Helix Vol.
4: 564- 567 (2014)
Qcciniaherb®: A Novel Herbal Medicine for Diabetes
1
Sajith Kumar NSP, *2Aparna Rajesh, 3Ahmed Hassan M Al Mansoori
1
Managing Director, 2Research Scholar, 3Rtd. Director General of Abu Dhabi Chamber
Commerce and Industry and CEO2 Al Mansouri Health Products, Abu Dhabi, U.A.E,
* Phone: 71506684183, Email: sajith@amhealthproducts.com
Received: March 17th 2014, Accepted: May 28th 2014, Published: July 1st 2014
Abstract:
Diabetes is prevalent world-wide and is stated to be a
silent killer. Diabetes mellitus (DM) is a metabolic
disorder characterized by hyperglycemia resulting
from defects in insulin secretion, insulin action or
both. There are hundreds of medicinal plants that
have a long history of curative properties against
various diseases and ailments. A variety of plant
preparations have been mentioned in Ayurveda and
other indigenous systems of medicine, which are
claimed to be useful in the treatment of diabetes
mellitus. In our study, the herb Coccinia indica was
targeted to treat diabetes mellitus. In present work,
Thermal refluence distillation concentrator is used as
the reactor for herbal plant extraction and the herb
residue should be drained out after the solvent
recovery. The content of the capsule powder is
dissolved in methanol and TLC studies of the
methanol extract has been carried out and compared
with the reference standard synthetic medicines used
for diabetes e.g. glibenclamide, tolbutamide,
acetohexamide, g1ipizide, tolazamide,
chlorpropamide, g1ucophage, repaglinide and actos
using different mobile phases. The above compounds
were found absent in the capsule contents. The
capsule content is chromatographed with the
Coccinia indica plant extract (provided with the
sample) which were found identical with each other.
Thus our studies have shown that the product
Qcciniaherb® is 100% natural extract from Coccinia
indica and it has an optimal effect in combination
with vitamin D3. The herbal medicine is used for
Diabetes mellitus and its late effect to regulate and
reduce blood sugar level naturally, improves blood
lipid levels and reduces insulin resistance, and helps
in glycemic control.
Keywords: Actos, Acetohexarnide, Chlorpropamide,
Coccinia indica, Diabetes mellitus, Glibenclamide,
G1ucophage, G1ipizide, Qcciniaherb®, Repaglinide,
Thermal refluence distillation concentrator, TLC,
Tolbutamide and Tolazamide.
Introduction:
Diabetes mellitus is a group of metabolic diseases in
which a person has high blood sugar, either because
the pancreas does not produce enough insulin
(Shoback, 2011). Diabetes doubles the risk of
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cardiovascular disease and it also damages the
capillaries. There are two major types of diabetes.
Type 1 diabetes mellitus is characterized by loss of
the insulin-producing beta cells of the islets of
Langerhans in the pancreas, leading to insulin
deficiency. Type 2 diabetes mellitus is characterized
by insulin resistance, which may be combined with
relatively reduced insulin secretion (Shoback, 2011).
Indian system of traditional knowledge (Ayurveda) is
well known for its effective herbal treatments. There
are about 7000 plant species found in India. Coccinia
indica a herb that belongs to Cucurbitaceae family
and that grows abundantly in India, has been widely
used in traditional treatment of diabetes (Chopra et al,
1958). The plant has also been used extensively in
Ayurvedic and Unani practice in the Indian
subcontinent (Wealth of India, 1992). Coccinia indica
is a good wound healer and reduces any kind of
inflammation occurring in body. Herbal substances
are new and scientifically well- to lower blood sugar
and reduce the late complications of diabetes
mellitus. Pectin isolated from many other plants has
also been reported to have hypoglycemic actions. The
pectin administration resulted in a significant
reduction in blood glucose and an increase in the
liver glycogen. Research suggests that vitamin D
could play a role in the prevention and treatment of a
number of disease conditions, including type1 and
type 2 diabetes, hypertension, glucose intolerance,
and multiple sclerosis. People with type 2 diabetes
who suffer from vitamin D3 deficiency can be treated
by the administration of vitamin D3 which improves
insulin secretion and promotes glucose intolerance
and impaired insulin secretion. Scientific studies
show a clear link between low vitamin D status and
increased number of new cases of type 2 diabetes.
Recent scientific studies have shown that regular
intake of vitamin D3 contributes to an improvement
in insulin secretion. Qcciniaherb® is 100% natural
extract from Coccinia indica for vitamin D3. The
herbal product has been specially adapted for
diabetes. It support pancreas to work healthy and
effectively. It is purely a natural product with out
chemical additives, thus it reduces and regulates
blood sugar naturally. It also reduces the blood lipids
 Helix Vol. 4: 564- 567 (2014)
such as cholesterol and triglycerides. Coccinia indica
seems like insulin work. The plant corrects the
activity of glucose 6 phospahatase, lactate
dehydrogenase in the glycolytic metabolism with
lipoprotein lipase activity in the controlled lipolytic
pathway. It helps in glycemic control. With regular
use of Qcciniaherb® there is less blood glucose
fluctuations. This means that the blood sugar level
drops and remains rather constant. The best evidence
for the effectiveness of a plant with diabetes,
however identify on Coccinia indica. It also reduces
the late damage or complication form diabetes
mellitus. The main ingredients of the herbal product
are Coccinia indica extract, 81.7% hydroxypropyl
methylcellulose, separating agent: magnesium salts
from edible fatty acids (vegetable), Silicon dioxide,
cholecalciferol 0.16% from of lactose, gluten and
genetically modified organism.
Qcciniaherb® is a green color ‘00’ capsule with cap
and body fill with brown colour. It has a saltish in
taste with aromatic smell. The capsule should be
stored at 15º-30º c or 59-86 F and should be protected
from heat, light and moisture. Two capsules must be
taken daily with food. The recommended daily
dosage should not be exceeded.
Mukherjee et a1., (1972) showed that the plant had
hypoglycaemic activity in alloxan-diabetic rats,
concluding that the active principle of the plant may
have insulin-like activity. Khuda et al., (1965)
suggested that the plant has only traces of alkaloid.
Several years ago, Hossain et al.,(1992) examined the
effect of Coccinia indica leaf preparation on 48h
starved normal male rats and showed that the leaf
extract depressed the activity of the enzyme glucose-
6-phosphatase. (Shakya, 2008; Venkateswaran et al.,
2003; Venkateswaran and Pari, 2003; Yeh et al.,
2003; Wasantwisut and Viriyapanich, 2003; Ajay et
al., 2009; Mallick et al., 2009 and Nahar et al., 1998)
reported plant is exhaustively studied for its
hypoglycemic, antidiabetic potential with different
animal models from 1953. (Jain et al., 1996.,
Shanmugasundaram et al., 1990., Sharma et al., 1990
and Serraclara et al., 1998) reported that a total of
108 clinical studies were found examining 25 single
herbs, 11 combination herb formulas, and 9
vitamin/mineral supplements as potential therapy for
diabetes. Of these, 58 were controlled clinical trials
in patients with diabetes impaired glucose tolerance
(42 randomized, 16 nonrandomized). Only four of the
controlled trials included patients with type 1
diabetes.
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Materials and Methods:
Herbal Processing:
The whole cultivated plant (leaves and fruit) used for
the experiment was taken and dried with the help of a
dryer machine. The plants should not be exposed to
sun rays for drying as the colour of the plant
materials gets changed when exposed to sun rays.
The extract ratio of the dried material is taken as
15:1.
Herbal Extraction:
Thermal refluence distillation concentrator is used as
the reactor for herbal plant extraction. The secondary
steam continues rising, and becomes condensed after
passing through the condenser. Later it will be
collected inside the extraction tank. The new solution
will go through the solution quickly into the bottom
of extraction tank. The extraction liquid will be
pumped into the concentrator extraction & filter pipe.
The secondary steam produced from that would be
retaken to the extraction as a new solvent or heat
source. The extraction of new solvent at high-
gradient extracts from solution is extracted
completely with great speed, after the extraction
liquid stops pumping to the concentrator and
concentrated secondary steam enters into the cooler.
But the concentration will be continued until extracts
reaches the proportion required (1.2-1.34) and
extracts in the extraction tank can be put into the
storage tank for next process. The herb residue will
be drained from the extraction tank door. If organic
solvent is added to the extract, proper water should
be added first to the tank and the steam valve must be
opened. The herb residue should be drained out after
the solvent recovery. After this process, the herbal
residue is taken to the vacuum drier. In vacuum dryer
heat is supplied by conduction or radiation (or
microwaves), while the vapor thus produced is
removed by the vacuum system. The
Chromatographic Finger Print Profile was analyzed
and the capsule content is chromatographed with the
Coccinia indica plant extract (provided with the
sample) ~d found identical with each other.
Magnesium stearate, stearic acid, carbohydrates,
amino acids especially phenyl alanine and vitamin
D3 are identify.
Results and Discussion:
In this study different parameters were analysed such
as physical, chemical, heavy metals and
microbiological control and it was concluded that the
test sample ‘Quccinia herb’ is 100% natural extract
from Coccinia indica with vitamin D3 combination.
Through FTNIR spectra, the shelf life is calculated
by plotting wavelength in x axis and reflectance in y
 Helix Vol. 4: 564- 567 (2014)
axis and the shelf life of the sample was found to be Table 3: Microbiological Control
two years. STANDARD
Table 1: Physical Analysis PARAMETER RESULT VALUE
Total Plate
STANDARD 200 cfu/g <1.000cfu/g
PARAMETER RESULT VALUE Count
Yeast and
Colour Passes Brown 55 cfu/g <100 cfu/g
Mould
Appearance Passes Dry powder Coliforms Absent Absent
Odour Passes Characteristic
Salmonella Absent Absent
Solubility in
92.17% NLT 70%
Water E.coli Absent Absent
Moisture 2.12% NMT 6%
Pseudomonas
Absent Absent
pH 5.75 NMT 7 aeruginosa
Staphylococcus
Smell and Absent Absent
Identification Passes aureus
Colour
The above table shows the physical analysis
parameters for the herb. Fig 1: FTNIR SPECTRA

Table 2: Chemical Analysis

STANDARD
PARAMETER RESULT VALUE
Alkaloid 0.9% NLT 0.8%

Fat Content 0.28% NMT 0.5%

Assay of
20.6% NLT 20%
Triterpenes
Pass 98%
100%
Particle size through 20
passes
mesh
Heavy metals(USP Method)

Arsenic as As Nil <3PPM

The Graph showing the half life calculation for the
herb. Wavelength was plotted in x axis and
Mercury as Hg Nil <1PPm reflectance in y axis and the shelf life of the sample
wass found to have two years.
Cadmium as Cd Nil <0.3PPM
Conclusion:
Coccinia indica may be useful for the treatment of
Lead as Pb Nil <10 PPM
patients with diabetes melltitus without having any
Pesticide Absent (by toxic effect. The combination with vitamin D3 have a
Residues Nil USP method) possitive effect of insulin secreation, improves
Residual glycemic control in diabetes patients themselves and
Solvents (USP <5000 PPM insulin resistance. The main advantage of
Method) Nil Ethyl Alcohol Qcciniaherb® from other product is that, it is purely
natural basis herbal product. It acts quiclky with
The above table shows the chemical analysis
regular use and no heavy metals are used in the
performed and the chemical parameters tested.
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 Helix Vol. 4: 564- 567 (2014)
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