Scribd Logo
Upload

Welcome to Scribd!

  • Clase IX Modelos Animales

    Uploaded by

    Enrique Benavente Aliaga
    4 views28 pages
    This document discusses the neurobiology of human development. It covers topics such as the structure and function of the cerebral cortex, cortical circuits including interneurons, the classification and layers of the cerebral cortex, and how imbalances in inhibition and excitation can lead to disorders. It also discusses the origin of interneurons from the dorsal and ventral pallium, subtypes of interneurons, and provides an overview of how synaptic problems can relate to disorders like schizophrenia, autism spectrum disorder (Rett's syndrome and fragile X syndrome specifically), and others.

    Original Description:

    Original Title

    Clase IX Modelos animales

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    This document discusses the neurobiology of human development. It covers topics such as the structure and function of the cerebral cortex, cortical circuits including interneurons, the classification and layers of the cerebral cortex, and how imbalances in inhibition and excitation can lead to disorders. It also discusses the origin of interneurons from the dorsal and ventral pallium, subtypes of interneurons, and provides an overview of how synaptic problems can relate to disorders like schizophrenia, autism spectrum disorder (Rett's syndrome and fragile X syndrome specifically), and others.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    4 views28 pages

    Clase IX Modelos Animales

    Uploaded by

    Enrique Benavente Aliaga
    This document discusses the neurobiology of human development. It covers topics such as the structure and function of the cerebral cortex, cortical circuits including interneurons, the classification and layers of the cerebral cortex, and how imbalances in inhibition and excitation can lead to disorders. It also discusses the origin of interneurons from the dorsal and ventral pallium, subtypes of interneurons, and provides an overview of how synaptic problems can relate to disorders like schizophrenia, autism spectrum disorder (Rett's syndrome and fragile X syndrome specifically), and others.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 28

    Neurobiología

    del desarrollo
    humano (2022)
    Magíster en Neuropsicología Pediátrica
    30 de abril de 2022

    Maxs Méndez-Ruette (mmendez@miuandes.cl)


    THE CEREBRAL CORTEX:
    MOTOR
    CORTEX
    SOMATIC
    SENSORY AREA

    CONSCIOUSNESS

    VISION
    SPEECH

    TASTE
    AUDITION CEREBELLUM

    Kandel E.R., 2013

    2
    CORTICAL CIRCUITS:

    3
    CORTICAL CIRCUITS:
    INTERNEURONS

    4
    CORTICAL CIRCUITS:
    INTERNEURONS

    5
    CLASSIFICATION: BY MORPHOLOGY
    BY CHARACTERISTIC MARKERS

    LAYERS

    II/III

    IV

    VI

    CEREBRAL CORTEX

    6
    INHIBITION/ECXITATORY UNBALANCE LEADS TO:

    OVER-INHIBITION
    Down's syndrome Neurofibromatosis type I
    Kleschevnikov et al, 2004 Costa et al, 2002

    7
    INHIBITION/ECXITATORY UNBALANCE LEADS TO:

    OVER-ECXITATION
    Schizophrenia Autism Fragile X syndrome Rett’s syndrome
    Flames et al, 2011 Penagarikano et al, 2011 Selby et al, 2007 Chao et al, 2010

    8
    ORIGIN OF INTERNEURONS

    DORSAL

    ANTERIOR E14.5

    POSTERIOR

    PALLIUM
    VENTRAL

    SUBPALLIUM

    9
    ORIGIN OF INTERNEURONS

    Marginal Zone

    INTERNEURON
    PALLIUM
    Cortical Plate

    RADIAL
    PYRAMIDAL Sub-plate
    CELL

    Intermediate zone

    Subventricula zone (SVZ)

    TANGENTIAL INTERMEDIATE
    PROGENITOR
    Ventricula zone (VZ)
    RADIAL GLIA
    SUBPALLIUM

    10
    ORIGIN OF INTERNEURONS

    E14.5

    11
    Subapical glia

    Interneuron progenitor

    Radial glia

    Neuron

    BrdU cell

    12
    INTERNEURON SUBTYPES

    Subapical glia

    Interneuron progenitor

    Radial glia

    Neuron

    BrdU cell

    13
    OVERVIEW
    OVERVIEW
    OVERVIEW
    Schizophrenia
    Schizophrenia
    Schizophrenia
    Rett’s síndrome (ASD)
    Rett’s síndrome (ASD)
    Rett’s síndrome (ASD)
    FXS (ASD)
    FXS (ASD)
    Synaptic problems
    Synaptic problems
    Synaptic problems
    Coordinador del curso: Maxs Méndez-Ruette (mmendez@miuandes.cl)
    Coordinador del Magister: Ana Karen Fernández (afernandezp@uandes.cl)

    You might also like