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Ao] ass} Beal Asa, WSs, ella Sola alee TALE | $7} PRAT CIBHS, SSEPAS, AA Fol] AIRS T AH] 7] Sol4to] Ba 152 3120} immune dysregulation, polyendocrinopathy, enteropathy, and X-linked syndrome (IPEX)?- Foxp3 Faiz}o] Seeiol7} Aelole) ALY B= Beal oo weyerps sejz seh ab HA Selo] AIA TAKS] BAAS Asay Qaedte ge dal aed aazae TASS) $7} S717) AAO} UAl ANd BAS o]-FSI} LH Paste] Stk F Bae AE Boks Bat eh Alel4Ab} USA T Aes] WIS SA AFoAE vidal yy HS DHS] Seto Sah a4) Sala Dao} val Aelettelo) Pets} selepoya] Waza TA) £2) eat Ga7} Betsiaic. alenale] Bs Sepa dale} AUst Flo] Welea T Ary aels}] vieveg T aijstol -32-O1 sy mposiom odo] NOW Wile) Bayt See + Uke AAS aS + Uh Hep] B aAzwse aed} EEF als) -as Hoh ol yee) AMS VI viglal we Woe ars Ala SRT. OP] AAQhsBo] WHS] BY WAN 50% BEF BAM Alo] xbso] glefar dey A OM, MAYS MS AMS BEE UAolgo] Pejeleta YZs]az Meh. BAS ols sola avy, Thi/Th2 OLE FBY ogo} Mis|z gor} Ueajes ola z A Bessa GRE Wl AHS Yehy=e Bowe Mela seh are] ae 3 ols ws] EAGHIS BIE CUSVS] We filsoh ut ol} asziel AVMs BS AT Of FAD, EU BH] Me UH ys RTOS Bec UPLATE RRS BA} 7\ sal Apa] SRARS AMHs}o} C4, CD2S, 1252 Foxp3h He BAS AAS AAlet flow cytometry aAla}sith B GFo}4| AAAUTILE CD4+Foxp3+ AES BojstAr. AS} CD4+Foxp4t/CD4+ AJ EO} WAS} ayalsaAt BF ela So}gQla Agkeh Fat ARES Ball Hol ALS AALS Foxp3+ AZ, CD4+CD25+Foxp3+ AEE, CD4+Foxp3+/CD4+ AEE BF MPo] Aas] USS FF URL oe KoA AealBwel WH oye VE 3S Vy ae Wl SPY AASY T ALY Y27} BSH, o]B gol ge] aga] 7] A glow Wyss olf) Zo) Holst MSS AAeHe AOe Abc aieca Aluvihare VR, Kallikourdis M, Betz AG. Regulatory T cells mediate matemal tolerance to the fetus. Nat Immunol 2004; 5: 266-71. Kwak JY, Beaman KD, Gilman-Sachs A, Ruiz JE, Schewitz DBeer AE, Up-regulated expression of CDS6+, CDS6+/CDI6+, and CDI9+ cells in peripheral blood lymphocytes in pregnant women with recurrent pregnancy losses. Am J Reprod Immunol 1995; 34: 93-9, Kwak-Kim JY, Chung-Bang HS, Ng SC, Nirivalas El, Mangubat CP, Beaman KD, Beer AE, Gilman-Sachs A. Increased T helper I cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failures after IVF. Hum Reprod 2003; 18: 767-73. Medawar PB, Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp Soc Exp Biol 1953; 7: 320-38. Roncador G, Brown PJ, Maestre L, Hue S, Martinez-Torrecuadrada JL, Ling KL, Pratap S, Toms C, Fox BC, Cerundolo V, et al. Analysis of FOXP3 protein expression in human CD4#+CD25+ regulatory T cells at the single-cell level. Eur J Immunol 2005; 35: 1681-91 Sakaguchi S, Sakaguchi N, Asano M, Itch M, Toda M. Immunologic selfolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of selftolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151-64. Sasaki Y, Sakai M, Miyazaki S, Higuma S, Shiozaki A, Saito S. Decidual and peripheral blood CD4+CD25+ regulatory TT cells in early pregnancy subjects and spontaneous abortion cases. Mol Hum Reprod 2004; 10: 347-53. -33-Symposium ——————__——_______-__.. piety Atala O1gt00 2101 Slee T ADE Somerset DA, Zheng Y, Kilby MD, Sansom DM, Drayson MT. Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset. Immunology 2004; 112: 38 43, Thellin O, Coumans B, Zorzi W, Igout A, Heinen E. Tolerance to the foeto-placental ‘graft’: ten ways to support a child for nine months. Curr Opin Immunol 2000; 12: 731-7. Walker MR, Kasprowicz DJ, Gersuk VH, Benard A, Van Landeghen M,Buckner JH, Ziegler SF. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J Clin Invest 2003; 112: 1437-43. Zenclussen ACGerlof KZenclussen MLRitschel SZambon Bertoja AFest SHontsu SUcha SMatsushima KLeber J, et al. Regulatory T cells induce a privileged tolerant microenvironment at the fetal-matemal interface. Eur J Immunol 2006; 36: 82-94, 34