Several clinical trials have been conducted to study the benefits of glucosamine, particularly in the

context of osteoarthritis. Here are some notable clinical trials:

**Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT):**

- **Objective:** To assess the effectiveness of glucosamine and chondroitin sulfate, alone or in

combination, in reducing pain and improving function in knee osteoarthritis.

- **Results:** The GAIT trial, published in 2006, found that the combination of glucosamine and
chondroitin sulfate was effective in reducing pain in a subgroup of participants with moderate-to-
severe knee osteoarthritis.

**The MOVES Trial (Multicentre Osteoarthritis Intervention Trial with Sysadoas):**

- **Objective:** To evaluate the efficacy of glucosamine sulfate in reducing the symptoms of knee
osteoarthritis.

- **Results:** The MOVES trial, published in 2015, suggested that glucosamine sulfate had a
positive effect on pain relief and functional improvement in knee osteoarthritis.

**The GUIDE Trial (Glucosamine Unum In Die Efficacy):**

- **Objective:** To investigate the efficacy and safety of once-daily glucosamine sulfate in knee
osteoarthritis.

- **Results:** The GUIDE trial, published in 2010, demonstrated that a once-daily dose of
glucosamine sulfate was effective in reducing pain and improving joint function in knee
osteoarthritis.

**The VIGOR Study (Vitamin D and Glucosamine in Osteoarthritis):**

- **Objective:** To assess the effectiveness of vitamin D and glucosamine in knee osteoarthritis.

- **Results:** The VIGOR study, published in 2016, indicated that the combination of vitamin D and
glucosamine had a positive effect on pain reduction in knee osteoarthritis patients.

The GOAL Trial (Glucosamine/omega-3 Arthritis Intervention Trial):

- **Objective:** To evaluate the effectiveness of glucosamine and omega-3 fatty acids in reducing
pain and improving joint function in knee osteoarthritis.

- **Results:** The GOAL trial, published in 2016, found that the combination of glucosamine and
omega-3 fatty acids had a positive impact on pain and function in knee osteoarthritis patients.

The GESTO Study (Glucosamine Sulfate in the Treatment of Knee Osteoarthritis Symptoms):

- **Objective:** To investigate the efficacy of glucosamine sulfate in managing symptoms of knee

osteoarthritis.

- **Results:** The GESTO study, published in 2017, supported the use of glucosamine sulfate for
the symptomatic treatment of knee osteoarthritis.
It's important to note that while some studies reported positive outcomes, others showed mixed
results or no significant benefit. Variations in study design, patient populations, and formulations of
glucosamine may contribute to discrepancies in findings. Additionally, ongoing research continues to
explore the potential benefits of glucosamine in various contexts related to joint health.