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Original Research

Temporal Augmentation: A Systematic Review


Sammy Othman, BA1 Jason E. Cohn, DO2 Jacob Burdett, DO2 Srihari Daggumati, MD3
Jason D. Bloom, MD4

1 College of Medicine, Drexel University, Philadelphia, Pennsylvania Address for correspondence Sammy Othman, BA, Drexel University,
2 Department of Otolaryngology - Head and Neck Surgery, Philadelphia 2900 West Queen Lane Philadelphia, PA 19129
College of Osteopathic Medicine, Philadelphia, Pennsylvania (e-mail: sothman13@gmail.com).
3 Drexel University College of Medicine, Philadelphia, Pennsylvania
4 Facial Plastic Surgery, Main Line Center for Laser Surgery, Ardmore,
Pennsylvania
Facial Plast Surg

Abstract Clinicians employ various modalities in order to achieve temporal augmentation;


however, no literature comprehensively describes these methods or provides perspec-
tive on available options. Understanding the available methodologies for cosmetic

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temporal augmentation allows for improved patient satisfaction with limited risk of
complications. To synthesize the available literature on cosmetic temporal augmenta-
tion, including all available methodologies, patient satisfaction data, and complication
rates, as well as to identify gaps in the available literature to encourage further
research. A literature search was performed using the databases PubMed, Ovid
Medline, Cochrane Library, and Web of Science. Using the key terms “temporal” or
“temple” and “augmentation” or “rejuvenation,” all article formats presenting primary
literature data involving cosmetic temporal augmentation were included. Articles not
presenting patient data or not discussing cosmetic indications were eliminated. A total
of 12 articles were deemed appropriate for analysis. Of the 12 articles included, 6 (50%)
evaluated filler techniques, 3 discussed fat grafting (25%), and 3 reviewed solid implant
Keywords (25%) techniques. Eight (67%) of these were retrospective reviews, with the remaining
► temporal being prospective trials (33%). All studies found high patient satisfaction rates and a
augmentation small number of complications with their respective methodology. Several methods
► temporal are employed for cosmetic temporal augmentation, including various types of
rejuvenation injectable fillers, solid implants, and fat grafting, with all reporting successful satisfac-
► temporal hollowing tion and complication outcomes. Further research is necessary to properly compare
► plastic surgery these modalities. Clinician discretion should guide procedural choice until future well-
► facial plastic surgery controlled studies are able to provide standardized outcomes.

Human aging is marked by a progressive loss of volume one of which being aesthetic enhancement of the temporal
and tissue elasticity in the face.1,2 Fat and muscle compo- anatomy for concavity correction.6 Several approaches
nents are particularly important in the shaping of the exist, including the use of grafts, implants, fillers, and
upper face region, and as the aging process occurs, a loss flaps. The method employed is dependent upon the goal
of soft tissue in the temporal area can result in a hollowed, of the procedure as well as clinician preference.7–9 Despite
gaunt appearance.3,4 This can be perceived as unappealing the variety of methods available for aesthetic temporal
due to increased facial concavity and can lead patients to augmentation, there is no comprehensive literature
seek correction of this area and achieve a more youthful or review of these various techniques. The purpose of this
aesthetically pleasing appearance.3,5 Temporal augmenta- systematic review is to describe the existing surgical
tion is a versatile procedure used for a variety of purposes, methodology and technique-specific complications and

Issue Theme Applied Anatomy for Facial Copyright © by Thieme Medical DOI https://doi.org/
Plastic Surgery; Guest Editors: Yves Publishers, Inc., 333 Seventh Avenue, 10.1055/s-0039-1694029.
Saban, MD, PHM, Peter Palhazi. New York, NY 10001, USA. ISSN 0736-6825.
Tel: +1(212) 584-4662.
Temporal Augmentation Othman et al.

to highlight previous study results on aesthetic temporal Results


augmentation.
In total, 12 articles were selected for the final manuscript
inclusion. ►Table 1 displays the study design and methodol-
Methods
ogy for each article analyzed in our review. Procedure
A systematic review of the literature in the English language on satisfaction results and complications are summarized in
articles describing temporal augmentation was conducted in ►Tables 2 and 3, respectively.
November 2018. The search strategy involved using the key
terms “temporal” or “temple” and “augmentation” or “rejuve- Fat Grafts
nation” using PubMed, Ovid Medline, Cochrane Library, and Autologous fat grafting is an approach used to contour the face,
Web of Science. This methodology yielded 3,213 articles. breast, and other body areas for cosmetic and/or reconstructive
Inclusion criteria consisted of articles discussing temporal purposes.10 Its advantages stem from low immunogenicity,
augmentation performed for aesthetic purposes, as well as low cost, malleability, accessibility, and induction of angiogen-
presenting original research involving patient data with a esis to promote tissue survival and long-term outcomes.11,12
specific procedural method. Exclusion criteria included any When used for temporal augmentation, intimate knowledge of
other primary procedure objectives, such as reconstructive neurovascular anatomy is necessary to avoid injury and com-
or pathological disease states, without mention of any data plications.3,5 These complications include poor aesthetic out-
comes, hematoma, seroma, nerve injury, and blindness.8,13,14

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discussing cosmetic temporal augmentation. Additionally,
review articles and research that did not present original Our review yielded studies evaluating traditional microautol-
patient data were eliminated. ogous fat with a specialized apparatus (the “MAFT-Gun”),
After removing duplicates and screening articles at the targeted volume restoration, and stromal vascular fraction
abstract level, 36 articles remained. A full-text analysis of the (SVF) assisted cell therapy.
remaining studies was conducted. Additionally, a search of
their reference sections was conducted to identify any Traditional Microautologous Fat Transfer-Gun
additional studies meeting criteria. The exclusion processes Traditional microautologous fat transfer (MAFT) is one well-
are summarized in the PRISMA (Preferred Reporting Items known procedure used for fat grafting. However, high variability
for Systematic Reviews and Meta-Analyses) flowchart in efficiency, efficacy, and complications led to the production of
(►Fig. 1). Once the list of articles was finalized, each study a specially designed graft placement device.15 The “MAFT-Gun”
was categorized into a specific modality, which included was developed to inject specific aliquots of fat and has shown
fillers, grafts, and implants. Satisfaction and complication previous success in other fat grafting procedures.16 This device
rates were collected or calculated from the information allows for more accurate injection volumes to increase efficacy
provided in each article. Note that the authors had intended and patient satisfaction and reduce major complications such as
for flaps to be analyzed in the review, but found no existing necrosis and fibrosis.14 Lee et al examined this methodology
literature to meet the inclusion criteria. applied to aesthetic temporal augmentation and found the

Fig. 1 Search strategy and results. Detailed processes of the search strategy, stratification, and results.

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Temporal Augmentation Othman et al.

Table 1 Study design and characteristics

Study (year) Modality Material/method Design Sample size Level of


evidence
Huang et al (2018) Fat graft Targeted volume restoration Retrospective review 96 3
Li et al (2013) Fat graft SVF-assisted cell therapy Controlled prospective trial 19 1
Lee et al (2017) Fat graft Microautologous fat graft Retrospective review 208 3
transplantation
Moreira-Gonzalez Filler Hydroxyapatite granules Retrospective review 12 3
et al (2003)
Moradi et al (2011) Filler Small gel hyaluronic acid Retrospective review 20 3
Moradi et al (2013) Filler Small gel hyaluronic acid FDA-approved, prospective 20 1
blinded, open-label trial
Lambros (2011) Filler Dilute hyaluronic acid Retrospective review 40 3
Juhász et al (2018) Filler Calcium hydroxyapatite Single-investigator, nonblinded 20 2
prospective study

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Byrd et al (1993) Filler Hydroxyapatite granules Retrospective review 43 3
Lin et al (2010) Implant Expanded Prospective series 16 2
polytetrafluoroethylene
Hirohi et al (2018) Implant Methyl methacrylate Retrospective review 41 3
Gordon and Implant Methyl methacrylate Retrospective review 35 3
Yaremchuk (2011)

Abbreviations: FDA, U.S. Food and Drug Administration; SVF, stromal vascular fraction.

Table 2 Reported patient satisfaction rates

Name Very Unsatisfied/no Neutral/minimal Satisfied/moderate Very satisfied/much


unsatisfied improvement improvement improvement improvement
Moreira-Gonzalez - 3.6% - 96.4% -
et al (2003)
Moradi et al (2011) - 0% 0% 100% -
Moradi et al (2013) - 0% 25% 30% 45%
Lambros (2011) “Most patients and author satisfied”
Juhász et al (2018) - 21% 36.8% 15.8% 31.6%
Byrd et al (1993) Not provided
Lin et al (2010) “Most satisfied”
Hirohi et al (2018) - 0% 6.1% 17.1% 76.8%
Gordon and Not provided
Yaremchuk(2011)
Huang et al (2018) - 8.3% - 25% 66.7%
Li (2013) “All improved”
Lee et al (2017) 0% 2.4% 16.3% 42.8% 38.5%

Note: Hyphen indicates “not discussed.”

patients to be overall satisfied with the results (►Table 2) to the superficial temporal fascia followed by a more superfi-
without major complications (►Table 3).16 cial, subcutaneous layer injection in the surrounding areas.19
Patients reported high satisfaction rates (►Table 2). Postoper-
Targeted Fat Volume Restoration atively, 94.8% of patients reported no or mild hollowness on
Recently, there has been a surge in interest for targeted volume the Hollowness Severity Rating Scale (HSRS).19,20 Minor com-
restoration. Recent studies have demonstrated an increased plications were reported (►Table 3). Volume restoration was
natural appearance along with decreased complications.17,18 also measured with a three-dimensional (3D) topographic
Huang et al used harvested fat to inject fat compartments deep scan, which showed a 91.8% increase in augmentation.

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Stromal Vascular Fraction Assisted Cell Therapy

Revision
One variation of pure fat grafting is SVF-assisted cell therapy.

12.2%
6.3%
NOS

14%
Previous literature showed that adipose stem cells increased

1
graft survival time through the promotion of vasculogenesis.21

-
Li et al demonstrated this method by fat harvesting with
Facial nerve

subsequent centrifugation into SVF.22 This stromal rich cen-


damage

trifugate was compared against a control group using tradi-

6.3%
2.4%
tional fat harvesting injected into various facial sites including

0
-

-
-
the temporal region. Volumes were measured using computed
tomography (CT) scans. The mean graft survival was 64.8 for
pain
Jaw

5%
5%

the SVF group and 46.4% for the control group at 6 months
-

-
-
-
-

-
postinjection. There were no reported complications
Tenderness/

(►Table 3), and all patients had cosmetic improvement, but


numbness

temporal outcomes were not specifically reported (►Table 2).


100%

2.4%
70%

Fillers
-

-
-

-
The advent of fillers allows for contouring and volumization of
asymmetrical or aged areas for a more aesthetic perception.23

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Infection

As a result, the role of fillers has grown in the correction and


preservation of temporal fossa volume. There are several
0%

0%
0%

0
-

different types of fillers with a variety of material compositions.


Most notably in our review, the use of hyaluronic acid (HA) and
Bruising

calcium hydroxyapatite fillers was described for aesthetic


30%
70%

temporal augmentation. Fillers carry a similar risk profile in


-

-
-
-
-

terms of complications and injury to neurovascular structures,


as listed in the Fat Grafts section.24,25 Specifically, the middle
Skin irregularities/

temporal vein (MTV) is one vessel responsible for filler-related


complications including, but not limited to, hematoma, embo-
lism, and obstruction.26
4.9%

5.2%
rash

10%
55%

Hyaluronic Acid
0%

0%
-

Hyaluronic acid is an intrinsic molecule that allows skin to


retain turgor and pliability, largely due to its moisturizing
Headache

and water-retentive properties.27 In cosmetics, the innate


7.3%

properties as well as clinical utility of HA-containing fillers


75%

vary because of differences in manufacturing. Moradi et al


-

-
-

-
-
-

evaluated the small gel particle HA (SGP-HA) filler, commer-


Swelling /

cially known as Restylane (Galderma).28 SGP-HA functions


seroma

by a particle-induced cohesive gel structure that provides the


100%

2.4%

3.1%
40%

30%
50%

0%

foundation for lift and support, as well possesses predictable


-

water absorption and swelling properties.27,28 All patients in


Redness

this study were injected in the subcutaneous plane superfi-


None reported

cial or just deep to the superficial temporal fascia through


40%

30%
65%

anterograde, retrograde, and depot injection methods. All


-

-
-
-
-

patients reported satisfaction with their appearance, some


None

None
Pain

55%
80%

with mild tenderness and bruising (►Tables 2 and 3).


Table 3 Reported complications rates

-
-
-
-

A follow-up prospective study by the same senior author


Note: Hyphen indicates “not discussed.”

evaluated SGP-HA filler (Restylane) in the correction of tempo-


Gordon and Yaremchuk (2011)
Moreira-Gonzalez et al (2003)

ral fossa volume loss.20 Creating a measure termed “Hollowness


Severity Rating Scale” (subsequently used by Huang, as
discussed in the Fat Grafts section) to grade the degree of
Moradi et al (2013)

hollowness in the temporal areas, the study showed significant


Huang et al (2018)
Juhász et al (2018)

Hirohi et al (2018)
Moradi et al 2011

Byrd et al (1993)

improvement comparing pre- and postinjection scores. Most


Lambros (2011)

Lee et al (2017)
Li et al (2013)

patients were satisfied, although the degree of satisfaction


Lin (2010)

dropped from the 6- to 12-month mark (►Table 2). No major


adverse effects were reported (►Table 3).20
Name

Lambros described an HA injection using a modified


dilution formula consisting of 2:1 saline:Restylane or Perlane

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HA.29 Juvéderm was not used, as it was it cited to have a tion and extrusion.35,36 Traditional complications are also
higher degree of injection difficulty due to its viscosity. The possible, including seroma, hematoma, and infection.36 In
hypothesis behind this method is a greater volume of solu- our review, we identified studies using methyl methacrylate
tion allowing for greater distribution of filler for a more (MMA) and polytetrafluoroethylene (PTFE) implants for
uniform, smooth look, extending from the lateral orbit/ aesthetic temporal augmentation.
eyebrow throughout the temporal area. The author reports
a high degree of satisfaction (►Table 2) with small, correct- Methyl Methacrylate
able adverse effects (►Table 3). Methyl methacrylate is a resin used for craniofacial and
temporal augmentation.37,38 This material successfully
Calcium Hydroxyapatite addresses full-thickness defects of the skull while being mal-
Calcium hydroxyapatite is a mineral found endogenously leable, biocompatible, and nonabsorbable. In addition, it is low
within human teeth and bone. It is a well-studied material, in cost and produces a predictable result.39,40 Unlike other
and its efficacy as a filler stems from its versatility and ability to implants, MMA is placed in a submuscular pocket rather than a
act as scaffolding material and stimulate growth of surround- supramuscular pocket, which significantly reduces damage to
ing tissue, more specifically collagenous dermal material.30 the frontal branch of facial nerve.39 Gordon and Yaremchuk
Moreira-Gonzalez et al studied porous hydroxyapatite gran- briefly discussed their experiences and results with MMA for
ules as filler material. Of note, the study combined aesthetic, aesthetic temporal augmentation.39 Satisfaction and appear-

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congenital, and posttraumatic indications for procedures, and ance scores were not explicitly discussed (►Table 2). However,
these indications were not distinguishable numerically.31 they mentioned that 14% of patients required revision surgery,
Additionally, facial locations were varied for placement of citing contour dissatisfaction, overcorrection, and coronoid
the material, but 3% of the study cohort had filler applied to process impingement as the etiology. No other complications
the temporal region. Of the patients, 96.4% (n ¼ 379/393) were reported (►Table 3).
reported satisfaction, but temporal satisfaction was not speci- Hirohi et al examined integrated forehead temporal aug-
fied (►Table 2). Complications were specified anatomically, mentation compared with single forehead augmentation
although none occurred in the temporal region (►Table 3). with MMA.40 Using a four-point pre- and postoperative
Byrd et al presented their experience with porous hy- rating scale, two blinded, unaffiliated plastic surgeons rated
droxyapatite granules as a filler in combination with patient temporal hollowing. Citing the growing popularity of 3D
blood and fibrillar collagen to form an injectable paste for printed technology, customized MMA implants were used.
craniofacial defects through fibrous incorporation.32 Similar Procedure technique began with a head CT scan for each
to the study by Moreira-Gonzalez et al, this study examined patient that was used to produce a 3D skull model to allow
both aesthetic and reconstructive indications without com- for MMA contouring and design followed by surgical implan-
paring the two. Multiple craniomaxillofacial locations were tation. Most results (76.8%) involving temporal augmenta-
treated, with 8% of cases occurring in the temporal region. tion were rated as “excellent” by the two reviewers, the
Patient satisfaction was not discussed, and no adverse out- maximum possible score (►Table 2). Despite good overall
comes were reported (►Tables 2 and 3). results, there are potential complications including the need
Juhász et al reported the off-label use of calcium hydroxy- for revision procedures (►Table 3).
apatite with integral lidocaine (Radiesse; Merz North America,
Inc.) for temporal fossa defects.33 They injected into the deep Polytetrafluoroethylene
facial plane using several technique variations including linear, Expanded-PTFE (e-PTFE) is a synthetic fluoropolymer with
bolus, threading, and fanning. Using the Merz-validated Tem- proven biocompatibility. It has been used for a wide variety
ple Scale Assessment, a previously validated scale that assesses of clinical applications including craniofacial reconstruc-
temporal fullness, results showed mixed patient satisfaction, tion.41,42 The advantages of e-PTFE include reduced incidence
although the largest group remained satisfied (►Table 2). of capsular formation and inflammatory response.43 Like MMA,
Expected minor complications were reported, such as tender- it also has good biocompatibility.44 Lin et al reported their
ness and swelling, but no major complications were observed experience using e-PTFE, with standard 60  40  2 mm
(►Table 3). sheets.45 The implant can be placed with the assistance of an
endoscope providing smaller incisions with fewer complica-
Implants tions. One patient had paralysis of the temporal branch of the
Cosmetic implants are generally a prosthetic or allogenic facial nerve that recovered, and most (96.2%) were satisfied
material used to augment certain anatomical areas for (►Table 2).
aesthetic contouring.34,35 The use of implants for temporal
augmentation was investigated because previous traditional
Discussion
modalities, such as injectable fillers and fat grafts, had less
predictable survival time, limited availability, and decreased In cosmetic surgery, temporal augmentation has the flexibility
pliability.34,35 However, implants present their own chal- of employing several modalities designed to accomplish simi-
lenges to clinicians, including difficulty in identifying good lar goals such as volume restoration and aesthetic facial
surgical candidates, improper implant size selection, and contouring.5,6,9 This approach is traditionally left to the clini-
inappropriate implant location placement, as well as migra- cian’s discretion. Understanding the various methods and

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Temporal Augmentation Othman et al.

complications can allow providers to opt for the best individ- biocompatibility, minimal foreign body reaction, low extru-
ualized option for their patients. sion rate, and lack of excessive capsule formation.37,55 Porous
One goal of a cosmetic procedure is to achieve a high level of polyethylene implants are mainly used for bone due to its
patient satisfaction. Understanding which techniques are most stiffness.37 In addition, these implants have micropores, which
effective in terms of patient satisfaction is difficult to accom- allow surrounding tissue to grow through lattice networks as
plish within a systematic review. The articles we examined opposed to encapsulation. The vascularized soft tissue
were largely retrospective reviews, whereas the prospective network throughout the implant reduces the likelihood of
studies were not randomized trials. Qualifying patient satis- infection and movement over time.37,39,55 In contrast, materi-
faction can be accomplished by standardizing age, gender, als with larger pore sizes can experience material breakdown
and degree of temporal volume deficits. Some studies used a and foreign body reactions when used improperly, such as
previously validated and standardized scale (HSRS), with woven Teflon and organic fibers (i.e., Proplast; Vitek Inc.).56,57
blinded reviewers and follow-up times in an attempt to The Eppley temporal shell implant, produced by Implantech, is
standardize results. Unfortunately, most of the other studies another option used by the senior author (J. B.) with good
relied on self-reported patient satisfaction scores. The majority results. Composed of solid silicone, it is believed to be advan-
of patients were satisfied with their procedures, with varying tageous due to its soft composition when compared against
categorization (►Table 2). The different measurement scales other silicone implants. This allows for greater contour adap-
were not standardized, which can skew results. Future tation to the natural shape of the skull.58 No studies have

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research should incorporate a validated patient questionnaire examined this material closely, making its tangible efficacy
on satisfaction in order to better qualify how patients self- and complications largely unknown. The ongoing controversy
perceive various procedural results. with these materials is their ideal location within the temporal
The studies included in this review reported several com- area, either submuscular or supramuscular.39 The literature
plications, but almost all were minor, known, or resolved has not defined the more effective method.
complications on follow-up (►Table 3). Some have reported Mersilene mesh is a less described implant used in
alopecia in the temporal area secondary to a disruption of hair temporal augmentation. It is often used for craniofacial
follicles.46 Another cosmetic concern is scaring and disruption reconstruction in the skull, sinus, cheek, nasolabial sulcus,
of natural skin textures.47 Nonablative and ablative fractional nasal septum, and chin.59 Mersilene mesh is constructed
resurfacing and radiofrequency skin tightening have helped from polyester, producing a smooth and pliable material
alleviate some concerns with a host of applications including with elastic properties that allow it to adapt to mechanical
scar and acne removal. By creating microdamage within the stresses. One study used the mesh for various reconstructive
dermal layer, neocollagenesis and contraction are stimulated, procedures with reported success.59 Further research should
helping tighten skin and eliminate defunct tissue, making examine its utility.
these complications less of a concern in terms of their long- Poly-L-lactic acid (PLLA, Sculputra [Dermik Laboratories])
term damage.47–49 is a widely used polysynthetic, biostimulatory injectable for
Previous research, much of which is purely anatomical, has facial and temporal volumization and rejuvenation.9 The
found more potential adverse effects of temporal augmenta- advantage of PLLA is believed to stem from its collagen
tion given the complex anatomical nature of the temporal area. stimulating mechanism of action. This allows for longer lasting
The superficial temporal fascia is thin in patients with tempo- and natural changes.60 Although the literature has shown its
ral hollowing and confers a great risk to all the neurovascular success in volumization, a study is necessary to specifically
structures it encompasses.37,50,51 Several studies in our review evaluate the application of PLLA in temporal augmentation.61
reported transient paresthesias secondary to facial nerve Ellansé (Sinclair Pharma Ltd.) is a collagen biostimulator
damage, but the risk of permanent damage remains unknown. composed of polycaprolactone filler based material used
When considering the vasculature, the frontal branch of the over several regions of the body including the temporal
superficial temporal artery and the sentinel vein course through region.62 This material has successful outcomes in nasolabial
the temporal regionwith several branches, including the MTV.52 fold injections.63 The injection should be placed between the
There have been reports of embolisms erroneously being superficial temporal fascia and the superficial layer of the
introduced into the vasculature during the injection of materials deep temporal fascia using a 22 or 25G blunt cannula,
for temporal augmentation, which can lead to pulmonary fanning from the posterior limit to the orbital rim and
embolism, blindness, and hemiplegia.53,54 Hematoma and ob- zygomatic arch. Deep, preperiosteal injections can also be
struction of vessels are also possible.25 The zone of caution, an employed using a low-pressure bolus injection technique.
area believed to be associated with the highest complication Although research describes its use in the temporal region,
rate, is the anterior half of the lower temporal compartment that there are very little existing data for this purpose.62 This
contains these crucial neurovascular structures.5,25 material is currently not approved by the U.S. Food and Drug
Several materials and surgical methods were not covered in Administration. However, given its success, it warrants an
our review due to the lack of cosmetic indications. Two of the examination for various facial cosmetic purposes.
more commonly used implants for temporal augmentation Fat grafts are well described in this review and in many
include PTFE (i.e., Gore-Tex) and porous polyethylene (i.e., other cosmetic procedures. Pessa et al conducted an ana-
MEDPOR) implants.37,39,55 PTFE implants are a favorable tomical study warning of the complications mentioned in the
alternative to other alloplastic implant materials in regard to Fat Grafts section.3 Further complications can include

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Temporal Augmentation Othman et al.

calcification and tissue necrosis.64 The long-standing issue augmentation has not been well described previously. We
with fat grafting, however, is the lower rate of survival owing were able to examine the existing methods used for aesthetic
to the lack of vascularization.65 temporal augmentation, which should encourage further
Bone grafting is another alternative used for temporal research on this topic.
augmentation. Temporal hollowing, for example, is a rela-
tively known common complication of craniotomies. Several Conflicts of Interest
studies cite autologous bone graft, often calvarial, as an Dr. Bloom reports personal fees from Allergan, Galderma,
effective method following craniotomy to combat loss of Merz, ThermiAesthetics, InMode, Prollenium, Revance
volume in the temporal area.66 Given the invasive nature of Therapeutics, Endo Pharmaceuticals, and Evolus outside
these procedures, they are unlikely to be used in aesthetic the submitted work. The other authors have no conflict of
temporal augmentation when compared with time-saving interest to disclose.
and cost-intensive options mentioned in this review.
We initially intended to include flap-based strategies for
cosmetic temporal augmentation. Flaps are vascularized References
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