ibSium®

A breakthrough for a better quality of life

Gnosis by Lesaffre 1
IBS, a common disorder of gut-brain interaction

IBS is a
DISORDER OF
GUT-BRAIN INTERACTION

SYMPTOMS

Multifactorial pathogenesis
Dysbiosis appears to play a key function ✓ Abdominal discomfort
✓ depression
✓ Anxiety
✓ emotional distress
✓ bloating
✓ constipation
✓ flatulence
✓ diarrhea
#1 PAIN ✓ loss of body control
Abdominal pain is the ✓ bad self-image
major symptom of IBS

Gnosis by Lesaffre 2

World Gastroenterology Organization Global Guidelines – Irritable Bowel Syndrome: a Global Perspective (2015)
 IBS: key feagures
Functional gastro intestinal disorders can affect anyone, anywhere and impact lifesyle

600 millions 2 out of 3 IBS is one

People affected patients are of the main cause
in the world women of consultation

10 % 30-40 years QUALITY OF LIFE

ADULTS affected Is the average age IBS greatly reduces
It cans reach 20% in of diagnosis patient's quality of life
certain areas

Gnosis by Lesaffre 3

World Gastroenterology Organization Global Guidelines – Irritable Bowel Syndrome: a Global Perspective (2015)
ibSium®, breakthrough for complete intestinal support

Unique probiotic yeast for digestive comfort

3 YEARS stability Lesaffre proprietary and

patented strain
Saccharomyces cerevisiae
CNCM I-3856

Produced in Europe
Clinically studied

High quality product

8x109 CFU*/g = 500 mg/day Resistance to gastric
acid and bile salts
Fast acting

Gnosis by Lesaffre 4
ibSium®, the most documented probiotic yeast for digestive
comfort

4 Clinical trials with consistent &

gold standard methodology Strain

1135
Volunteers included
1 Individual Patient Data
Meta-Analysis in randomized
clinical trials

years of clinical substantiation

15 development
100%
Studies in humans
demonstrating consistent
beneficial effects in
of consumers say clinical evidence on digestive symptoms
68% probiotic packaging to support health management
Gnosis by Lesaffre 5
claims is important
ibSium® : a complete intestinal support

bdominal pain Relief

loating relief

onstipation reduction

iarrhea reduction

nhanced quality of life Gnosis by Lesaffre 6

ibSium, A strong clinical support

Consistent & gold standard clinical methodology

Randomized, double-blind,
placebo-controlled, balanced
clinical studies

Daily evaluation of digestive

symptoms

Confirmation of IBS
diagnostics (ROME criteria)

Sufficient follow-up duration

Endpoints definition aligned

with current
recommendation Daily follow-up of gastrointestinal symptoms & bowel habits

Gnosis by Lesaffre 7
 S. Cerevisiae I-3856 impacts major symptoms and improves quality of life

C&D
A B E

Abdominal pain Bloating relief Bowel habits Empowerment

alleviation normalization (Quality of Life)
Percentage of
responders S. cerevisiae I-3856

63%
Placebo
47%

Percentage of abdominal pain

-13,6%
responders of bloating intensity after ibSium
supplementation period, compared with
the placebo group. Gnosis by Lesaffre 8
ibSium, Abdominal pain/discomfort relief
Product Follow
consumption up

1
1 Same baseline for both groups

W0-W8: stronger discomfort reduction

2 with ibSium® than placebo
37% vs 27% compared to baseline
(p<0.001 in both groups) 4

63% vs 47% of volunteers experienced

3 pain reduction with ibSium® during the 2
second month
(p=0.04)
3
When ibSium® is stopped, discomfort is
4 back and is at the same level than Evolution of abdominal pain/discomfort scores
placebo

ibSium® improves significantly bowel pain and discomfort in 63% of volunteers against 47% in the
placebo group, during the second month of consumption (p=0,04)

Gnosis by Lesaffre 9
NB: IBS is evaluated on the basis of subjective symptoms and is correlated with emotional feelings. That is why the placebo effect is strong.
 B
S. cerevisiae I-3856, bloating relief

Evolution of bloating score in IBS-C volunteers

S. cerevisiae
I-3856

Throughout the study ,(volunteers consuming S. cerevisiae I-3856 felt

significantly less bloated *(p=0.008)
Gnosis by Lesaffre 10
ibSium, normalization of bowel habits

Gnosis by Lesaffre 11
NB: IBS is evaluated on the basis of subjective symptoms and is correlated with emotional feelings. That is why the placebo effect is strong.
ibSium, improvements in quality of life

Irritable bowel syndrome-specific quality of life questionnaire scores at the end of the intervention

ibSium® has been shown to improve quality of life (IBS-QOL scores) Gnosis by Lesaffre 12