Increased
b. Decrease
c. Unaffected
d. Never mind

42. What is the rate of glucose metabolism if specimen is left

at room temperature?
a. 7 mg/dl/hr
b. 2mg/dl/hr
c. 5 mg/dl/hr
d. 10 mg/dl/hr

43. Method of urea testing which is inexpensive but lacks

specificity?
a. Colorimetric: diacetyl
b. Enzymatic: NH3 formation
c. Both
d. None of the above
44. Which of these are glands that produce hormones?
a. Thyroid and parathyroid
b. Anterior and posterior pituitary
c. Thyroid, parathyroid, anterior and posterior pituitary
d. Thyroid, parathyroid, anterior

45. Blood alcohol level wherein there are some changes

observable on performance testing?
a. <0.05%
b. 0.03-0.12%
c. >0.05%
d. 0.18-0.30%

46. Grade of water used for preparation of Standard Solution/

a. Type I
b. Type II
c. Type III
d. None of the above

47. Meaning of R in the acronym “RACE”

a. Redness
b. Relay
c. Rescue
d. Retrieve

48. True about diabetes mellitus type I.

a. Early onset
b. Absolute insulin deficiency
c. All of the above
d. With antibodies against beta cells of pancreas
49. What enzyme is used for investigation of alleged rape?
a. Alanine aminotransferase
b. Acid phosphatase
c. Creatinine kinase
d. Lactate dehydrogenase

50. Drug used to treat people with manic depression?

a. Valproic acid
b. Phenytoin
c. Lithium
d. Carbamazepine

KEY TO CORRECTION
1. B 11. B 21. C 31. A 41. A
2. B 12. A 22. C 32. B 42. A
3. A 13. B 23. B 33. A 43. A
4. A 14. B 24. B 34. B 44. A
5. B 15. B 25. B 35. B 45. A
6. C 16. B 26. D 36. C 46. A
7. A 17. B 27. A 37. C 47. C
8. B 18. C 28. A 38. C 48. C
9. B 19. A 29. C 38. B 49. B
10. C 20. A 30. D 40. C 50. C