V IS T R Å W

o
a rn ı n g s a n d P r e c a u tio n s : D o c to r m
u st be c o n s u ı
f jo in t d is e a s e fo r w h ic h o th e r tr e a tm e n t s h ı
te d to ru ı e o u t th e p re s e n c e

o u d b e c o n s id e re d
1 U se w ith cau tio n in a s th m a tic p a tie n ts b e c a u s e it m ay in c re a s e ris k o f a s th m a tic
a tta c k
2 Use w ith cau tio n in d ia b e tic p a tie n t s o r p a tie n ts w ith im p a ire d g ı u co se
to le ra n c e ito ririg o f th e b lo o d g ı
m on y d u rin g tre a tm e n t
u c o s e le v e l p e rio d ic a ı
ı
D o s a g e a d ju s tm e n t o f in s u lin o r a n tid ia b e tic d ru g m a y b e n e c e s s a ry
3 L o n g te rm tre a tm en t w ith g ı in re q u ire m e n t
u c o s a m in e m a y in c re a s e in s u ı

P e r io d ic m o n ito rin g o f b lo o d g lu c o s e le v e l is re c o m m e n e d
4 In p a tie n ts w ith a k n o w n ris k fa c to r fo r c a rd io v a s c u la r d is e a s e m o n ito rin g o f
th e b lo o d lip id le v e ls is r e c o m m e n d e d s in c e hı y p e rc h o le s te ro le m ia h a s b e e n
o b s e rv e d in a fe w cases in p a tie n ts tr e a te d w u c o s a m in e
ith g ı
C o m p o s itio n s E a c h s a c h e t c o n ta in s In te ra c tio ns w ith O th e r M e d ic a m e n ts
fa te S o d iu m C h lo r id e
G lu c o s a m in e S u ı e q u iv a le n t to G ı
u c o s a m in e S u ı 1 C o n c u r re n t tre a tm e n t w ith w a r fa rin m a y in c re a s e a n tic o a g u la n t e ffe c t o f w a r fa rin
fa te 1 5 o o m g
S o d iu m C o n te n t 15 1 1 6 m g /s a c h e t 2 ı
t m a y re du ce e ffe c tiv e n e s s o f a n tid ia b e tic s
p r o d u c t d e s c r ip tio n V io le t p o w d e r P re g n a ncy a n d la c ta tio n : T h e re is no a d e q u a te d a ta o n th e s a fe u s e o f
p h a rm aco dyn am ic s : G lu c o s a m in e is a n o rm a ıc o n s titu e n t o f th e p o ly s a c c h a r id e gıu c o s a m in e in p re g n a n t o r b re a s tfe e d in g w om en T h e re fo re it is no t re c o m m en ded
c h a in s o f c a rtiı
a ge m a trix a n d
l flu id g ly c o s a m
s y n o v ia in o g ly c a n s G lu c o s a m in e in p re g n a n c y o r b re a s tfe e d in g
f h
s tim u la te s th e s y n th e s is o p y s io lo g ic a l g ly c o s a m in o g ly c a n s a n d U n d e s ira b ı
e e « e c ts : T h e m o s t c o m m o n a d v e rs e re a c ŭ o n s a s s o c ia te d w ith e n t
p ro te o g ı
yc a n s
b y c h o n d ro c y te s a n d o f h y a lu ro n ic a c id b y s y n o v io c y te s T h e m e c h a n is m o f a c tio n w ith g lu c o s a m in e a re e p ig a s tr ic p a in o r tenderness heartburn d ia rrh e a a n d n a u s e a

o f g lu c o s a m in e in h u m a n s is u n k n o w n T h e o n s e t o f re s p o n s e c a n n o t b e a s s e s s e d In a d d itio n h e a d a c h e in c re a s e d b lo o d p re s s u re tire d n e s s ra s h itc h in g a n d

p h a rm a c o k in e tic s : R a p id o ra ıb io a v a ila b ility o f th e c o m p o u n d w a s fo u n d w ith flu s h in g h a v e b e e n re p o rte d

a v e ra g e m a x im u m c o n c e n tra tio n s (C m a x ) in p ı a s m a in th e 1 0 LIM r a n g e fte r O v e rd o s e a n d T re a tm e n t : No c a se o f o v e rd o s e h a s b e e n re p o r te d

a

a b o u t 3 h o u rs d is trib u tio n to b o th v a s c u la r a n d e x tra v a s c u la r c o m p a rtm e n ts t or ag e co n d i tion s : S t or e a t the t em p e r at ur e b e l ow 30 ° an d pr ot ec t from ıigh t.

G lu c o s a m in e is m e ta b o lìz e d p re d o m in a n tly in th e liv e r to e r m o le c u le s a n d u

s m a lı ltim a te ly D o sa ge Fo rm s a n d P a c k a g in g A va ila b le : Po w de r : 30 sa c h e ts /b o x
to c a rb o n d io x id e w a te r a n d u re a An e lim in a tio n h a lf life o f a p p ro x im a te ly 1 5 h o u rs th a t

a rg e ly
ı j u s tifie s th e o n c e d a ily d o s in g re g im en T h e p h a rm a c o kin e tic s o f g lu c o s a m in e
a re lin e a r in th e 7 5 0 1 5 0 0 m g D o s e ra n g e w h ile h ig h e r d o s e d e v ia te fro m lin e a rity
The a bso ı u te b io a v a ila b ility is a b o u t 2 5 %
M a n u fa c tu r e d by : B a n gko k La b & C o s m e tic C o Ltd ,

4 8 /1 M oo 5 N on g s h a e s a o R d A m p u r M e u n g R a tc h a b u ri 7 0 0 0 0 T h a ila n d
In d ic a tio n R e lie f o f s y m p to m in p r im a ry o s te o a r th ritis o f th e k n e e
:
D is tr ib u te d b y : N B D H e a lth c a re C o L td
Reco m m e n de d d o s e : A d u ı t O ra ı1 s a c h e t d is s o ıv e d in w a te r o n c e d a ily
fo r 3 898 S o i N uanc ha n 56 N uanc ha n B u e n g ku m B a n g k o k 1 0 2 4 0 T h a lı
and
m o n th s C o n s u lt p h y s ic ia n if a re e a te d c o u rs e is n e e d e d
p
M o de o f A d m in is tr a tio n O l T e l 0 2 7 9 1 3 809
: ra
之1
C o n b a in d ic a tio n s P a tie n t w h o a lı
e rg y to s he fis h g ı
lı u c o s a m in e 书 畚
o r a ny co m p o n e n ts
in th e p re p a ra tio n

45 03 8 3 S T /3 2 17
 V IS T R Å W
o
a r n in gs an

f jo in t d is e a s e fo r
d P re c a tr tio n s

w h ic h
:

o th e r
D o c to r m u st be
tr e a tm e n t s h o u ı
co n su ı
te d to
d b e c o n s id e re d
ru le o u t th e p re s e n c e

1 U se w ith cau tio n in a s th m a tic p a tie n ts b e c a u s e it m a y in c re a s e ris k o f a s th m a tic

a tta c k
2 U se w ith c au tio n in d ia b e tic p a tie n ts o r p a tie n ts w it h im p a ir e d g lu c o s e

to le ra n c e m on ito rin g o y d u r in g tre a tm e n t

f th e b lo o d g lu c o s e re v e ıp e rio d ic a lı
D o sa ge a d ju s tm o r a n tid ia b e tic d ru g m a y b e n e c e s s a ry
ent o f in s u lin
3 L o n g te rm w h g u c o s a m in e m a y in c re a s e in s u lin re q u ire m a ì
i
tre a tm e n t
t ï t

P e rio d ic m o n ito r in g o f b lo o d g lu c o s e ıe v e t is re c o m m e n e d

4 In p a tie n ts w ith a k n o w n ris k fa c to r fo r c a rd io v a s c u ı a r d is e a s e m o n ito rin g o

f

th e b ı o o d p d le v e ls is re c o m m e n e
li i d d i h h ı
e s te ro le m ia h a s b e en
s nce yp e rc o

o b s e rv e d in a fe w c a s e s in p a tie n ts tre a te d w ith g lu c o s a m in e

C o m po sı tio n s E a c h s a c h e t c o n ta in s In te r a c tio n s w ith O th e r M e d ic a m e n ts

a n tic o a g u la n t e ffe c t o fw a rfa rin

fa te S o d iu m C h lo r id e
G tu c o s a m in e S u ı e q u iv a le n t to G lu co sam in e S u lfa te 1 5 o o 1 C o n c u rre n t tre a tm e n t w ith w a rfa r in m a y in c re a s e
m g
S o d iu m C o n te n t 1 5 1 1 6 m g /s a c h e t
2 ı
t m a y re duc e e ffe c tiv e n e s s o f a n tid ia b e tic s
V io le t p o w d e r P re g n a n c y a n d ı a c ta tio n T h e re is n o a d e q u a te d a ta o n th e s a fe u s E o f
p r D d u c t d e s c ń p tio n
de d
p h a r m a c o d y n a m ic s Gı u c o s a m in e is
a n o rm a ıc o n s titu e n t o f th e
p o ly s a c c h a rid e g u c o s a m n e n p re g n a n o r b re a s tfe e d in g w o m e n T h e re fo re it is n o t re c o m m
l i i t en

m a trix d
l flu id g ly c o s a m in o g ly c a n s G lu c o s a m in e
s y n o v ia in p re g n a n c y o r b re a s tfe e d in g
c h a in s o f c a rtiıa ge an
U n d e s ira b le ffe c ts T he m o st c o m m o n a d v e rs e re a c tio n s a s s o c ia te d w ith tr e a tm e n t
a te s th e s y n th e s is o f p y s io lo g ic a l g ly c o s a m in o g ly c a n s a n d p ro te o g [y c a n s
h e :
s tim u ı
w ith g lu c o s a m in e a re e p ig a s tric p a in o r tenderness heartburn d ia rrh e a a n d n a u s e a
b y c h o n d ro c y te s a n d o f h y a lu r o n ic a c id b y s y n o v io c y te s T h e m e c h a n is m o f a c tio n
is kn o w The f In a d d itio n h e a d a c h e in c re a s e d b lo o d p re s s u re tire d n e s s ra s h itc h in g a n d
o f g lu c o s a m in e in h u m ans u n n o nset o re s po nse c an no t be a sse sse d
R a p id l b io ila b ility f th e flu s h in g h a v e b e e n re p o r te d
p h a rm aco k in e ü c s o ra ava o co m po und w as fo un d w ith
O v e rd o s e a n d T re a tm en t : No c a se o f o v e rd o s e ha s b e e n re p o rte d
a v e rag e m a x im u m c o n c e n tra tio n s (C m a x ) in p la s m a in th e 1 0 LIM ra n ge a fte r
t or i tion : S t or e a t the t em p e r at ur e b e ıow 30 ° an d pr ot ec t from ılgh t ,
a b o u t 3 h o u rs d is trib u tio n to b o th v a s c u la r a n d e x tra v a s c u la r co m p a rtm e n ts
ag e co n d s

iz e d p re d o
D o sa ge Fo rm s a n d P a c k a g in g A va ila b le : p o w de r : 30 sac h e ts /b o x
u c o s a m in e is
Gı m e ta b o ı m in a n tly in th e liv e r to le r m o le c u le s a n d u
sm a ı ltim a te ly
to c a rb o n d io x id e w a te r a n d u re a An eı
im in a tio n h a lf ı
ife o f a p p ro x im a te ly 1 5 h o u rs th a t
la rg e ly ju s tifie s th e o nce d a ily d o s in g
re g im e n T h e p h a rm a c o kin e tic s o f g lu c o s a m in e

a re lin e a r in th e 75 0 1 5 0 0 g D o s e ra n g e w h iı
m e h ig h e r d o s e d e v ia te fro m lin e a r ity
M d b y : B a n g ko k La b & C o s m e tic C o , Ltd
a n u fa c tu re
The a bso ı u te b io a v a ila b ility is a b o u t 2 5 %
4 8 /1 M oo g s h a e s a o R d A m p u r M e u n g R a tc h a b u rí 7 0 0 0 0 T h a ila n d
5 N o n
In d ic a tio n R e lie f o f s y m p to m in p r im a ry o s te o a rth r itis o f th e k n e e
D is tr ib u te d b y : N B D H e a lth c a r e C o L td
R e co m m en de d do se t O
A duı ra l1 sac h e t d is s o lv e d in w a te r o n c e d a ily
8 9 8 S o i N u a n c h a n 5 6 N u a n c h a n B u e n g k u m B a n g k o k 1 0 2 4 0 T h a iı and
fo r 3 m o n th s C o n s u lt p h y s ic ia n if a re p e a te d c o u rs e is nee de d
T e l 0 279 1 3809
M o de o f A d m in is tra tio n O ra l
C o n tr a in d im ons P a tie n t w ho a lle rg y to s h e lfis h g ı
ı u c o s a m in e o r an y co m w »n e n ts
in th e p re p a ra tio n

A
50 3 83 S T 13 2 17
 il U ltıu
￠ ￡u n nwMnuuwwdriotngkdxiąđ
uhnfl l Ðu m m ì ￡u r
V lS T R /
lLa s J ıı* :

Į innin»ìfl ww ì au

1 N i lì niį wuı
auēůı
uìiFlMÐ
u$in nNì1uìdÐmtiÐımllĵ Rrinßutđ
2 Nit Ġ i luĦ11 ınH ii tu w ıu LU 1 M 7 1U 门
mìi]nn吖wiiį jRnilul i园
田

3 iÝlī￠ uìd$in￠ iÐ
ñ\ł uluRimllmĵñu山Ħ1 Ħlu lā Ðm a w - U ￥ Į wĦ￥uıđÐıqh

:
7 t￠iSìüniuopioãuqñaèí
4 神 Ü荫 Į 儿 。 ņiÐn 7 ĵ \fIĦÏ コ・ .- 旧 . - °。L丽a M N ì ì 加 1 W 5 ıi 叻il 。础 诮 Ð回
LIĴ uÌ uLWĴ ı
Ĵ z￠
IuĦÑÐ LiÏ ËÏ LmÐ
Ðil Tuu$ÐĦÐıqqlĠinu iį jnąīnqì￡ u

1 Uìđ
lwqnśĞhunì uqtlnıa lā a n a a q u ì w a r fa r in

d ı= n o u : lu 1 9 ÐQ 1hznauiıu G ı
u c o sa m in e s u lfa te s o d iu m c h lo r id e 2 wDÐ1 ĦUT nåwllaÐ n
«uìamr\JmlatuuiÐ
e q u iv a le n t to G lu c o s a m in e S u lfa te 1 5 0 0 x ln uì d ￡fa Li u u 1 5 1 1 6 a ln /56 o o đ
niifı
iāJimĦ iuNnî û«ìı
￥amT=Mj1t￠ ￥aflwaluq\řluı
iñÐ ñį mı
āinwusaÐ
*ıł
iniiiu+i W bh q n ąľ nuı§iuīuĉ ï mâimiua iï m u￥uduı
inĵ útajĦ
uinąlnÐ
ı ììii
iĮuìwilqaĦ
◆ň n « a fn « R ś nąīnmiiulauwdutuđ
ìuĵznĐuuÐ
qÑı
u p o ly s a c c h a r id e lu v S Ðuiuouumĵ

c a rtila ge M a trix tLĦ=S y n o v ia ï flu id G ly c o s a m in o g ly c a n s n ąīn u ì iil A u n ĵ z qu aı

mtailiioŊ
hsa«￠
i : anTlļ iiıiĵ aq￠
iÝlwuīiomēťhufll￡
nąinaı
iJu$a
c h o n d ro c y te s ı ￠i
Ĥ T 1n ii G ly c o s a m in o g ly c a n s LLĦ p ro te o g ly c a n 5 lLll￥nTiu
u lF ı Ðıninåuf U1niaq iÐqãm i ÐL Āu \lil lLÑuÐumqlqÐn uÐ
nf*inđ
ûqĐı
wu
s y n o v io c y te s 1 i Ħħ H y a lu r o n ic A c id lLPinalnmrÐ onqvrśaĐanąīĦ uSu ı u»tśd Ð1 m l q l m ĵ u q d Ðu L W u i $ u lLamlLnqldinuu1Ųìı
fmNĠiiiľafiĦ u
đajlñuńï lmudM T t》Eiū tx iiï ì u T 西口Ħın n n n i ĵ zuuı qztåuaanqĦ ś nrđ$UUı\ñuuTnlLĦz￡$inw : tłiìıuqıumuıuiu1lun
n u ı \ři j fl
m q a u m 《n ( ln ā h Ħu ĦĦn ś a Ð《u i n ąľ ĦÐl iJu g ã】
t￠ia u ım tn o dlw h a 7 5 o 15 o o iĵ Ħinšb īnunrĵ šuılzwru §
Ħııa l翻 翻 ś w q \iihłn m lńÐ

]FiTauluìmimaonqmś
a m ız n l l i i
ı
q n ıv ņá 1 n j 1 3 o c uiłilÐqlLđq
Įīluı ua￥auìnul\flii￠ ìudlu : U l a ū ØW q trw n u ì ì ìa Ðú ÐeiJUlu»t￠Ðui
\unĵ zu《 UiamoEiìı aĵ nUılm u iJF iì Ħııw し翻 翻 g ú iï n īn u la lulun- u a l a m 1 l u m 3590 nĦi n

u Ħw Ðn n ì nąlRaijudı
iÐĦ
lLÑ \Ë utĦ ĺgqnlqjiuuuljaqÝidiĺin ıilulwlanĦ fllin
n j1 Lõiu uĦ lufląnqt￠ ĺ lñuĦıÐ mÐ Ð nlÐöi LLA!Lŝ U FiTĦ ąq$固 山Ðqnnam w iin ï ñ u : § i n iibı
<i
Ðū \N iin
u fĽ n u l q n a n u /I \\Ðu i fı
u ì u i u n u 1 5 l N q \laiiFinJwıĺ u nıĵÐ Ðnqwâāinĵnĵ h H 1 n ı 2 5 % q
4 8 /1 v Į i5 n u u v u Ðq m iし们 Piìut】
hvl 1u10Laaıa qvììHqL 7 o o o o M t
Fï n u
w ı

# Ðl i* t$i ĽììumÐ1nnhRÐLliì\iÐ HH(im1IĵNñ ￠m d ì u tn u : u N n \âu o ii m a + u n ( ñíin

imd￡ ua=au1ñulfluunin : MĹU j ıl v n u i Áa ￥ 1 ø Ð ıaĪ nuï iū1ulqu?Ì u 898 ÐÐUUıaiłvk 5 6 \\m quamn$ \a n oq ￠
» n l ıw Iw ı 10 2 4 0 th m piln u
ń ólu i Ħ￠i Ð 3 LóiÐu 1 6 n u ì uwwúnìnñnìıal\ñuGioūt lm i 0 2 79 1 3809
iíÐ￠ i ëiñÐ
il łt￠ ı mìlLnąlĦ ali]UMÐiłuı
hnÐuàul ttłu ıđ