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Alzheimer's

disease
A brain disorder...

Hadia Saif
CHEM51F20R030
BS (R)
. Brain: An overview
Neurons • Communication
• Metabolism
Parts of brain
effected:

• Memory
• Reasoning
• Social behavior
• Language
• Ability to live and
function
Dementia vs Alzheimer's disease
.
. Dr. Alzheimer and Auguste D.
Alzheimer's Disease: First glance
the progressive
accumulation of
toxic proteins

leak into the brain


from fat carrying
particles in blood,
called lipoprotein.

brain cells die and


damages functions
controlled by the
brain.
Beta Amyloid plaques form between Neurons
Amyloid
plaques
.
Vascular
contribution

➢Less blood flow


➢Less oxygen
➢Less glucose
➢Inflammation
➢No clearance of plaques
Tau
protein tan
gles
Synaptic dysfunction
Progression of AZ Disease

Centrifugal progress
How diabetes
leads to
Alzheimer's
disease?
Alzheimer's disease genetics
• SORL1 (11)
• APP (21)
• APOE4 (19)

Down's syndrome
.

Some major
causes of
Alzheimer's
disease
Treatment

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