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Cytotherapy
Volume 21, Issue 5, Supplement, May 2019, Page S60
207
1 Immunohematology and Transfusion Medicine, Armed Forces Medical College, Pune, Maharashtra, India
2 Transfusion Medicine, All India Institute of Medical Sciences, Raipur, India
3 Transfusion Medicine, AFTC, New Delhi, India
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Results
CD 34 count, TLC, and Hb of the product were measured before as well as after RBC depletion
(Table attached). Recovered CD 34 was found to be in the range of 75-80 % in all the cases. The
depletion process was highly effective as the final product had less than 1 gm% of hemoglobin.
No adverse transfusion reaction was observed during transfusion of PBSCs in any recipient.
Chimerism studies by VNTR analysis showed increasing donor chimerism. Successful
engraftment was achieved in 80% of these cases.
Conclusion
As automated platforms and cell sorters for RBC depletion in PBSC are not available at most of
the centers in developing counties, use of HES can be successfully employed using the modified
method suggested, especially in case of an unexpected acute hemolytic transfusion reaction.
Considering the limited literature available regarding this procedure, this case series provides
significant insight into the expected challenges and modifications to resolve them.
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