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  • Classical Pathway

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    Miki Abera
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    This document describes the classic complement pathway and its roles in immune responses. It involves an activation cascade where C1, C4, C2, C3, and C5 are activated in sequence. This leads to opsonization, chemotaxis, anaphylaxis, and formation of the membrane attack complex to lyse targeted cells in less than 3 sentences.

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    This document describes the classic complement pathway and its roles in immune responses. It involves an activation cascade where C1, C4, C2, C3, and C5 are activated in sequence. This leads to opsonization, chemotaxis, anaphylaxis, and formation of the membrane attack complex to lyse targeted cells in less than 3 sentences.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    8 views1 page

    Classical Pathway

    Uploaded by

    Miki Abera
    This document describes the classic complement pathway and its roles in immune responses. It involves an activation cascade where C1, C4, C2, C3, and C5 are activated in sequence. This leads to opsonization, chemotaxis, anaphylaxis, and formation of the membrane attack complex to lyse targeted cells in less than 3 sentences.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    Classicdpathwayme

    recognition unit
    trimolecular Ctgirs

    activation Ct + Fc ¢-112 -

    /
    IgG CHS IgM]
    -

    Gq→CLq a
    1- Gr → are

    Too
    Cts - Gsg

    C4a+C4b ← C. 4 +
    ]
    anaphylaxis #
    →mast
    cell degranulation bind to all membranes
    release of vasoactive amines

    =
    C2 ,C3,C5 → Activated

    anaphylaxis Csa
    Opsonization Csb
    →§5a C5b
    →

    →
    anaphylaxis + chemotaxis

    1st component of
    ME

    1) Opsonizqtion Gb / IgG
    :

    2) chemotaxis •• C5q / 0567 [


    + 1134,21-8 Bacterial products]
    ,

    3) tnaphylotoxin ••C3a,C4a,C5a
    4) Cytolysis •• MAC :.C5b E- Cg]

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