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Pharmacology Chapter 2
Pharmacology Chapter 2
• Drug half-life
• Site of excretion
• Critical concentration
– The amount of a drug that is needed to cause a
therapeutic effect too much toxic/poisonous; too little will not produce the desired effects
• Loading dose
– A higher dose than that usually used for
treatment to reach the critical concentration
• Dynamic equilibrium
– The actual concentration that a drug reaches in
the body
Copyright © 2008 Lippincott Williams & Wilkins.
The Processes by Which Drugs Are
Handled in the Body
– Absorption
– Distribution
– Biotransformation
– Excretion
Copyright © 2008 Lippincott Williams & Wilkins.
Absorption
• Refers to what happens to a drug from
the time it is introduced to the body
until it reaches the circulating fluids
and tissues.
• GI tract- orally/rectally
• Mucous membrane
• Through the skin, lungs or through
muscle/ SQ
• First-pass effect
•Passive diffusion
•Active transport
•filtration
• Protein binding
• Blood–brain barrier
• Placenta/breast milk
• People can
develop allergy
• Exposure to its
proteins, pt can
develop
antibodies to a
drug; w/ future
exposure- may
experience full
blown allergic
reaction
– During distribution compete for protein binding site (aspirin & methotrexate)
– During excretion 1 drug competes 4 excretion w/ other drug leading to accumulation & toxic effects of 1 drug
– At the site of action 1drug maybe antagonist of the other drug leading to no therapeutic effect 9antihypertensive
w/ allergy drug that also causes inc BP