SHARDA UNIVERSITY

SHARDA SCHOOL OF NURSING SCIENCE AND RESEARCH

DRUG
BOOK

SUBMITTED TO - SUBMITTED BY –
JOSHUA SAMUEL
BSC NURSING 4TH YEAR
2020402848
 SERAIL
NUMBER DRUG NAME page no. signature
1 Oxytocin
2 Methergine
3
Carboprost
4
Misoprostol
5
6 Magnesium sulfate
7 Mifepristone
Dinoprostone
8
9 Nifedipine
10 Terbutaline
Indomethacin
11
12 ESTRADIOL
13 Clomiphene citrate
14 Ergometrine
15 Carbetocin injection
Solifenacin
Name of the classification Preparation, Indication contraindication Mode of Factors Adverse Nursing
drug strength and action affecting effect responsibility
dose action of
oxytocin drug

Trade name – oxytocic For mothers prematurity, activate cervical Confusion. It is essential to
Pitocin, hormones Preparation - dilatation,
adding 1 mL who have borderline receptors on monitor patient
Syntocinon, preeclampsia, cephalopelvic smooth muscle parity, and convulsions fluids (both
Viatocinon (containing 10 gestational
units of maternal disproportion, cells and trigger (seizures) intake and
diabetes, previous major calcium ion age outtake) while
oxytocin) to
Generic name- premature surgery on the release from the difficulty in administering
1000 mL of
Synthetic rupture of the cervix or uterus sarcoplasmic breathing. oxytocin and the
0.9% aqueous
oxytocin membranes including Caesarean reticulum. This frequency of
sodium
chloride or For mothers section, increase in fast or uterine
Ringer's lactate with inactive overdistention of intracellular irregular contractions,
uteri that the uterus, grand calcium will heartbeat. patient blood
Strength and require multiparity or cause the pressure, and
dose - 10 stimulation to invasive cervical muscle to headache heart rate of the
units/mL start labor. carcinoma. contract harder (continuing unborn fetus.
with increased or severe)
frequency and
duration in hives.
order to help
with the pelvic or
delivery. abdominal
pain (severe)

skin rash or
itching
Name of classification Preparation, Indication contraindicatio Mode of Factors affecting Adverse Nursing
the drug strength and n action action of drug effect responsibility
Iron sucrose dose
injection

Trade name Administer IV iron Iron Bloating or Monitor BP

iron Ensuring the correct
– Venofer 200 sucrose General sucrose is swelling of the during infusion.
replacement dosage and proper
Venofer mg undiluted should be contraindications dissociated face, arms, May cause
administration according
as a slow considered are iron overload, into iron hands, lower hypotension;
to healthcare provider
Generic intravenous only when non-Iron and legs, or feet. usually related
instructions is crucial for
name – injection over 2 Hb levels deficiency anemia sucrose blurred vision. to rate of
the desired therapeutic
iron sucrose to 5 minutes or are above 7 and known and the chest pain or administration
effect.
as an infusion gm %. In hypersensitivity to iron is tightness in the and total dose
of 200 mg in a case of 7 gm iron sucrose. transported chest. administered.
Response to iron sucrose
maximum of % and as a confusion. Assess for
can vary among
100 mL of below, complex difficult or hypersensitivity
individuals due to
0.9% NaCl blood with labored reactions and
differences in
overa period of transfusion transferrin breathing. anaphylaxis
metabolism and health
15 minutes should be to target dizziness, (rash, dyspnea,
status.
considered. cells faintness, or loss of
20mg (Fe)/m including lightheadedness consciousness,
erythroid The frequency with when getting hypotension,
precursor which iron sucrose is up suddenly collapse,
cells.. administered can impact from a lying or convulsions) for
its effectiveness. sitting position. at least 30 min
Following the prescribed headache. following
schedule is important. nervousness injection.
Name of the classification Preparation, Indication contraindication Mode of Factors Adverse Nursing
drug strength and action affecting effect responsibility
dose action of
carboprost drug
carboprost Fast or The injections
Trade name – 7.2 FDA To treat In patients with a Carboprost Gestational slow
trometamol is should be given
Hemabate Pharmacological severe history of asthma, tromethamine Age heartbeat.
489.65. Excipients in a large
Classification bleeding hypo- or administered
included in the muscle
Generic name - after hypertension, intramuscularly Uterine headache
formulation are aspiration
Carboprost Prostaglandin childbirth cardiovascular, stimulates in the Receptivity
trometamol, should be
Tromethamine Analog. renal, or hepatic gravid uterus increased
sodium chloride performed to
used to disease, anemia, myometrial Dose and pain of
and benzyl alcohol avoid injection
produce an jaundice, diabetes, contractions Route of the into blood
abortion by or epilepsy, similar to Administratio uterus.
At first, 100 to vessel which
causing labour n
250(mcg) injected can result in
deep into a uterine contractions at shortness Broncho spasm,
muscle. Then, 250 contractions the end of a full of breath. and shock.
to 500 mcg every term pregnancy Check vital
one and one-half signs
to three and one- After
half hours for up administration
to two days. monitor uterine
status and
bleeding
carefully.
Name of the classification Preparation, Indication contraindication Mode of Factors Adverse Nursing
drug strength and action affecting effect responsibility
dose action of
Misoprostol drug

the reagent prevention pelvic infection or inhibits basal chills, Assess patient
synthetic and sepsis, and nocturnal Dosage and diarrhoea, requiring
needed for the Administration abdominal
Trade name – prostaglandin treatment of hemodynamic gastric acid induction/cervical
cuprate
Cytotec E1 analog NSAID- instability or shock, secretion pain, ripening.
coupling is Timing of
prepared by the induced allergy to through direct hyperthermia,
Generic name gastric ulcers misoprostol, known stimulation of Administration nausea, understand the
reaction of
- Mifepristone in patients bleeding disorder, prostaglandin vomiting, physiology of
vinyl stannane Patient-
(85:15 ratio taking concurrent E1 receptors flatulence, prostaglandins
NSAIDs and anticoagulant on parietal Specific constipation, and management
mixture of the Factors
trans and cis at high risk therapy, and cells in the dyspepsia, of misoprostol in
isomers) with for confirmed or stomach. headache, labor
copper iodide ulceration. suspected ectopic breakthrough
and or molar bleeding, and
methyllithium. pregnancy. menstrual
irregularity.
100mcg
200mcg
Name of the classification Preparation, Indication contraindication Mode of Factors Adverse Nursing
drug strength and action affecting effect responsibility
dose action of
Magnesium drug
sulfate
Magnesium
Trade name – alkaline earth sulfate is for women Hypersensitivity. Its mechanism attitudes and flushing Monitor vital
Epsom salt metal usually with pre- of action is beliefs, signs, oxygen
obtained eclampsia for Myocardial likely multi- complexities feeling saturation,
Generic name directly from whom there is damage, factorial, of uncomfortably respiration, deep
- magnesium dry lake beds concern about encompassing administering warm tendon reflexes,
sulfate and other the risk of diabetic coma, both vascular , knowledge level of
natural eclampsia • and and headache consciousness,
first-line heart block. neurological experience, fetal heart rate,
sources. It can
also be management of mechanisms. capability of dry mouth maternal uterine
an eclamptic Hypermagnesemia. Being a health activity, and
prepared by
reacting seizure • first- calcium systems to nausea renal function
line treatment Hypercalcemia. antagonist, its ensure when used
magnesite
(magnesium of any seizure effect on blurred vision during
during Administration vascular MgSO4 pregnancy.
carbonate,
pregnancy • during 2 hours smooth muscle availability at Monitor
MgCO 3)
neuroprotectio preceding delivery to promote point of use magnesium
n of preterm for mothers with relaxation and (availability, concentrations
40mg/mL infants. toxemia of vasodilation resourcing every 4 hr in
80mg/mL pregnancy. may have a and pathways patients with
50% role in to care) and renal dysfunction
lowering total knowledge (every 2 hr if
peripheral translation serum
vascular magnesium is
resistance elevated).
Name of the classification Preparation, Indication contraindication Mode of Factors affecting Adverse Nursing
drug strength and action action of drug effect responsibility
dose
Mifepristone

antiprogestational Cervical Chronic adrenal Some products that

200 mg PO Mifepristone Bacterial Instruct patient
Trade name – steroids. ripening failure may interact with
followed 48 works by infections to notify health
Mifeprex before MTP this drug include:
hours later by being an and care
up to 24 Suspected ectopic long-term
misoprostol. antagonist of prolonged, professional
Generic name – hours. pregnancy corticosteroid
glucocorticoid heavy immediately if
Mifepristone therapy (such as,
and menstrual she develops
Labor Severe asthma and prednisone), other
progesterone bleeding. weakness,
induction in acute porphyrias drugs that can cause
receptors. At nausea,
IUFD bleeding/bruising
low doses, vomiting,
(including
mifepristone diarrhea, with
antiplatelet drugs
works by or without
such as clopidogrel,
being a abdominal pain
NSAIDs such as
selective or fever more
ibuprofen/naproxen,
antagonist of than 24 hr after
"blood thinners"
progesterone. taking
such as
It does so by mifepristone;
warfarin/dabigatran).
binding to the may indicate
intracellular life-threatening
progesterone sepsis. Inform
receptor. At patient that
high doses, vaginal
mifepristone bleeding and
blocks cortisol uterine
at the cramping will
glucocorticoid probably occur.
receptor.
Name of classification Preparation, Indication contraindication Mode of Factors affecting Adverse Nursing
the drug strength action action of drug effect responsibility
Tab and dose
calcium

Trade name Ensuring the correct

1000 mg to A pregnancy hypersensitivity, acts constipation, Monitor the vital
– dosage, as prescribed by
calcium complication renal calculus, by directly severe signs.
Caltrate, Os- supplement 1300 mg a healthcare
daily marked by high urine calcium increasing diarrhea,
Cal, Oysco, professional, is crucial
high blood levels, elevated calcium and encouraging
Citracal for achieving the
pressure and serum calcium, stores within abdominal fluid intake and
desired therapeutic
protein in the low serum the body. pain. ambulation.
Generic effect.
urine (pre- phosphate, Fluids containing
name – eclampsia). achlorhydria, or sodium should
CaCl Certain medical
suspected digoxin be used unless
conditions may
toxicity. contraindicated
influence how the body
processes and responds as sodium
to calcium channel increases
blockers. Conditions calcium
like liver or kidney excretion.
problems can impact Cardiac rhythm
the medication's action. should be
monitored.
People may respond Calcium levels
differently to should be
medications due to monitored as
variations in their ordered, as well
metabolism and genetic as sodium and
makeup. potassium levels
due to use of
diuretics.
Name of classification Preparation, Indication contraindication Mode of Factors Adverse Nursing
the drug strength and action affecting effect responsibility
dose action of
Nifedipine drug

Trade name dihydropyridine The process for the It is used to In severe aortic inhibits the Dosage and Dizziness monitor the
subclass preparation of
– nifedipine of the treat high stenosis, nifedipine entry of Administration patient blood
Adalat, invention is blood can cause calcium lightheadedness pressure as well
Adipine, preferably carried pressure ventricular ions by Timing of as their pulse.
Coracten, out in such a way (hypertension) collapse and blocking Administration fainting Be sure to also
Fortipine, that the methyl 2- and chest pain dysfunction. In these monitor your
Nifedipress (2- (angina). unstable angina, voltage- Patient- patient's
nitrobenzylidene) nifedipine causes a dependent Specific calcium levels
Generic acetoacetate and reflexive increase L-type Factors when they are
name – the methyl 3- in cardiac calcium on this drug and
nifedipine aminocrotonate are contractility, channels in teach the patient
reacted in a molar which increases vascular to not drink
ratio of methyl 2- myocardial oxygen smooth grapefruit juice
(2- demand and muscle and and also teach
nitrobenzylidene) worsens the myocardial them how to
acetoacetate/methy ischemia. cells take their blood
l 3-aminocrotonate pressure and
of 1 to 1.5. pulse.

capsule
10mg
20mg
Name of the classification Preparation, Indication contraindication Mode of Factors Adverse Nursing
drug strength and action affecting effect responsibility
dose action of
Terbutaline drug

Trade name – beta agonists to prevent Using this medicine Terbutaline is

Bronclyn, hydroxyl
protection, the and treat to prevent or treat a selective b2- Dosage and tremors Informed
Brethine, wheezing, preterm labor can receptor Administration Consent
Bricanyl, bromination
reaction, shortness of harm pregnant agonist that tachycardia
Brethaire, breath, and women. This produces Timing of Monitoring
Marex, carbonyl
reduction, the chest medicine may relaxation of Administration hypotension
condensation tightness increase risk of smooth Patient Safety
Generic name- caused by heart problems and muscle found Patient- pulmonary
terbutaline reaction and
sulphating. asthma, other serious side principally in Specific edema Patient
chronic effects when given bronchial, Factors Counselling
tablet- bronchitis, to a pregnant vascular and hyperglycemia.
2.5mg and woman for a long uterine tissues. Regular Follow-
5mg emphysema. time. up

injectable
solution-

1mg/mL
Name of the classifi Preparation, Indication contraindic Mode of Factors affecting Adverse effect Nursing
drug cation strength and ation action action of drug responsibility
dose
Labetalol

Trade name – Monitor BP and

Trandate Withdraw Factors like age,
beta 40mL sodium Labetalol Labetalol is It works Feeling sleepy, pulse frequently
weight, and overall
blockers chloride 0.9% injections contraindicat by relaxing dizzy or weak. If during dose
Generic name – health can impact
from a 100mL are ed blood vessels labetalol makes you adjustment and
labetalol how the body
bag of sodium indicated to in cardiogeni and slowing feel dizzy or weak, periodically
responds to
chloride control c shock, sinus heart rate to stop what you're during therapy
labetalol.
0.9%. Draw up blood bradycardia improve blood doing and sit or lie
200mg labetalol pressure in and greater flow and down until you feel Check frequency
People may
(40 mL) and add severe than first decrease blood better. ... of refills to
respond differently
to remaining 60 hypertensio degree block, pressure. Headaches. Make determine
to medications due
mL in the bag of n bronchial sure you rest and compliance.
to variations in
sodium chloride asthma, drink plenty of
their metabolism
0.9%. Final congestive fluids. Patients receiving
and genetic
concentration is heart failure makeup. IV labetalol must
2 mg/mL. Cold fingers or toes. be supine during
The effectiveness and for 3 hr after
injectable Feeling sick or administration.
of labetalol can be
solution being sick (nausea
influenced by the
 5mg/mL
or vomiting) ... Monitor intake
prescribed dosage.
tablet Diarrhoea. ... and output ratios
Ensuring the
 100mg
Stomach pain. and daily weight.
correct dosage is
 200mg crucial for
 300mg achieving the
desired therapeutic
effect.
Name of the classification Preparation, Indication contraindication Mode of Factors Adverse Nursing
drug strength and action affecting effect responsibility
dose action of
ESTRADIO drug
L Estrone is
- Estrogen Injectable Dosage and
solution Estradiol is Documented converted to Nausea, Informed
Trade name - receptor indicated in hypersensitivity estradiol in the Administration Breast Consent
 5
Vivelle-Dot, agonist various granulosa cells Tenderness,
mg/mL Individual
Delestrogen, preparations for Known of the ovary Blood Monitoring
 10
EstroGel the treatment of anaphylactic by the enzyme Variability Clotting
mg/mL
 20
moderate to reaction or 17-beta- Risk, Patient Safety
Generic name – severe angioedema with hydroxysteroid Health bloating,
mg/mL Conditions
estradiol vasomotor topical emulsion dehydrogenase abdominal Patient
 40
mg/mL symptoms and (17-beta- cramps, skin Counselling
vulvar and Known protein C, HSD). The Route of pigmentation
Tablet Administration , melasma,
 0.45
vaginal atrophy protein S, or aromatization Regular
mg (as due to antithrombin of testosterone Weight Follow-up
menopause, for deficiency or other synthesizes Hormonal Changes,
acetate) Status
 0.5 mg
the treatment of known estradiol. swelling in
 0.9 mg
hypoestrogenis thrombophilic Estradiol is a the hands and
m due to disorder steroid Menstrual Headache.
(as Cycle
acetate) hypogonadism, hormone and,
 1 mg
castration, or Active or previous therefore, can
 1.5 mg
primary ovarian breast cancer easily cross
 2 mg
failure, and for the cell
the prevention membrane
of
postmenopausal
osteoporosis
Name of the classification Preparation, Indication contraindication Mode of Factors Adverse Nursing
drug strength and action affecting effect responsibility
dose action of
Clomiphen drug
e citrate
To treat Pregnancy Clomiphene Adherence to headache, Assess the
Trade name – Estrogen patients citrate, a widely the prescribed dizziness, patient's
A solution of
Clomid, receptor diagnosed Breastfeeding used medication dosage and exacerbation understanding of
racemic
Serophene antagonist with in the realm of administration of psychiatric the medication,
binaphthyl-
anovulatory History of hepatic infertility schedule is illnesses, its purpose, and
phosphoric acid
or oligo- impairment treatment, crucial. gynecomastia, potential side
45 gr in 1000 mL
Generic name was added at T= ovulatory Hepatic disease exerts its testicular effects.
– clomiphene infertility to primary mode medical tumor, Discuss the
30°C. The
citrate. induce Abnormal uterine of action history is vasomotor importance of
obtained solution
ovulation bleeding through the essential. flushing, adherence to the
was stirred at r.t.
for patients intricate Factors such gastrointestinal prescribed
for 1 h. The
wishing to Uncontrolled regulation of as polycystic disturbance, treatment plan
suspension was
conceive. It adrenal hormonal ovary and mastalgia and the timing
filtered and the
is also dysfunction processes syndrome of medication
solid was wash
indicated Non-PCOS related involving the (PCOS), administration
with 100 mL of
for the ovarian cyst hypothalamus, thyroid Assess for any
Methanol. 79.7 gr
treatment of pituitary gland, disorders, and signs of ovarian
of E-Clomiphene
male Organic and ovaries. other hyperstimulation
salt with racemic
infertility to intracranial lesions hormonal syndrome
binaphthyl-
induce imbalances (OHSS), such as
phosphoric acid
spermatoge Uncontrolled can influence abdominal pain,
were obtained.
nesis thyroid disease the response bloating, or
to clomiphene respiratory
50 mg orally citrate. distress
Name of the classification Preparation, Indication contraindication Mode of action Factors Adverse Nursing
drug strength affecting effect responsibility
and dose action of
Ergometrin drug
e
Used to treat Hypersensitivity Ergometrine, also The timing of Anaphylactic, Maintain
water-soluble 500 administratio
micrograms postpartum to the active known as Headache, accurate and
Trade name – lysergic acid haemorrhage substance or to ergonovine, n dizziness, detailed
Ergotrate, derivative and post any of the operates as an Cardiac documentation
Ergostat, and abortion excipients ergot alkaloid with aiming to arrhythmias, of the patient's
Syntometrine haemorrhage a multifaceted enhance palpitations, treatment plan,
in patients Primary or mode of action uterine bradycardia, including
Generic name – with uterine secondary uterine primarily centered contraction chest pain, dosage
ergonovine atony. inertia on uterine smooth and prevent Hypertension, adjustments,
muscle excessive vasoconstriction, monitoring
Severe contraction. bleeding Nausea, results, and any
hypertension, pre- Widely utilized in vomiting, patient-
eclampsia, obstetrics to previous abdominal pain, reported
eclampsia prevent and uterine Dyspnoea, symptoms or
manage surgery or the pulmonary concerns.
Severe cardiac postpartum presence of edema
disorders haemorrhage, its fibroids, plays
mechanism a pivotal role
Sepsis involves binding in
to various determining
receptors, the drug's
particularly alpha- response
adrenergic and
serotonin receptors
on smooth muscle
cells.
Name of the classification Preparation, Indication contraindication Mode of Factors Adverse Nursing
drug strength and action affecting effect responsibility
Carbetocin dose action of
drug
injection

Mix buffer and To control Conditions that are Carbetocin is a Nausea, Informed Consent
oxytocin agent Acetonitrile in postpartum prone to synthetic Dosage and vomitus
Trade name – hormone haemorrhage vasoconstriction, Administration and
ratio of 50: 50. analogue of Dosage
Duratocin and bleeding such as vascular
Degas and filter oxytocin with a flushing are Calculation
through 0.22 µ after giving disorders or certain longer duration Timing of the most
Generic name birth. neurological Administration frequent
filter paper. of activity. It Medication
– Carbetocin Carbetocin is conditions
Diluent: Water. selectively adverse Preparation
Assay a drug used to binds to Patient- effects
preparation control Individuals with oxytocin Specific encountered Monitoring
(Test solution): postpartum severe receptors in the Factors when
Take ten haemorrhage, cardiovascular uterine smooth carbetocin Administer
Lyophilized bleeding after diseases, such as muscle, thereby Uterine Tone or oxytocin carbetocin using
vials and each giving birth. heart failure or stimulating is used for the prescribed
vial It significant valvular rhythmic Labor the route (intravenous
reconstituted disorders uterine Induction or prevention or intramuscular)
with 1 ml water contractions Augmentation of PPH. with careful
for Injection and increasing High bp attention to
both the and heart proper injection
100 frequency of rate are also techniques.
micrograms (1 existing Change the
mL) contractions needle to a new,
and uterine sterile one before
tone. administration
Name of the classification Preparation, Indication contraindication Mode of Factors Adverse Nursing
drug strength and action affecting effect responsibility
dose action of
Solifenacin drug

Trade name- Tablet used to treat contraindicated in decrease Dosage and dry mouth. top taking this
Vesicare antimuscarinics  5mg bladder patients with bladder Administration headache. drug and report
(VESIcare) problems, urinary retention, activity by feeling to physician if
generic name-  10mg including gastric retention, inhibiting Timing of dizzy, urinary retention
Solifenacin (VESIcare) neurogenic uncontrolled contraction of Administration sleepy, or a occurs.
detrusor narrow-angle the smooth spinning Report promptly
overactivity glaucoma, and in muscle wall Patient- sensation any of the
and patients who have surrounding Specific (vertigo) following:
symptoms of demonstrated the bladder. Factors diarrhoea or blurred vision or
an overactive hypersensitivity to being sick difficulty
bladder, such the drug substance Uterine Tone (vomiting) focusing vision,
as or other constipation. palpitations,
incontinence components of the farting and confusion, or
(loss of product. burping severe dizziness.
bladder (wind)
control), a stomach
strong need pain.
to urinate dry eyes
right away,
or a frequent
need to
urinate.
Name of classification Preparation, Indication contraindication Mode of Factors Adverse Nursing
the drug strength and action affecting effect responsibility
dose action of drug
Ampicillin

Ampicillin is Nausea
Trade name Mix 2 g Amp usually
beta-lactam reduce the
powder into 20 mL Ampicillin is The Watch for seizures;
– antibiotic proportion of contraindicated in mechanisms administered on Skin notify physician
Ampi, of MilliQ H2O. 2. an empty
Vortex until preterm the treatment of action of immediately if
Omnipen birth in of infections ampicillin are stomach for rashes patient develops or
powder is optimal
thoroughly pregnant caused by interference increases seizure
Generic women with penicillinase- with cell wall absorption. Itching activity. Monitor
name- dissolved However, it can
acute producing synthesis by signs of
Principen infectious organisms. attachment to be taken with Abdominal pseudomembranous
capsules food to reduce
 250mg
diseases of penicillin- pain colitis, including
the binding the likelihood of diarrhea, abdominal
 500mg
genitourinary proteins gastrointestinal pain, fever, pus or
oral suspension upset.
 125mg/5mL
and (PBPs), mucus in stool, and
respiratory inhibition of Maintaining other severe or
 250mg/5mL
system. cell wall therapeutic prolonged GI
powder for levels in the
injection peptidoglycan problems (nausea,
synthesis and body usually vomiting,
 125mg
inactivation requires a heartburn).
 250mg
of inhibitors consistent
 500mg
to autolytic dosing schedule.
 1g
 2g enzymes.
 10g
 Conclusion
The field of obstetrics thus deals with the wellbeing of the pregnant mother as well as the
delivery and healthy outcome. Obstetricians closely work with the pediatricians and
neonatologists to deal with care of the newborn baby to reduce the chances of mortality and
disease of the newborn.
 Bibliography
 Schenkel L, Simões-Wüst AP, Hösli I, von Mandach U. Drugs in pregnancy and lactation–medications used in Swiss
obstetrics. Zeitschrift für Geburtshilfe und Neonatologie. 2018 Aug;222(04):152-65.

 Roelants F. The use of neuraxial adjuvant drugs (neostigmine, clonidine) in obstetrics. Current Opinion in
Anesthesiology. 2006 Jun 1;19(3):233-7.