Cephalosporins: Generic Names, Brand Names & Indications

II.
CEPHALOSPORINS
Generic Name Brand Name Indication

Cefuroxime axetil 2- Gen Treatment of susceptible infections which include bone &
joint infections, bronchitis & other lower resp tract
infections, gonorrhea, meningitis, otitis media, peritonitis,
pharyngitis, sinusitis, skin infections (including soft tissue
infections) & UTI. 2-Gen 750 Prophylaxis for surgical
infection.
A. CHEMISTRY: C20H22N4O10S
B. MODE OF ACTION: Cefuroxime Axetil is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefuroxime Axetil has activity in the presence of some
beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria.
C. ADVERSE DRUG REACTION: Diarrhea & nausea. 2-Gen Vomiting. Mild to moderate hearing loss. 2-Gen 750 Transient pain at IM inj site; skin rashes (maculopapular &
urticaria), drug fever; pseudomembranous colitis; decreased Hb conc &/or eosinophilia, leukopenia & neutropenia; transient rise in SGOT, SGPT & bilirubin.

Cefoxitin Na Acifox Principal treatment & prophylaxis of anaerobic & mixed
bacterial infections especially intra-abdominal & pelvic
infections.
A. CHEMISTRY: C16H16N3NaO7S2
B. MODE OF ACTION: Cefoxitin is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefoxitin has activity in the presence of some beta-lactamases,
both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria.
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions, anaphylaxis. Neutropenia, thrombocytopenia. Acute interstitial
nephritis, transient increase in liver enzyme. Pain at the inj site in IM use & thrombophlebitis in IV use.

Cefaclor monohydrate Aclor Treatment of susceptible infections including UTI, skin,
upper & lower resp tract infections.
A. CHEMISTRY: C15H16ClN3O5S
B. MODE OF ACTION: Cefaclor is a bactericidal cephalosporin and like other cephalosporins is an inhibitor of bacterial cell wall synthesis. It acylates membrane-bound
transpeptidase enzymes thus preventing the cross-linking of peptidoglycan necessary for bacterial cell wall strength and rigidity.
C. ADVERSE DRUG REACTION: GI disturbances, hypersensitivity reactions; serum sickness-like, skin reactions, arthralgia; pseudomembranous colitis.

Ceftriaxone Na Acrexon Treatment of susceptible infections eg chancroid,
endocarditis, gastroenteritis (invasive salmonellosis,
shigellosis), gonorrhea, Lyme disease, meningitis
(including meningococcal meningitis prophylaxis),
septicemia, surgical infection (as prophylaxis), syphilis,
typhoid fever & Whipple's disease.
A. CHEMISTRY: C18H16N8Na2O7S3.31/2H2O
B. MODE OF ACTION: Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of Ceftriaxone binds to carboxypeptidases,
endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell-wall synthesis and cell division. By binding to these
enzymes, Ceftriaxone results in the formation of of defective cell walls and cell death.
C. ADVERSE DRUG REACTION: Shock, hypersensitivity, blood abnormality. Liver & kidney failure, GI & resp disturbances, superinfection, vit deficiency.

Cefixime Actimax Treatment of susceptible infections including gonorrhea,
otitis media, pharyngitis, lower resp tract (eg bronchitis)
& UTI.
A. CHEMISTRY: C16H15N5O7S2
B. MODE OF ACTION: Like all beta-lactam antibiotics, cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition
of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefixime
interferes with an autolysin inhibitor.
C. ADVERSE DRUG REACTION: Diarrhea, stool changes; nausea, abdominal pain, dyspepsia, vomiting, flatulence. Pseudomembranous colitis. Headache, dizziness; rash,
pruritus, urticaria, drug fever, arthralgia. Thrombocytopenia, leukopenia & eosinophilia.

Cefuroxime Actimed cefuroxime Treatment of bone & joint, skin & soft tissue infections;
bronchitis (& other lower resp tract infections),
gonorrhea, meningitis, otitis media, peritonitis,
pharyngitis, sinusitis, UTI. Surgical infection prophylaxis.
B. MODE OF ACTION: Cefuroxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall,
it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that
cefuroxime interferes with an autolysin inhibitor.
C. ADVERSE DRUG REACTION: GI disturbances including diarrhea, nausea & vomiting. Rarely erythema multiforme, Stevens-Johnson syndrome & toxic epidermal
necrolysis. Mild to moderate hearing loss (in childn treated for meningitis).

Cefaclor monohydrate Aczebri Treatment of susceptible infections including UTI, upper
& lower resp tract & skin infections.
B. MODE OF ACTION: Cefaclor exerts its bactericidal activity by interfering with the synthesis of the bacterial cell wall. It binds to specific penicillin-binding proteins
responsible for the synthesis of peptidoglycan, a heteropolymeric structure that gives the cell wall its mechanical stability. The final stage of the peptidoglycan synthesis
involves the completion of the cross-linking of the terminal glycine residue of the pentaglycine bridge to the 4th residue of the pentapeptide. The transpeptidase that
catalyzes this step is inhibited by β-lactam antibiotics. Thus, inhibition of the transpeptidase interrupts peptidoglycan synthesis, causing spheroplast formation and lysis of
the bacteria.
C. ADVERSE DRUG REACTION: Occasionally, agranulocytosis & granulocytopenia.

Cefoxitin Na Aefox Treatment & prophylaxis of anaerobic & mixed bacterial
infections especially intra-abdominal & pelvic infections
(ie endometritis, pelvic inflammatory disease, surgical
infection). Treatment of gonorrhea & UTI.
B. MODE OF ACTION: The bactericidal action of cefoxitin results from inhibition of cell wall synthesis.
C. ADVERSE DRUG REACTION: Local reactions eg thrombophlebitis.

Cefuroxime Aeruginox Treatment of infections caused by susceptible organisms
including lower resp tract infections, UTI, skin & soft
tissue infections, septicemia, meningitis, gonorrhea &
bone & joint infections
B. MODE OF ACTION: Cefuroxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in
bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
C. ADVERSE DRUG REACTION:Thrombophlebitis, GI disturbances. Skin rash, itching, urticaria.

Ceftazidime Aerum Treatment of biliary tract, bone & joint infections, cystic
fibrosis (resp tract infections), endophthalmis, infections
in immunocompromised patients (neutropenic patients),
melioidosis, meningitis, peritonitis, pneumonia,
septicemia, upper resp tract & skin infections (including
burns, ecthyma gangrenosum & ulceration) & UTI;
surgical infection prophylaxis.
B. MODE OF ACTION: Ceftazidime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in
C. ADVERSE DRUG REACTION: Vomiting, pseudomembranous colitis, diarrhea, cramps, dizziness, hypoprothrombinemia & toxic epidermal necrolysis, pruritus, rash, fever,
nausea, abdominal pain & mild phlebitis at the inj site.

Ceftriaxone Na Afrixon Treatment of susceptible infections including chancroid,
endocarditis, gastroenteritis, gonorrhea, Lyme disease,
meningitis, septicemia, surgical infection prophylaxis,
syphilis, typhoid fever & Whipple's disease.
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever reactions eg serum sickness & anaphylaxis. Hypoprothrombinemia &/or platelet dysfunction.
Transient increase in liver enzyme levels. Hyperbilirubinemia. Neutropenia.
Ceftriaxone Na Aglophin Treatment of infections due to susceptible organisms eg
chancroid, endocarditis, gastroenteritis (invasive
salmonellosis, shigellosis), gonorrhea, Lyme disease,
meningitis (including meningococcal meningitis
prophylaxis), pneumonia, septicemia, syphilis, typhoid
fever & Whipple's disease. Surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Shock; hypersensitivity reactions eg exanthema, urticaria, erythema, flare, pruritus, shivering, fever, allergic dermatitis, edema, erythema
multiforme, anaphylactic or anaphylactic-like reaction.

Cefalexin monohydrate Airex Cefalexin monohydrate
A. CHEMISTRY: C16H17N3O4S.H2O
B. MODE OF ACTION: Cephalexin disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan
synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors)
to crosslink the peptidoglycan. Cephalexin antibiotics mimic the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan.
C. ADVERSE DRUG REACTION: GI discomfort, diarrhea, skin rashes, urticaria, eosinophilia, angioedema, anaphylaxis.

Cefuroxime axetil Altacef Infections of the bone & joint, upper & lower resp tract,
skin & soft tissue; surgical infections, UTI, gonorrhea.
B. MODE OF ACTION: Cefuroxime Axetil is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefuroxime Axetil has activity in the presence of some
beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria.
C. ADVERSE DRUG REACTION: Candida overgrowth; eosinophilia; +ve Coombs' test, thrombocytopenia, leucopenia; skin rashes; headache, dizziness; GI disturbances
including diarrhoea, nausea, abdominal pain, vomiting; transient increases of hepatic enzyme levels.

Ceftriaxone na Altaxone Treatment of susceptible infections including chancroids,
meningitis, septicemia, surgical infections, syphilis,
Cefuroxime axetil Altoxime Treatment of susceptible infections including bone &
jointinfections,bronchitis,gonorrhea,meningitis(although
treatment failures have been reported in H.influenza
meningitis),otitis
media,perotinitis,pharyngitis,sinusitis,skin(soft tissue)
infection & UTI surgical infection prophylasis.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions including skin rashes, urticarial, eosinophilia, fever, serum sickness-like reation, anaphylaxis.

Ceftriaxone na Ambiceph Treatment of
chancroid,endocarditis,gastroenteritis,gonorrhea,lyme
disease,meningitis,pneumonia,sepsepticemia,sysphilis,typhoid
fever & whipple’s disease.surgical infection prophylaxis.

Ceftriaxone Na Auroxone 1000 Treatment of chancroid, endocarditis, gastroenteritis
(invasive salmonellosis, shigellosis), gonorrhea, Lyme
disease, meningitis (including meningococcal meningitis
prophylaxis), septicemia, syphilis, typhoid fever,
Whipple's disease & surgical infection prophylaxis.
enzymes, Ceftriaxone results in the formation of of defective cell walls and cell death
C. ADVERSE DRUG REACTION: Diarrhea, nausea, vomiting; allergic skin & anaphylactic reactions, secondary infection w/ yeast, fungi or resistant organisms; changes in
blood cell counts.

Cefuroxime axetil Axet FC tab: Infections due to gm +ve & gm -ve bacteria;
surgical prophylaxis; more active against Haemophilus
influenzae & Neisseria gonorrhea; Lyme disease. Oral
susp: Treatment of susceptible infections including bone
& joint; bronchitis (& other lower resp tract infections),
infections) & UTI. Surgical infection prophylaxis.
B. MODE OF ACTION: Cefuroxime Axetil is a second generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefuroxime's effect is
dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase
enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan
chains. As a result, cefuroxime inhibits bacterial septum and cell wall synthesis formation.
C. ADVERSE DRUG REACTION: GI disturbances including diarrhea, nausea & vomiting.

Cefuroxime Na Axetine Resp tract infections including sinusitis, tonsillitis,
pharyngitis & acute/chronic bronchitis, bacterial
pneumonia & post-op lung infections. UTI including
pyelonephritis, cystitis & bacteriuria. Skin & soft tissue
infections including phlegmon, erysipelas, peritonitis &
traumatic infections. Septicemia, gonorrhea & articular
infections. Surgical prophylaxis & otitis media.
A. CHEMISTRY: C16H15N4NaO8S
B. MODE OF ACTION: Cefuroxime Sodium is the sodium salt form of cefuroxime and a semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation
cephalosporin antibiotic with bactericidal activity. Cefuroxime sodium inhibits bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby
interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall. Lack of cross-linking results in a
reduction of cell wall stability and leads to cell lysis.
C. ADVERSE DRUG REACTION: Rash, GI disturbances, eosinophilia, +ve Coombs' test, transient rise in serum liver enzymes or bilirubin, transient pain at inj site.

Ceftriaxone Na Bactrias Treatment of susceptible infections including chancroid,
meningitis, septicemia, syphilis, typhoid fever &
Whipple's disease.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions eg skin rashes, urticaria, eosinophilia, fever, reaction resembling serum sickness, anaphylaxis.

Ceftazidime pentahydrate Baxidyme Treatment of infections caused by susceptible organisms
eg lower resp tract, skin & soft tissue, UTI, bacterial
septicemia, bone & joint, gynecological, intra-abdominal
& CNS infections.
B. MODE OF ACTION: Ceftazidime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in
C. ADVERSE DRUG REACTION: Local reactions eg pain, inflammation, phlebitis & thrombophlebitis. Hypersensitivity reactions. Candidiasis & vaginitis. CNS effects &
transient lab changes.

Cefoxitin Na B Braun Cefoxitin Treatment of serious infections caused by susceptible
strains of designated microorganisms eg lower resp tract,
intra-abdominal, gynecological, bone & joint, skin & skin
structure infections; UTI & septicemia.
A. CHEMISTRY: C16H16N3O7S2 • Na
B. MODE OF ACTION: Cefoxitin can induce β-lactamase production by some bacteria. It is resistant to a wide range of β-lactamases, including those produced by
Bacteroides spp.
C. ADVERSE DRUG REACTION: Thrombophlebitis; allergic reactions; hypotension; diarrhea, pseudomembranous colitis; possible exacerbation of myasthenia gravis;
hematologic disorders; transient elevation in SGOT, SGPT, serum lactate dehydrogenase & alkaline phosphatase, jaundice; increased serum creatinine &/or BUN.

Ceftriaxone Na B Braun Cefttriaxone Treatment of ceftriaxone-susceptible infections including
chancroid, endocarditis, gastroenteritis, gonorrhea, Lyme
disease, meningitis, septicemia, syphilis, typhoid fever &
Whipple's disease. Surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Rash; eosinophilia, thrombocytosis, leukopenia; diarrhea; BUN, SGOT & SGPT elevations; pain, induration & tenderness at site of inj.

Cefuroxime Na Betcef Treatment of susceptible infections eg bone & joint, lower
resp tract, skin & urinary tract infections. Gonorrhea,
meningitis, otitis media, peritonitis, pharyngitis, sinusitis.
Surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Diarrhea, nausea, vomiting.

Ceftriaxone Na Bettrix Treatment of ceftriaxone-susceptible infections including
disease, meningitis, septicemia, syphilis, typhoid fever &
C. ADVERSE DRUG REACTION: Hypersensitivity reactions including skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions & anaphylaxis.

Cefalexin monohydrate Boie Cefalexin Treatment of resp tract & UTI, otitis media, pharyngitis &
shigellosis, gonorrhea & syphilis.
A. CHEMISTRY: C16H17N3O4S, H2O
B. MODE OF ACTION: Ceftriaxone binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibit the final transpeptidation step of peptidoglycan synthesis in
C. ADVERSE DRUG REACTION: Nausea, vomiting, diarrhea, abdominal discomfort & skin rash.

Ceftriaxone Na Carvezone Treatment of susceptible infections including chancroid,
C. ADVERSE DRUG REACTION: Diarrhea, occasional nausea/vomiting, glossitis or stomatitis; hypersensitivity reactions eg rash, pruritus, urticaria & edema; transient pain at
inj site & local phlebitis.

Cefaclor monohydrate Ceclobid Resp tract infections, otitis media, UTI, skin & soft tissue
infection & gonococcal urethritis.
B. MODE OF ACTION: Cefaclor binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in
bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. It has bactericidal activity against gm-ve bacteria including E.
coli, S. pneumoniae, N. gonorrhoea, P. mirabilis and H. influenzae.
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever, serum sickness-like anaphylactic reactions, hemolytic anemia & acute interstitial nephritis.
Overgrowth of nonsusceptible organism.

Cefaclor Ceclor/ Ceclor-DS Resp tract infection including pneumonia,
pharyngitis/tonsillitis & sinusitis. Skin & skin structure
infections; UTI including pyelonephritis & cystitis. Otitis
media, gonococcal urethritis.
C. ADVERSE DRUG REACTION: Serum sickness-like reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis. Diarrhea symptoms of pseudomembranous colitis,
eosinophilia, genital pruritus or vaginitis, moniliasis, angioedema. Slight elevations of SGOT, SGPT or alkaline phosphatase & BUN. Transient lymphocytosis & leukopenia.

Ceftibuten Cedax Treatment of infections caused by susceptible
microorganisms: Upper resp tract infections in adults &
childn (pharyngitis, tonsillitis & scarlet fever), & lower
resp tract infections in adults (acute bronchitis, acute
exacerbations of chronic bronchitis & acute pneumonia in
patients appropriately considered for oral therapy), UTI in
adults & childn (complicated & uncomplicated infections),
enteritis & gastroenteritis in childn caused by Salmonella,
Shigella or E. coli.
B. MODE OF ACTION: Ceftibuten inhibits bacterial cell wall synthesis. It is stable to hydrolysis by many β-lactamases and has greater activity than 1st or 2nd generation
cephalosporins against gm-ve bacteria. It is less active in vitro than cefexime against S. pneumoniae.
C. ADVERSE DRUG REACTION:
D. Nausea, diarrhea, headache. Rarely, dyspepsia, gastritis, vomiting, abdominal pain, dizziness & serum sickness-like disorders.

Cefpodoxime proxetil Cefadox Treatment of susceptible infection of the upper & lower
resp tract, skin & soft tissues. Uncomplicated UTI &
uncomplicated gonorrhea.
B. MODE OF ACTION Cefpodoxime Proxetil is a third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefpodoxime's effect is
chains. As a result, cefpodoxime inhibits bacterial septum and cell wall synthesis formation.
C. ADVERSE DRUG REACTION: Chest pain, hypotension. Fungal skin infection, skin scaling/peeling. Menstrual irregularity. Pruritus. Diarrhea, flatulence, decreased
salivation, candidiasis & pseudomembranous colitis. Anaphylactic shock. Decreased appetite. Dizziness, fatigue, anxiety, insomnia, flushing, nightmares & weakness.
Cough & epistaxis. Taste alteration, eye itching & tinnitus. Malaise, fever.

Cefadroxil monohydrate Cefadrox-500 Treatment of susceptible infections including those of the
resp & urinary tract, & of the skin.
A. CHEMISTRY: C16H17N3O5S·H2O
B. MODE OF ACTION: Cefadroxil binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in
bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Cefadroxil is not active against Proteus, Pseudomonas,
Enterobacter, Morganella, Serratia and Listeria monocytogenes.
C. ADVERSE DRUG REACTION: GI disturbance, hypersensitivity reaction including skin rashes, urticaria, eosinophilia, fever, serum sickness-like reaction, anaphylaxis.

Cefuroxime axetil Cefakind-500 Treatment of susceptible infections including bone &
joint, skin & soft tissue infections, UTI; bronchitis (& other
lower resp tract infections), gonorrhea, meningitis, otitis
media, peritonitis, pharyngitis, sinusitis. Surgical infection
prophylaxis.
C. ADVERSE DRUG REACTION: Nausea, vomiting, diarrhea; headache, dizziness; rashes, pruritus, urticaria; Jarisch-Herxheimer reaction (in patient w/ Lyme disease);
elevation of liver enzyme during therapy.

Cefalexin monohydrate Cefalin suspension drops Infections of the resp tract, GUT, ear & bone, skin & soft
tissues including penicillinase-producing S. aureus
infections. Dental infections.
C. ADVERSE DRUG REACTION: GI disturbances; diarrhea, hypersensitivity reactions.

Cefazolin Na Cefavex Treatment of infections eg resp tract, GIT, GUT, skin,
soft tissue & post-op infections.
B. MODE OF ACTION: Cefazolin Sodium is the sodium salt of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds
to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of
peptidoglycan chains necessary for bacterial cell wall strength and rigidity, which results in the weakening of the bacterial cell wall and cell lysis.
C. ADVERSE DRUG REACTION: Allergic reactions including skin rashes, urticaria & anaphylaxis; neutropenia & leucopenia; transient rise in SGOT, SGPT, alkaline
phosphates & BUN.

Cefazolin Na Cefazole Treatment of variety of infections due to susceptible
organisms including biliary-tract infections, endocarditis
& peritonitis. Surgical infection prophylaxis including
endometritis at caesarean section.
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever, serum-sickness like reactions, anaphylaxis.

Cefepime Cefevex Treatment of infections due to susceptible organisms that
include UTI, resp tract & skin infections.
B. MODE OF ACTION: Cefepime is a semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefepime binds to and inactivates penicillin-
binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall
and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall
strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions including skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions & anaphylaxis. Bleeding
complications related to hypoprothrombinemia &/or platelet dysfunction. Nephrotoxicity; transient increases in liver enzyme values. Inj site pain (IM) or thrombophlebitis (IV
infusion).

Cefaclor monohydrate Cefmed Susp: Treatment of susceptible infections including upper
& lower resp tract & skin infections; UTI. Drops:
Infections due to sensitive gm +ve & gm -ve bacteria.
C. ADVERSE DRUG REACTION: GI disturbances, hypersensitivity reactions; serum sickness-like reactions; skin reactions, arthralgia; pseudomembranous colitis.

Cefotaxime Na Cefolan Treatment of severe infections (eg sepsis, meningitis)
due to susceptible bacteria.
B. MODE OF ACTION: Cefotaxime is a third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding
to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component
of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis.
C. ADVERSE DRUG REACTION: Pseudomembranous colitis associated w/ Clostridium difficile infection.

Cefuroxime Na Cefopti Treatment of susceptible infections including bone & joint
infections, bronchitis (& other lower resp tract infections),
pharyngitis, sinusitis, skin infections (including soft
tissue) & UTI. Surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions including skin rashes, urticaria, eosinophilia, fever, reactions resembling serum sickness & anaphylaxis.

Cefotaxime Na Cefotax Treatment of severe infections (eg sepsis, meningitis)
due to susceptible bacteria.
C. ADVERSE DRUG REACTION: Pseudomembranous colitis associated w/ Clostridium difficile infection.

Cefpirome sulfate Cefrin For urinary tract, lower respiratory tract and skin
infections, bacteremia and infections associated with
neutropenia.
B. MODE OF ACTION: Cefpirome binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in
C. ADVERSE DRUG REACTION: Rash, urticaria, drug fever, severe acute allergic reaction. Nausea & vomiting, diarrhea. Slight increase in serum creatinine & urea. Increase
in liver enzymes in the serum, γ-GT, LDH &/or bilirubin. Thrombocytopenia, eosinophilia. Inflammatory irritation of the venous wall & pain at the site of inj. Reversible
encephalopathy w/ high-dose treatment. Superinfection, taste &/or smell disturbances shortly after inj, headache, fever.

Cefixime Cefsea 25 Treatment of susceptible infections, including gonorrhea,
otitis media, pharyngitis, lower resp tract infections eg
bronchitis & UTI.
B. MODE OF ACTION: Cefixime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in
C. ADVERSE DRUG REACTION: Anaphylactic/anaphylactoid reactions (including shock & fatalities), skin rashes, urticaria, fever, angioedema & facial edema, erythema
multiforme, Stevens-Johnson syndrome & serum sickness-like reactions; diarrhea, loose stools, abdominal pain, dyspepsia, nausea & vomiting; transient elevation of ALT,
AST, alkaline phosphatase, BUN or creatinine levels, hepatitis, jaundice; headache, dizziness, seizures; transient thrombocytopenia, leukopenia, neutropenia, eosinophilia.
Cefuroxime axetil Ceft Treatment of susceptible infections including bone & joint
infections, bronchitis, gonorrhea, meningitis, otitis media,
peritonitis, pharyngitis, sinusitis, skin infections & UTI.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions including skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions, anaphylaxis; GI disturbances
including diarrhea, nausea, vomiting. Mild to moderate hearing loss in childn (for meningitis treatment).

Ceftazidime pentahydrate Ceftibac Treatment of susceptible aerobic gm -ve organism; also
used in empiric therapy of febrile granulocytopenic
patient's usually in combination w/ antipseudomonal
aminoglycosides.
B. MODE OF ACTION: Ceftazidime is a semisynthetic, broad-spectrum, beta-lactam antibiotic for parenteral administration. Ceftazidime is bactericidal in action exerting its
effect by inhibition of enzymes responsible for cell-wall synthesis, primarily penicillin binding protein 3 (PBP3). A wide range of gram-negative organisms is susceptible to
ceftazidime in vitro, including strains resistant to gentamicin and other aminoglycosides. In addition, ceftazidime has been shown to be active against gram-positive
organisms. It is highly stable to most clinically important beta-lactamases, plasmid or chromosomal, which are produced by both gram-negative and gram-positive
organisms and, consequently, is active against many strains resistant to ampicillin and other cephalosporins. Ceftazidime has activity against the gram-negative organisms
Pseudomonas and Enterobacteriaceae. Its activity against Pseudomonas is a distinguishing feature of ceftazidime among the cephalosporins.
C. ADVERSE DRUG REACTION: Allergic reaction including anaphylaxis; burning, discomfort, pain at inj site; diarrhea; elevated alkaline phosphate, SGOT, SGPT & BUN;
nausea & vomiting; +ve direct Coombs' test; pseudomembranous colitis; seizures (in large doses).

Ceftriaxone Ceftibet Treatment of susceptible infections including chancroid,
endocarditis, gastoenteritis (invasive salmonellosis,
pneumonia, septicemia, syphilis, typhoid fever &
B. MODE OF ACTION: Ceftriaxone is a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding
proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the
cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results
in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-
negative bacteria and less active against gram-positive bacteria. Ceftriaxone also crosses the blood-brain barrier and reaches therapeutic concentrations in the central
nervous system (CNS).

Ceftazidime pentahydrate Ceftime Treatment of susceptible infections eg biliary tract, bone
& joint & upper resp tract infections (cystic fibrosis),
endophthalmitis, infections in immunocompromised
patients (neutropenia), melioidosis, meningitis,
peritonitis, pneumonia, septicemia, skin infections
(including burns, ecthyma gangrenosum & ulceration),
surgical infections (prophylaxis) & UTI.
C. ADVERSE DRUG REACTION: Phlebitis & inflammation at inj site. Pruritus, rash, fever, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme.
Diarrhea, nausea, vomiting, abdominal pain.

Cefoxitin Na Ceftin Treatment & prophylaxis of anaerobic & mixed bacterial
infections especially intra-abdominal & pelvic infections.
Treatment of gonorrhea & UTI.
B. MODE OF ACTION: Cefoxitin Sodium is the sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefoxitin
sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of
assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary
for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
C. ADVERSE DRUG REACTION: Diarrhea including pseudomembranous colitis; eosinophilia, leukopenia, neutropenia, hemolytic anemia, thrombocytopenia, bone marrow
depression; transient AST, ALT, serum LDH & alkaline phosphatase elevations, jaundice; hypotension; serum creatinine &/or BUN elevations; worsening myasthenia gravis
(single case); thrombophlebitis (IV administration), rash (including exfoliative dermatitis, TEN), urticaria, pruritus, eosinophilia, fever.

Ceftriaxone Na Ceftiflor Treatment of susceptible infections eg chancroid,
shigellosis), gonorrhea, Lyme disease, meningitis,
septicemia, syphilis, typhoid fever & Whipple's disease;
surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions & anaphylaxis.

Cefixime Ceftrimed Treatment of infections due to sensitive gm +ve & gm -ve
bacteria (acute infections only).
C. ADVERSE DRUG REACTION: Shock: Discomfort, paresthesias of the mouth, wheezing, vertigo, desire to defecate, tinnitus, sweating.

Ceftriaxone Na Ceftrina Treatment of susceptible infections including chancroid,
endocarditis, gastroenteritis (invasive salmonellosis;
shigellosis), gonorrhoea, Lyme disease, meningitis
pneumonia, septicaemia, syphilis, typhoid fever &
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions & anaphylaxis.

Ceftriaxone Na Ceftrox Treatment of susceptible infections eg chancroid,
Whipple's disease & for surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Thrombocytopenia, eosinophilia, leukopenia, GI effects.

Cefuroxime Na Cefucil Treatment of susceptible infections including bone & joint
pharyngitis, sinusitis, skin infections (including soft
tissue) & UTI. Surgical infection prophylaxis

Cefuroxime Cefuget Tab: Treatment of infections caused by susceptible
organisms. Inj: Infections due to sensitive gm +ve & gm
-ve bacteria; more active against H. influenzae &
Neisseria gonorrhea; Lyme disease; surgical prophylaxis.
B. MODE OF ACTION: Cefuroxime is a semisynthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin with antibacterial activity. Cefuroxime
binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of
assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains
necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
C. ADVERSE DRUG REACTION: GI disturbances including diarrhea, nausea, vomiting; headache; eosinophilia, transient increase in SGPT, SGOT & lactate dehydrogenase
enzyme levels. Inj: Hypersensitivity reactions.

Cefuroxime Cefumax Tab Infections due to sensitive gm +ve & gm -ve bacteria
& has greater activity against H. influenzae & Neisseria
gonorrhoeae. Powd for inj Alternative drug for infections
due to susceptible organisms eg in otitis media, orbital
cellulitis; urinary tract, skin & soft tissue, bone & joint
infections & post-splenectomy sepsis of unclear etiology.
C. ADVERSE DRUG REACTION: Tab Anaphylaxis, angioedema, pruritus, rash, serum sickness-like reaction, urticaria, pseudomembranous colitis; hemolytic anemia,
leukopenia, pancytopenia, thrombocytopenia, increased prothrombin time, hepatic impairment including hepatitis & cholestasis, jaundice, seizure, erythema multiforme,
Stevens-Johnson syndrome, toxic epidermal necrolysis, renal dysfunction; diarrhea/loose, nausea/vomiting, transient elevation in AST, ALT & lactate dehydrogenase,
eosinophilia, abdominal pain & cramps, flatulence, indigestion, headache, vaginitis, vulvar itch, hives, itch, dysuria, chills, chest pain, shortness of breath, mouth ulcers,
swollen tongue, sleepiness, thirst, anorexia, +ve Coombs' test & mild to moderate hearing loss. Powd for inj Glossitis, nausea, vomiting, gastric pyrosis, abdominal pain &
diarrhea.

Cefuroxime axetil Cefurax Treatment of susceptible infection eg bone & joint
infections, bronchitis, gonorrhea, meningitis (although
treatment failures have been reported in H. influenzae
meningitis), otitis media, peritonitis, pharyngitis, sinusitis,
skin infections (including soft tissue infections), UTI.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions including skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions, anaphylaxis; GI disturbances
including diarrhea, nausea, vomiting. Mild to moderate hearing loss in childn (for meningitis treatment).

Cefuroxime Na Cefurax injection Treatment of infections caused by susceptible strains of
gm +ve and gm -ve microorganisms including resp tract
infections, acute & chronic bronchitis, bacterial
pneumonia, paranasal sinusitis, tonsillitis, acute &
chronic pyelonephritis, cystitis, peritonitis, wound
infection, gonorrhea, sepsis, meningitis & pelvic
inflammatory disease.
C. ADVERSE DRUG REACTION: Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis; itching, eruption, pyrexia, swelling of lymph node, arthrodynia
or anaphylactic reaction; nephrotoxicity; symptoms of pseudomembranous colitis accompanied by bloody stool, nausea, diarrhea; resp disorders.

Cefuroxime Na Cefuremed Treatment of susceptible infections including bone & joint
infections, bronchitis & other lower resp tract infections,
gonorrhea, meningitis), otitis media, peritonitis,
pharyngitis, sinusitis, skin disorders, surgical infection &
UTI.
C. ADVERSE DRUG REACTION:GI disturbances including diarrhea, nausea & vomiting.

Cefuroxime axetil Cefurex/ Cefurex 125 Treatment of infections due to sensitive gm +ve & gm -ve
bacteria. Infections caused by susceptible organisms eg
bone & joint infections, bronchitis, gonorrhea, meningitis,
otitis media, peritonitis, pharyngitis, sinusitis, skin & skin
structure infections, UTI; surgical infection prophylaxis,
Lyme disease.
C. ADVERSE DRUG REACTION: Diarrhea; decreased Hb/hematocrit, eosinophilia, nausea/vomiting, vaginitis, transient rise in hepatic transaminases, thrombophlebitis.

Cefuroxime axetil Cefurox Treatment of infections due to sensitive gm +ve & gm -ve
bacteria. Infections caused by susceptible organisms eg
bone & joint infections, bronchitis, gonorrhea, meningitis,
otitis media, peritonitis, pharyngitis, sinusitis, skin & skin
structure infections, UTI; surgical infection prophylaxis,
Lyme disease.
C. ADVERSE DRUG REACTION: Diarrhea; decreased Hb/hematocrit, eosinophilia, nausea/vomiting, vaginitis, transient rise in hepatic transaminases, thrombophlebitis.

Cefuroxime Na Cefuvex Treatment of susceptible infections including bone & joint
gonorrhea, meningitis), otitis media, peritonitis,
pharyngitis, sinusitis, skin disorders, surgical infection &
UTI.
C. ADVERSE DRUG REACTION: Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis; itching, eruption, pyrexia, swelling of lymph node, arthrodynia
or anaphylactic reaction; nephrotoxicity; symptoms of pseudomembranous colitis accompanied by bloody stool, nausea, diarrhea; resp disorders.

Cefuroxime axetil Cefuxime 500 Treatment of susceptible infections including bone & joint
infections) & UTI. Surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Anaphylaxis, angioedema, pruritus, rash, serum sickness-like reaction, urticaria; pseudomembranous colitis; hepatic impairment including
hepatitis & cholestatic jaundice; seizure; erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis; renal dysfunction.

Cefuroxime axetil Cefwin- 500 Treatment of septicemia, pneumonia, meningitis, biliary
tract infections, peritonitis & UTI.
C. ADVERSE DRUG REACTION: GI disturbances including diarrhea, nausea & vomiting.

Cefuroxime Cefzime Tab: Treatment of susceptible infections including bone
& joint infections, bronchitis & other lower resp tract
infections, gonorrhea, meningitis, otitis media, peritonitis,
pharyngitis, sinusitis, skin & soft tissue infections & UTI.
Prophylaxis of surgical infection. Inj: Treatment of
infections due to sensitive gm +ve & gm -ve bacteria.
More active against H. influenzae & Neisseria gonorrhea;
Lyme disease; surgical prophylaxis.
C. ADVERSE DRUG REACTION: Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis. Tab: GI disturbances (eg diarrhea, nausea & vomiting). Inj:
Rash & eosinophilia; anaphylaxis, urticaria, pruritus & drug fever. Thrombophlebitis, stiffness & inflammatory reactions at inj site. Increased ESR & decreased Hb,
eosinophilia, leukopenia, neutropenia; +ve direct Coombs' test. Increased BUN, serum creatinine, bilirubin, transaminases & alkaline phosphatase. Drowsiness, loose
stools, faint feeling, sweating, palpitations & Candida intertrigo.
Cefixime trihydrate Cefzin Treatment of susceptible infections including gonorrhea,
bronchitis & UTI.
C. ADVERSE DRUG REACTION: Diarrhea, changes in the color of stool, nausea, abdominal pain, dyspepsia, vomiting, flatulence; hypersensitivity reactions, headache,
dizziness; infrequent & reversible hematological changes, elevation of serum amylase.

Cefepime HCl Cepiram Treatment of infections due to susceptible organisms
including UTI, skin & resp tract infections eg severe
nosocomial pneumonia infections caused by multi-
resistant microorganisms.
A. CHEMISTRY: C19H28Cl2N6O6S2
B. MODE OF ACTION: Cefepime Hydrochloride is the hydrochloride salt of a semi-synthetic, beta-lactamase-resistant, fourth-generation cephalosporin antibiotic derived from
an Acremonium fungal species with broad-spectrum bactericidal activity. Administered parenterally, cefepime inhibits bacterial cell wall synthesis by binding to and
inactivating penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan
chains necessary for bacterial cell wall strength and rigidity, resulting in a reduction of bacterial cell wall stability and cell lysis. This agent is more active against a variety of
Gram-positive pathogens compared to third-generation cephalosporins.
C. ADVERSE DRUG REACTION: Local reactions including phlebitis, pain &/or inflammation, rash. Anaphylaxis including anaphylactic shock, transient leukopenia,
neutropenia, agranulocytosis & thrombocytopenia.

Cefalexin Ceporex Treatment of UTI & resp tract infections; ENT, skin, soft
tissue, otitis media & other infections due to sensitive
organisms.
B. MODE OF ACTION: Cephalexin Anhydrous is the anhydrous form of cephalexin, a semisynthetic first-generation cephalosporin with antibacterial activity. Cephalexin binds
to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of
C. ADVERSE DRUG REACTION: Diarrhea; GI disturbances eg nausea, vomiting, abdominal discomfort; allergic reactions eg rash, urtcaria, angioedema; genital & anal
pruritus, genital candidiasis, vaginitis, vag discharge, dizziness, fatigue, headache, agitation, confusion, hallucinations, arthralgia, arthritis; joint disorders; eosinophilia,
neutropenia, thrombocytopenia, slight elevations in AST/ALT.; vulvovaginitis.
Ceftazidime pentahydrate Cestazid-1000 Treatment of susceptible infections due to Pseudomonas
spp including biliary tract infections, bone & joint
infections, cystic fibrosis (resp tract infections),
peritonitis, pneumonia, upper resp tract infections,
septicemia, skin infections (including burns, ecthyma
gangrenosum & ulceration), surgical infection prophylaxis
& UTI.
B. MODE OF ACTION: Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative
infections in debilitated patients.
C. ADVERSE DRUG REACTION: GI disorders, pseudomembranous colitis, candidosis, eosinophilia, neutropenia, leukopenia, thrombocytopenia, increased liver enzymes &
blood urea, pain at inj site.

Ceftazidime pentahydrate Cimex Treatment of susceptible infections due to Pseudomonas
spp including biliary tract infections, bone & joint
infections, cystic fibrosis (resp tract infections),
peritonitis, pneumonia, upper resp tract infections,
septicemia, skin infections (including burns, ecthyma
gangrenosum & ulceration), surgical infection prophylaxis
& UTI.
C. ADVERSE DRUG REACTION: GI disorders, pseudomembranous colitis, candidosis, eosinophilia, neutropenia, leukopenia, thrombocytopenia, increased liver enzymes &
blood urea, pain at inj site.

Cefazolin Na Cizo Treatment of resp, biliary & GUT infections, septicemia,
ENT, bone & joint infections, endocarditis, skin & soft
tissue infections. Pre-op prophylaxis.
C. ADVERSE DRUG REACTION: Pseudomembranous colitis, nausea, anorexia, vomiting, diarrhea & oral candidiasis. Convulsions (high doses). Hypersensitivity reactions.
Transient rise in BUN levels. Hematological effects. Pain on IM inj, phlebitis at the site of IV inj. Genital & anal pruritus, genital candidiasis & vaginitis.
Cefotaxime Na Cladex Infections due to susceptible organisms, especially
serious & life-threatening infections.
B. MODE OF ACTION: Cefotaxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in
C. ADVERSE DRUG REACTION: Anorexia, diarrhea, nausea, vomiting, abdominal cramps & colitis; transient neutropenia, granulocytopenia, leukopenia, eosinophilia,
thrombocytopenia & agranulocytopenia; rash (maculopapular or erythematous), pruritus, fever; phlebitis & thrombophlebitis; headache, agitation, confusion, fatigue &
sweating at night may also occur.

Cefotaxime Na Claforan Infections due to sensitive gm -ve & gm +ve bacteria;
gonorrhea; surgical prophylaxis, Haemophilus epiglottitis
& meningitis.
C. ADVERSE DRUG REACTION: GI symptoms eg nausea, vomiting, diarrhea including pseudomembranous colitis. Increased serum liver enzymes & bilirubin. Transient
increase in serum creatinine & urea, interstitial nephritis. Hemolytic anemia, leukopenia, agranulocytosis, thrombocytopenia, eosinophilia. Local irritation & pain at inj site.
Allergic skin reactions eg urticaria, exanthema, itching, bullous eruptions (eg erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis).
Encephalopathy w/ impairment of consciousness, abnormal movements, convulsions (high doses esp in patient w/ renal insufficiency). Proliferation of resistant
microorganisms. Treatment of spirochaetal infections: Herxheimer's reaction. Treatment of borreliosis: Skin rash, itching, fever, leukopenia, increase in liver enzymes,
difficulty in breathing, joint discomfort.

Cefotaxime Na Clinbaxef Lower resp tract & GUT & gynecological infections.
Bacteremia, septicemia. Skin & skin structure, intra-
abdominal, bone & joint & CNS infections.
bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.:
C. ADVERSE DRUG REACTION: Pain at the site of IM inj & thrombophlebitis following IV infusion.

Cefuroxime Na Clovixime Acute & chronic bronchitis, infected bronchiectasis,
bacterial pneumonia, lung abscess & post-op chest
infections, sinusitis, tonsillitis, pharyngitis & otitis media,
acute & chronic pyelonephritis, cystitis & symptomatic
bacteriuria, cellulitis, erysipelas & wound infections,
osteomyelitis & septic arthritis, O & G infections, pelvic
inflammatory diseases, gonorrhea, septicemia,
meningitis & peritonitis, prophylaxis against infection in
abdominal, pelvic, orthopedic, cardiac, pulmonary,
esophageal & vascular surgery.
C. ADVERSE DRUG REACTION: Rarely, skin rash, urticaria, pruritus, interstitial nephritis, drug fever, erythema multiforme, Stevens-Johnson syndrome & toxic epidermal
necrolysis.

Cefazolin Na Cloviz Treatment of a variety of infections due to susceptible
organisms including biliary tract infections, Staph
endocarditis, endometritis (surgical infection prophylaxis
at caesarian section), peritonitis associated w/
continuous ambulatory peritoneal dialysis & surgical
infection prophylaxis.
C. ADVERSE DRUG REACTION: Shock & related signs & symptoms; hypersensitivity, hematologic, hepatic & renal effects. Pseudomembranous colitis; convulsions in
patients w/ renal failure when given very large doses. Alteration of bacterial flora w/ stomatitis or candidiasis. Vit K & vit B deficiency.

Ceftriaxone Na Cryaxon Infections of the lower resp tract, skin & skin structure,
urinary tract, intra-abdominal, bone & joint.
Uncomplicated gonorrhea, pelvic inflammatory disease,
bacterial septicemia, meningitis. Surgical prophylaxis.
B. MODE OF ACTION: Ceftriaxone is a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding
in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-
negative bacteria and less active against gram-positive bacteria. Ceftriaxone also crosses the blood-brain barrier and reaches therapeutic concentrations in the central
C. ADVERSE DRUG REACTION: Diarrhea, nausea, vomiting, stomatitis & glossitis. Hematological changes. Skin reactions eg exanthema, allergic dermatitis, pruritus,
urticaria, edema, erythema multiforme.
Cefixime trihydrate Dancef-DS Treatment of susceptible infections including gonorrhea,
bronchitis & UTI.
C. ADVERSE DRUG REACTION: Diarrhea, changes in the color of stool, nausea, abdominal pain, dyspepsia, vomiting, flatulence; hypersensitivity reactions, headache,
dizziness; infrequent & reversible hematological changes, elevation of serum amylase.

Ceftazidime pentahydrate Dimzef Treatment of susceptible infections esp due to
Pseudomonas eg biliary tract, bone & joint infections,
meningitis, peritonitis, pneumonia, upper resp tract, skin
infections & UTI.
C. ADVERSE DRUG REACTION: Shock, rash, anaphylaxis, Lyell's syndrome, headache, dizziness, paresthesia, bad taste, hematologic effects, jaundice, GI disorders,
interstitial pneumonia, dyspnea, stomatitis, candidiasis, vit K deficiency & neurological sequelae.

Cefuroxime Na Dincef Treatment of resp tract, ENT, urinary tract, soft tissue,
bone & joint, O & G infections; gonorrhea, septicemia &
meningitis; surgical infections prophylaxis.
C. ADVERSE DRUG REACTION: Skin rashes (maculopapular & urticaria), interstitial nephritis, drug fever. Decreased Hb conc, eosinophilia, leukopenia & neutropenia; +ve
Coombs' test. Transient increases in liver enzymes & serum bilirubin.

Cefuroxime Dinfurox Susp: Alternative drug for infections due to susceptible
organisms eg otitis media, orbital cellulitis, UTI, skin &
soft tissue, bone & joint infections & post-splenectomy
sepsis of unclear etiology. Inj: Infections due to sensitive
gm +ve & gm -ve bacteria; surgical prophylaxis;
Haemophilus influenzae & Neisseria gonorrhoeae. Lyme
disease.
C. ADVERSE DRUG REACTION: Inj: Pruritus, urticaria; diarrhea & nausea; increased erythrocyte sedimentation rate, decreased Hb, eosinophilia, leukopenia, neutropenia &
thrombocytopenia; +ve Coombs' test; thrombophlebitis, stiffness & inflammation at inj site. Transient increases in serum bilirubin, transaminases & alkaline phosphatase.
Drowsiness, loose stools, faint feeling, sweating, palpitations & Candida intertrigo.

Cefixime trihydrate Dinofix Treatment of susceptible infections including gonorrhea,
bronchitis & UTI.
B. MODE OF ACTION: CEFIXIME is a third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.
C. ADVERSE DRUG REACTION: GI disturbances esp diarrhea.

Cefuroxime Dinoxime Tab: Alternative drug for infections due to susceptible
soft tissue, bone & joint infections & post-splenectomy
sepsis of unclear etiology. Inj: Treatment of GI, urinary &
genitourinary tract infections caused by susceptible gm
+ve & gm -ve organisms.
C. ADVERSE DRUG REACTION: Anaphylaxis, angioedema, pruritus, serum sickness-like reaction & urticaria; pseudomembranous colitis; hemolytic anemia, leukopenia,
pancytopenia, thrombocytopenia & increased prothrombin time; hepatic impairment including hepatitis & cholestatic jaundice; seizure; erythema multiforme, Stevens-
Johnson syndrome & toxic epidermal necrolysis; renal dysfunction.

Cefadroxil monohydrate Drozid Resp tract infections: Tonsilitis, pharyngitis, pneumonia,
bronchitis, bronchiectasis, lung abscesses, emphysema,
pleuritis, sinusitis, laryngitis, otitis media. UTI:
Pyelonephritis, cystitis, adnexitis, endometritis. Skin &
soft tissue infections: Lymphangitis, abscesses, cellulitis,
decubitus ulcers, mastitis, furunculosis, erysipelas.
B. MODE OF ACTION: Cefadroxil binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in
bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Cefadroxil is not active against Proteus, Pseudomonas,
Enterobacter, Morganella, Serratia and Listeria monocytogenes.
C. ADVERSE DRUG REACTION: Nausea, vomiting & diarrhea. Rash, urticaria & angioedema. Pyrosis, anorexia, dyspepsia, abdominal pain, headache, dizziness, moniliasis,
vaginitis & pseudomembranous colitis.

Cefuroxime Na Ecocef Infections due to sensitive gm +ve & gm -ve bacteria.
Surgical prophylaxis. Lyme disease.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions, GI disturbances.

Cefuroxime axetil Educef Infections due to sensitive gm +ve & gm -ve bacteria;
surgical infection prophylaxis; more active against H.
influenzae & Neisseria gonorrhea; Lyme disease.
C. ADVERSE DRUG REACTION: Diarrhea, abdominal pain/cramps, flatulence, indigestion, headache, vaginitis, vulvar itch, rash, hives, itch, dysuria, chills, chest pain,
shortness of breath, mouth ulcers, swollen tongue, sleepiness, thirst, anorexia.

Cefuroxime axetil Efrox Treatment of bone & joint, bronchitis & other lower resp
tract, skin & soft tissue infections; UTI, gonorrhea,
C. ADVERSE DRUG REACTION: GI disturbances including diarrhea, nausea & vomiting, erythema multiforme, Stevens-Johnson syndrome & toxic epidermal necrolysis.
Cefalexin monohydrate Eliphorin Mild to moderate infections of the resp & urinary tract,
bones, skin & skin structures caused by susceptible
organisms.
C. ADVERSE DRUG REACTION: Nausea, vomiting, diarrhea, abdominal discomfort; allergic reactions; superinfection.

Cefuroxime Na Elixime Injection Treatment of susceptible infections including bone & joint
pharyngitis, sinusitis, skin & soft tissue infections & UTI.
Prophylaxis of surgical infections.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions. Occasionally SGOT, SGPT & alkaline phosphatase elevations; nausea & diarrhea.

Cefuroxime axetil Elixime tablet Treatment of susceptible infections including bone & joint
Prophylaxis of surgical infections.
C. ADVERSE DRUG REACTION: Diarrhea, nausea & vomiting.

Ceftriaxone Na Eluxone Treatment of susceptible infections including chancroid,
meningitis, pneumonia, septicemia, syphilis, typhoid
fever & Whipple's disease; surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Occasionally, nausea, vomiting, loose stools, diarrhea; granulocytopenia, eosinophilia, thrombocytopenia, leukopenia; headache, dizziness.
Edema, premature ventricular contraction, increased blood creatinine, genitalia mycosis, sweating, flushing, palpitation, epistaxis.

Cefaclor monohydrate Ephron Treatment of upper & lower resp tract, skin infections &
UTI.
B. MODE OF ACTION: Cefaclor is a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefaclor binds to and inactivates penicillin-binding
proteins (PBP) located in bacterial cytoplasmic membranes. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the
cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This
results in the weakening of the bacterial cell wall and causes cell lysis.
C. ADVERSE DRUG REACTION: Allergic reactions, GI side effects, thrombocytopenia, eosinophilia, pseudomembranous colitis.

Cefuroxime Na Eroxmit Treatment of susceptible infections eg bone & joint,
bronchitis & other lower resp tract infections, gonorrhea,
meningitis, otitis media, peritonitis, pharyngitis, sinusitis,
skin & soft tissue infections, UTI. Surgical infection
prophylaxis.
C. ADVERSE DRUG REACTION: Pseudomembranous colitis, allergic reactions, hypoprothrombinemia, oral candidiasis, seizures, GI & serum sickness-like reactions,
vaginitis, thrombophlebitis.

Cefuroxime axetil Eroxmit 500 Treatment of upper & lower resp tract, nose & throat,
GUT, skin & soft tissue infections; gonorrhea, acute
gonococcal urethritis & cervicitis; early Lyme disease;
subsequent prevention of late Lyme disease in adults &
childn.
C. ADVERSE DRUG REACTION: Candida overgrowth; eosinophilia; transient increase in hepatic enzyme levels (ALT, AST, LDH).
Cefuroxime Eurimax Treatment of susceptible infections including UTI, bone &
joint, skin & soft tissue & lower resp tract infections eg
bronchitis; gonorrhea, meningitis, otitis media, peritonitis,
pharyngitis, sinusitis. Surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: GI disturbances eg diarrhea, nausea & vomiting. Inj: Thrombophlebitis, hypersensitivity reaction eg rash.

Cefixime Evofix Treatment of infections due to sensitive gm +ve & gm -ve
bacteria.
C. ADVERSE DRUG REACTION: Anaphylactic reaction including shock, internal swelling of the larynx w/ airway constriction; fever, Stevens-Johnson syndrome; rash,
erythema, pruritus, leukopenia, eosinophilia, thrombocytopenia; increases in GOT, GPT & alkaline phosphatase; serious colitis (eg pseudomembranous colitis), diarrhea,
abdominal pain, vomiting, nausea; transient elevation in BUN or creatinine; headache, dizziness.

Cefixime trihydrate Ezcef-100/ Ezcef-200/ Ezcef Treatment of acute infections including gonorrhea, otitis
media, pharyngitis, lower resp tract infections eg
bronchitis & UTI. Also for infections due to sensitive gm
+ve & -ve bacteria.
A. CHEMISTRY: C16H15N5O7S2·3H2O
C. ADVERSE DRUG REACTION: Diarrhea, stool changes, nausea & abdominal pain.

Cefalexin monohydrate Falex Treatment of infections of the resp tract, GI & urinary
tract, skin & soft tissues & bone caused by susceptible
gm+ve & gm-ve bacteria.
B. MODE OF ACTION: Cefalexin is a semisynthetic 1st generation cephalosporin antibiotic Inhibiting cell wall biosynthesis. It is used especially in the treatment of respiratory
and urinary tract infections and is intended for oral administration. Cephalosporins differ from penicillins in the structure of the bicyclic ring system. Cefalexin has an
unsubstituted methyl group at the 3-position and a D-phenylglycyl group as substituent at the 7-amino position. It's chemical name is 7-(D-alpha-Amino-alpha-phenyl
acetamido)- 3-methyl-3-cephem- 4-carboxylic acid. Commercial cefalexin is available in a monohydrate form which is a white crystalline powder with a bitter taste and low
solubility in water.
C. ADVERSE DRUG REACTION: Nausea, vomiting & diarrhea. Skin rashes, urticaria, eosinophilia, fever, reactions resembling serum sickness & anaphylaxis.
Pseudomembranous colitis.

Cefazolin Na Fazonil Treatment of a variety of infections due to susceptible
organisms including biliary tract infections, endocarditis
(staphylococcal), endometritis (prophylaxis at caesarian
section), peritonitis (associated by continuous
ambulatory peritoneal dialysis) & prophylaxis for surgical
infections.
C. ADVERSE DRUG REACTION: GI disturbances & hypersensitivity. Allergic reactions eg urticaria, pruritus, exfoliative dermatitis, morbiliform eruptions, rashes, drug fever,
chills, serum sickness & eosinophilia.

Ceftriaxone Na Fenadef Treatment of susceptible infections eg chancroid,
septicemia, surgical infection (prophylaxis), syphilis,
C. ADVERSE DRUG REACTION: Hypersensitivity reaction. GI effects eg pseudomembranous colitis. Vit K & vit B deficiency symptoms.

Cefuroxime axetil Fetnal Treatment of susceptible infections including bone & joint
pharyngitis, sinusitis, skin & soft tissue infections, UTI.
C. ADVERSE DRUG REACTION: GI disturbances including diarrhea, nausea & vomiting. Mild to moderate hearing loss in childn treated for meningitis.
Cefuroxime axetil Finax Treatment of susceptible infections eg bone & joint
C. ADVERSE DRUG REACTION: GI disturbances eg diarrhea, nausea & vomiting. Headache.

Cefepime Fipam Treatment of UTI, infections of the resp tract & skin due
to susceptible organisms.
B. MODE OF ACTION: Cefepime is a semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefepime binds to and inactivates penicillin-
binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall
and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall
strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
C. ADVERSE DRUG REACTION: GI symptoms & hypersensitivity reactions.

Cefixime trihydrate Fix-A Bronchitis, bronchiectasis w/ infection, secondary
infections of chronic resp tract disease, pneumonia;
pyelonephritis, cystitis, gonococcal urethritis;
cholecystitis, cholangitis; scarlet fever; otitis media &
sinusitis.
A. CHEMISTRY: C16H15N5O7S2 · 3H2O
C. ADVERSE DRUG REACTION: Diarrhea & stool changes. Nausea, abdominal pain, dyspepsia, vomiting, flatulence, headache & dizziness; rash, pruritus, urticaria, drug
fever & arthralgia.

Cefixime trihydrate Fixcef Acute infections caused by susceptible microorganisms
eg upper & lower resp tract infection, otitis media,
sinusitis, pharyngitis, tonsillitis, bronchitis, UTI, cystitis,
cystourethritis, uncomplicated pyelonephritis &
uncomplicated gonorrhea.
C. ADVERSE DRUG REACTION: Diarrhea & stool change; headache, dizziness; allergy; thrombocytopenia, leukopenia, eosinophilia.

Cefixime trihydrate Fixim Alternative treatment of UTI, otitis media, resp infections
caused by susceptible organisms including penicillin
susceptible S. pneumoniae, S. pyogenes, H. infuenzae &
Enterobacteriaceae w/ documented poor compliance or
response to conventional oral antibiotics, outpatient
therapy of serious soft tissue or skeletal infection due to
susceptible organisms; single dose oral treatment of
uncomplicated cervical/urethral gonorrhea.
C. ADVERSE DRUG REACTION: Diarrhea, nausea, vomiting, dyspepsia, abdominal pain, skin rash, urticaria, drug fever, pruritus, dizziness, headache.

Cefixime trihydrate Fixxx Treatment of susceptible infections including gonorrhea,
bronchitis & UTI.
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions, anaphylaxis. GI disturbances esp diarrhea.

Cefazolin Na Fonvicol Treatment of infections due to susceptible organisms
including UTI, skin & soft tissue, bone & joint, resp tract
infections.
B. MODE OF ACTION: Cefazolin Na is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains
high serum levels and is excreted quickly via the urine.
C. ADVERSE DRUG REACTION: Rash, allergic reactions, hematologic disorders, digestive disorders (eg nausea, vomiting, anorexia, diarrhea), local reactions at inj site.
Rarely, transient rise in SGOT, SGPT, alkaline phosphatase & BUN.

Cefalexin monohydrate Forexine Resp tract, ENT, GUT, skin & soft tissue infections
caused by susceptible microorganisms.
C. ADVERSE DRUG REACTION: Pseudomembranous colitis, allergic reactions, oral candidiasis, hypersensitivity reactions, GI reactions, vaginitis, thrombophlebitis.

Ceftriaxone Na Forgram Treatment of infections of the lower resp tract, acute
bacterial otitis media, skin & skin structure infection, UTI,
uncomplicated gonorrhea, pelvic inflammatory disease,
bacterial septicemia, bone & joint infections, intra-
abdominal infections, meningitis.
C. ADVERSE DRUG REACTION: Pain, induration, ecchymosis, tenderness at inj site; rash; eosinophilia, thrombocytosis, leukopenia; diarrhea; elevated AST, ALT & BUN.

Ceftazidime Fortum Treatment of single or multiple infections. Used as 1st
choice drug before the results of sensitivity tests are
available; in combination w/ an aminoglycoside or most
other β-lactamss; w/ an antibiotic against anaerobes
when the presence of Bacteroides fragilis is suspected.
Infections including resp tract, ENT, skin, soft tissue,
GIT, biliary, abdominal, bone & joints, UTI. Infection
associated w/ hemo- & peritoneal dialysis & other severe
infections as septicemia, bactercemia, peritonitis,
meningitis & infections in immunosuppressed & ICU
patients.
B. MODE OF ACTION: Ceftazidime is a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin-binding
in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftazidime is more active against gram-
negative bacteria and less active against gram-positive bacteria. Ceftazidine also crosses the blood-brain barrier and reaches therapeutic concentrations in the central
C. ADVERSE DRUG REACTION: Eosinophilia, thrombocytosis, phlebitis or thrombophlebitis (IV), diarrhea, transient elevations in ALT, AST, LDH, GGT & alkaline
phosphatase, maculopapular or urticarial rash, pain &/or inflammation after IM inj, +ve Coombs' test. Slight interference w/ copper reduction methods (Benedict's, Fehling's,
clinitest).

Cefoxitin Na Foxitin Treatment & prophylaxis of anaerobic & mixed bacterial
infection especially intra-abdominal & pelvic infections.
Indications include endometritis, pelvic inflammatory
disease & surgical infection (prophylaxis). Also used in
the treatment of gonorrhea & UTI.
C. ADVERSE DRUG REACTION: Local reactions following IV inj. Thrombophlebitis, rash, urticaria, flushing, pruritus, eosinophilia, fever, dyspnea, other allergic reactions
including anaphylaxis, interstitial nephritis & angioedema. Hypotension. Diarrhea. Leukopenia, eosinophilia. Transient elevations in SGOT, SGPT, serum LDH & serum
alkaline phosphatase. Elevation in serum creatinine &/or BUN. Jaundice.

Cefuroxime Na Fumerix-750
C. ADVERSE DRUG REACTION: Thrombophlebitis; diarrhea & nausea; hypersensitivity reactions including rash; decrease in Hb & hematocrit; transient increase in SGOT,
SGPT, alkaline phosphatase, lactate dehydrogenase & bilirubin levels; elevation in serum creatinine &/ or BUN, decrease CrCl.

Cefuroxime na Furocef Infections of the resp tract, ENT, soft tissues & bones. O
& G infections, wound infections, erysipelas & peritonitis.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions, GI disturbances, transient pain at IM inj site.

Cefuroxime Na Furocem Infections of the resp tract, ENT, soft tissues & bones. O
& G infections, wound infections, erysipelas & peritonitis.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions, GI disturbances, transient pain at IM inj site.
Cefuroxime Furoxy Treatment of infections of resp tract, ENT, UTI, soft
tissue, bone & joint, O & G, pelvic inflammatory
diseases. Gonorrhea. Other infections eg septicemia,
meningitis & peritonitis. Pre-op prophylaxis.
C. ADVERSE DRUG REACTION: Tab: Diarrhea or loose stools, nausea & vomiting, transient ALT, AST, LDH elevation, eosinophilia. Inj: Skin rashes, urticaria, pruritus, drug
fever & very rarely anaphylaxis.

Cefoxitin Na Geoxin Treatment & prophylaxis of anaerobic & mixed bacterial
A. CHEMISTRY: C16H16N3O7S2 • Na
B. MODE OF ACTION: Cefoxitin is a second generation cephalosporin antibiotic that has been used to treat a wide range of gram-negative and gram-positive bacteria
including anaerobes.1 It acts by interfering with bacterial cell wall synthesis and has also been shown to induce β-lactamase synthesis

Cefixime Gracefix Treatment of infections due to sensitive gm +ve & gm -ve
bacteria
C. ADVERSE DRUG REACTION: Hypersensitivity reactions including skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions & anaphylaxis. GI disturbances
especially diarrhea.

Cefuroxime Na Groxime Treatment of bone & joint, skin & soft tissue, bronchitis &
other lower resp tract infections; UTI, gonorrhea,
C. ADVERSE DRUG REACTION: GI disturbances including diarrhea, nausea & vomiting. Rarely erythema multiforme; Stevens-Johnson syndrome & toxic epidermal
necrolysis.

Ceftriaxone Na Groxone Treatment of susceptible infections including chancroid,
gastroenteritis (invasive salmonellosis, shigellosis),
gonorrhea, Lyme disease, meningitis (including
meningococcal meningitis prophylaxis), septicemia,
C. ADVERSE DRUG REACTION: Changes in bowel flora; diarrhea (especially in childn); biliary sludge or pseudolithiasis; hyperbilirubinemia; neutropenia.

Ceftazidime pentahydrate Hacef Treatment of infection due to sensitive gm +ve & gm -ve
bacteria.
C. ADVERSE DRUG REACTION: Burning, discomfort & pain at inj site; diarrhea; elevated alkaline phosphate, SGOT, SGPT; nausea & vomiting; +ve Coombs' test;
pseudomembranous colitis; seizures (large doses).

Cefepime HCl, arginine Hapimax Treatment of infections due to susceptible organisms
including UTI, resp tract & skin infection.
A. CHEMISTRY: Cefepime Hydrochloride: C19H28Cl2N6O6S2 Arginine: C6H14N4O2
Gram-positive pathogens compared to third-generation cephalosporins. Arginine is an essential amino acid in juvenile humans, Arginine is a complex amino acid, often
found at active site in proteins and enzymes due to its amine-containing side chain. Arginine may prevent or treat heart and circulatory diseases, combat fatigue, and
stimulate the immune system. It also boosts production of nitric oxide, relaxing blood vessels, and treating angina and other cardiovascular problems. Arginine is also an
important intermediate in the urea cycle and in detoxification of nitrogenous wastes.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions. +ve Coombs' test. Neutropenia, thrombocytopenia & agranulocytosis. Preexisting renal impairment. GI
disturbances. Pain at inj site & thrombophlebitis.
Cefuroxime Na Harox Treatment of bone & joint infection, bronchitis,
pharyngitis, sinusitis, skin disorders. Prophylaxis for
surgical infection & UTI.
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions, anaphylaxis. Bleeding complication related to hypothrombinemia
&/or platelet dysfunction. Nephrotoxicity. Acute renal tubular necrosis. Prolonged use. Pseudomembranous colitis.

Cefotaxime Na Haxim Treatment of infections due to susceptible organisms that
are serious & life-threatening. Also used as prophylaxis
for surgical infections.
C. ADVERSE DRUG REACTION: Thrombocytopenia, eosinophilia, leukopenia, hypersensitivity reactions & GI effects.

Ceftriaxone Na Haxon Treatment of susceptible infections eg chancroid,
C. ADVERSE DRUG REACTION: Pain, induration or tenderness at the site of inj. Rash, eosinophilia, thrombocytosis & leukopenia. Diarrhea, elevated SGOT or SGPT &
BUN.

Cefoxitin Na Haxotin Infections due to sensitive gm +ve & gm -ve bacteria;
surgical prophylaxis.
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever, reactions resembling serum sickness & anaphylaxis; +ve Coombs' test; neutropenia &
thrombocytopenia; bleeding complications, nephrotoxicity, acute renal tubular necrosis, acute interstitial nephritis. CNS toxicity, convulsions; pseudomembranous colitis.
Pain at inj site & thrombophlebitis.

Cefazolin Na Hazolin Treatment of infections due to susceptible organisms
including biliary tract infection, endocarditis & peritonitis.
C. ADVERSE DRUG REACTION: Pain at inj site. GI disturbances & hypersensitivity reactions. Allergic reaction eg urticaria, pruritis, exfoliative dermatitis, morbilliform
eruptions, rashes, drug fever, chills, serum sickness & eosinophilia.

Ceftriaxone Na Hoftrex Treatment of infections caused by susceptible organisms
eg bone & joint infections, uncomplicated gonorrhea,
intra-abdominal infections, Lyme disease, meningitis,
otitis media, pelvic infections (female), resp tract
infections, bacterial septicemia, skin & soft tissue
infections & bacterial UTI.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions (eg fever, swelling, itching, rash, redness), hematological changes (eg leukopenia, neutropenia,
thrombocytopenia, agranulocytosis, aplastic or hemolytic anemia), skin reactions (eg erythema multiforme or Stevens-Johnson syndrome) & thrombophlebitis.

Cefazolin Na Ilozef Biliary tract & urogenital, resp infection, endocarditis,
endometritis, peritonitis, prophylaxis for surgical infection,
pneumonia, cholecystitis, hepatic abscess. Septicemia,
tonsillitis, otitis media, pyelonephritis, phlegmon.
C. ADVERSE DRUG REACTION: Skin rash, fever, urticaria, eosinophilia, serum sickness & anaphylaxis, neutropenia, thrombocytopenia, nephrotoxicity, transient increases
in liver enzymes, hepatitis, cholestatic jaundice & convulsions. Nausea, anorexia, vomiting & diarrhea. Pain at IM inj site.
Cefuroxime Na Infekor Treatment of susceptible infections eg bone & joint
C. ADVERSE DRUG REACTION: Shock; pruritus, shivering, exanthema, fever, urticaria, lymph node tumidity, arthrodynia, anaphylactic reaction.

Cefalexin Ivynall Infection of the resp tract, ENT, urinary tract, skin & soft
tissue.
C. ADVERSE DRUG REACTION: GI disturbances eg, nausea, vomiting, diarrhea; allergic reactions eg, skin rashes urticarial, eosinophilia, angioedema, anaphylaxis. Rises in
liver enzyme values. Neutropenia; suprainfection w/ resistant microorganism, eg, candida, pseudomembraneous colitis.

Cefuroxime Na Kaftax Treatment of bone & joint infections, bronchitis,
pharyngitis, sinusitis, skin infections & UTI. Surgical

Cefuroxime Na Karixime Treatment of susceptible infections eg bone & joint, skin
& soft tissue infections; bronchitis, gonorrhea, meningitis,
otitis media, peritonitis, pharyngitis, sinusitis & UTI; early
Lyme disease. Surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Diarrhea, nausea & vomiting, pseudomembranous colitis, headache.

Cefuroxime axetil Kefezy Treatment of susceptible infections eg bone & joint
peritonitis, pharyngitis, sinusitis, skin & soft tissue
infections, UTI, surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Diarrhea, nausea, vomiting.

Cefuroxime Na Kefox Resp tract, ENT, urinary tract, skin & soft tissue, O & G,
bone & joint infections, surgical prophylaxis.
C. ADVERSE DRUG REACTION: Glossitis, nausea, vomiting, diarrhea, gastric pyrosis, abdominal pain. Very seldom, urticaria or cutaneous rash, pruritus & arthralgia.

Cefuroxime Kefstar Treatment of susceptible infections including bone & joint
pharyngitis, sinusitis, skin & soft tissue infections, UTI.
Inj: Surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions eg skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions, anaphylaxis.

Ceftriaxone Na Kenaxef Treatment of chancroid, gastroenteritis (invasive
salmonellosis, shigellosis), gonorrhea, Lyme's disease,
C. ADVERSE DRUG REACTION: Changes in bowel flora, diarrhea; hyperbilirubinemia; neutropenia; hypoprothrombinemia. Pseudolithiasis, gallbladder disease (discontinue).

Cefuroxime axetil Kepox Treatment of susceptible infections including pharyngitis,
tonsillitis, otitis media, sinusitis, bronchitis, skin & soft
tissue infections, uncomplicated UTI, gonorrhea & Lyme
disease.
C. ADVERSE DRUG REACTION: Diarrhea, nausea, vomiting, transient elevation of AST, ALT & lactate dehydrogenase, eosinophilia

Ceftriaxone Na Keptrix Lower resp tract infection, skin & skin structure infection,
bone & joint infection, intra-abdominal infection, UTI,
meningitis & septicemia caused by susceptible
organisms.
C. ADVERSE DRUG REACTION: GI disturbances, hematological changes, skin reactions. Rarely, headache & dizziness, increase in liver enzymes, gallbladder sludge,
oliguria, increase in serum creatinine, mycosis of the genital tract, shivering & anaphylactoid reactions, phlebitis.

Cefepime HCl Kevon Infections due to suspected or documented gm -ve
organisms resistant to older cephalosporins (eg sepsis,
pneumonia, meningitis); severe mixed gm +ve & gm -ve
infections; empiric monotherapy in febrile neutropenia.
Neutropenia & thrombocytopenia. Bleeding complications related to hypoprothrombinemia &/or platelet dysfunction. Acute renal tubular necrosis (excessive dosage); acute
interstitial nephritis; transient increases in liver enzymes. Convulsions & other signs of CNS toxicity (at high doses).

Cefalexin monohydrate Lewimycin Resp tract & skin infections, UTI, otitis media.
C. ADVERSE DRUG REACTION: GI disturbances, hypersensitivity, pseudomembraneous colitis.

Cefalexin Madexin UTI, ENT, O & G, resp, skin, soft tissue & bone infection.
C. ADVERSE DRUG REACTION: Nausea, vomiting, diarrhea; rash; superinfection.

Cefuroxime axetil Medxil For infections due to sensitive gm +ve & gm -ve bacteria,
surgical prophylaxis, more active against Haemophilus
influenzae & Neisseria gonorrhoea. Lyme disease.
C. ADVERSE DRUG REACTION: Skin rash, drug fever, transient increase of hepatic enzymes.

Cefuroxime Na Medxime Treatment of infection due to sensitive gm +ve & gm -ve
bacteria; surgical prophylaxis; more active against H.
influenza & Neisseria gonorrhea; Lyme disease.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions, renal insufficiency, hemolytic anemia, hepatic function disorders, GI & resp disorders, interstitial pneumonia,
fever. Rarely shock, Stevens-Johnson syndrome, erythema multiforme, Lyell syndrome, severe enterocolitis, superinfection, vit deficiency.

Ceftriaxone Na Medzef Treatment of susceptible infections eg chancroid,
meningitis, septicemia, surgical infection, syphilis,
C. ADVERSE DRUG REACTION: Occasionally, agranulocytosis, eosinophilia, thrombocytopenia; elevations of GOT, GPT, alkaline phosphatase; nausea, vomiting, loose
stools/diarrhea; headache.

Cefuroxime axetil Medzyme Treatment of susceptible infections eg, bone & joint
pharyngitis, sinusitis, skin & soft tissue infections,
prophylaxis of surgical infections & UTI.
C. ADVERSE DRUG REACTION: Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, skin rashes, urticaria, pruritus, interstitial nephritis, drug
fever, serum sickness; GI disturbances eg diarrhea, nausea, pseudomembranous colitis, headache; decrease Hb conc.

Cefuroxime Na Medzyme vial Treatment of susceptible infections eg bone & joint, skin
& soft tissue infections; bronchitis (& other lower resp
tract infections), gonorrhea, meningitis, otitis media,
peritonitis, pharyngitis, sinusitis, UTI. Surgical infection
prophylaxis.
C. ADVERSE DRUG REACTION: Local irritation & thrombophlebitis following IV inj, diarrhea, maculopapular rash. Anaphylactic reaction, Candida infection, eosinophilia,
leukopenia, neutropenia, nausea, vomiting, urticaria, pruritus. 750 mg inj: Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, skin rashes,
interstitial nephritis, drug fever, serum sickness; GI disturbances (eg pseudomembranous colitis), headache; decreased Hb conc. Transient pain at IM inj site; severe renal,
liver & resp disorders.

Cefuroxime Mefurox Treatment of bone & joint, bronchitis & other lower resp
tract, skin & soft tissue infections; UTI, gonorrhea,
C. ADVERSE DRUG REACTION: Diarrhea, nausea, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis. Tab: GI disturbances (including vomiting).
Inj: Pruritus, urticaria, drug fever, interstitial nephritis; increased erythrocyte sedimentation rate & decreased Hb, eosinophilia, leukopenia, neutropenia & thrombocytopenia;
thrombophlebitis, stiffness, inflammatory reactions at inj site; transient increase in serum bilirubin, transaminases & alkaline phosphatase; drowsiness, loose stools, faint
feeling, sweating, palpitations & candida intertrigo.

Cefepime HCl Megapime Treatment of lower resp tract infections, UTI, skin & skin
structure infections, intra-abdominal infections & febrile
neutropenia.
Gram-positive pathogens compared to third-generation cephalosporins:
C. ADVERSE DRUG REACTION: Anaphylaxis, rash, pruritus, urticaria, fever; diarrhea, nausea, vomiting, oral moniliasis, pseudomembranous colitis, taste perversion,
constipation, abdominal pain, dyspepsia; vasodilatation; dyspnea; headache, dizziness, paresthesia, seizures.

Ceftriaxone Na Megion Sepsis; meningitis; abdominal infections; infections of the
bones, joints, soft tissues & wounds, kidney & lower UTI;
peri-op prophylaxis; prophylaxis of infections in
immunocompromised patients; resp tract & ENT
infections; GUT infections; Lyme disease from the 2nd
stage.
C. ADVERSE DRUG REACTION: Diarrhea, nausea & vomiting, abdominal discomfort, headache; allergic reactions; disturbances in liver enzymes, transient hepatitis &
cholestatic jaundice. Rarely, antibiotic-associated colitis, erythema multiforme, toxic epidermal necrolysis.

Ceftriaxone Na Monocrin Treatment of susceptible infections including sepsis,
meningitis, abdominal, biliary tract, GIT, bone, joint, soft
tissue, renal, resp tract, ENT, genital, skin & wound
infections, UTI & gonorrhea. Surgical prophylaxis.
C. ADVERSE DRUG REACTION: Local reactions eg pain, induration & tenderness. Rash. Eosinophilia, thrombocytosis & leucopenia. GI effects. Hepatic & renal changes.
Headache & dizziness. Diaphoresis & flushing.

Cefoxitin Na Monowel Peritonitis & other intra-abdominal & intrapelvic
infections; septicemia, endocarditis, gynecological, resp
tract, bone & joint, skin & soft tissue infections; UTI
including uncomplicated gonorrhea.
C. ADVERSE DRUG REACTION: Phlebitis, inflammation at the inj site, GI reactions eg nausea & vomiting.

Cefixime trihydrate Mycefix Treatment of susceptible infections including gonorrhea,
otitis media, pharyngitis, lower resp tract infections (eg
bronchitis), UTI.
A. CHEMISTRY: C16H15N5O7S2·3H2O
B. MODE OF ACTION: Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase
enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The
antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.
C. ADVERSE DRUG REACTION: GI events eg diarrhea, loose or frequent stools, abdominal pain, nausea, dyspepsia, flatulence.

Cefalexin monohydrate Neolecsin Infections caused by susceptible organisms in resp &
urinary tract, skin & soft tissues.
solubility in water
C. ADVERSE DRUG REACTION: Diarrhea, vomiting, dyspepsia, abdominal pain. Rarely, pseudomembranous colitis, hypersensitivity reactions.

Ceftriaxone Na Oncef Treatment of susceptible infections including chancroids,
meningitis, septicemia, surgical infections, syphilis,
C. ADVERSE DRUG REACTION: Hypersensitivity reactions eg exanthema, urticaria, erythema, flare, pruritus, shivering, fever, allergic dermatitis, edema, erythema

Cefalexin Oneflex UTI, otitis media & other infections due to sensitive
organisms.
C. ADVERSE DRUG REACTION: Abdominal discomfort & diarrhea; skin rashes, urticaria, eosinophilia, angioedema & anaphylaxis.

Ceftazidime pentahydrate Onetazid Infections due to sensitive gm +ve & gm -ve bacteria.
C. ADVERSE DRUG REACTION: Shock; hypersensitivity, skin, hepatic & renal reactions; digestive, resp, hematologic, central nervous & reproductive system effects;
superinfection; vit deficiencies; phlebitis, thrombophlebitis after IV inj & pain or infection after IM inj.
Ceftriaxone Na Onizef Treatment of susceptible infections eg chancroid,
endocarditis, gastroenteritis (invasive salmonellosis),
gonorrhea, Lyme disease, meningitis (including
meningococcal meningitis prophylaxis), septicemia,
syphilis, typhoid fever, Whipple's disease. Prophylaxis for
surgical infection.
C. ADVERSE DRUG REACTION: Pain, induration or tenderness at inj site; rash; eosinophilia, thrombocytosis & leukopenia; diarrhea & pseudomembranous colitis symptoms;
SGOT, SGPT & BUN elevations.

Cefdinir Orcef-DS Treatment of resp, skin, soft tissue & ENT infections
caused by H. influenzae, H. parainfluenzae, Strep
pyogenes & Staph aureus (including β-lactamase-
producing strains); Strep pneumoniae (penicillin-
susceptible strains) & Moraxella catarrhalis.
B. MODE OF ACTION: Cefdinir is a semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefdinir's effect is dependent on its binding to
penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-
linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefdinir inhibits
bacterial septum and cell wall synthesis formation.
C. ADVERSE DRUG REACTION: Diarrhea, nausea, vag infection & rash.

Cefoxitin Na Oximed Treatment & prophylaxis of anaerobic & mixed bacterial

Cefoxitin Na Panafox Treatment of intra-abdominal & pelvic infection; for
surgical infection prophylaxis. Endometritis (prophylaxis
at caesarian section), pelvic inflammatory disease.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions, acute renal tubular necrosis, acute interstitial nephritis. Convulsions & other signs of CNS toxicity w/ high doses.
Pain at the inj site w/ IM inj & thrombophlebitis w/ IV inj.

Cefuroxime Panaxim Treatment of susceptible infections including skin & soft
tissue, bone & joint infections, bronchitis, gonorrhea,
UTI; surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Tab/Inj: GI disturbances, pseudomembranous colitis, dizziness, headache, hypersensitivity reactions, local inj site reactions. Susp: Skin
rashes, urticaria, eosinophilia, fever, serum sickness-like reactions & anaphylaxis.

Cefotaxime Na Pantaxin Treatment of serious & life-threatening infections due to
susceptible organisms eg brain abscess, gonorrhea,
Lyme disease, meningitis, peritonitis, pneumonia,
septicemia, typhoid fever, prophylaxis for surgical
infection, intensive care.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions, acute renal tubular necrosis, acute interstitial nephritis. Convulsions & other signs of CNS toxicity w/ high doses.
Pain at the inj site w/ IM inj & thrombophlebitis w/ IV inj.

Ceftriaxone Na Pantrixon Chancroid, endocarditis, gastroenteritis, gonorrhea,
Whipple's disease, Lyme disease, surgical infection
prophylaxis for prostate transurethral resection.
C. ADVERSE DRUG REACTION: Skin, hypersensitivity, digestive & hematological reactions. Pancreatic, hepatobiliary, renal & CNS disorders. Pain at inj site w/ IM inj &
phlebitis w/ IV inj.

Cefuroxime axetil Pediacef Treatment of susceptible infections including bone & joint
peritonitis, pharyngitis, sinusitis, skin & soft tissue
infections, UTI; surgical infection prophylaxis.

Cefaclor Pharex cefaclor Susceptible infections including upper & lower resp tract
infections, skin infections & UTI.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions, GI disturbances, Stevens-Johnson syndrome, eosinophilia, serum sickness-resembling reactions & anaphylaxis.

Cefalexin Pharex cefalexin Infections caused by susceptible organisms in the GUT,
skin & soft tissues. Cellulitis, SC abscesses, wound
infections due to Staph or Strep, bone infections due to
Staph &/or Proteus mirabilis. Pneumonia &
bronchopneumonia.
C. ADVERSE DRUG REACTION: Nausea, vomiting, anorexia, diarrhea, colitis; hypersensitivity reactions; +ve Coomb’s test; nephrotoxicity; transient increases in liver
enzyme values.

Cefixime Pharex cefixime Treatment of susceptible infection including gonorrhe,
bronchitis & UTI.
B. MODE OF ACTION: Cefixime is a third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.
C. ADVERSE DRUG REACTION: Skin rashes, urticarial, eosinophilia, fever, serum sickness-like reactions, anaphylaxis, GI disturbances, diarrhea.

Cefotaxime Na Pharex cefotaxime Treatment of infections due to susceptible organisms,
especially serious & life threatening infections. Brain
abscess, endocarditis, gonorrhea, intensive care, Lyme
disease, meningitis, peritonitis, septicemia & thyphoid
fever. Surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions including skin rashes, urticarial, eosinophilia, fever, serum sickness-like reactions, anaphylaxis, Local reactions at
inj site, thrombophlebitis (IV inj.) Thrombocytopenia, leukopenia.

Ceftazidime pentahydrate Pharex ceftazidime Infections caused by susceptible organisms incl biliary-
tract infections, bone & joint infections, cystic fibrosis
(RTIs), endophthalmitis, infections in
immunocompromised patients, melioidosis, meningitis,
peritonitis, pneumonia, upper RTI, septicemia, skin
infections & UTIs. Surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: GI reactions.

Ceftriaxone Na Pharex ceftriaxone Treatment of lower resp tract infections, skin & soft tissue
infections, UTI, gonorrhea, pelvic inflammatory disease,
bone & joint infections & intra-abdominal infections
caused by susceptible pathogens.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions including skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions, anaphylaxis. Transient
increase in liver enzyme values. Pseudomembranous colitis may develop on prolonged use. Diarrhea; biliary sludge or pseudolithiasis.
Cefuroxime Pharex cefuroxime Treatment of infections caused by susceptible organisms
including lower resp tract infections, UTI, skin & soft
tissue infections, septicemia, meningitis, gonorrhea &
bone & joint infections.
C. ADVERSE DRUG REACTION: GI disturbances eg diarrhea, nausea & vomiting. Tab: Eosinophilia & transient increase in SGPT, OT & LIH. Rarely jaundice, Stevens-
Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, serum sickness-like reactions, anaphylaxis & angioedema. Inj: Local reactions at inj site.

Cefuroxime axetil Pheoronex Treatment of susceptible infections: Bone & joint
infections, bronchitis, gonorrhea, meningitis, sinusitis,
skin & surgical infections & UTI.
C. ADVERSE DRUG REACTION: Diarrhea, nausea, vomiting, abdominal pain, cramps, flatulence, indigestion, dysuria, chest pain, shortness of breath, mouth, ulcers, swollen
tongue, sleepiness, thirst, anorexia.

Cefepime HCl Pimevex 1000/ Pimevex 2000 Adult: Treatment of infections caused by susceptible
organisms that include lower resp tract (pneumonia,
bronchitis), UTI (complicated & uncomplicated), skin &
skin structure, intra-abdominal infections, empiric
treatment in febrile neutropenia. Childn (≥2 mth): Lower
resp tract infection, UTI, skin & skin structure, empiric
treatment in febrile neutropenia.
C. ADVERSE DRUG REACTION: Anaphylaxis, rash, pruritus, urticaria, fever; diarrhea, nausea, vomiting, oral moniliasis, colitis, taste perversion, constipation, abdominal
pain, dyspepsia; vasodilation, dyspnea; headache, dizziness, paresthesia, seizures; phlebitis & inflammation at inj site; transient BUN &/or serum creatinine elevations,
leukopenia, neutropenia, agranulocytosis & thrombocytopenia; Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, toxic nephropathy, aplastic
anemia, hemolytic anemia, hemorrhage.
Cefuroxime axetil Pneumosolv Treatment of susceptible infections eg charancroid,
endocardotos, gastroenteritis, gonorrhea, Lyme disease,
meningitis, septicemia, surgical infection, syphilis,
typhoid fever & Whipple’s disease.
C. ADVERSE DRUG REACTION: Diarrhea, nausea, vomiting, abdominal pain, cramps, flatulence, indigestion, dysuria, chest pain, shortness of breath, mouth, ulcers, swollen
tongue, sleepiness, thirst, anorexia.

Cefepime HCl Pozineg 1000 Treatment of infections due to susceptible organisms eg
UTI, resp tract & skin infections.
C. ADVERSE DRUG REACTION: Headache, rash, diarrhea, nausea, vomiting; local reactions including phlebitis, pain &/or inflammation, pruritus or fever.

Cefuroxime Na Profunex Pre- & post-op prophylaxis, resp tract infections, ENT
infections, UTI, soft tissue infections, bone & joint
infections, O & G infection, pelvic inflammatory diseases,
gonorrhea, septicemia, meningitis.
C. ADVERSE DRUG REACTION: Rashes, GI disturbances, candida intertrigo.

Ceftriaxone Na Protriaxone Treatment of susceptible infections including chancroid,
C. ADVERSE DRUG REACTION: GI disturbances. Occasionally, headache & dizziness.

Cefuroxime Na Provixime Treatment of bone & joint, skin & soft tissue, bronchitis &
C. ADVERSE DRUG REACTION: Occasionally, neutropenia, eosinophilia, hemolytic anemia.

Cefradine monohydrate Racep Tonsillitis, pharyngitis, lobar pneumonia & bronchitis;
prostatitis, cystitis, nephropyelitis & urethritis; abscess,
cellulitis, furuncle & impetigo; otitis media, bone infection
& septicemia.
B. MODE OF ACTION: Cefradine is a 1st generation cephalosporin which inhibits the final transpeptidation step of the peptidoglycan synthesis in bacterial cell wall by binding
to one or more of the penicillin-binding proteins (PBPs), thus arresting cell wall synthesis leading to bacterial cell death.
C. ADVERSE DRUG REACTION: Shock, hypersensitivity; hematologic reactions; renal impairment, GI disorders, interstitial pneumonia, PIE syndrome, stomatitis,
candidiasis, vit K deficiency; headache, dizziness, malaise, epigastric distress & glossitis.

Cefotaxime Na Rafotax Infections due to sensitive gm + ve & gm –ve.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions including skin rashes, urticarial, eosinophilia, fever, serum sickness-like reactions & anaphylaxis.

Cefaclor monohydrate Remedlor Treatment of resp tract infection, acute bronchitis & acute
exacerbation of chronic bronchitis, pneumonia, otitis
media, pharyngitis, tonsillitis, sinusitis, UTI, skin & soft
tissue infections.
C. ADVERSE DRUG REACTION: Rash, urticaria, eosinophilia, fever, reactions resembling serum sickness & anaphylaxis.

Cefuroxime Na Restum 750 Treatment of infections due to sensitive gm +ve & gm -ve
bacteria; more active against H. influenzae & Neisseria
gonorrhea; Lyme disease; surgical prophylaxis.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions including maculopapular & urticarial skin rashes; interstitial nephritis & fever; decrease Hb conc, eosinophilia,
leukopenia & neutropenia; transient rise in liver enzymes or serum bilirubin. Dizziness & headache. Mild to moderate hearing loss in childn treated for meningitis. Transient
pain & burning sensation after IV administration.

Cefixime trihydrate Retracef Infections due to sensitive gm +ve & gm -ve bacteria;
gonorrhea.
C. ADVERSE DRUG REACTION: Diarrhea & stool changes; rash, pruritus, urticaria, drug fever & arthralgia.

Ceftriaxone Na Retrokor Resp infections eg pneumonia, bronchitis,
otorhinolaryngology, renal or UTI, meningitis, bone &
joint, skin, wound & soft tissue, GIT, genital infections
including gonorrhea, peritonitis, cholecystitis, cholangitis,
peri-op prophylaxis of infections & in patients w/ impaired
immunologic function.
C. ADVERSE DRUG REACTION: Shock, hypersensitivity reactions, hematologic, hepatic & renal effects. GI effects eg severe colitis. Resp disorders, superinfection,
avitaminosis.
Cefuroxime Na Rezafil WFI Treatment of susceptible infections eg UTI, skin, surgical
& bone & joint infections, bronchitis, gonorrhea,
meningitis, otitis media, peritonitis, pharyngitis &
sinusitis.
C. ADVERSE DRUG REACTION: Thrombophlebitis, diarrhea & nausea. Pruritus, urticaria & +ve Coombs' test. Decrease in hemoglobin & hematocrit. Transient rise in SGOT
& SGPT, alkaline phosphatase, LDM & bilirubin levels. Elevations of serum creatinine &/or BUN & decreased CrCl.

Cefaclor monohydrate RiteMED Cefaclor Treatment of otitis media, pharyngitis & tonsillitis, acute
bacterial exacerbations of chronic bronchitis, secondary
bacterial infections of acute bronchitis, pneumonia,
uncomplicated skin & skin structure infections, lower UTI.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions, GI disturbances, eosinophilia, genital pruritus or vaginitis.

Cefalexin monohydrate RiteMED Cefalexin Infections of the resp tract including otitis media, GUT,
skin & skin structure & bone due to susceptible
organisms.
C. ADVERSE DRUG REACTION: GI disturbances, allergic reactions, genital & anal pruritus, genital moniliasis, vaginitis & vag discharge, dizziness, fatigue, headache,
agitation, confusion, hallucination, arthralgia, arthritis & joint disorders. Hematological disorders, reversible interstitial nephritis.

Cefuroxime axetil RiteMED Cefuroxime Treatment of susceptible infections including upper &
lower resp tract, uncomplicated skin & skin structure
infections, uncomplicated UTI, uncomplicated gonorrhea
& early Lyme disease.
C. ADVERSE DRUG REACTION: Dermatologic/hypersensitivity reactions, GI, hematologic, nervous system, musculoskeletal, genitourinary, hepatic, resp & CV effects;
Jarisch-Herxheimer reaction, mild to severe hearing loss, increased or decreased serum glucose conc, lockjaw-type reactions & viral illness.

Cefuroxime Na Robisef Treatment of susceptible infections eg bone & joint, lower
resp tract & skin infections, UTI.

Ceftriaxone Na Rocephin Sepsis, meningitis; abdominal, biliary tract, GIT, bone,
joints, soft tissue, renal, resp tract, ENT, genital & skin &
wound infections. UTI, gonorrhea. Perioperative
prophylaxis of infections.
C. ADVERSE DRUG REACTION: GI upset, hematological changes, skin reactions, coagulation disorders, phlebitis (IV administration). Rarely, agranulocytosis, headache,
dizziness, renal & gallbladder precipitation, increase in liver enzymes, oliguria, increased serum creatinine, anaphylactoid reactions, fever, chills, cyanosis in infants, renal
precipitation (mostly childn on ≥80 mg/kg/day or total dose >10 g), pseudomembranous enterocolitis. Isolated cases of severe cutaneous adverse reactions.

Ceftriaxone Na Rophex Sepsis, meningitis; abdominal, biliary tract, GIT, bone,
joints, soft tissue, renal, resp tract, ENT, genital & skin &
wound infections. UTI, gonorrhea. Perioperative
prophylaxis of infections.
C. ADVERSE DRUG REACTION:

Cefuroxime Na Roxicef Treatment of susceptible infections which include bone &
joint infections, bronchitis, gonorrhea, meningitis, otitis
media, peritonitis, pharyngitis, sinusitis, skin infections,
surgical infections & UTI.
C. ADVERSE DRUG REACTION: Pain at IM inj site, thrombophlebitis after IV admin. Pseudomembranous colitis, leucopenia, thrombocytopenia, +ve Coombs' test.
Hypersensitivity reactions eg rash, urticaria & anaphylaxis.

Cefuroxime axetil Roxime Treatment of susceptible infections including bone & joint
peritonitis, pharyngitis, skin & soft tissue infections,
surgical & UTI.
C. ADVERSE DRUG REACTION: GI disturbances eg diarrhea, nausea & vomiting.

Cefuroxime axetil Rucef Treatment of susceptible infections including bone & joint
peritonitis, pharyngitis, sinusitis, skin infections (including
soft tissue infections) & UTI. Surgical infection
prophylaxis.
C. ADVERSE DRUG REACTION: GI disturbances eg diarrhea, nausea & vomiting.

Ceftriaxone Na Samjizon Treatment of resp tract, bone & joint, skin & soft tissue,
wound & GIT infections; sepsis, meningitis, peritonitis,
cholecystitis, cholangitis, genital infections eg gonorrhea;
perioperative prophylaxis of infections.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions; granulocytopenia, eosinophilia, thrombocytosis, leukopenia, rarely anemia, hemolytic anemia, thrombocytopenia,
prothrombin abnormality; occasional elevation of liver enzymes; GI & resp effects; superinfection; vit deficiency.

Cefepime HCl Sefpime Treatment of infections due to susceptible organisms
including urinary tract, resp tract & skin.
C. ADVERSE DRUG REACTION: Rash, pruritus, uriticaria; nausea, vomiting, oral moniliasis, diarrhea, colitis (including pseudomembranous colitis); headache; fever,
vaginitis, erythema.

Cefepime HCl Sepime Treatment of infections due to susceptible organisms
which include skin, urinary & resp tract infections.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions eg skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions & anaphylaxis.

Cefixime trihydrate Septipan Treatment of bronchiectasis w/ infection, bronchitis,
secondary infections of chronic resp tract diseases,
pneumonia, pyelonephritis, cystitis, gonococcal urethritis,
cholecystitis, cholangitis, scarlet fever, otitis media &
sinusitis.
C. ADVERSE DRUG REACTION: GI disturbances eg diarrhea, loose stools, dyspepsia, nausea & vomiting, pseudomembranous colitis. Skin rashes, fever, pruritus. Erythema
multiforme, Stevens-Johnson syndrome & serum sickness-like reactions. Transient elevations in SGPT, SGOT, alkaline phosphatase & creatinine. Headache or dizziness.
Genital candidiasis.
Cefuroxime Na Shincef Treatment of susceptible infections including bone & joint
pharyngitis, sinusitis, skin & soft tissue infections, UTI &
prophylaxis of surgical infection.
C. ADVERSE DRUG REACTION: Occasionally, neutropenia, eosinophilia, hemolytic anemia; elevation of SGOT, SGPT & alkaline phosphatase; nausea, diarrhea.

Cefepime HCl Silex Treatment of infections due to susceptible organisms
C. ADVERSE DRUG REACTION: Rash, pruritus, uriticaria; nausea, vomiting, oral moniliasis, diarrhea, colitis (including pseudomembranous colitis); headache; fever,
vaginitis, erythema.

Cefradine Solphride Treatment of infections caused by susceptible organisms
eg tonsillitis, pharyngitis, lobar pneumonia, bronchitis,
prostatitis, cystitis, pyelonephritis, urethritis, abscess,
cellulitis, impetigo, otitis media. Prophylaxis of infections
during surgical procedures.
B. MODE OF ACTION: Cephradine Anhydrous is the anhydrous form of cephradine, a semisynthetic, broad-spectrum, first-generation cephalosporin with antibacterial activity.
Cephradine binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal
stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan
chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
C. ADVERSE DRUG REACTION: diarrhea that is watery or bloody; fever, chills, body aches, flu symptoms; tightness in your chest; unusual bleeding; seizure
(convulsions);pale or yellowed skin, dark colored urine, fever, confusion or weakness; jaundice (yellowing of the skin or eyes); skin rash, bruising, severe tingling,
numbness, pain, muscle weakness;
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or increased thirst, loss of appetite, swelling, weight gain, feeling short of breath,
urinating less than usual or not at all.
Cefepime HCl Stafipime Treatment of infections due to susceptible organisms
C. ADVERSE DRUG REACTION: Anaphylaxis, rash, pruritus, urticaria, fever; diarrhea, nausea, vomiting, oral moniliasis, pseudomembranous colitis, taste perversion,
constipation, abdominal pain, dyspepsia; vasodilation; dyspnea; headache, dizziness, paresthesia, seizures.

Cefazolin Na Stancef Infections of the resp, GIT & GUT, otic & bone; skin, soft
tissue & post-op infections; bacteremia, septicemia,
endocarditis & other infections due to susceptible
organisms; surgical prophylaxis.
C. ADVERSE DRUG REACTION: Shock; hypersensitivity reactions; hematologic eg granulocytopenia, eosinophilia or thrombocytopenia; hepatic, renal impairment; GIT
disease eg colitis; CNS signs including convulsions; alteration in bacterial flora; vit deficiencies & others eg headache, dizziness or malaise.

Cefuroxime Na Sufrexim Treatment of bone & joint, skin & soft tissue, bronchitis &
C. ADVERSE DRUG REACTION: Mild to moderate hearing loss (in some childn for the treatment of meningitis). Rarely erythema multiforme, Stevens-Johnson syndrome &
toxic epidermal necrolysis.

Cefoperazone Na 1 g, sulbactam Na 0.5 g Sulperazone Resp tract infection, UTI, peritonitis, cholecystitis,
cholangitis, other intra-abdominal infections. Septicemia,
meningitis, bone & joint, skin & soft tissue infections.
Pelvic inflammatory disease, endometriosis, gonorrhea,
other genital tract & other infections.
A. CHEMISTRY: Cefoperazone Na: C25H26N9NaO8S2 sulbactam Na: C8H10NNaO5S
B. MODE OF ACTION: Cefoperazone Sodium is the sodium salt form of cefoperazone and a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation
cephalosporin antibiotic with bactericidal activity. Cefoperazone sodium inhibits bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby
interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of
cell wall stability and causes cell lysis. Sulbactam Sodium is the sodium salt form of sulbactam, a beta-lactam with weak antibacterial property. Sulbactam sodium contains
a beta-lactam ring and irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabolism of other beta-lactam
antibiotics. Combining this agent with a beta-lactamase sensitive antibiotic such as penicillins and cephalosporins against penicillinase-producing and beta-lactamase-
producing organisms, results in a decreased turnover rate of the sensitive antibiotic and enhances its antibacterial property.
C. ADVERSE DRUG REACTION: Leukopenia, neutropenia, positive Coombs' direct test, decreased Hb & hematocrit, thrombocytopenia, eosinophilia, diarrhea, nausea,
vomiting; increased AST/ALT, blood alkaline phosphatase & blood bilirubin. False +ve reaction for glucose w/ Benedict's or Fehling's soln.

Cefepime HCl Supime Infections due to suspected or documented gm -ve
organisms resistant to older cephalosporins eg sepsis,
pneumonia & meningitis. Severe mixed gm +ve & gm -ve
infections & for empiric monotherapy in febrile
neutropenic patients.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions, skin rashes, urticaria, eosinophilia, fever, reaction resembling serum & anaphylaxis.

Ceftriaxone Na Supraxone Treatment of susceptible infections eg chancroid,
septicemia, syphilis, typhoid fever & Whipple's disease.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions including skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions, anaphylaxis.

Cefaclor monohydrate Surecef Treatment of susceptible infections including upper &
lower resp tract, skin & UTI.
C. ADVERSE DRUG REACTION: Allergic reaction & GI upset.

Cefpodoxime proxetil Swich Treatment of susceptible infection of the upper & lower
resp tract, skin & soft tissues. Uncomplicated UTI &
gonorrhea.
B. MODE OF ACTION: Cefpodoxime Proxetil is a third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefpodoxime's effect is
C. ADVERSE DRUG REACTION: Diarrhea, nausea, vomiting, abdominal pains; headache, dizziness, tinnitus, paresthesia, asthenia; cutaneous eruptions, pruritus, urticaria,
purpura & bullous eruptions; anaphylactic reactions eg angioedema, bronchospasm, malaise; reduced Hb, thrombocytosis, thrombocytopenia, leukopenia, eosinophilia;
elevated AST, ALT, alkaline phosphatase, blood urea & creatinine.

Cefixime trihydrate Synmex Infections due to sensitive gm +ve & gm -ve bacteria;
gonorrhea.
C. ADVERSE DRUG REACTION: Diarrhea & stool changes; rash, pruritus, urticaria, drug fever & arthralgia.

Cefixime trihydrate Taxim-O/ Taxim-o Forte Alternative treatment of UTI, otitis media, resp tract
infections caused by susceptible organisms including
penicillin-susceptible S. pneumoniae, S. pyogenes, H.
influenzae & Enterobacteriaceae w/ poor compliance or
poor response to conventional oral antibiotics; outpatient
therapy of serious soft tissue or skeletal infection due to
susceptible organisms & single oral dose treatment of
C. ADVERSE DRUG REACTION: Diarrhea, loose stools, nausea, abdominal pain, dyspepsia, vomiting & flatulence; pseudomembranous colitis. Headache & dizziness. Skin
rashes, urticaria, drug fever, pruritus, arthralgia. Serum sickness-like reactions. Thrombocytosis, thrombocytopenia, leukopenia, hypereosinophilia, neutropenia &
agranulocytosis. Transient increase in liver transaminases, alkaline phosphatase & jaundice. Genital pruritus & vaginitis.

Ceftazidime pentahydrate Tazicef Treatment of susceptible infections caused by gm +ve &
gm -ve organisms esp those due to Pseudomonas spp.
C. ADVERSE DRUG REACTION: Shock, rash, urticaria, erythema, pruritus, fever, maculopapular rash, angioedema or anaphylaxis. Headache, dizziness, paresthesia, bitter
taste. Nausea, vomiting or diarrhea.

Ceftazidime pentahydrate Tazidem Treatment of susceptible infections caused by gm +ve &
gm -ve organisms esp those due to Pseudomonas spp.
C. ADVERSE DRUG REACTION: Occasionally, nausea, vomiting, diarrhea; granulocytopenia, eosinophilia, thrombocytosis; headache, dizziness; transient elevation of urea
in blood, BUN & serum creatinine; vaginitis; phlebitis & thrombotic phlebitis in IV inj; pain & inflammation in IM inj.

Ceftazidime pentahydrate Tazim Treatment of infections due to sensitive bacteria, esp
those due to Pseudomonas spp & including those
resistant to aminoglycosides.
C. ADVERSE DRUG REACTION: Thrombophlebitis, pain &/or inflammation at inj site, allergic reactions, GI disturbances eg diarrhea, nausea, vomiting, abdominal pain,
pseudomembranous colitis.

Ceftazidime Tazivex Treatment of infections eg biliary tract infection due to E.
coli, skin & skin structure infections due to S. aureus,
bone & joint infections, resp tract infections, pneumonia,
septicemia, meningitis.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions.

Cefuroxime axetil Teikeden-250/ Teikeden-500 Infections due to sensitive gm +ve & gm -ve bacteria;
surgical prophylaxis; more active against H. influenzae &
N. gonorrhea; Lyme disease.
C. ADVERSE DRUG REACTION: Diarrhea. Headache, vaginitis, vulvar itch, rash, hives, itch, dysuria, chills, chest pain, shortness of breath, mouth ulcers, swollen tongue,
sleepiness, thirst, anorexia.

Cefixime Tergecef Acute bronchitis, bronchiectasis w/ infection, secondary
infections of chronic resp tract diseases, pneumonia.
Pyelonephritis, cystitis, gonococcal urethritis.
Cholecystitis, cholangitis, sinusitis, tonsillitis, pharyngitis.
Scarlet fever.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions; GI, hepatic, renal & CNS effects; hematologic & lymphatic systems disorders.
Ceftriaxone Na Triavex 1 Treatment of susceptible infections which includes
chancroid, endocarditis, gastroenteritis (invasive
salmonellosis, shigellosis), gonorrhea, Lyme disease,
B. MODE OF ACTION: Ceftriaxone is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Ceftriaxone has activity in the presence of some beta-
lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria.
C. ADVERSE DRUG REACTION: Diarrhea, occasional nausea/vomiting, glossitis or stomatitis; hypersensitivity reactions eg rash, pruritus, urticaria & edema, transient pain at
the site of IM inj & local phlebitis.

Ceftriaxone Na Triax-1 Treatment of susceptible infections eg chancroid,
syphilis, septicemia, typhoid fever & Whipple's disease.
Prophylaxis for surgical infections.
C. ADVERSE DRUG REACTION: Exanthema, urticaria, erythema, flare, pruritus, shivering, fever, dermatitis, edema, erythema multiforme, anaphylaxis or anaphylaxis-like
reaction; acute renal insufficiency; interstitial pneumonia w/ flush, cough, dyspnea, abnormal chest x-ray, neutrophilia.

Ceftriaxone Na Triaxone Treatment of susceptible infections eg chancroid,
septicemia, surgical infection prophylaxis, syphilis,
C. ADVERSE DRUG REACTION: Shock; hypersensitivity; blood, liver, kidney, GI & resp system reactions; superinfection, avitaminosis; headache, dizziness, edema,
precipitation in gallbladder, ventricular extrasystole, elevated blood creatinine, genital mycosis.

Cefixime trihydrate Trifix Treatment of susceptible infections including gonorrhea,
bronchitis & UTI.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions including skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions, anaphylaxis; +ve result to
Coombs' test; bleeding complications.

Cefixime trihydrate Trifixime Treatment of susceptible infections including gonorrhea,
otitis media, pharyngitis, lower resp tract infections &
UTI.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions including skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions, anaphylaxis; +ve result to
Coombs' test; bleeding complications.

Cefuroxime axetil Trigenna Treatment of infections due to sensitive gm +ve & gm -ve
bacteria, surgical prophylaxis & more active against
Haemophilus influenzae & Neisseria gonorrhoeae.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions: Anaphylaxis, angioedema, pruritus, rash, serum sickness-like reaction, urticaria, pseudomembranous colitis,
hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia, increased prothrombin time, hepatic impairment including hepatitis & cholestasis, jaundice, seizure,
erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, renal dysfunction.

Cefixime trihydrate Triocef Treatment of susceptible infections including gonorrhea,
bronchitis & UTI.
C. ADVERSE DRUG REACTION: GI disturbances eg diarrhea & stool changes; headache, dizziness; skin rashes, pruritus, urticaria, fever, serum sickness-like reactions,
arthralgia, anaphylaxis; thrombocytopenia, leukopenia, eosinophilia.
Ceftriaxone Na Trixcef Treatment of chancroid, endocarditis, gastroenteritis
(invasive salmonellosis, shigellosis), gonorrhea, Lyme
disease, meningitis (including meningococcal meningitis
prophylaxis), septicemia, surgical infection prophylaxis,
C. ADVERSE DRUG REACTION: Neutropenia, hyperbilirubinemia, hypoprothrombinemia. Diarrhea, occasionally biliary sludge or pseudolithiasis.

Ceftriaxone Na Trixophin Resp tract, renal & urogenital, abdominal, joints, soft
tissue, skin & wound infections, UTI. Prophylaxis for pre-
& post-op infection. Otorhinolaryngologic & burn
infections. Meningitis, septicemia, syphilis, typhoid fever,
Lyme & Whipple's disease.
C. ADVERSE DRUG REACTION: Diarrhea, nausea, vomiting, soft feces, rash, itching, urticaria, edema, Stevens-Johnson syndrome. Eosinophilia, leukocytopenia, hemolytic
anemia, granulocytopenia, neutropenia, thrombocytopenia. Headache, hepatitis, nephrotoxicity & convulsions.

Cefpodoxime proxetil Trizef Treatment of susceptible infections including gonorrhea,
otitis media, lower resp tract infections eg pharyngitis &
UTI.
B. MODE OF ACTION: Cefpodoxime Proxetil is a third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefpodoxime's effect is
C. ADVERSE DRUG REACTION: GI disturbances esp diarrhea.

Ceftriaxone Na Trizone Treatment of susceptible infections eg bone & joint
infections) & UTI.
C. ADVERSE DRUG REACTION: Diarrhea, vomiting, nausea, stomatitis; eosinophilia, leukopenia, granulocytopenia; allergic dermatitis, pruritus, edema, urticaria.

Cefuroxime axetil Trucef Alternative for infections due to susceptible organisms eg
in otitis media, orbital cellulitis, urinary tract, skin & soft
tissue, bone & joint infections & post-splenectomy sepsis
of unclear etiology.
C. ADVERSE DRUG REACTION: Anaphylaxis, angioedema, pruritus, serum sickness-like reaction, urticaria; pseudomembranous colitis; hemolytic anemia, leukopenia,
pancytopenia, thrombocytopenia, increased prothrombin time; hepatic impairment including hepatitis & cholestatic jaundice; seizure; erythema multiforme, Stevens-
Johnson syndrome, toxic epidermal necrolysis; renal dysfunction.

Cefixime trihydrate Trufix Treatment of susceptible infections including gonorrhea,
bronchitis & UTI.
C. ADVERSE DRUG REACTION: Diarrhea, stool changes, pseudomembranous colitis, headache, dizziness, rash, pruritus, urticaria, drug fever, arthralgia, thrombocytopenia,
leukopenia, eosinophilia, genital pruritus, vaginitis.

Cefixime Ultraxime Treatment of infections caused by gm +ve & gm -ve
microorganisms including bronchitis, bronchiectasis w/
infection, secondary infections of chronic resp tract
diseases, pneumonia. Pyelonephritis, cystitis,
cystourethritis, uncomplicated gonorrhea. Cholecystitis,
cholangitis, scarlet fever, otitis media, sinusitis, tonsilitis,
pharyngitis, typhoid fever.
C. ADVERSE DRUG REACTION: CNS & GI disorders; hypersensitivity reactions; hepatic, renal & hematologic effects. Dysuria, pyuria, genital pruritus, vaginitis, vag
candidiasis; hyperbilirubinemia; increased serum amylase conc.
Ceftriaxone Na Unixone Treatment of susceptible infections eg chancroid,
endocarditis, gastroenteritis (invasive salmonellosis;
septicemia, surgical infection (prophylaxis), syphilis,
C. ADVERSE DRUG REACTION: Shock eg stridor, dizziness, tenesmus, tinnitus. Exanthema, urticaria, erythema, pruritus, shivering, fever, edema. Granulocytopenia,
eosinophilia, thrombocytosis, leukopenia. Severe renal disorder. GI effects eg abdominal pain & diarrhea. Pneumonia w/ flush, cough, dyspnea. Stomatitis & candidiasis.
Avitaminosis K eg hypoprothrombinemia & bleeding tendencies.

Ceftriaxone Na Vexon Treatment of susceptible infections eg chancroid,
gonorrhea, Lyme disease, meningitis, septicemia,
prophylaxis of surgical infection, syphilis, typhoid fever,
lower resp tract infections, UTI & Whipple's disease.
C. ADVERSE DRUG REACTION: Diarrhea, pseudolithiasis & hyperbilirubinemia.

Cefuroxime Na Vhersef Treatment of bone & joint, skin & soft tissue, bronchitis &
Surgical infection prophylaxis
C. ADVERSE DRUG REACTION: Occasionally, neutropenia, eosinophilia, hemolytic anemia; elevation of SGOT, SGPT & alkaline phosphatase; nausea, diarrhea.

Cefuroxime axetil Viasef Treatment of susceptible infections eg chancroid,
gonorrhea, Lyme disease, meningitis, septicemia,
prophylaxis of surgical infection, syphilis, typhoid fever,
lower resp tract infections, UTI & Whipple's disease.
C. ADVERSE DRUG REACTION: : Anaphylaxis, angioedema, pruritus, serum sickness-like reaction, urticaria; pseudomembranous colitis; hemolytic anemia, leukopenia,

Ceftriaxone Na Viatrex Treatment of susceptible infections eg chancroid,
septicemia, surgical infection prophylaxis, syphilis,
C. ADVERSE DRUG REACTION: Hypersensitivity reactions eg exanthema, urticaria, erythema, flare, pruritus, shivering, fever, allergic dermatitis, edema, erythema
multiforme & anaphylactic or anaphylactic-like reaction.

Cefadroxil monohydrate Wincocef-500 Treatment of susceptible infections including those of the
resp, urinary tract & skin.
B. MODE OF ACTION: Cephalosporin: any of a group of broad-spectrum derived from species of fungi of the genus Cephalosporium and are related to the penicillins in both
structure and mode of action but relatively penicillinase-resistant antibiotics. These antibiotics have low toxicity for the host, considering their broad antibacterial spectrum.
They have the active nucleus of beta-lactam ring which results in a variety of antibacterial and pharmacologic characteristics when modified mainly by substitution at 3 and
7 positions. Their antibacterial activities result from the inhibition of mucopeptide synthesis in the cell wall. They are widely used to treat gonorrhea, meningitis,
pneumococcal, staphylococcal and streptococcal infections. The cephalosporin class of antibiotics is usually divided into generations by their antimicrobial properties.
Three generations of cephalosporins are recognized and the fourth has been grouped. Each newer generation of cephalosporins has broader range of activity against
gram-negative organisms but a narrower range of activity against gram-positive organisms than the preceding generation. The newer agents have much longer half-lives
resulting in the decrease of dosing frequency. Accordingly, the third-generation cephalosporins can penetrate into tissues well, and thus antibiotic levels are good in various
body fluids.
C. ADVERSE DRUG REACTION: GI disturbances, hypersensitivity reactions including skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions & anaphylaxis.

Cefaclor monohydrate Xelent Treatment of otitis media, pharyngitis & tonsillitis, acute
bacterial exacerbations of chronic bronchitis, secondary
bacterial infections of acute bronchitis, pneumonia,
uncomplicated skin & skin structure infections, lower UTI.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions, diarrhea, nausea, vomiting, eosinophilia, genital pruritus or vaginitis. Rarely, transient hepatitis & cholestatic
jaundice, thrombocytopenia, reversible interstitial nephritis.

Cefoxitin Na Xifox Treatment & prophylaxis of anaerobic & mixed bacterial
infections especially intra-abdominal & pelvic infections;
gonorrhea & UTI.
C. ADVERSE DRUG REACTION: Diarrhea including pseudomembranous colitis; eosinophilia, leukopenia, neutropenia, hemolytic anemia, thrombocytopenia & bone marrow
depression; transient elevations in AST, ALT, serum LDH & alkaline phosphatase, jaundice; hypotension; elevations in serum creatinine &/or BUN; thrombophlebitis (IV
administration); some degree of pain & tenderness (IM inj).

Cefuroxime Na Ximerox Treatment of susceptible infection including bone & joint
pharyngitis, sinusitis, skin (including soft tissue)
infections & UTI. Surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Pseudomembranous colitis; diarrhea, nausea, vomiting, abdominal pain & cramps, flatulence, dyspepsia. Increased in SGOT, SGPT,
alkaline phosphatase, LDH & bilirubin.

Cefalexin Xinflex Treatment of infections of the resp tract, ENT, urinary
tract; O&G, skin, soft tissue & bone infections & dental
procedures.
B. MODE OF ACTION: Cefalexin binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in
C. ADVERSE DRUG REACTION: Pseudomembranous colitis, nausea, vomiting, diarrhea, dyspepsia, abdominal pain. Hypersensitivity reactions. Genital & anal pruritus,
genital moniliasis, vaginitis, vag discharge, dizziness, fatigue & headache.

Cefuroxime axetil Xorimax Tablet: Treatment of infections caused by cefuroxime-
sensitive organisms eg, infections of the airways
(including throat and ear infections), kidneys and/or the
urinary tract, skin and soft tissues; acute, uncomplicated
gonorrhea; Lyme borreliosis.
Suspension: Treatment of mild to moderately severe
infections caused by microorganisms susceptible to
cefuroxime eg, upper respiratory tract infections (acute
otitis media, sinusitis, tonsillitis and pharyngitis); acute
bronchitis, acute exacerbation of chronic bronchitis;
lower uncomplicated urinary tract infections (cystitis);
skin and soft tissue infections (furunculosis, pyoderma
and impetigo); uncomplicated gonorrhea (urethritis and
cervicitis); treatment at early stage Lyme disease
(stadium I) and subsequent prevention of late
complications is adults and children >12 yrs.
C. ADVERSE DRUG REACTION: Tablet: Xorimax has been found to be well tolerated. The side effects which have been observed are usually slight and transitory.
Gastrointestinal Tract: Nausea, vomiting, abdominal pain and diarrhea. These side effects occur somewhat more frequently on intake of higher daily doses.
Hypersensitivity Reactions: Allergic cutaneous reactions (eg, nettle rash and measles-like skin rashes, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal
necrolysis), itching, shortness of breath, drug-induced fever, serum sickness. Hypersensitivity reactions of all types and severities (anaphylactic shock, anaphylactoid
reactions) with circulatory failure have been observed after intake of cephalosporins.
Hypersensitivity reactions may occur in patients with a predisposition to such reactions owing to the content of preservatives (parabens).
Blood, Blood Cells and Coagulation: A change in the number of white blood cells (eg, eosinophilia, leukopenia, neutropenia) and a decrease in platelets
(thrombocytopenia) and, very rarely, a reduction in red blood cells (hemolytic anemia).
Liver and Biliary Tract: Transient rise in liver function test results (SGOT, SGPT, LDH); these manifestations are transient and are no reason for concern. Jaundice may
occur in very rare cases.
Nervous System: Headaches, dizziness.
Others: Inflammation of the mucous membrane of the mouth (very thick coating on the tongue) and the vagina (itching and discharge), sometimes caused by supervening
infection with Candida (fungus).
Treatment of Lyme borreliosis may be associated with drug-induced fever and serum sickness.
Suspension: Common (≤10%, but >1%), uncommon (≤1%, but >0.1%), rare (≤0.1%, but >0.01%), very rare (≤0.01).
Infection and Infestations: Rare: Pseudomembranous colitis.
As with other antibiotics, prolonged use may lead to secondary superinfection caused by insusceptible oragnisms eg, Candida, Enterococci and Clostridium difficile (see
Precautions).
Blood and Lymphatic System Disorders: Rare: Decrease hemoglobin concentration, eosinophilia, leukopenia, neutropenia, thrombocytopenia. Very Rare: Hemolytic
anemia.
Immune System Disorders: Common: Jarisch-Herxheimer reaction following cefuroxime axetil treatment of Lyme disease (see Precautions). Rare: Serum sickness. Very
Rare: Anaphylaxis.
Nervous System Disorders: Uncommon: Headache, dizziness. Very Rare: Restlessness, nervousness, confusion.
Gastrointestinal Disorders: Common: Diarrhea, nausea and vomiting. The frequency of diarrhea is related to the administered dose and may rate up to 10% with tablets.
The incidence is (approximately 13%) at prolonged treatment of 20 days of early Lyme disease.
Hepatobiliary Disorders: Rare: Transient increase of hepatic enzyme levels (AST, ALT and LDH) and serum bilirubin. Very Rare: Jaundice.
Skin and Subcutaneous Tissue Disorders: Common: Skin rash, urticaria, pruritus. Very Rare: Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal
necrolysis.
Renal and Urinary Disorders: Common: increase levels of creatinine and urea in serum, especially in patients with impaired renal function. Uncommon: Acute interstitial
nephritis. General Disorders and Administration site Conditions: Rare: Drug fever.
Investigations: The use of cefuroxime axetil may be accompanied by false positive Coombs' test. This may interfere with the performance of cross matching tests with
blood.

Ceftriaxone Na Xtenda Lower resp tract infections, acute bacterial otitis media,
skin & skin structure infections, UTI, uncomplicated
gonorrhea, pelvic inflammatory disease, bacterial
septicemia, bone & joint infections, intra-abdominal
infections, meningitis, surgical prophylaxis.
C. ADVERSE DRUG REACTION: Inj site reaction after IM administration. Rash, thrombocytosis, leukopenia, diarrhea, elevations of SGOT, SGPT & BUN.

Cefuroxime axetil Xyfrox Infections due to sensitive gm +ve & gm -ve bacteria;
surgical prophylaxis; more active against Haemophilus
influenzae & Neisseria gonorrhea; Lyme disease.
C. ADVERSE DRUG REACTION: Anaphylaxis, angioedema, pruritus, serum sickness-like reaction, urticaria; pseudomembranous colitis; hemolytic anemia, leukopenia,
Cefuroxime axetil Zefcure-500 Treatment of mild to moderate infections of the following:
Pharyngitis/tonsillitis; acute bronchitis; otitis media; acute
bacterial maxillary sinusitis, exacerbation of chronic
bronchitis and secondary bacterial infections of acute
bronchitis; uncomplicated skin and skin structure
infections; uncomplicated urinary tract infections;
uncomplicated gonorrhea, urethral and endocervical;
early Lyme disease.
C. ADVERSE DRUG REACTION: Diarrhea, abdominal pain and cramps, flatulence, indigestion, headache, vaginitis, vulvar itch, rash, hives, itch, dysuria, chills, chest pain,

Cefuroxime axetil Zefcure-750 Treatment of mild to moderate infections of the following:
Pharyngitis/tonsillitis; acute bronchitis; otitis media; acute
bacterial maxillary sinusitis, exacerbation of chronic
bronchitis and secondary bacterial infections of acute
bronchitis; uncomplicated skin and skin structure
infections; uncomplicated urinary tract infections;
uncomplicated gonorrhea, urethral and endocervical;
early Lyme disease.
C. ADVERSE DRUG REACTION: Diarrhea, abdominal pain and cramps, flatulence, indigestion, headache, vaginitis, vulvar itch, rash, hives, itch, dysuria, chills, chest pain,

Cefixime Zefitas Treatment of UTI, otitis media, resp tract infections
caused by susceptible organisms including penicillin-
susceptible S. pneumoniae, S. pyogenes, H. influenzae,
& Enterobacteriaceae & w/ documented poor compliance
or response to conventional oral antibiotics. Outpatient
therapy of serious soft tissue or skeletal infections due to
susceptible organisms & single dose oral treatment of
C. ADVERSE DRUG REACTION: Diarrhea & stool changes; pseudomembranous colitis. Headache & dizziness. Hypersensitivity reactions eg rash, pruritus, urticaria, drug
fever & arthralgia. Thrombocytopenia, leukopenia & eosinophilia; mild transient changes in liver & renal function tests.

Cefotaxime Na Zefocent Shock, hypersensitivity reactions, hematologic, renal &
hepatic disturbances. Digestive & resp effects. Vit
deficiencies & alteration in bacterial flora.
C. ADVERSE DRUG REACTION: Shock, hypersensitivity reactions, hematologic, renal & hepatic disturbances. Digestive & resp effects. Vit deficiencies & alteration in
bacterial flora.

Cefotaxime Zefotax Treatment of infections due to susceptible organisms esp
serious & life-threatening infections which include brain
abscess, endocarditis, gonorrhea, intensive care
(selective parenteral & enteral antisepsis regimens),
Lyme disease, meningitis, peritonitis, pneumonia,
septicemia & typhoid fever. Surgical infection
prophylaxis.
C. ADVERSE DRUG REACTION: Occasionally rash, pruritus, fever, itching; granulocytosis, hemolytic anemia, anemia, thrombocytopenia, eosinophilia, neutropenia, transient
leukocytopenia, agranulocytosis; interstitial nephritis, transient elevation of BUN; SGPT, SGOT, lactate dehydrogenase & alkaline phosphatase elevations; colitis, diarrhea;
dyspnea, edema, headache, systemic fatigue, vaginitis, moniliasis, visual disturbance, carpopedal spasm.

Cefuroxime Zefsur-250/ Zefsur-500/ Zefsur Treatment of infections due to sensitive gm +ve & gm -ve
bacteria eg bone & joint infections, bronchitis, gonorrhea,
skin infections & UTI; surgical prophylaxis; more active
against Haemophilus influenzae & Neisseria gonorrheae;
Lyme disease.
C. ADVERSE DRUG REACTION: Tab: Anaphylaxis, angioedema, pruritus, rash, drug fever, serum sickness-like reaction, urticaria; pseudomembranous colitis, GI
disturbances, hemolytic anemia, eosinophilia, leukopenia, pancytopenia, neutropenia, thrombocytopenia, increased prothrombin time; hepatitis, cholestasis, jaundice,
headache, sleepiness, seizure, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis; renal dysfunction. Inj: Diarrhea, nausea, vomiting.

Ceftazidime pentahydrate Zeftacare Treatment of susceptible infections especially those due
to Pseudomonas spp including biliary tract, bone & joint
infections, cystic fibrosis, endophthalmitis, infections in
peritonitis, upper resp tract infections, septicemia, skin &
UTI.
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions & anaphylaxis. Neutropenia & thrombocytopenia. Acute interstitial
nephritis; transient increase in liver enzymes; convulsions & other signs of CNS toxicity (high dose). Inj site pain (IM use) & thrombophlebitis (IV infusion use).
Pseudomembranous colitis w/ Clostridium difficile infection.

Ceftazidime pentahydrate Zeftahl Treatment of susceptible infections especially those due
to Pseudomonas spp including biliary tract, bone & joint
infections, cystic fibrosis, endophthalmitis, infections in
peritonitis, upper resp tract infections, septicemia, skin &
UTI.
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions & anaphylaxis. Neutropenia & thrombocytopenia. Acute interstitial
nephritis; transient increase in liver enzymes; convulsions & other signs of CNS toxicity (high dose). Inj site pain (IM use) & thrombophlebitis (IV infusion use).
Pseudomembranous colitis w/ Clostridium difficile infection.

Cefuroxime axetil Zefur Treatment of susceptible infections including bone & joint
infections, bronchitis, gonorrhea, otitis media, peritonitis,
pharyngitis, sinusitis, skin & soft tissue infections & UTIs.
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever, reactions resembling serum sickness & anaphylaxis.

Cefuroxime Na Zefur IV/ IM Treatment of susceptible infections eg bone & joint
infections, lower resp tract infections, gonorrhea,
meningitis, skin & soft tissue infections & UTI.
C. ADVERSE DRUG REACTION: Diarrhea including pseudomembranous colitis; eosinophilia, leukopenia, neutropenia, hemolytic anemia, thrombocytopenia & bone marrow
depression; transient elevations in AST, ALT, serum LDH & alkaline phosphatase, jaundice; hypotension; elevations in serum creatinine &/or BUN; thrombophlebitis (IV
administration); some degree of pain & tenderness (IM inj).

Cefuroxime Na Zefuxim Alternative drug for infections due to susceptible
soft tissue, bone & joint infection & post-splenectomy
sepsis of unclear etiology.
C. ADVERSE DRUG REACTION: Skin rash, urticaria, eosinophilia, fever, serum-sickness reactions, anaphylaxis.

Cefuroxime Zegen Tab: Treatment of infections caused by susceptible
strains of microorganisms including upper & lower resp
tract, uncomplicated skin & skin structure infections,
uncomplicated UTI & gonorrhea; early Lyme disease. Inj:
Treatment of bone & joint infections, bronchitis (& other
lower resp tract infections), gonorrhea, meningitis, otitis
media, peritonitis, pharyngitis, sinusitis, skin infections,
surgical infections & UTI.
C. ADVERSE DRUG REACTION: Diarrhea, nausea, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis. Tab: GI disturbances (including vomiting).
Inj: Pruritus, urticaria, drug fever, interstitial nephritis; increased erythrocyte sedimentation rate & decreased Hb, eosinophilia, leukopenia, neutropenia & thrombocytopenia;
thrombophlebitis, stiffness, inflammatory reactions at inj site; transient increase in serum bilirubin, transaminases & alkaline phosphatase; drowsiness, loose stools, faint
feeling, sweating, palpitations & candida intertrigo.

Cefoxitin Na Zepax Treatment of lower resp tract infections including
pneumonia & lung abscess, pyelonephritis, cystitis,
gonorrhea, intra-abdominal infections, septicemia, bone
& joint infections, skin & soft tissue infections caused by
susceptible microorganisms.
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever, serum sickness reactions & anaphylaxis. Nephrotoxicity. Transient increases in liver enzyme
values; hepatitis & cholestatic jaundice. Convulsions. GI disturbances. Pseudomembranous colitis.

Cefalexin Zepharyl Infection of the resp tract, GUT, ENT, skin & soft tissue,
bone & joint, O & G, gonorrhea & other infections
including septicemia, meningitis, acute prostatitis &
dental infections.
B. MODE OF ACTION: Cefalexin binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in
C. ADVERSE DRUG REACTION: Occasional mild GI disturbances.

Cefepime HCl Zepim Treatment of infections due to susceptible organisms eg
C. ADVERSE DRUG REACTION: Rash, local reactions, diarrhea, nausea, phlebitis, pain inflammation, pruritus, fever, headache, +ve Coombs' test.
Cefepime HCl w/ arginine Zepime Treatment of infections due to susceptible organisms eg
A. CHEMISTRY: Cefepime HCl: C19H28Cl2N6O6S2 arginine: C6H14N4O2
Gram-positive pathogens compared to third-generation cephalosporins. Arginine is an essential amino acid in juvenile humans, Arginine is a complex amino acid, often
found at active site in proteins and enzymes due to its amine-containing side chain. Arginine may prevent or treat heart and circulatory diseases, combat fatigue, and
stimulate the immune system. It also boosts production of nitric oxide, relaxing blood vessels, and treating angina and other cardiovascular problems. Arginine is also an
important intermediate in the urea cycle and in detoxification of nitrogenous wastes. (NCI04)
C. ADVERSE DRUG REACTION: Rash, local reactions, diarrhea, nausea, phlebitis, pain inflammation, pruritus, fever, headache, +ve Coombs' test.

Cefalexin monohydrate Zeporin Infections of the resp, urinary tract, skin; otitis media &
other infections due to sensitive organisms.
A. CHEMISTRY: C16H17N3O4S, H2O
C. ADVERSE DRUG REACTION: Diarrhea, nausea, vomiting, dyspepsia, abdominal pain; allergic reactions.

Cefoxitin Na Zepotin Treatment of lower resp tract infections including
pneumonia & lung abscess, pyelonephritis, cystitis,
gonorrhea, intra-abdominal infections, septicemia, bone
& joint infections, skin & soft tissue infections caused by
susceptible microorganisms.
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever, serum sickness reactions & anaphylaxis. Nephrotoxicity. Transient increases in liver enzyme
values; hepatitis & cholestatic jaundice. Convulsions. GI disturbances. Pseudomembranous colitis.

Ceftazidime Zeptrigen Treatment of infections of the lower resp tract, skin &
skin structure, UTI, bacterial septicemia, bone & joint
infections, gynecological infections, intra-abdominal
infections, CNS infections.
A. CHEMISTRY: Ceftazidime: C22H22N6O7S2
C. ADVERSE DRUG REACTION: Phlebitis & inflammation at inj site, allergic reactions, GI disturbances.

Ceftriaxone Na Zerone Treatment of ceftriaxone-susceptible infections including
disease, meningitis, septicemia, syphilis, typhoid fever,
Whipple's disease & surgical infection prophylaxis.

Ceftazidime pentahydrate Ziftaz Treatment of susceptible infections especially those due
to Pseudomonas spp. These include biliary-tract
infections, bone and joint infections, cystic fibrosis
(respiratory tract infections), endophthalmitis, infections
in immunocompromised patients (neutropenic patients),
melioidosis, meningitis, pneumonia, upper respiratory
tract infections, septicemia, skin infections (including
burns, ecthyma gangrenosum and ulceration) and
urinary tract infections (UTI). It is also used for surgical
C. ADVERSE DRUG REACTION: Most common adverse reactions are: Local: Phlebitis or thrombophlebitis, pain and/or inflammation at the injection site.
Hypersensitivity: Pruritus, rash, urticaria, erythema multiforme and fever. Toxic epidermal necrolysis and Stevens-Johnson syndrome have been reported rarely.
Angioedema and anaphylaxis (bronchospasm and/or hypotension).
Gastrointestinal: Diarrhea, nausea, vomiting and abdominal pain. Very Rarely: Oral thrush and pseudomembranous colitis.
Central Nervous System: Headache, dizziness, paresthesia and bad taste. There have been reports of neurological sequelae including tremor, myoclonia, convulsions,
encephalopathy and coma in patients with renal impairment in whom the dose of ceftazidime has not been appropriately reduced.
Genitourinary: Candidiasis and vaginitis.
Hepatic Enzymes: Very Rarely: Jaundice.

Cefuroxime Na Ziglo Treatment of bone & joint infections, bronchitis & other
lower resp tract infections, gonorrhea, meningitis, otitis
media, peritonitis, pharyngitis, sinusitis, skin & soft tissue
infections, UTI. Surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Rarely, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis. Mild to moderate hearing loss in childn treated for
meningitis.

Cefuroxime Na Zinacare Treatment of bone & joint, lower resp tract, skin & soft
tissue infections, UTI, gonorrhea, meningitis, otitis media,
peritonitis, sinusitis due to susceptible microorganisms.
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever, serum sickness-like reactions & anaphylaxis. Neutropenia & thrombocytopenia; acute interstitial
nephritis; transient increase in liver enzymes; hepatitis & cholestatic jaundice; convulsions & other signs of CNS toxicity (high dose); inj site pain (IM use) &
thrombophlebitis (IV infusion use). Mild to moderate hearing loss in childn.

Cefuroxime Zinacef Resp & urinary tract, ENT, soft tissue, bone & joint, O &
G infections, gonorrhea & other infections including
septicemia, meningitis & peritonitis. Prophylaxis against
infections in abdominal, pelvic, orthopedic, cardiac,
pulmonary, esophageal & vascular surgery where there
is increased risk from infections.
C. ADVERSE DRUG REACTION: Neutropenia, eosinophilia, transient rise in liver enzymes, inj site reactions eg pain & thrombophlebitis.
Cefuroxime axetil Zinnat Lower & upper resp tract, GUT, skin & soft tissue
infections; gonorrhea including acute uncomplicated
gonococcal urethritis & cervicitis. Early & late Lyme
disease in adults & childn >12 yr.
C. ADVERSE DRUG REACTION: Eosinophilia, headache, dizziness, GI disturbances including diarrhea, nausea, abdominal pain; transient increases of hepatic enzyme
levels (ALT/AST, LDH).

Cefuroxime Zocef Treatment of infections due to susceptible organisms eg
otitis media, orbital cellulitis, UTI, skin & soft tissue, bone
& joint infections & post-splenectomy sepsis of unclear
etiology. Susp Bronchitis (& other lower resp tract
infections), gonorrhea, meningitis, peritonitis, pharyngitis,
sinusitis. Surgical infection prophylaxis.
C. ADVERSE DRUG REACTION: Hypersensitivity reactions eg anaphylaxis, angioedema, pruritus, rash, serum sickness-like reaction, urticaria; pseudomembranous colitis;
hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia, increased prothrombin time; hepatitis, cholestasis, jaundice, transient elevation of liver enzymes; seizure;
erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis; renal dysfunction. Susp: Candida overgrowth, eosinophilia, headache, dizziness, GI
disturbances including diarrhea, nausea, abdominal pain.

Cefazolin Na Zofadep Treatment of infectious resp diseases, sepsis, peritonitis,
endocarditis, UTI, syphilis & gonorrhea, skin & joint
infections, burns & post-op prophylaxis.
C. ADVERSE DRUG REACTION: Skin rash, pruritus, eosinophilia, Quincke's edema, arthritis & anaphylactic shock. Renal impairment, GI disorders eg anorexia, diarrhea,
nausea, vomiting, pseudomembranous colitis & transient increase in liver transaminase. Neutropenia, leukopenia & thrombocytopenia.

Cephradine Zolicef Treatment of infections caused by susceptible organisms
eg resp tract infections, UTI, skin & soft tissue infections,
biliary tract infections, endocarditis & peritonitis & for
surgical prophylaxis including endometritis at caesarian
section.
B. MODE OF ACTION: Cephradine Anhydrous is the anhydrous form of cephradine, a semisynthetic, broad-spectrum, first-generation cephalosporin with antibacterial activity.
Cephradine binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal
stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan
chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
C. ADVERSE DRUG REACTION: GI disturbances, skin & hypersensitivity reactions, thrombophlebitis, mild transient eosinophilia, leukopenia & neutropenia; dizziness,
tightness of the chest & candidal vaginitis.

Cefuroxime axetil Zoltax Treatment of infections caused by susceptible organisms
eg bone & joint infections, bronchitis, gonorrhea,
skin & soft tissue infections, UTI & for surgical infection
prophylaxis.
C. ADVERSE DRUG REACTION: Diarrhea, nausea, vomiting, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Cefuroxime axetil Zoltax Injection Treatment of infections caused by susceptible organisms
eg bone & joint infections, bronchitis, gonorrhea,
skin & soft tissue infections, UTI & for surgical infection
prophylaxis.
C. ADVERSE DRUG REACTION: Diarrhea, nausea, vomiting, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Ceftriaxone Na Zulox Lower resp tract infections, acute bacterial otitis media,
skin & skin structure infections, UTI, uncomplicated
gonorrhea, pelvic inflammatory disease, bacterial
septicemia, bone & joint infections, intra-abdominal
infections, meningitis, surgical prophylaxis.

Cefuroxime Na Zyrex Infections due to sensitive gm +ve & gm -ve bacteria;
surgical prophylaxis; more active against H.
C. ADVERSE DRUG REACTION: Skin rashes, urticaria, eosinophilia, fever, serum sickness-like reaction, anaphylaxis; acute renal tubular necrosis; acute interstitial nephritis;
inj site pain, thrombophlebitis; diarrhea, nausea, vomiting.

Cephalosporins: Generic Names, Brand Names & Indications

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Cephalosporins: Generic Names, Brand Names & Indications

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