Chapter Title: Table of Contents

Book Title: Nanofibres in Drug Delivery

Book Author(s): Gareth R. Williams, Bahijja T. Raimi-Abraham and C. J. Luo
Published by: UCL Press

Stable URL: https://www.jstor.org/stable/j.ctv550dd1.2

JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide
range of content in a trusted digital archive. We use information technology and tools to increase productivity and
facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.

Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at
https://about.jstor.org/terms
This content is licensed under a Creative Commons Attribution 4.0 International License (CC BY
4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

UCL Press is collaborating with JSTOR to digitize, preserve and extend access to Nanofibres in
Drug Delivery

This content downloaded from

202.94.83.95 on Fri, 12 Jan 2024 05:09:34 +00:00
All use subject to https://about.jstor.org/terms
vi

Contents

List of figures  x
List of abbreviations  xxvii

1 Introduction  1
1.1 Preamble  1
1.2 Nanofibres  1
1.3 Key concepts in drug delivery  2
1.4 Nanofibre characterisation  9
1.5 An overview of contemporary pharmaceutical technology  19
1.6 Summary  22
1.7 References  23
1.8 Bibliography  23

2 Electrospinning fundamentals  24
2.1 Background  24
2.2 A brief history of electrospinning  25
2.3 EHD fundamentals  26
2.4 Understanding the electrospinning process  29
2.5 The parameters affecting electrospinning  37
2.6 The experimental set-​up  45
2.7 Fibre properties  54
2.8 Characterisation  54
2.9 Summary  55
2.10 References  55

3 Monoaxial electrospinning  60
3.1 Introduction  60
3.2 Experimental considerations  61
3.3 Fibre properties  66
3.4 Some typical results  67
3.5 Fast-​dissolving drug delivery systems  69
3.6 Extended-​release systems  75

vii

This content downloaded from

202.94.83.95 on Fri, 12 Jan 2024 05:09:34 +00:00
All use subject to https://about.jstor.org/terms
vi

3.7 pH-​controlled delivery  80

3.8 Pulsatile release  83
3.9 Multilayer materials  84
3.10 Thermoresponsive systems  86
3.11 Emulsion and suspension electrospinning  87
3.12 Tissue-​engineering applications  92
3.13 Using fibres as sacrificial templates  93
3.14 Conclusions  96
3.15 References  96

4 Coaxial and multi-​axial electrospinning  106

4.1 Introduction  106
4.2 Experimental considerations  107
4.3 Extended-​release systems  112
4.4 Targeted drug delivery  118
4.5 Multifunctional materials  121
4.6 Other applications  124
4.7 Protein delivery systems  124
4.8 Cell electrospinning  129
4.9 Modified coaxial spinning  130
4.10 Triaxial and quad-​axial systems  135
4.11 Conclusions  139
4.12 References  140

5 Side-​by-​side electrospinning  149

5.1 Introduction  149
5.2 Experimental considerations  150
5.3 Janus fibres in drug delivery  156
5.4 Conclusions  158
5.5 References  158

6 Alternative nanofibre fabrication approaches  160

6.1 Introduction  160
6.2 Alternating current electrospinning  160
6.3 Melt electrospinning  162
6.4 Centrifugal spinning  165
6.5 Solution blowing and melt blowing  167
6.6 Electroblowing  169
6.7 Pressurised gyration  170
6.8 Electrospraying  172
6.9 Microfluidic spinning  176
6.10 Fibre production on the move  176

viii Con t en ts

This content downloaded from

202.94.83.95 on Fri, 12 Jan 2024 05:09:34 +00:00
All use subject to https://about.jstor.org/terms
ix

6.11 Other techniques  177

6.12 Conclusions  180
6.13 References  180

7 Moving from the bench to the clinic  187

7.1 Introduction  187
7.2 Scale-​up  187
7.3 Regulatory requirements and GMP manufacturing  198
7.4 Conclusions  200
7.5 References  201

8 Conclusions and outlook  204

Index  207

Con t en ts ix

This content downloaded from

202.94.83.95 on Fri, 12 Jan 2024 05:09:34 +00:00
All use subject to https://about.jstor.org/terms