M al a r i a kills a child every minute1...

...and threatens the lives of

pregnant women and their babies2

Progress to defeat the disease has stalled over recent years

Cases Deaths
(Millions) Estimated global malaria cases2 (Thousands) Estimated Global malaria deaths2
250 241 900
million
800
240

700 627
thousand
ne of
230
227 600
ia is o
million Malar est killers
g
the big ren under
220
500 558 d
of ch il
thousand
years
e of 5
the ag 3
210 400

lly
globa
2000 2002 2004 2006 2008 2010 2012 2014 2016 2018 2020 2000 2002 2004 2006 2008 2010 2012 2014 2016 2018 2020
Time (years) Time (years)

PREVENTION
45%
Malaria Rates of indoor residual
Indoor spraying in endemic
reduction

By combining
residual in the risk of countries declined
spraying contracting from 5.8% in 2010 to
malaria4 2.6% in 2020 2

prevention
tools, we can Insecticide-
41%
reduction
50% of households
in sub-Saharan

maximize benefits, treated

nets
in the risk of
contracting
Africa do not
have access to

yet gaps still

malaria5 insectide-treated
bed nets 2

remain Perennial 58–83% Despite being

malaria chemo- lower incidence recommended by
prevention in of clinical malaria the World Health
vs placebo after Organization (WHO),
infants & children
the first dose6,a adoption of
perennial malaria
chemoprevention
is limited7

Post-discharge 77% New WHO

reduction in recommendation
malaria chemo-
all-cause to reduce hospital
prevention mortality8 re-admission and death
among children due to
severe anaemia8

Intermittent
preventive 56% In 2020, only
reduction one-third of eligible
treatment of in the risk of pregnant women
malaria in contracting in sub-Saharan
pregnancy (IPTp) malaria9
Africa received
the recommended
three doses of IPTp2

Seasonal Currently limited to

malaria 88% children aged 3 months
protection

RTS,S
chemo- to 5 years.10 Expanding
(28 days)10 SMC would protect
prevention (SMC)
older children

The new RTS,S

from malaria7

vaccine will 28–46% protection Vaccine is only

help protect against malaria
indicated for children
aged 6 weeks to

some of in children11,b 17 months,11 and at

current stock levels,

those most
fewer than 4 million
children per year can

NO SINGLE LAYER OFFERS

be fully vaccinated 12,13

vulnerable COMPLETE PROTECTION AGAINST MALARIA

Recommended
treatment
Injectable medicines:2 Artemisinin-based
– artesunate combination
– artemether therapies8
– quinine – With or without
Severe Uncomplicated single low-dose
malaria Rectal capsules:2 malaria
– artesunate primaquine

To protect and treat all those at Medicines for Malaria Venture

risk, multiple complementary and its partners have developed
14 quality-assured medicines,
interventions are needed, saving almost 3 million lives
each contributing to cumulative protection from malaria

Medicines offer a flexible and affordable

approach to malaria control

To eliminate and eradicate malaria...

...more new and innovative medicines are needed
to fill the gaps in both protection and treatment
Better
New
chemoprevention treatments for
options for pregnant women
children and with malaria
pregnant women

Malaria remains a top killer of children

Continued investment in the research and development
for new tools, including medicines for prevention and
treatment, is critical to reach malaria eradication

a
Prophylactic effect for infants receiving intervention at 3 months old until 35 days after start of time at risk.
b
Vaccine efficacy after 30 months of follow-up in young infants aged 6–12 weeks and children aged 5–17 months who received 4 vaccine doses.

1. Malaria in Africa, UNICEF. July 2022.

2. World Malaria Report 2021. WHO. December 2021.
3. Childhood diseases. UNICEF.
4. Wangdi K, et al. Parasit Vectors. 2018; 11:210.
5. Yang GG, et al. Int J Environ Res Public Health. 2018; 15:546.
6. Aponte JJ, et al. Lancet. 2009; 374:1533–1542.
7. Updated WHO recommendations for malaria chemoprevention among children and pregnant women. WHO. June 2022.
8. WHO Guidelines for malaria. WHO. June 2022.
9. Agyeman NY, et al. J Trop Med. 2020; 2020:2325304.
10. ACCESS-SMC Partnership. Lancet. 2020; 396:1829–1840.
11. Mosquirix SmPC. EMA. Updated August 2022.
12. Over 1 million African children protected by first malaria vaccine. WHO. April 2022.
13. RTS,S Malaria Vaccine, a Promising Tool in the Fight Against Malaria. JSI. April 2022.
All webpages accessed in November 2022.