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  • Nitrofurantoin

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    Nitrofurantoin, also known as Macrobid, is a broad spectrum antibiotic used to treat and prevent urinary tract infections. It works by being reduced by bacterial enzymes to reactive intermediates that inhibit vital bacterial processes like DNA, RNA, and protein synthesis. It is contraindicated in patients with kidney problems, during labor, or in infants under 1 month due to the risk of lung or liver toxicity. The standard dose is 50-100mg orally 4 times daily for 1 week to treat UTIs or nightly for prophylaxis, with common side effects including nausea and changes in urine color.

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    Nitrofurantoin, also known as Macrobid, is a broad spectrum antibiotic used to treat and prevent urinary tract infections. It works by being reduced by bacterial enzymes to reactive intermediates that inhibit vital bacterial processes like DNA, RNA, and protein synthesis. It is contraindicated in patients with kidney problems, during labor, or in infants under 1 month due to the risk of lung or liver toxicity. The standard dose is 50-100mg orally 4 times daily for 1 week to treat UTIs or nightly for prophylaxis, with common side effects including nausea and changes in urine color.

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    © All Rights Reserved
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    11 views1 page

    Nitrofurantoin

    Uploaded by

    victorkabale
    Nitrofurantoin, also known as Macrobid, is a broad spectrum antibiotic used to treat and prevent urinary tract infections. It works by being reduced by bacterial enzymes to reactive intermediates that inhibit vital bacterial processes like DNA, RNA, and protein synthesis. It is contraindicated in patients with kidney problems, during labor, or in infants under 1 month due to the risk of lung or liver toxicity. The standard dose is 50-100mg orally 4 times daily for 1 week to treat UTIs or nightly for prophylaxis, with common side effects including nausea and changes in urine color.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    Nitrofurantoin

    aka Macrobid
    Spectrum : Broad spectrum

    Mechanism of Action:
    Reduced by baterial flavoproteins to reactive intermediates.
    These intermediates inactive or alter batcterial ribosomal proteins and other macromolecules
    cause the inhibition of vital biochemical processes and the synthesis of bacterial DNA, RNA,
    Cell wall and proteins

    Indication
    Urinary tract infectious disease
    Prophylaxis of urinary tract infectious disease

    Contraindication
    Hypersensitivity to Nitrofurantoin
    Anuria
    Significant renal impairment
    Pregnant patients during labour and delivery
    infants under the one month of age

    Dosing

    in UTI
    50-100mg orally 4 times daily for 1 week
    Prophylaxis of a UTI
    50-100mg orally nightly

    side effect
    common: Nausea , Vomiting , Flatulence , change in colour of urine
    Serious: Lung Disease , Liver problems , Numbness or tingling

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