Professional Documents
Culture Documents
Wolfish
Suicide Attempts in the Adolescent
SUMMARY: SOMMAIRE
Suicide is a leading cause of death among Le suicide est l'une des principales causes de dec's
North American adolescents. Drugs are the chez les adolescents nord-americains. Les
medicaments, en particulier ceux que l'on retrouve
commonest method used, and are most dans les foyers, constituent la methode de suicide la
frequently those found in the home. plus utilisees. Les demenagements frequents, les
Common factors such as frequent moves, difficultes conjugales des parents et un passe
marital difficulties of the parents, and a medical familial ponctue de depression sont au
family history of depression occur in these nombre des raisons susceptibles d'entrainer un
patients. In 47 cases seen at a Toronto suicide. Des quarante-sept cas releves par un hopital
de Toronto, vingt-deux patients ont ete admis a
hospital, 22 patients were admitted. Of l'hopital. De ce nombre, vingt avaient attente a leur
these, 20 had made suicidal gestures; two vie et deux avaient failli reussir. La plupart de ces
had made serious attempts. Most were of cas etaient de famille de classe inferieure ou
lower or middle class background. There is moyenne. On remarque souvent un probleme de
often a long-standing problem in the longue date et un evenement decisif. La
connaissance des facteurs peut aider les medecins de
history, plus a triggering event. Knowledge famille a depister les patients les plus susceptibles
of risk factors can help family physicians de se suicider. L'hospitalisation des adolescents qui
identify high risk patients. Hospitalization ont des intentions de suicide est evidemment
of teenagers with suicidal intent is souhaitable parce qu'elle sert a convaincre le patient
obviously preferable, especially since it ainsi que ces parents que la tentative ou l'intention
n'a pas ete prise 'a la legee.
convinces patient and family that the
attempt or intent has been taken seriously.
(Can Fam Physician 1982; 28:773-780).
Mr. Weiss is presently a final after a self-destructive act is a prime the degree of psychopathology pres-
year medical student at the medical and psychiatric priority. ent, and the youth's concept of
University of Toronto. Dr. Wolfish When a teenager has attempted self- death.3
is chief of pediatrics at North York harm, suicide is a major concern, yet Of adolescents who gesture suicide,
General Hospital. Reprint requests self-destructive behavior can have a females outnumber males three to one.
to: Dr. M. Wolfish, North York variety of intents ranging from acts of Drug intoxication is the most fre-
General Hospital, 4001 Leslie St., low lethality to more serious actions. quently used method.2 These teen-
Willowdale, Ont. M2K lEl. This contrasts with the suicidal act agers do not truly wish to die-rather
which is "done in desperation to mod- the gesture is an attention-seeking de-
ify an intensely painful state".2 Often vice or a plea for help, directed com-
it is difficult to determine the true in- monly at parents or friends.' These
UICIDE ATTEMPTS and other tent of the act. While the teenager may teenagers are often mildly to modera-
bforms of self-destructive behavior deny the seriousness of the attempt, no tely depressed and the attempt is
are endemic among the adolescent self-destructive act should automati- usually poorly planned.
North American population. In fact, cally be considered benign. Males are more frequently involved
accidents and suicides are the two Suicidal behavior can range through in serious suicide attempts. These are
main causes of death in teenagers and threats to a suicidal gesture, to a often carefully planned and they may
young adults today. ' While the major- serious attempt. The suicidal threat have attempted suicide in the past. The
ity of suicidal acts are unsuccessful, may be written or verbalized and can ability to communicate with others is
the morbidity is significant both in be expressed directly or in more subtle more severely compromised as the at-
terms of self-inflicted physical harm ways. Both the suicidal gesture and the tempts become more serious. 1 Suicidal
and the emotional scars the adolescent serious attempt are actual attempts at tendencies in adolescents can be quite
must bear as a result. Thus, early re- self-harm. They differ in many ways variable: awareness of the wide range
cognition and treatment of teenagers including the intent, level of planning, of behaviors that the suicidal adoles-
CAN. FAM. PHYSICIAN Vol. 28: APRIL 1982 773
Berotec® fenoterol hydrobromide
Prescribing Information cent can present is extremely impor- conscious level.6' I In an attempt to
tant in managing these youths. seek love, the child turns to suicide.
INDICATIONS AND CLINICAL USES: Berotec is indicated for Psychodynamic theories examine
the symptomatic relief of bronchial asthma and other condi-
tions in which reversible bronchospasm is a complicating fac- Epidemiology the developmental changes adoles-
tor, such as chronic bronchitis or emphysema.
CONTRAINDICATIONS: Like other sympathomimetic amines, The frequency of suicide increases cents must cope with as they approach
Berotec should not be used in patients with tachyarrhythmias with age in the pediatric and adoles- adulthood. Having to deal with new
or in those with known sensitivity to sympathomimetic
amines. cent population. Few cases of suicide feelings of sexuality and aggressive
3-blocking agents, e.g., propranolol, effectively antagonize have been reported under age five. impulses, rejection of one's parents
the action of Berotec. Their concomitant use is therefore con-
traindicated. Children aged five to nine years may and the quest for new challenges in
WARNINGS: Special care and supervision is required in pa- threaten but rarely attempt or suc- life, the developing adolescent may be
tients with thyrotoxicosis, cardiac arrhythmias and idiopathic
hypertrophic subvalvular aortic stenosis, when an increase in ceed.2 Amongst adolescents, the com- unable to cope with these stresses.'
the pressure gradient between the left ventricle and the aorta
may occur causing increased strain on the left ventricle. monest method of attempted suicide is The youth sees the world as less pro-
Use In Pregnancy: The safety of Berotec in pregnancy has not drugs such as ASA, alcohol, barbitu- tective and feels more isolated, lonely
been established. rates, diazepam and antidepressants.' and sad. He may defend against these
Use In Children: There is insufficient data at this time to
establish the safety and efficacy of Berotec in children. The source of the toxic substance is conflicts by acting out. This is compli-
PRECAUTIONS: Berotec should be used with care in usually the home.' Although less fre- cated by the fact that the adolescent
asthmatic or emphysematous patients who also have systemic
hypertension, coronary artery disease, acute and recurring quent in the adolescent population, vi- may not have developed an adult per-
congestive heart failure, diabetes mellitus, glaucoma or olent suicide attempts usually involve spective that things do get better.2 It is
hyperthyroidism.
Care must also be exercised in the concomitant use of Berotec males and are understandably asso- therefore understandable that suicidal
with other sympathomimetic amines or MAO inhibitors. ciated with a higher mortality. behavior occurs in the adolescent
As with all sympathomimetic aerosol drugs, failure to respond
to a previously effective dose usually indicates a significant
Factors common amongst teenagers years.
deterioration in the patient's asthmatic conditic:i. He should who turn to suicide include broken Considering suicidal behavior as an
be instructed to contact his physician immediately in these
circumstances, and on no account should he exceed the re- homes, unemployed breadwinners and isolated event may not be totally ap-
commended dose of aerosol. Occasional patients have been a high frequency of family moves.4 propriate. Rather, it may suggest an
reported to have developed severe paradoxical airway resis- underlying psychiatric disorder. In a
tance with repeated use of sympathomimetic inhalant prepa- Accordingly, adolescents from lower
rations. Fatalities have been reported following excessive use
of aerosol preparations containing sympathomimetic amines, socioeconomic backgrounds are more recent study, Crumley8 placed psy-
the exact cause of which is unknown. likely to attempt suicide than their chiatric diagnoses on 40 adolescents
ADVERSE REACTIONS: Berotec Inhaler: The following ad-
verse reactions have been reported at therapeutic dosage counterparts in the higher socio- who attempted suicide. Of these pa-
levels (1-2 whiffs): tremor, restlessness, palpitations, dizzi-
ness, headache, nausea, lightheadedness and weakness.
economic groups.4 As one moves up tients, two-thirds had an affective dis-
Other occasional reactions include vomiting, heartburn, the socioeconomic ladder, the relative order, and substance abuse was also
sweating, nervousness, bad taste, fatigue, prickling and
tingling sensations over the body, and agitation. proportion of suicidal gestures de- frequently diagnosed. Personality dis-
Berotec Tablets: The most frequently observed adverse reac- clines-but serious attempts increase.4 turbance occurred in 62%, most fre-
tions reported at therapeutic dosage levels (2.5 mg b.i.d.
-5 mg t.i.d.) were tremor and nervousness. Other adverse Other associated factors include mari- quently a borderline personality dis-
effects in decreasing order of frequency are: palpitations,
headache, nausea, tachycardia, insomnia and muscle
tal discord, alcoholism, child abuse order.
cramps. Other rare reactions included irritability, weakness, and a family history of suicide and Mattsson9 has proposed a classifica-
stomach pains, anxiety, dizziness, rash, tiredness, vomiting,
coughing, numbness in hands and legs, and dry mouth. death.2'
24 tion system for suicidal intent, to con-
SYMPTOMS AND TREATMENT OF OVERDOSAGE: The symp- Clearly these are numerous predis- sider the teenagers' state at the time of
toms of overdosage are those of excess beta stimulation listed
under Adverse Reactions. The use of a beta-blocker should be posing and associated factors common the act rather than the predisposing
considered in cases of severe overdosage. to teenagers who attempt suicide. psychiatric causes (see Table 1). In
DOSAGE AND ADMINISTRATION: Berotec Inhaler: A single
dose of one or two inhalations (0.2-0.4 mg) to control bron- Knowledge of these factors in a teen- any case, simply labelling a suicide at-
chospasm. If required, this dose of 1 or 2 inhalations may be ager's history may be helpful in identi- tempt as a reactive disorder is clearly
repeated up to 4 times daily. With repeated dosing, drug
should not be given more often than every 4. hours. Patients fying the teenager at risk. unwarranted. Psychiatric intervention
should not exceed a total of 8 inhalations per day (See Pre- may not only prevent further attempts,
cautions).
Berotec Tablets: The recommended starting dose is 2.5 mg Psychopathology but also improve longterm manage-
twice daily. If a greater therapeutic effect is desired, the
dosage may be increased up to a maximum of 5 mg 3 times Attempts to analyze suicidal behav- ment.
per day. The maximum single dose is 5 mg and this should ior have ranged from psychoanalytic TABLE 1
not be administered more often than every 6 hours. The maxi-
mum daily dose should not exceed 15 mg. theories, such as Freud's "classical External and Internal
AVAILABILITY: Berotec Inhaler: Each valve depression
delivers 0.2 mg of Berotec as a micronized powder. Each In- theory of melancholia", to dynamic Precipitating Suicidal Factors9
haler Unit contains 200 doses of 0.2 mg Berotec. changes that explore the developmen- Loss of a love object followed by
Berotec Tablets 2.5 mg: Round, white, flat, bevelled edge, tal changes of adolescence.5 In the 1. acute grief
"expendable child theory", Gould 2. "The badprolonged
compressed tablets, engraved with the symbol: j,
9
or
The reverse side is scored with each halft
engraved as follows: B. me": self-depreciating pa-
Supplied in amber glass bottles of 100 and 500 tablets. postulated that all developing children tients
Berotec Solution: Supplied as an aqueous solution in amber have an intense need for, and constant 3. The final "cry for help" directed
screw cap glass vials with internal dropping assembly. Each
20 mL vial is supplied in an individual carton with a package fear of losing, love.6 When a child is beyond immediate family
insert of detailed instructions for use. Berotec 0.1%: Con- rejected, the need for love increases as 4. The revengeful angry teenager
tains fenoterol hydrobromide 1 mg/mL solution.
For further information, consult the Berotec Product Mono- the child attempts to fight the loss. Be- 5. The psychotic adolescent
graph or your Boehringer Ingelheim representative. cause the child has an omnipotent 6. The suicidal game
REFERENCES: 1. Anderson, S.D. et al.: J. Allergy Clin. Im- image of his parents, the feelings of
munol. 64:612, 1979. 2. Anderson, S.D. et al.: Aust. N.Z.J.
Med. 5:554, 1975. 3 Leife, N and Wittig, H.J.: Ann. anger and rage he has towards his re-
jecting parents are directed inwards. Suicide Attempts in
Allergy 35:69, 1975. 4. Weinberg, E.G. et at.: Med. Proc.
18:73, 1972. 5. Wettengel, R. and Fabel, H.: lot. J. Clin.
Pharmacol. 4(Suppl):96, 1972.
Subsequently, the child develops a The Toronto Area
"sense of expendability"' which may Because suicide attempts are rela-
Boehrlnger Ingelhelm (Canada) Ltd. PA be manifested explicitly or on an un- tively common in the adolescent years,
g2,,97 Century Drive
(i) CP
'-j- Burlington, Ontario L7LS5J8 775
the results are frequently seen in the life, including difficulties in interper- .(n.u8X cephalexin
hospital emergency department. In one sonal and family relationships.2 There DESCRPfO: Keflex is a semisynthetic cephalosporin antibiotic
particular study conducted during four may also be recent increases in new intended for oral administration. It is 7-(D-a-amino-a-phenylaceta-
mido)-3-methyl-3-cephem-4-carboxylic acid monohydrate.
months in 1977, the emergency de- problems, with fewer perceived solu- ACTO: Cephalexin is bactericidal against many gram-positive and
partment at North York General Hos- tions. How these teenagers at risk react gram-negative organisms. In vitro tests demonstrate that the cephalo-
sporins are bactericidal through their inhibition of cell-wall synthesis.
pital in Willowdale, Ontario, reported under these stresses is similar. INDICAT S: Keflex may be indicated in the treatment of bacterial
infections of the respiratory tract, including otitis media, genitourinary
47 cases of teenage suicide attempts Prior to the attempt, these adoles- tract, bones and joints, skin and soft tissue when the infection is
caused by susceptible organisms.
(Table 2).10 Just less than half were cents are commonly depressed and CONTRNDICAlTIMS: Keflex is contraindicated in patients with
admitted to hospital. The remainder show signs of increased tension such known allergy to the cephalosporin group of antibiotics.
PRECAUTIS: Antibiotics, including Keflex, should be administered
were sent home for a variety of rea- as restlessness, irritability and over- cautiously to any patient who has demonstrated some form of allergy.
particularly to drugs.
sons, usually because they or their sensitivity .2' 12 They may have experi- In penicillin-allergic patients, cephalosporin antibiotics should be
used with caution. There is some evidence of partial cross-allergenicity
families rejected hospital admission. enced difficulty in school, including of the penicillins and the cephalosporins. Of 7.450 clinical trial
The hospitalized group were classified truancy, and show a general decrease patients, 291 had histories of penicillin allergy. Nineteen of them
(about 6.5 percent) were among those in whom possible allergic
as having made a gesture or a serious in social behavior and functioning. reactions to cephalexin were observed.
Patients should be followed carefully so that any side-effects or
attempt, depending on whether the at- Symptoms include feelings of sadness, unusual manifestations of drug idiosyncrasy may be detected. If an
allergic reaction to Keflex occurs. the drug should be discontinued and
tempt was communicated to family or emptiness and lack of energy. More the patient treated with the usual agents (e.g., epinephrine or other
pressor amines, antihistamines, or corticosteroids).
friends. The majority of the hospital- specific complaints include changes in Prolonged use of Keflex may result in overgrowth of non-suscep-
tible organisms. Careful observation of the patient is essential. If
ized group came from middle or lower sleep and eating, boredom, and loss of superinfection occurs during therapy, appropriate measures should be
class backgrounds and the most com- interest in school and social activites. taken.
Keflex should be administered with caution in the presence of
mon methods involved ingestion of There may be a previous history of a markedly impaired renal function. Under such conditions, careful
clinical observation and laboratory studies should be made because
ASA, diazepam, acetominophen, vari- suicide attempt or other forms of self- safe dosage may be lower than that usually recommended.
If Keflex is to be used for long term therapy, periodic monitoring of
ous sedatives, and alcohol. Half of destructive behavior. hematology, renal and hepatic functions should be done. Indicated
surgical procedures should be performed in conlunction with antibiotic
those admitted were repeat attempts. The specific event that triggers a therapy: e.g., the incision and drainage of abscesses.
suicide attempt can vary from a seem- Safety of this product for use during pregnancy has not been
TABLE 2 established.
Records of Attempted Suicide in ingly harmless incident to a highly Positive direct Coombs tests have been reported during treatment
with the cephalosporin antibiotics. In hematologic studies or in trans-
Teenagers at a Toronto Hospital traumatic experience. Often it may not fusion cross-matching procedures when antigkobulin tests are per-
formed on the minor side or in Coombs testing of newborns whose
be clear. Conflicts between the child mothers have received cephalosporin antibiotics before parturition. it
should be recognized that a positive Coombs test may be due to the
Emergency room cases 47 and his parental figures are a common drug.
22 In patients being treated with Keflex. a false-positive reaction for
Admitted to peds. Ipsychiatry precipitating stress, as are grief reac- glucose in the urine may occur with Benedict's or Fehling's solutions
Females 17 tions, loss of loved people or things, or with Clinitest tablets, but not with Tes-Tapeo.
5 ADVERSE REACTIONS: Gasro-intestinal-Diarrhea has been reported
Males sexual conflicts and school difficul- in only 1.5 percent of 7.450 clinical trial patients. It was very rarely
Serious attempts 2 ties.9 In reviewing a number of adoles- severe enough to warrant cessation of therapy. Nausea. vomiting,
dyspepsia and abdominal pain have also occured.
Suicidal gestures 20 cent suicide attempts, Scheer and Kay Hypeensity-Allergies (in the form of rash, urticaria and angio-
10 edema) have been observed. These reactions usually subsided upon
-communicated with friends divided the precipitating stresses into discontinuation of the drug.
-communicated with parents 10 Other reactions have included genital and anal pruritus, genital
Average age at admission 15 six main areas:'3 moniliasis. vaginitis and vaginal discharge, dizziness, fatigue, and
headache. Eosinophilia, leucopenia due to neutropenia, and slight
(range 12-19) 1. Disclosure of a forbidden activity elevations in SGOT and SGPT have been reported.
SYMPTOMS AND TREATMENT OF ORERDOSAGE: No information is
Socioeconomic background (i.e. alcohol) available on the treatment of overdose with Keflex. There is no
specific antidote.
-lower and middle class 17 2. Separation from parents (and MICROBIOLOGY: Keflex is active against the following organisms in
-upper middle class 5 others) vitro:
Beta-hemolytic and other streptococci (many strains of entero
Discharged by casualty officer 25 3. Defiance cocci; e.g.. Streptococcus faecalis, are resistant)
Staphylococci. including coagulase-positive, coagulase-negative.
(Refused admission, outpatient 4. Restriction and penicillinase-producing strans (a few strains of staphylococci are
follow up arranged, casualty officer 5. Criticism
resistant to cephalexin)
Diplococcus pneumrrniae Hemophilus influenzae
felt admission was unwarranted) 6. Exclusion Escherichia coli
Klebsiella pneumoniae
Proteus mirabilis
Neisseria catarrhalis
Keflex is not active against most strains of Enterobacter sp., Pr,
Predisposing and precipitating fac- The vast majority of teenagers who morganii. and Pr. vulgaris. It has no activity against Pseudomonas or
tors were also examined: parents' mar- exhibit suicidal behavior share this Herellea species. When tested by in vitro methods, staphylococci
exhibit cross-resistance between Keflex and methicillin-type
ital difficulties, conflicts with parents, type of clinical picture. However, the antibiotics.
DOSAGE AND ADMINISTRATION: Keflex is administered orally. The
and alcohol/cannabis abuse were fre- occasional youth may demonstrate adult dosage ranges from I to 4 g daily in divided doses. The usual
adult dose is 250 mg every six hours. For more severe infections or
quent themes. Obviously the make-up more severe psychopathology, such as those caused by less susceptible organisms, larger doses may be
needed. If daily doses of Keflex greater than 4 g are required.
of teenagers who attempt suicide can thought disturbances and hallucina- parenteral cephalosporins. in appropriate doses should be considered.
vary from one locale to the next. Fur- tions beyond the acute episode, and The recommended daily dosage for children is 25 to 50 mg per kg
divided into four doses.
ther, it has been estimated that as few may have a history of longstanding Kelfex Su_psion
Child's Weight 125 mg/5 ml 250 mg/5 ml
as one in 100 suicide attempts actually psychiatric difficulties.8 10 kg (22 lb.)
20 kg (44 lb.)
r to tsp. q.i.d.
I to 2 tsp. q.i.d.
-
I? to I tsp. q.i.d.
receive medical attention.1" However, 40kg (88 lb.) 2 to 4 tsp. q.i.d. Ito 2 tsp. q.i.d.
this study does at least provide a sam- Case Histories In severe infections. the dosage may be doubled.
In the therapy of otitis media, clinical studies have shown that a
pling of adolescent suicide attempts in Case I dosage of 75 to 100 mg per kg per day in four divided doses is
required,
the Toronto area. S.A., a 15 year old girl, attempted In the treatment of beta-hemolytic streptococcal infections, antibi-
otic therapy should be administered for at least ten days.
suicide by ingesting 24 ounces of To obtain maximum peak levels, cephalexin should be administered
o,i an empty stomach.
The Clinical Presentation vodka. There were no witnesses, but DOSAGE FORMS:
Tablets Keflex. equivalent to 250 mg cephalexin (No. 1894), Identi-
The teenager who presents with sui- she showed up at a girlfriend's home Code 057. are supplied in bottles sf 100. and 500.
Tablets Ketlex. equivalent to 500 mg cephalexin (No. 1095). Identi-
cidal behavior almost certainly has had and collapsed. Code 049. are supplied in botlIes sf 100. and 250.
Keflen. for Oral Suspension, equivalent to 125 mg cephaleorn per
difficulties in the past. In fact, the sui- The major stress at the time of the 5 ml teaspoonful. is supplied In a 100 ml size packeage INs. M-201),
Identi Code W21.
cidal act may be the climax of a long attempt was a final school exam in a Ketlex. for Oral Suspension, equivalent to 250 mg cephaleorn per
5 ml teaspoonful. Is sapplred in a 100 ml size packtage (No. M-202).
series of struggles in the adolescent's course she felt she was unable to pass. idpvi, Curie W6o