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  • Polymorphism and Expression Profile

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    Jaya Kunal Dubey
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    This study investigated the relationship between a polymorphism (rs1800857 T/C) of the Cholecystokinin type A receptor (CCKAR) gene and gallstone disease susceptibility. The researchers genotyped 502 subjects (272 gallstone patients and 230 controls) and analyzed CCKAR expression levels in gallbladder tissue samples. They found that the C allele of the CCKAR polymorphism was associated with increased gallstone disease risk. CCKAR expression was also higher in gallbladder tissues from patients with the C allele compared to those with the T allele.

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    This study investigated the relationship between a polymorphism (rs1800857 T/C) of the Cholecystokinin type A receptor (CCKAR) gene and gallstone disease susceptibility. The researchers genotyped 502 subjects (272 gallstone patients and 230 controls) and analyzed CCKAR expression levels in gallbladder tissue samples. They found that the C allele of the CCKAR polymorphism was associated with increased gallstone disease risk. CCKAR expression was also higher in gallbladder tissues from patients with the C allele compared to those with the T allele.

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    7 views1 page

    Polymorphism and Expression Profile

    Uploaded by

    Jaya Kunal Dubey
    This study investigated the relationship between a polymorphism (rs1800857 T/C) of the Cholecystokinin type A receptor (CCKAR) gene and gallstone disease susceptibility. The researchers genotyped 502 subjects (272 gallstone patients and 230 controls) and analyzed CCKAR expression levels in gallbladder tissue samples. They found that the C allele of the CCKAR polymorphism was associated with increased gallstone disease risk. CCKAR expression was also higher in gallbladder tissues from patients with the C allele compared to those with the T allele.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 1

    Biochem Genet

    DOI 10.1007/s10528-016-9745-x

    ORIGINAL ARTICLE

    Polymorphism and Expression Profile


    of Cholecystokinin Type A Receptor in Relation
    to Gallstone Disease Susceptibility

    Hasan Raza Kazmi1 • Abhijit Chandra2 •


    Jaya Nigam2 • Kavita Baghel2 • Meenu Srivastava2 •

    Shailendra S. Maurya3 • Devendra Parmar3

    Received: 16 December 2015 / Accepted: 27 May 2016


    ! Springer Science+Business Media New York 2016

    Abstract In the present study, we investigated expression pattern of Cholecys-


    tokinin type A receptor (CCKAR) in relation to its commonly studied polymor-
    phism (rs1800857, T/C) in gallstone disease (GSD) patients and controls. A total of
    502 subjects (272 GSD and 230 controls) were enrolled, and genotyping was per-
    formed by evaluating restriction fragments of PstI digested DNA. For analyzing
    expression pattern of CCKAR in relation to polymorphism, gallbladder tissue

    & Abhijit Chandra


    abhijitchandra@hotmail.com
    Hasan Raza Kazmi
    hasanrazakazmi@yahoo.co.in
    Jaya Nigam
    jayanigam27@gmail.com
    Kavita Baghel
    kavita.baghel08@gmail.com
    Meenu Srivastava
    meenu.srivastava12@gmail.com
    Shailendra S. Maurya
    shailendrabt@gmail.com
    Devendra Parmar
    parmar_devendra1@rediffmail.com
    1
    Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi 221005,
    India
    2
    Department of Surgical Gastroenterology, King George’s Medical University,
    Lucknow 226003, India
    3
    Developmental Toxicology Division, Indian Institute of Toxicology Research,
    Lucknow 226003, India

    123

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