MOHI-UD-DIN ISLAMIC MEDICAL COLLEGE MIRPUR AJ&K

MOHI-UD-DIN ISLAMIC UNIVERSITY

NERIAN SHARIF AJ&K
MBBS 1st Professional Examination

Subject/Paper: Physiology (SAQs)

Total Marks: 60 Time: 02 hours and 25 minutes

(Attempt two sections on different sheets)

Q-1

a. What are the types of RNA? Briefly describe function of each type. (3)
b. Tabulate the differences between lysosomes and peroxisomes. (2)

Q-2

a. Enlist self-replicating organelles. (2)

b. Give the function of these organelles. (3)

Q-3

a. What is latch phenomena in a smooth muscle fiber? How it is regulated. (2.5)

And what is its importance?
b. Briefly discuss the steps of walk along theory of contraction. (2.5)

Q-4

A 25 years old female presented with complaint of bilateral ptosis proximal and

severe weakness in her right arm during combing hair or brushing teeth. The

symptoms got worse and widespread at the end of the day. The doctor gave her

a trial of Injection Neostigmine, which improved her condition.

 a. What is the most likely diagnosis? Give the pathophysiology of this
Condition. (2.5)
b. How calcium ions are released by the Sarcoplasmic Reticulum? (2.5)

Q-5

A female of 25 years with complaints of weakness and breathlessness on exertion

Consulted her family doctor, she was having pallor of the skin. Her blood reports

Showed; hemoglobin = 8g/dl, RBCs = 3.8 million/microL, MCV = 75 fl, MCH = 24pg

a. From which disorder women was suffering?

Give causes of the disorder. (2.5)
b. Classify anemias and what are the factors that influence the rate of (2.5)
erythropoiesis.

Q-6

Rashid was stared on blood transfusion pre-operatively to improve hb

Prior to surgery. He began to feel irritability, chills and palpitation within

5 minutes after the start of transfusion. But the transfusion was continued

And patient developed fever, shock like state with fall of blood pressure

And scanty urine output.

a. What was the possible reason of Rashid’s symptoms?

What is the reason of kidney shutdown? (3)
b. Give the mechanism in detail for development of these symptoms? (2)
 Section B (30 Marks)
Q-7

A 10 years old boy presented in ER of MOTH with complains of vomiting and

Diarrhea since yesterday. He was lethargic unable to wake-up and eat anything.

On examination his pulse rate was 100 bpm, feeble and weak while

pulse rate was 70/50 mmHg and his skin became cold and clammy. He was given

immediate therapy and got survived.

a. What is your diagnosis? Give the pathophysiology of this type of shock? (3)
b. Enumerate the types of shock.
What are the stages of shock? (2)

Q-8

a. Explain the control of heart by Sympathetic and Parasympathetic nerves (2.5)

b. Define cardiac cycle. Compare and Contrast the features of iso-volumic (2.5)
contraction and relaxation.

Q-9

a. What are peripheral chemoreceptors? (2.5)

b. Define cardiac cycle. Compare and Contrast the features of iso-volumic
contraction and relaxation. (2.5)

Q-10

A premature infant is brought to the paediatric emergency with marked

Difficulty in breathing, blush discoloration of skin and tachypnoea of 30-

minutes.

a. What is your diagnosis?

How obstruction of the airways causes atelectasis? (2.5)
b. What is physiological basis of this disorder? (2.5)
Q-11

a. What is the role of Anterior hypothalamic-preoptic area in thermostatic

detection of temperature? (1.5)
b. Explain the mechanism of sweat-secretion. (3.5)

Q-12

A middle age woman is suffering from severe UTI due to which the set point

Of hypothalamic thermostat is raised to 39⁰C.

a. Explain the mechanism by which body temperature will increase to the point
39⁰C. (2.5)
b. How temperature of body is regulated in hypothermic and hyper-thermic
State? (2.5)

[THE END]