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T h u m b Ba s a l J o i n t A r t h r i t i s

Brent B. Pickrell, MD, Kyle R. Eberlin, MD*

KEYWORDS
 Basal joint arthritis  CMC arthritis  Trapezial-metacarpal joint  Osteoarthritis  Trapeziectomy
 Ligament reconstruction tendon interposition

KEY POINTS
 Thumb basal joint arthritis is a common condition that may be treated with both nonoperative and
operative modalities.
 Nonoperative treatment modalities include splinting, corticosteroid injections, and behavioral modi-
fication with hand therapy.
 Options for surgical intervention include arthroscopic debridement, trapeziectomy alone, trapeziec-
tomy with ligament reconstruction and tendon interposition, trapeziectomy with tightrope suspen-
sion, extension osteotomy, and arthrodesis, although high-level evidence is currently lacking to
support one surgical treatment over another.

INTRODUCTION relief, maintenance of thumb motion, and provi-


sion of joint stability.
Degenerative arthritis of the thumb carpometacar-
pal (CMC) joint is a common condition that can
result in pain, progressive deformity, weakness, PATHOPHYSIOLOGY
and loss of motion. It can be a cause of functional
disability, particularly in postmenopausal women,1 Because of the common nature of this condition,
and is a frequently noted radiologic finding that there has been a focus on elucidating the etiology
seems to correlate with advanced age and female of the disease process. Many prior reports impli-
gender.2 The age-adjusted prevalence of thumb cate the anterior oblique ligament in the patho-
CMC arthritis is 7% for men and 15% for women.3 physiology of this condition; however, some
Radiographically, it has been estimated to affect contemporary anatomic studies indicate that the
up to 36% of postmenopausal women.4,5 pathomechanics may involve the dorsoradial liga-
Despite the ubiquitous nature of thumb CMC ment.7,8 Clifton and colleagues9 suggested a
arthritis, not all patients with radiographic changes possible role for the peptide hormone relaxin to
are symptomatic and present for evaluation by a explain female predilection, although this mecha-
hand surgeon. In fact, most patients with arthritic nism is still not well understood.
changes at the thumb CMC joint are able to adapt Regardless of the cause, patients develop sub-
their activities and do not undergo intervention. luxation of the thumb metacarpal on the trape-
In some individuals, however, nonoperative zium10 and progressive erosive changes of the
modalities are unsuccessful in mitigating symp- trapeziometacarpal joint, resulting in wear and
toms. Surgical interventions for thumb CMC progressive deterioration of the articular cartilage.
arthritis are among the most common procedures Over time, thumb mechanics are altered and there
performed by US hand surgeons, with only carpal can be hyperextension of the metacarpophalan-
plasticsurgery.theclinics.com

tunnel and trigger finger release being more geal (MP) joint, resulting in further pain and
common.6 The goals of treatment include pain instability.

Disclosures: Dr B.B. Pickrell has no disclosures. Dr K.R. Eberlin is a consultant for AxoGen and Integra.
Division of Plastic and Reconstructive Surgery, Harvard Medical School, Massachusetts General Hospital, Wang
Building, 55 Fruit Street, Boston, MA 02114, USA
* Corresponding author.
E-mail address: keberlin@mgh.harvard.edu

Clin Plastic Surg 46 (2019) 407–413


https://doi.org/10.1016/j.cps.2019.02.010
0094-1298/19/Ó 2019 Elsevier Inc. All rights reserved.
408 Pickrell & Eberlin

DIAGNOSIS
Table 1
The diagnosis of thumb CMC arthritis is made Eaton classification of thumb carpometacarpal
primarily based on history and physical examina- arthritis
tion and is further supported by radiographic
Eaton
imaging.1 Patients typically present with a Stage Radiographic Characteristics
gradual, insidious onset of progressively wors-
ening pain at the base of the thumb at the I Normal or slightly widened
CMC joint. They may describe pain with pinching trapeziometacarpal joint;
trapeziometacarpal subluxation
and gripping maneuvers and/or difficulty turning
up to one-third of the articular
keys, opening jars, or gripping door knobs. surface; normal articular contours
Symptoms should be differentiated from first
II Decreased trapeziometacarpal joint
extensor compartment tenosynovitis (de Quer- space; trapeziometacarpal
vain disease) and stenosing tenosynovitis of the subluxation up to one-third of the
thumb (trigger thumb). articular surface; osteophytes or
On examination, there is often point tenderness loose bodies <2 mm
over the thumb CMC joint. Axial grind test is pos- III Decreased trapeziometacarpal joint
itive if there is pain on axial compression and rota- space; trapeziometacarpal
tion of the thumb metacarpal. This test has a 97% subluxation more than one-third of
specificity but only 30% sensitivity.11 A more sen- the articular surface; osteophytes or
sitive test may be the “traction-shift” test in which loose bodies 2 mm; subchondral
the metacarpal is passively subluxed and then cysts or sclerosis
relocated, eliciting pain with this motion (67% IV Involvement of the scaphotrapezial
sensitivity, 100% specificity).11 The senior investi- joint or less commonly the trapezio-
gator typically uses both maneuvers during phys- trapezoid or trapeziometacarpal
ical examination of patients with suspected CMC joint of the index
arthritis. (From Bakri K, Moran SL. Thumb carpometacarpal
With progressive disease, examination findings arthritis. Plast Reconstr Surg 2015;135:508–20; with
include a dorsoradial prominence of the base of permission.)
the thumb metacarpal caused by dorsal subluxa-
in patients with mild or moderate symptoms
tion: the “shoulder sign.”10 In addition, the thumb
and/or early-stage radiographic disease. Nonoper-
may develop an adduction deformity with
ative management options include activity modifi-
compensatory hyperextension of the MP joint
cation, oral analgesics, provision of orthoses,
and flexion of the interphalangeal joint: the char-
strengthening/flexibility exercises, and corticoste-
acteristic “Z deformity.”1 Pinch and grip strength
roid injections.
are often diminished.1
Radiographic evaluation includes posteroante-
Orthoses
rior, lateral, and oblique views of the hand to visu-
Splinting is a common first-line treatment for many
alize the CMC joint. The Robert view12 may be
patients. The goals of splinting for CMC arthritis
helpful, as it allows visualization of all 4 trapezial
are to increase stability and reduce mechanical
articulations; the thumb is positioned with the dor-
stress, thereby decreasing pain and improving
sal side of the hand flat on the plate with pronation
function. Orthoses have been shown to provide
of the wrist. The Lewis modification13–15 of the
modest pain relief for CMC arthritis in several prior
Robert view angles 15 proximally and is preferred
studies,19–21 but results may take up to 12 months
by some investigators.16 Advanced imaging is
to fully manifest.22 A systematic review published
rarely performed. In 1973, Eaton and Littler17
in 2015 concluded that orthoses can provide
devised a widely accepted radiographic staging
pain relief but do not seem to alter function,
system for thumb CMC arthritis (Table 1). Howev-
strength, or dexterity.23 Recently, Becker and col-
er, this classification system has been recently
leagues19 showed that Neoprene orthoses may be
challenged due to suboptimal interobserver
more comfortable, as effective, and cheaper than
reliability.18
customized thermoplastic splints. Similarly, a re-
view by Egan and Brousseau24 concluded that
TREATMENT
most splints are equivalent in terms of comfort,
Nonoperative Management
pain relief, or function. Patients may wear ortho-
Treatment for CMC arthritis of the thumb often ses either at nighttime only or as needed during
begins with nonoperative management, particularly the day.
Thumb Basal Joint Arthritis 409

Fig. 1. (A, B) After performing an apex volar osteotomy, the osteotomized segments are stabilized with a 20-
gauze steel wire passed through drill holes made in the proximal and distal portions of the osteotomized meta-
carpal. The wires are then twist-tied to compress the surfaces together. (Courtesy of Neal Chen, MD, Massachu-
setts General Hospital.)

Oral analgesics of synovial fluid in the joint space.29 A recent system-


Oral analgesics (eg, nonsteroidal antiinflammatory atic review23 found evidence for pain relief from both
drugs) are commonly used by patients and can steroid and hyaluronate injections and noted that
be supplemented with topical Diclofenac gel, most studies found hyaluronate to be more effective
which has been shown in a double-blind random- and longer-lasting than steroid injections.
ized control trial (RCT)25 to reduce pain by 40% in
hand osteoarthritis. These medications may pro-
Operative Treatment
vide pain relief but do not alter the natural history
of disease (ie, articular changes). Older patients Many surgical options are available for patients
and those with renal dysfunction should be who remain symptomatic despite nonoperative
cautioned about the prolonged use of NSAIDs. management. Surgical options include extension
osteotomy, CMC arthroscopy with debridement,
Injections trapeziectomy alone, trapeziectomy with ligament
Corticosteroid injections may provide short- reconstruction and tendon interposition (LRTI),
term pain relief for patients with early CMC trapeziectomy with tightrope suspension, CMC
arthritis.26,27 Injecting 2.5 to 40 mg of triamcino- arthrodesis, and implant arthroplasty. However,
lone with or without local anesthetic is common there is little high-level evidence to favor one oper-
practice and may be effective.1 Despite its use ation over another.30
for early stage arthritis, an RCT in 2004 showed
no benefit from intraarticular steroid injection in Extension osteotomy
moderate to severe CMC arthritis compared An osteotomy of the thumb metacarpal may
with placebo injection.28 There is significant decrease attritional wear of the CMC joint. This is
practice variation with regard to steroid injec- done by performing a 30-degree metacarpal clos-
tions; some surgeons use them regularly, ing wedge extension osteotomy (Fig. 1), which can
whereas others use them infrequently in the inhibit dorsoradial subluxation and alter the force
care of patients with CMC arthritis. distribution to unload the volar segment of the
Hyaluronic acid injections may also be effective CMC joint.31 Although it does not surgically alter
and aim to restore the reduced viscoelasticity the trapeziometacarpal joint, it has been shown
410 Pickrell & Eberlin

to be successful in improving symptoms.32–34 Trapeziectomy alone


Chou and colleagues32 found high satisfaction Surgical excision of the trapezium was first
rates and low pain levels, as well as similar pinch described by Gervis in 194716 and remains a com-
strength and thumb radial abduction compared mon component of many surgical techniques for
with contralateral untreated thumbs. At 2-year the treatment of CMC arthritis.1 With this tech-
follow-up, Tomaino34 reported increased grip nique, the trapezium is excised in its entirety and
and pinch strength in patients with Eaton stage I the joint space is maintained through the develop-
disease and greater than 90% patient satisfaction. ment of hematoma. A Cochrane review published
Hobby and colleagues33 reported long-term pain in 2009 indicated that trapeziectomy alone was
relief (mean 6.8 years) in 80% of patients undergo- associated with fewer complications than trape-
ing this technique. ziectomy with LRTI, while providing similar func-
tional outcomes with regard to improvement in
Carpometacarpal arthroscopy with pain, grip, and pinch strength.40 Other studies
debridement have indicated equivalency of trapeziectomy alone
Another surgical option for early stage CMC compared with trapeziectomy with LRTI, and it is
arthritis that has recently gained popularity is unknown if further benefit is conferred through
CMC arthroscopy with debridement and syno- the addition of adjunctive techniques other than
vectomy. Arthroscopy avoids the need for a larger trapeziectomy alone.
incision over the CMC joint with less soft tissue
dissection, offering the theoretic benefit of a mini- Trapeziectomy with ligament reconstruction
mally invasive approach with limited morbidity and tendon interposition
and quicker recovery. In this technique, first First described by Burton and Pellegrini,41 trape-
described by Menon35 and Berger,36 a 1.9-mm- ziectomy with LRTI was designed to reconstruct
diameter arthroscope is placed through the 1-R the anterior oblique ligament of the thumb CMC
(radial) and 1-U (ulnar) portals. Synovectomy is joint in order to maintain the length of the thumb
performed with a 2-mm shaver. The distal trape- metacarpal to prevent subsidence. This is the
zium is debrided with a 2.9-mm arthroscopic most common operation performed for CMC
bur, removing 2 mm of distal trapezium and 1 to arthritis in the United States and is considered by
2 mm of the thumb metacarpal base. Depending many to be the standard for surgical interven-
on the patient’s demands and stage of disease, tion.42,43 In this procedure, a trapeziectomy is
various adjunctive arthroscopic procedures can performed and either half or all of the flexor carpi
be considered, including capsuloligamentous radialis (FCR) tendon is woven through the base
shrinkage, suture button suspensionplasty, or lig- of the thumb metacarpal in an oblique orientation
ament reconstruction.37 to provide support and reconstruct the beak liga-
Both medium- and long-term outcomes for ment (Fig. 2). Suspensionplasty with the abductor
arthroscopic techniques have been reported and pollicis longus has also been performed with good
seem to be similar to those of other treatment results.44
modalities. Wong and Ho37 reviewed their experi- Yuan and colleagues42 found an increasing
ence with debridement and synovectomy alone in trend in the utilization of trapeziectomy with LRTI
65 patients with predominantly Eaton stage II/III between 2001 (84%) and 2010 (90%). Female
disease and found that excellent to good pain re- sex was significantly associated with LRTI, and
lief occurred in 44.7% of patients in an average women were less likely to undergo trapeziectomy
follow-up of 7 years. However, there was only alone (odds ratio 0.49). In addition, the investiga-
minimal improvement in strength. Culp and tors noted that 95% of surgeons perform only 1
Rekant38 performed 24 cases of arthroscopic type of surgical procedure, and among those,
debridement, shrinkage, and partial/complete 93% perform only trapeziectomy with LRTI.
trapeziectomy and reported good to excellent Despite widespread surgeon preference in the
outcomes in 88%. They concluded that arthro- literature, there is no conclusive evidence to indi-
scopic debridement and synovectomy was best cate superiority of trapeziectomy with LRTI over
in Eaton I/II disease. Hofmeister and colleagues39 simple trapeziectomy, ligament reconstruction, or
reported favorable long-term results on 18 tendon interposition.1 Nonetheless, this technique
thumbs at 7.6-year follow-up using arthroscopic is technically straightforward and generally has
shrinkage, trapeziectomy, and Kirchner wire fixa- reliable results.
tion. A subjective improvement in pain, pinch
activities, strength, and range of motion (ROM) Trapeziectomy with tightrope suspensionplasty
was noted in all patients, and no patient had An alternative technique to address the length and
further surgery on his/her thumb. suspension of the thumb metacarpal is the
Thumb Basal Joint Arthritis 411

Fig. 2. (A) A longitudinal capsulotomy is made be-


tween extensor pollicis longus muscle and extensor
pollicis brevis tendons to expose the thumb CMC joint.
(B) The trapezium is then removed en block or piece-
meal. (C) The flexor carpi radialis tendon is harvested
proximally and then delivered distally. (D) The tendon
is passed through a bone tunnel made at the base of
the first metacarpal. (E) At 1-year postoperative.
(Courtesy of Jesse Jupiter, MD, Massachusetts General
Hospital.)

tightrope suspensionplasty. This technique is patients. Recent modifications of traditional


similar to others described in which trapeziectomy arthrodesis techniques have been described.
is first performed, either arthroscopically or open. Harston and colleagues49 reported a V-shaped
Next, an incision is made on the dorsal hand, just osteotomy at the base of the thumb metacarpal
ulnar to base of the index metacarpal. A 0.045-in with an 83% fusion rate, significant improvement
guidewire with integrated retriever loop is then in disability scores, and no significant complica-
passed obliquely from the base of the thumb tions. Kazmers and colleagues50 reported a lock-
metacarpal to the facet at the radial base of the ing cage plate construct in 14 patients and
index metacarpal. The suture from the mini compared it with 22 patients undergoing LRTI.
TightRope system (Arthrex, Naples, FL) is then The modified arthrodesis showed 25% greater
passed from an ulnar to radial direction through pinch strength as well as similar range of motion
the 2 drill holes made with the guidewire.45 The compared with LRTI.
tightrope suspension acts to resist migration of Not all patients benefit from arthrodesis. A 2016
the thumb metacarpal into the space remaining study indicated that in women older than 40 years
after trapeziectomy. Other purported benefits with Eaton stage II or III disease, arthrodesis was
include decreased operative time, a possible inferior to trapeziectomy with LRTI.51 In a recent
decrease in recovery time, limited dissection, RCT, arthrodesis was found to result in signifi-
and sparing of the FCR muscle tendon.45 cantly more complications compared with trape-
Roman and colleagues45 found that patients ziectomy with LRTI.52
with Eaton III/IV osteoarthritis undergoing trape-
ziectomy and suture suspension had increased Implant arthroplasty
thumb strength and ROM with complete relief of Prosthetic arthroplasty of the trapezium has been
pain. Yao and colleagues46,47 similarly published used to treat CMC arthritis. Implant arthroplasty
reassuring data at both 2- and 5-year follow-ups seeks to preserve joint biomechanics, avoid meta-
without significant complications. carpal subsidence, and provide immediate stabil-
ity.53 Current available options include silicone,
Arthrodesis Artelon, Stablyx, metallic, and pyrolytic carbon im-
Arthrodesis is an alternative to other surgical treat- plants. Vitale and colleagues53 provide a compre-
ments for patients with higher physical demands.7 hensive summary of the various implants and their
Although this technique is most often used for evolution. Overall, functional outcomes data are
younger patients, older and less physically active mixed with an increased complication rate and
patients may benefit as well.43,48 Hattori and cost associated with implants. Many implants suf-
colleagues48 found that arthrodesis was equally fer from extrusion, inflammatory reactions, loos-
effective for improving DASH scores and grip ening, and failure that may require revision
strength in older and younger patients, with the surgery.53 At present, long-term data are limited
exception of improved pinch strength in younger and current studies do not suggest that implant
412 Pickrell & Eberlin

arthroplasty is superior to trapeziectomy. Compli- specificity of the grind and traction-shift (subluxa-
cation rates have limited widespread acceptance tion-relocation) clinical tests in osteoarthritis of the
of this technique. thumb carpometacarpal joint. J Hand Surg Eur
Vol 2014;39:282–5.
12. Robert P. Bulletins et memoires de la Societe de
SUMMARY
Radiologie Medicale de France 1936;24:687–90.
Thumb CMC arthritis is a common condition treated 13. Lewis S. New angles on the radiographic examina-
by hand surgeons. Most patients are treated tion of the hand—III. Radiogr Today 1988;54:47–8.
without surgery, but those with persistent and 14. Ballinger P, Frank E, Merrill V. Merrill’s atlas of radio-
recalcitrant symptoms affecting quality of life may graphic positions & radiologic procedures. 10th edi-
benefit from surgical intervention. There are myriad tion. St Louis (MO): Elsevier; 2003. p. 108–9.
surgical options, and the best option depends on 15. Ladd AL. The Robert’s view: a historical and clinical
the patient’s goals and functional demands, sur- perspective. Clin Orthop Relat Res 2014;472:
geon experience, and patient preference. 1097–100.
16. Gervis WH. Osteo-arthritis of the trapezio-metacarpal
joint treated by excision of the trapezium. Proc R Soc
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