'

TH VOI DANN PH E QUAD

m u m my -

( phair bi.it voi COPD)

RE Ntttttihlm
.
:
'
Kho tho tai phat voi
'

co the phi.ec hot .

that
'

tho bi hep Co
towing .
do : PQ → Thuioo doin cotton PQ .

Vie
'm a phil NE nie
'm mac
,
PQ

tie chat
't
t
nhciy .

chiong Kho trio

kho-khei.na.ngngu.co
'

Trieu : ho , , .

Fc E receptor

+ Phair ving hen sayin cair link →

lo that cotton PQ

ctieiiai Y vein't phivni-niimmo.ec

/
ko d- a , .

being thud l
.

ko dish nhoiy
v

9 tie .

tiefixui di
nguyen v
# acute .

tints
) y viimmqn
.

Viim main : IL 5 Eosinophils

y tai cai
→

Neuron ,
Mast cells u 's Hui
Om alizumab : gain can
.hr Hank Ige .
Auto
ng
tho Cn
guy
'mI
hit

→
d- iii. chink aunt
Khang Ht .
Smooth muscle contraction :
Catt calmodulin ( Cam )
[Cast ) T → bind to →

→
active
myosin light chain kinase →
phosphorylates
chains and
light in
myosin heads
'
increases
myosin
gain vai sa actin bi
's xue tai ATP
ATPase
activity →

→
actin theft Hero
myosin gang co co .

calmodulin
Khong
'

Do co then co
troponin C rien
cast
tietfnh.am
ca d- c dei teu Hong 'tmqng live as
tiring →
ra

TB kink ca boi tai cud inositol

ngooii qua dung
faith thick bit true the
'

tht -
P .
bhi → w

↳
I
'

tin hie.in Tk
*TA law
they En .

I [ Catt ) rig bat cotton PQ .

Smooth Muscle Relaxation :

unbinds from Cam → ko boat

'

[cast ] In →
Cad
how MICK →
actin ko gain myelin → doin e 'd .
 '

http hit
LABA ke
't colticoids
doing .

art ( 3 6h)
tgian tai dung ng
-

DAIN
!
SABA
TH VIC
:

PQ : phot phat Hd nhanh to -5 p)

mhm

eat corn hen PQ ,

dieng nhieiokio .

Agonists :
A. N him chink ,
cuing for motent .

SD
Hong giaid-oa.in hen ccip .

t co that nhanh cluing .

Stimulate P2 -

adrenergic win 2 lungs .

Phair
mm
loaf :
~

°
Non selective adrenergic G) : a
receptor fu ( trim)
-

- ,
,

VD :
epinephrine ladle nature ) pa C phir )
Choir BL : SABA ( short acting Pa agonist ) :
lo ?
°

dei nhaiiometopeolol alls utero ( salbutamol) levabuterob

-

, ,

i
met
r n
aprotelenol
r n
,
terbutaline , .
.
.

LABA : sal met owl ,

for motel
,
indacatewl.CL4h)
'

Cd chi : hoc
.it how Ba -

receptor →
kick hoqt CAMP →

khi
'

"
gian co thin PQ
→ gian PQ er
tang thong .

tuong vai
't
Co che phair tie t [ Cast 3
regain dong ca tu bio
'
t :
:

kho du? the nip bail rang oat TB .

Vic
cluing
'

che nhanh
+ an
ctuiong PLC -
IB voi
Catt cud TB
su
? buy d-orig
myiosin
'
?
che ho.at hoci chair nhe
'
+ U' c .

.
 ?
boat phosphatase chair nhe
Ho .at
myosin
+
.

e
doing doin ein Catt ho.at
Mio 1
,
ho a- Boi
kink Kt gang tai phair ad TB as thin c r ht
,
,

? hath true cadtuaokhod.us the

su net bat .

Tai dung khat :

photng
'
C-I tho ch HC
gian tu TB Mast
+
' Hung .

't
+
T tiet choi
nhaij voi uk ion
qua
bruh mi
otuing
hath long ehuyein
'
he →
T hat lain sa.ch aia eat T B w .

+
t dat
they En TK cholinergic auto ng bhaji hot tqi :

the p
' '

truth synape true uh chi pho thick Ach de

,

ng → →

pxa.co
that PQ
cholinergic -i
gian PQ .

'

C-I see cud cat vimeo.ch I NE intern

+
ri ri →
phii
khi te voi ha nhu '
histamine LT D 4
map thing gian , .

Chi
mm
otinh rn r
:

e
co that PQ do : hen ,
viein PQ , bnqnh phir t .

tu sink
+
Gian
cung ,
n
goin nguia non .

+
T Kt mail .

du.ngngoa.iy.rkophaitaodu.ngd-engunglhuoii.ru
Tai - - -
- -

+
Run at :
thriving gap ,
ht B. receptor ed vain
Tim d- nhanh
+
:p
a .

d-our date
+ 'm
Hiei : ha K Maui , loa.nnh.in ,
T
glucose , ,

't ngii
.

man .
Caii tuiohoa hog : dma teen eaiituio catecholamine bei ?
su
.

'
catechol chive can
thay the nhoin vai bean
.h .

'
cleome
Aebutelol thay the chair bein
CSABA ) LABA
{
→
→
.
.

'

N hanh ma 't tai dung do tai dung cud cai men :

catechol methyl Hanferase methyl how hydroxyl is vi. Hi

'

thu 3 Men mount diving Keio hour

'

ph a- hug lain →

tgian iheart or da dat .

E II
- c -
'

.
'

Ce che boat ctomg '

:
'

Ps -

agonist goin ein receptor → hoqtfwa Gs →

huat hua

ATP
Adenyb cyclase Area protein
-

+ → CAMP → ho.at
channel otcho.at

ae.ajaingeaifmafgmi.cn
kinase T Cott 1kt
:
.

→
. hear .

¥ innate:B
§
'
.
dah cotton
T Nat .
Catt -
ATPase PQ .

✓
d M LOK .

that
'

Khong cain bitt tai nhain gciy co .

Tai dying ngoqi '

:
y
+ Tim ctap nhanh : nguy 'm
hiei tihhma.mg do :

Kt true the p n E nhi

o
.
→
him
atop nhanh .

o
Dain cotton made main →
px gary trim nhanh .

•
Rt this trip Ba receptor 8
-
tain nhi .

+
khi
ding lien cao
Ba →
fat bein fr ( salbutamol ) .

+
Hq Kt mail do T hath true k vair as vain .
Anticholinergic s
nv m -
:

that phei apian

' '

co chi : Ach gciy co

'

Anticholinergic goin thee the Ach regain Ach ,

gain Muscarinic -
M3 .

Cho
'
that PQ I Dain PQ
ng co .

Phair
mm
loaf : -

o
tpattopium bromide ( Alto vent)

o
Tio thopium Cspiiiva) ;
long lasting
-
action → ngcinngua
Umeclidinium .

Kaeding phy Kheng -

: ghinho.in TT timid .

ng l mui atop nhanh

'

Khon mine
.
co
hong .
-

Nghet -
Tim
D- au da
,
dciy -
Aau d-air -
Ho -
Lo ate
Ko gang Noi eoa.nnh.ir .

Ching
~ -
CA : Glaucoma got doing
Phi day tuyen tie-in lift .

t.ihi.ie cap ninth

'
Ko da SD d-oh anticholinergic moi

phai 't
ki hep Ba -

agonist trong hen cait tinh .

 ' phospholipase .
C
Cd chi w al :
T
( Gq)

+
Ach gari M 's →
hoof hood PLC →
Inositol Triphosphate
Catt
'

pho ng tu
'

→
Thi ch SR →
co co .

+
Ach gott Ma C Gi ) →
vic che
"
AC → t cAMP
'

w do .
PQ nho
→
,

+
Doin the dong ,
ko Ivi d-omg =
Ba -

agonist
↳ PQ loin → hi
.in quoi COPD ? Hen
phong Kiu dai
?
+ Tiottipiwm d- a SD du? hen PQ che khi
'

kit hip corticosteroids .

Umeolidiniwm Auto SD dieu
ai
.
chuy th tac ng
hens living KK
Hong COPD .

Anticholinergic : CA E BN hen PQ
ng ?
d-
Io shunt at
org
vain Ba .

.
 Nhoinxanthines.mn Methyl xanthine
no nhieii TD
"

re
+
3
loaf : caffeine Ceci phi) y plus .

d- iii. tu hen tu
theophylline Ata) 1930
'

→
.

theo bromine ( cacao) to Dain PQ Kein Ba

( -

agonist
Kha view or d-a'
glad
-

'
ng
chi tai d-omg .

it a chef
'
men phosphodiesterase →
ko tho ai bien cAMP
th daei PQ
→
day .

Chain true
.
the Adenosine 't
he? Tk ( chat
gang co that PQ

pho ng thick
'
do Histamine & LT )
'

apoptosis
' '

Theophylline uic che hit nhi t

ng you
'

: .
rn
Tae d-
omg
ein TB vie
'm Ct Eosinophils )
t cytokine traffic
t Mediators cytokine, .

t
phir NE
tr co that
T hot as vain he? hh ?
Tai
dung plug :

(t) CNS ,
Ct ) trim .
.
.

SE
throng gap
:
d-au da
.
dciy ,
wot

Thuoi hive d- air

.

do? Ahh
chen p dung Hong ngua.co
via theophylline loin trim .

't DD
'
tieri sie
ng chiding
'

Choi : ret loan PUD Cloe -

teething)
than Hong being : tim .

Khong new nghieii lnhai → faith ving da doig -

lhuoil :
.

Taing tae cimetidine .

lhuoiingua thai allopueinol ,
,

mit Vai KS lain T xanthine maei -

the ath tim

'

Dring chung Nicotine a captain co .

 Dat PQ -

Antileukotriene g 'm
mmmm
: →
Khong vie .

coin
got : Leukotriene receptor antagonists CLRTAS
)
Gorin :

monteeukast (
singularly
zafieukast ( Accolade)
zileuton (
Zyflo) Aspirin y
,
run -

steroids

f
' v

Cd che taedong : PG

acid
chiming
PLA I → Arachidonic .

,
are,

zileuton I

' :÷If
Tain BN hen steroids

.fi
dieng Aspirin ( non

LTC4-i.ae
,
-

:c:c:c:: :c :c:' .

chiding :
n
adult
¥ tin d-
khi 's
gidon
what
I hiving
'

cotton rhoa
+ Du?
phong r then may > tht -

"
Koco tae
du.ngehocinheneaipl.d-d.mg CHO
'
+
Histamine)

+
Montelukast : FDA chophqi dinette hen 8 child 72T ,

vain mui de: ieng .

Tai du
.mg phu i Montelukast iE SE Nhat .

chi d-E qua

'm
'

0 hen
Anti -
LT ding ly er
map ,
ko

cluing cho hen 're

eat Caio lhie.in ht .

cluing Rhi
ding
Chee I tuan moi
,
toi !
.

bhi
d-ant gia coxing doing
'

Luis y gantu .

't can
ta think dari PQ d-eii lain T cAMP .
 co that cotton PQ → T HUGE DEN PQ
- .

I
Hen PQ Viein a
phir NE mein mac
.
PQ

i hit chat nhaij .

Agonist 't
Ea
C
tf;
e-
Nig
: - -

+ Non -
selective :
epinephrine
+ Selective →
SABA ( short
acting B -

agonist )
↳ LABA ( long acting p -

agonist) .

acute asthenic reaction

Emergency : .

+ Mechanism
's : As → T CAMP →
relaxation .

'
+ Side effect :
ally thm ,
run co .

Anticholinergic : →
COPD .

1-