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Clinical Significance: T3
• Diagnostically, T3 concentration is more sensitive to certain thyroid conditions than T4.
• T4 levels are a sensitive (and superior) indicator of hypothyroidism, T3 blood levels better define hyperthyroidism.
• Because T3 concentration in serum changes faster and more markedly than T4, the T3 level is also an excellent indicator of the ability of
the thyroid to respond to both stimulatory and suppressive tests.
• Under conditions of strong thyroid stimulation, the T3 level offers a good estimation of thyroidal reserve as well.
Clinical Significance: T4
• Thyroxine (T4) is a hormone synthesized and secreted by the thyroid gland, and plays an important role in regulating metabolism.
• Primary malfunction of the thyroid gland may result in excessive (hyper) or below normal (hypo) release of T4 or T3.
• Thyroid function is directly affected by TSH and malfunction of the pituitary or the hypothalamus influences the thyroid gland activity.
• Disease in any portion of the thyroid-pituitary-hypothalamus system may influence the levels of T4 and T3 in the blood.
Mr Krishna Dr G Srinivas
Verified by Director - Lab Services
Note: Please contact us for possible remedial action if test results are unexpected.
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