Parkinson's

disease
Brain disorder

Hadia Saif
CHEM51F20R030
BS-8th Regular
. Part of brain effected
• Neurodegenerative
disease
• Associated with
Motor symptoms
• Basal ganglia

In 1817, described
Parkinson's disease
Mitochondrial dysfunction
.
LRRK2 highest risk of familial impairment of synaptic
LRRK2
PD vesicle trafficking

enhances α-synuclein
accumulation in
impairs dopamine
cultured primary
signal neurons and in
dopaminergic neurons

close relationship with

inhibits neuronal
mitochondrial
survival
dysfunction.
 . Parkinsonism
Brady Kinesia
Rigidity
Gait disturbance

Pill rolling
Hypomimia
tremors
Other treatments
• Deep brain stimulation
• Physiotherapy
• Massage therapy to reduce tension
• Exercises to strengthen muscles
Any
question?